Prlr (prolactin receptor) - Rat Genome Database

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Gene: Prlr (prolactin receptor) Rattus norvegicus
Analyze
Symbol: Prlr
Name: prolactin receptor
RGD ID: 3407
Description: Enables prolactin receptor activity and protein kinase binding activity. Involved in cellular response to granulocyte macrophage colony-stimulating factor stimulus; positive regulation of B cell proliferation; and positive regulation of protein autophosphorylation. Predicted to be located in cell surface. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in hyperprolactinemia. Orthologous to human PRLR (prolactin receptor); PARTICIPATES IN cytokine mediated signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: lactogen receptor; MGC105486; PRL-R; RATPRLR
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   SD   SS.LEW-(Prlr-D2Rat143)/Ayd  
QTLs:   Bp99   Smcn1   Bp270  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2259,134,147 - 59,324,719 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl259,134,588 - 59,324,718 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx266,245,300 - 66,425,431 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0264,366,825 - 64,546,955 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0259,368,154 - 59,548,295 (+)NCBIRnor_WKY
Rnor_6.0260,131,410 - 60,325,686 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl260,131,776 - 60,325,692 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0284,360,850 - 84,554,681 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4259,507,966 - 59,701,221 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1259,485,049 - 59,629,454 (+)NCBI
Celera259,347,111 - 59,534,658 (-)NCBICelera
Cytogenetic Map2q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
2-methoxyethanol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,7-dihydropurine-6-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
Azaspiracid  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Butylparaben  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
capsaicin  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroquine  (EXP)
chlorpyrifos  (ISO)
chromium(6+)  (EXP,ISO)
clofibric acid  (EXP)
clothianidin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cyproconazole  (ISO)
cyproterone acetate  (EXP)
DDT  (ISO)
dexamethasone  (EXP)
dextran sulfate  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP)
diethylstilbestrol  (EXP)
doxorubicin  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
ethylenediaminetetraacetic acid  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glycidol  (EXP)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
irinotecan  (EXP)
latrunculin A  (ISO)
lead diacetate  (EXP)
leflunomide  (EXP)
magnesium atom  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
mercaptopurine  (EXP)
metacetamol  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury(1+)  (EXP)
methylparaben  (ISO)
methylphenidate  (ISO)
metoclopramide  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-L-cysteine  (EXP)
N-nitrosodiethylamine  (EXP)
naproxen  (EXP)
nickel atom  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
orphenadrine  (EXP)
oxycodone  (EXP)
paracetamol  (ISO)
parathion  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (EXP)
prednisolone  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (EXP,ISO)
propiconazole  (ISO)
prostaglandin F2alpha  (EXP)
purine-6-thiol  (EXP)
silicon dioxide  (ISO)
sirolimus  (EXP)
sodium arsenite  (ISO)
sulforaphane  (ISO)
sulpiride  (EXP)
sumatriptan  (EXP)
tacrolimus hydrate  (EXP)
tamoxifen  (EXP,ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (EXP)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
theophylline  (ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A prolactin-dependent immune cell line (Nb2) expresses a mutant form of prolactin receptor. Ali S, etal., J Biol Chem 1991 Oct 25;266(30):20110-7.
2. Modulation of growth factor receptor function by isoform heterodimerization. Chang WP and Clevenger CV, Proc Natl Acad Sci U S A. 1996 Jun 11;93(12):5947-52. doi: 10.1073/pnas.93.12.5947.
3. Stoichiometric structure-function analysis of the prolactin receptor signaling domain by receptor chimeras. Chang WP, etal., Mol Cell Biol. 1998 Feb;18(2):896-905. doi: 10.1128/MCB.18.2.896.
4. The protein tyrosine kinase P59fyn is associated with prolactin (PRL) receptor and is activated by PRL stimulation of T-lymphocytes. Clevenger CV and Medaglia MV, Mol Endocrinol. 1994 Jun;8(6):674-81.
5. Mapping of a quantitative trait locus for blood pressure on rat chromosome 2. Deng AY, etal., J Clin Invest 1994 Jul;94(1):431-6
6. Mapping of rat chromosome 2 markers generated from chromosome-sorted DNA. Deng AY, etal., Mamm Genome 1997 Oct;8(10):731-5.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. Sex difference and estrous cycle: expression of prolactin receptor mRNA in rat brain. Pi X and Voogt JL, Brain Res Mol Brain Res 2002 Jun 30;103(1-2):130-9.
13. Detection of prolactin receptor mRNA in the corpus striatum and substantia nigra of the rat. Pi X, etal., J Neurosci Res 2002 Feb 15;67(4):551-8.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. Characterization of a rat uterine cell line, U(III) cells: prolactin (PRL) expression and endogenous regulation of PRL-dependent genes; estrogen receptor beta, alpha(2)-macroglobulin, and decidual PRL involving the Jak2 and Stat5 pathway. Prigent-Tessier A, etal., Endocrinology 2001 Mar;142(3):1242-50.
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Global gene expression profiling of chemically induced rat mammary gland carcinomas and adenomas. Shan L, etal., Toxicol Pathol. 2005;33(7):768-75.
19. Identification of a novel first exon of prolactin receptor gene expressed in the rat brain. Tanaka M, etal., Endocrinology 2002 Jun;143(6):2080-4.
20. Prolactin receptor signaling is essential for perinatal brown adipocyte function: a role for insulin-like growth factor-2. Viengchareun S, etal., PLoS One. 2008 Feb 6;3(2):e1535. doi: 10.1371/journal.pone.0001535.
Additional References at PubMed
PMID:2159291   PMID:2293022   PMID:2832068   PMID:6303755   PMID:7929319   PMID:7984244   PMID:9632658   PMID:10585417   PMID:11445538   PMID:11706048   PMID:11735251   PMID:11862718  
PMID:12040017   PMID:12477932   PMID:12673052   PMID:12782310   PMID:12810576   PMID:12865306   PMID:12914538   PMID:15845620   PMID:16107292   PMID:16280030   PMID:16469767   PMID:16489923  
PMID:17317019   PMID:17322574   PMID:17433256   PMID:17620100   PMID:17785459   PMID:18092198   PMID:18313837   PMID:18372733   PMID:18665386   PMID:18679052   PMID:18765257   PMID:19103603  
PMID:20462969   PMID:21177834   PMID:21508351   PMID:22977841   PMID:23012479   PMID:24114406   PMID:25446202   PMID:26874070   PMID:30500398  


