Prps2 (phosphoribosyl pyrophosphate synthetase 2) - Rat Genome Database

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Gene: Prps2 (phosphoribosyl pyrophosphate synthetase 2) Rattus norvegicus
Analyze
Symbol: Prps2
Name: phosphoribosyl pyrophosphate synthetase 2
RGD ID: 3415
Description: Enables several functions, including magnesium ion binding activity; purine ribonucleotide binding activity; and ribose phosphate diphosphokinase activity. Involved in 5-phosphoribose 1-diphosphate biosynthetic process; AMP biosynthetic process; and animal organ regeneration. Part of ribose phosphate diphosphokinase complex. Orthologous to human PRPS2 (phosphoribosyl pyrophosphate synthetase 2); PARTICIPATES IN de novo purine biosynthetic pathway; pentose phosphate pathway; purine metabolic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC100910245; Phophoribosylpyrophosphate synthetase subunit II; Phophoribosylpyrophosphate synthetase, subunit II; phosphoribosyl pyrophosphate synthase II; phosphoribosyl pyrophosphate synthetase II; PRS-II; ribose-phosphate pyrophosphokinase 2; ribose-phosphate pyrophosphokinase 2-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: QTLs:   Iddm5  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X30,592,845 - 30,630,127 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX30,593,019 - 30,630,126 (+)EnsemblGRCr8
mRatBN7.2X26,975,915 - 27,013,184 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX26,976,061 - 27,013,181 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX28,044,842 - 28,082,133 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X31,451,654 - 31,486,764 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X27,662,446 - 27,699,733 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X28,435,275 - 28,472,882 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX28,435,507 - 28,472,880 (+)Ensemblrn6Rnor6.0
Rnor_5.0X28,831,387 - 28,868,992 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X47,274,362 - 47,315,274 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX27,388,118 - 27,424,061 (+)NCBICelera
RGSC_v3.1X47,327,830 - 47,368,743 (+)NCBI
Cytogenetic MapXq13NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
cetrorelix  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
ethanol  (EXP,ISO)
fenvalerate  (EXP)
gentamycin  (EXP)
hexane  (EXP)
indometacin  (EXP)
ivermectin  (ISO)
kojic acid  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
microcystin RR  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitrates  (ISO)
Nutlin-3  (ISO)
ozone  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
sulforaphane  (ISO)
tanespimycin  (ISO)
temozolomide  (ISO)
testosterone enanthate  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Pediatric neurological syndromes and inborn errors of purine metabolism. Camici M, etal., Neurochem Int. 2010 Feb;56(3):367-78. Epub 2009 Dec 11.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Partial reconstitution of mammalian phosphoribosylpyrophosphate synthetase in Escherichia coli cells. Coexpression of catalytic subunits with the 39-kDa associated protein leads to formation of soluble multimeric complexes of various compositions. Ishijima S, etal., Biochim Biophys Acta. 1997 Sep 26;1342(1):28-36.
5. Expression of rat phosphoribosylpyrophosphate synthetase subunits I and II in Escherichia coli. Isolation and characterization of the recombinant isoforms. Ishijima S, etal., J Biol Chem. 1991 Aug 25;266(24):15693-7.
6. Complete cDNA sequence of rat phosphoribosylpyrophosphate synthetase subunit II (PRS II). Ishijima S, etal., Nucleic Acids Res 1989 Nov 11;17(21):8859.
7. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
8. Rat liver phosphoribosyl pyrophosphate synthetase: existence of the purified enzyme as heterogeneous aggregates and identification of the catalytic subunit. Kita K, etal., J Biochem. 1989 May;105(5):736-41.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Rat liver phosphoribosylpyrophosphate synthetase is activated by free Mg2+ in a manner that overcomes its inhibition by nucleotides. Sonoda T, etal., Biochim Biophys Acta. 1998 Sep 8;1387(1-2):32-40.
15. Kinetic and regulatory properties of rat liver phosphoribosylpyrophosphate synthetase complex are partly distinct from those of isolated recombinant component catalytic subunits. Sonoda T, etal., J Biochem. 1997 Sep;122(3):635-40.
16. Nucleotide and deduced amino acid sequences of two distinct cDNAs for rat phosphoribosylpyrophosphate synthetase. Taira M, etal., J Biol Chem 1987 Nov 5;262(31):14867-70.
Additional References at PubMed
PMID:23376485   PMID:25416956   PMID:28259758   PMID:35352799  


Genomics

Comparative Map Data
Prps2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X30,592,845 - 30,630,127 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX30,593,019 - 30,630,126 (+)EnsemblGRCr8
mRatBN7.2X26,975,915 - 27,013,184 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX26,976,061 - 27,013,181 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX28,044,842 - 28,082,133 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X31,451,654 - 31,486,764 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X27,662,446 - 27,699,733 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X28,435,275 - 28,472,882 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX28,435,507 - 28,472,880 (+)Ensemblrn6Rnor6.0
Rnor_5.0X28,831,387 - 28,868,992 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X47,274,362 - 47,315,274 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX27,388,118 - 27,424,061 (+)NCBICelera
RGSC_v3.1X47,327,830 - 47,368,743 (+)NCBI
Cytogenetic MapXq13NCBI
PRPS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X12,791,412 - 12,824,222 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX12,791,355 - 12,824,222 (+)Ensemblhg38GRCh38
GRCh37X12,809,531 - 12,842,341 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X12,719,414 - 12,752,264 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34X12,569,187 - 12,601,996NCBI
CeleraX16,923,480 - 16,956,355 (+)NCBICelera
Cytogenetic MapXp22.2NCBI
HuRefX10,576,287 - 10,608,838 (+)NCBIHuRef
CHM1_1X12,839,890 - 12,872,768 (+)NCBICHM1_1
T2T-CHM13v2.0X12,372,896 - 12,405,716 (+)NCBIT2T-CHM13v2.0
Prps2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X166,129,316 - 166,165,887 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX166,129,318 - 166,165,745 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38X167,346,320 - 167,382,872 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX167,346,322 - 167,382,749 (-)Ensemblmm10GRCm38
MGSCv37X163,784,265 - 163,820,631 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X162,690,438 - 162,726,804 (-)NCBIMGSCv36mm8
CeleraX150,519,899 - 150,556,214 (-)NCBICelera
Cytogenetic MapXF5NCBI
cM MapX78.32NCBI
Prps2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955544478,954 - 512,614 (-)Ensembl
ChiLan1.0NW_004955544480,587 - 512,019 (-)NCBIChiLan1.0ChiLan1.0
PRPS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X14,575,640 - 14,608,923 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X14,579,306 - 14,612,589 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X5,403,465 - 5,436,751 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X12,693,286 - 12,726,355 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX12,693,286 - 12,726,355 (+)EnsemblpanPan2panpan1.1
PRPS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X9,281,686 - 9,326,551 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX9,281,730 - 9,418,289 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_TashaX9,237,918 - 9,283,251 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0X9,233,376 - 9,278,743 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX9,233,390 - 9,275,394 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X9,217,987 - 9,263,321 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X9,257,264 - 9,302,594 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X9,249,560 - 9,294,897 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Prps2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X2,547,014 - 2,576,951 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364702,546,985 - 2,576,953 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364702,547,038 - 2,576,951 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRPS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX9,503,953 - 9,530,086 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X9,505,034 - 9,531,044 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X10,404,804 - 10,432,367 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRPS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X11,282,248 - 11,316,214 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX11,282,389 - 11,316,423 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605613,074,038 - 13,107,909 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prps2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248821,456,572 - 1,489,605 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248821,456,885 - 1,489,489 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Prps2
264 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:627
Count of miRNA genes:298
Interacting mature miRNAs:380
Transcripts:ENSRNOT00000005615
Prediction methods:Microtar, Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598873Memor2Memory QTL 22.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)X2099094741052531Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
2290375Gluco34Glucose level QTL 342.75blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X2099094741203591Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat

Markers in Region
DXWox6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X26,976,075 - 26,976,219 (+)MAPPERmRatBN7.2
Rnor_6.0X29,157,379 - 29,157,522NCBIRnor6.0
Rnor_6.0X28,435,436 - 28,435,579NCBIRnor6.0
Rnor_5.0X29,545,768 - 29,545,911UniSTSRnor5.0
Rnor_5.0X28,831,548 - 28,831,691UniSTSRnor5.0
RGSC_v3.4X47,274,522 - 47,274,666RGDRGSC3.4
RGSC_v3.4X47,274,523 - 47,274,666UniSTSRGSC3.4
CeleraX27,388,279 - 27,388,422UniSTS
RGSC_v3.1X47,327,991 - 47,328,135RGD
Cytogenetic MapXq21UniSTS
DXWox14  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8X30,592,981 - 30,593,203 (+)Marker Load Pipeline
mRatBN7.2X26,976,051 - 26,976,273 (+)MAPPERmRatBN7.2
Rnor_6.0X29,157,355 - 29,157,576NCBIRnor6.0
Rnor_6.0X28,435,412 - 28,435,633NCBIRnor6.0
Rnor_5.0X28,831,524 - 28,831,745UniSTSRnor5.0
Rnor_5.0X29,545,744 - 29,545,965UniSTSRnor5.0
RGSC_v3.4X47,274,499 - 47,274,720UniSTSRGSC3.4
RGSC_v3.4X47,274,498 - 47,274,720RGDRGSC3.4
CeleraX27,388,255 - 27,388,476UniSTS
RGSC_v3.1X47,327,967 - 47,328,189RGD
RH 3.4 MapX327.0UniSTS
RH 3.4 MapX327.0RGD
RH 2.0 Map21270.1RGD
Cytogenetic MapXq21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000005615   ⟹   ENSRNOP00000005615
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX30,593,019 - 30,630,126 (+)Ensembl
mRatBN7.2 EnsemblX26,976,061 - 27,013,181 (+)Ensembl
Rnor_6.0 EnsemblX28,435,507 - 28,472,880 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000081986   ⟹   ENSRNOP00000069408
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX29,157,470 - 29,176,539 (+)Ensembl
RefSeq Acc Id: NM_012634   ⟹   NP_036766
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X30,592,845 - 30,629,014 (+)NCBI
mRatBN7.2X26,975,915 - 27,012,069 (+)NCBI
Rnor_6.0X28,435,275 - 28,471,767 (+)NCBI
Rnor_5.0X28,831,387 - 28,868,992 (+)NCBI
RGSC_v3.4X47,274,362 - 47,315,274 (+)RGD
CeleraX27,388,118 - 27,424,061 (+)RGD
Sequence:
RefSeq Acc Id: XM_006256829   ⟹   XP_006256891
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X30,592,985 - 30,630,127 (+)NCBI
mRatBN7.2X26,976,060 - 27,013,184 (+)NCBI
Rnor_6.0X28,435,411 - 28,472,882 (+)NCBI
Rnor_5.0X28,831,387 - 28,868,992 (+)NCBI
Sequence:
RefSeq Acc Id: NP_036766   ⟸   NM_012634
- UniProtKB: Q63462 (UniProtKB/Swiss-Prot),   P09330 (UniProtKB/Swiss-Prot),   A6K2F9 (UniProtKB/TrEMBL),   A0A8L2R3X1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256891   ⟸   XM_006256829
- Peptide Label: isoform X1
- UniProtKB: A0A8L2Q1L2 (UniProtKB/TrEMBL),   A0A8L2R3X1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005615   ⟸   ENSRNOT00000005615
Ensembl Acc Id: ENSRNOP00000069408   ⟸   ENSRNOT00000081986
Protein Domains
Ribose-phosphate pyrophosphokinase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JVA5-F1-model_v2 AlphaFold A0A0G2JVA5 1-203 view protein structure
AF-P09330-F1-model_v2 AlphaFold P09330 1-318 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3415 AgrOrtholog
BioCyc Gene G2FUF-2663 BioCyc
BioCyc Pathway PWY0-662 [PRPP biosynthesis] BioCyc
BioCyc Pathway Image PWY0-662 BioCyc
Ensembl Genes ENSRNOG00000004160 Ensembl, ENTREZGENE
  ENSRNOG00000052455 Ensembl
Ensembl Transcript ENSRNOT00000005615 ENTREZGENE
Gene3D-CATH 3.40.50.2020 UniProtKB/Swiss-Prot
InterPro PRib_PP_synth_CS UniProtKB/Swiss-Prot
  Pribosyltran_N UniProtKB/Swiss-Prot
  PRibTrfase_dom UniProtKB/Swiss-Prot
  PRTase-like UniProtKB/Swiss-Prot
  Rib-P_diPkinase UniProtKB/Swiss-Prot
  Rib-P_diPkinase_bac UniProtKB/Swiss-Prot
KEGG Report rno:24689 UniProtKB/Swiss-Prot
NCBI Gene 24689 ENTREZGENE
PANTHER PTHR10210 UniProtKB/Swiss-Prot
  RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 2 UniProtKB/Swiss-Prot
Pfam Pribosyl_synth UniProtKB/Swiss-Prot
  Pribosyltran_N UniProtKB/Swiss-Prot
PhenoGen Prps2 PhenoGen
PROSITE PRPP_SYNTHASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000004160 RatGTEx
  ENSRNOG00000052455 RatGTEx
SMART Pribosyltran_N UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53271 UniProtKB/Swiss-Prot
UniProt A0A8L2Q1L2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2R3X1 ENTREZGENE, UniProtKB/TrEMBL
  A6K2F9 ENTREZGENE, UniProtKB/TrEMBL
  A6K2G0_RAT UniProtKB/TrEMBL
  P09330 ENTREZGENE, UniProtKB/Swiss-Prot
  Q63462 ENTREZGENE
UniProt Secondary Q63462 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Prps2  phosphoribosyl pyrophosphate synthetase 2  LOC100910245  ribose-phosphate pyrophosphokinase 2-like  Data merged from RGD:6499548 737654 PROVISIONAL
2012-07-05 LOC100910245  ribose-phosphate pyrophosphokinase 2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2003-04-09 Prps2  phosphoribosyl pyrophosphate synthetase 2    Phophoribosylpyrophosphate synthetase, subunit II  Name updated 629478 APPROVED
2002-06-10 Prps2  Phophoribosylpyrophosphate synthetase, subunit II      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation expression induced by partial hepatectomy 633743