Genomics

Comparative Map Data
Prlr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2259,134,147 - 59,324,719 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl259,134,588 - 59,324,718 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx266,245,300 - 66,425,431 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0264,366,825 - 64,546,955 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0259,368,154 - 59,548,295 (+)NCBIRnor_WKY
Rnor_6.0260,131,410 - 60,325,686 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl260,131,776 - 60,325,692 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0284,360,850 - 84,554,681 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4259,507,966 - 59,701,221 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1259,485,049 - 59,629,454 (+)NCBI
Celera259,347,111 - 59,534,658 (-)NCBICelera
Cytogenetic Map2q16NCBI
PRLR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38535,048,756 - 35,230,487 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl535,048,756 - 35,230,487 (-)EnsemblGRCh38hg38GRCh38
GRCh37535,048,861 - 35,230,589 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36535,099,985 - 35,266,334 (-)NCBINCBI36Build 36hg18NCBI36
Build 34535,099,984 - 35,266,334NCBI
Celera534,937,982 - 35,112,885 (-)NCBICelera
Cytogenetic Map5p13.2NCBI
HuRef534,997,595 - 35,179,481 (-)NCBIHuRef
CHM1_1535,051,181 - 35,233,094 (-)NCBICHM1_1
T2T-CHM13v2.0535,295,805 - 35,477,471 (-)NCBIT2T-CHM13v2.0
Prlr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391510,177,324 - 10,349,276 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1510,177,324 - 10,349,266 (+)EnsemblGRCm39 Ensembl
GRCm381510,177,238 - 10,349,190 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1510,177,238 - 10,349,180 (+)EnsemblGRCm38mm10GRCm38
MGSCv371510,106,993 - 10,266,775 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361510,122,380 - 10,274,111 (+)NCBIMGSCv36mm8
Celera159,973,912 - 10,134,326 (+)NCBICelera
Cytogenetic Map15A1NCBI
cM Map155.23NCBI
Prlr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542620,168,830 - 20,326,840 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542620,161,406 - 20,326,688 (-)NCBIChiLan1.0ChiLan1.0
PRLR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1580,420,061 - 80,585,559 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl580,532,058 - 80,600,403 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0575,139,852 - 75,321,695 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PRLR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1473,147,919 - 73,280,970 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl473,110,858 - 73,273,916 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha472,720,596 - 72,897,403 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0473,614,203 - 73,786,894 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl473,614,226 - 73,779,840 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1473,362,835 - 73,534,628 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0473,486,988 - 73,657,508 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0474,020,052 - 74,186,420 (+)NCBIUU_Cfam_GSD_1.0
Prlr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213224,874,923 - 225,019,820 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365186,473,536 - 6,487,757 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365186,352,133 - 6,495,242 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRLR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1620,618,875 - 20,810,140 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11620,637,568 - 20,655,881 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21621,520,678 - 21,569,349 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRLR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1433,933,601 - 34,108,653 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl433,949,935 - 34,108,619 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607124,243,842 - 24,414,480 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prlr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475919,653,600 - 19,833,848 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475919,653,626 - 19,836,877 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prlr
1016 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:350
Count of miRNA genes:208
Interacting mature miRNAs:252
Transcripts:ENSRNOT00000023941, ENSRNOT00000023960, ENSRNOT00000059970, ENSRNOT00000059973
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
5684990Bmd82Bone mineral density QTL 822.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)259324377103795077Rat
5684996Bmd85Bone mineral density QTL 854.70.024tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)259324377103795077Rat
6480225Gdil1Gastrointestinal dilation QTL 1enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)25666087974786777Rat
631500Bp99Blood pressure QTL 992.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)259324719102755241Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22715716072157160Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)24280460760653831Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1354592Rf50Renal function QTL 503.5urine output (VT:0003620)timed urine volume (CMO:0000260)25382274774786777Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22691781781754745Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)259134147127460910Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
1579916Bp270Blood pressure QTL 2700.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)25653191259324719Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23513484188029593Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)259324377141596857Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
631208Bw1Body weight QTL15.09mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)24317101783575226Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23502311780023117Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243162366111362592Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
10755434Coatc7Coat color QTL 70.04794coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23064806575648065Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)243162366111362592Rat
1582246Cm60Cardiac mass QTL 605.8heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)25760561276539510Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)240067944102785628Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat

Markers in Region
D2Wox14  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2259,324,454 - 59,324,636 (+)MAPPERmRatBN7.2
Rnor_6.0260,325,429 - 60,325,610NCBIRnor6.0
Rnor_5.0284,360,926 - 84,361,107UniSTSRnor5.0
RGSC_v3.4259,700,964 - 59,701,145UniSTSRGSC3.4
RGSC_v3.4259,700,963 - 59,701,145RGDRGSC3.4
Celera259,347,187 - 59,347,368UniSTS
Cytogenetic Map2q16UniSTS
D2Mit24  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2259,324,377 - 59,324,691 (+)MAPPERmRatBN7.2
Rnor_6.0260,325,352 - 60,325,665NCBIRnor6.0
Rnor_5.0284,360,871 - 84,361,184UniSTSRnor5.0
RGSC_v3.4259,700,886 - 59,701,200RGDRGSC3.4
RGSC_v3.4259,700,887 - 59,701,200UniSTSRGSC3.4
RGSC_v3.1259,629,119 - 59,629,433RGD
Celera259,347,132 - 59,347,445UniSTS
RH 3.4 Map2408.7UniSTS
RH 3.4 Map2408.7RGD
Cytogenetic Map2q16UniSTS
D2Arb6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2259,324,307 - 59,324,662 (+)MAPPERmRatBN7.2
Rnor_6.0260,325,282 - 60,325,636NCBIRnor6.0
Rnor_5.0284,360,900 - 84,361,254UniSTSRnor5.0
RGSC_v3.4259,700,816 - 59,701,171RGDRGSC3.4
RGSC_v3.4259,700,817 - 59,701,171UniSTSRGSC3.4
RGSC_v3.1259,629,049 - 59,629,404RGD
Celera259,347,161 - 59,347,515UniSTS
SHRSP x BN Map227.5198UniSTS
SHRSP x BN Map227.5198RGD
Cytogenetic Map2q16UniSTS
D12Uia2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2259,172,704 - 59,172,974 (+)MAPPERmRatBN7.2
Rnor_6.0260,170,165 - 60,170,434NCBIRnor6.0
Rnor_5.0284,516,208 - 84,516,477UniSTSRnor5.0
RGSC_v3.4259,547,040 - 59,547,307RGDRGSC3.4
RGSC_v3.4259,547,038 - 59,547,307UniSTSRGSC3.4
RGSC_v3.1259,475,273 - 59,475,540RGD
Celera259,496,188 - 59,496,561UniSTS
Cytogenetic Map2q16UniSTS
D2Chm280  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2259,179,853 - 59,180,074 (+)MAPPERmRatBN7.2
Rnor_6.0260,177,314 - 60,177,534NCBIRnor6.0
Rnor_5.0284,509,108 - 84,509,328UniSTSRnor5.0
RGSC_v3.4259,554,187 - 59,554,407UniSTSRGSC3.4
Celera259,489,085 - 59,489,305UniSTS
Cytogenetic Map2q16UniSTS
Prlr  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2259,290,897 - 59,291,032 (+)MAPPERmRatBN7.2
Rnor_6.0260,285,969 - 60,286,103NCBIRnor6.0
Rnor_5.0284,400,544 - 84,400,678UniSTSRnor5.0
RGSC_v3.4259,666,361 - 59,666,495UniSTSRGSC3.4
Celera259,378,767 - 59,378,901UniSTS
Cytogenetic Map2q16UniSTS
Prlr  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2259,306,261 - 59,306,381 (+)MAPPERmRatBN7.2
Rnor_6.0260,307,857 - 60,307,976NCBIRnor6.0
Rnor_6.0260,298,031 - 60,298,150NCBIRnor6.0
Rnor_5.0284,378,241 - 84,378,360UniSTSRnor5.0
Rnor_5.0284,388,496 - 84,388,615UniSTSRnor5.0
RGSC_v3.4259,681,382 - 59,681,501UniSTSRGSC3.4
Celera259,365,410 - 59,365,529UniSTS
Cytogenetic Map2q16UniSTS


Related Rat Strains
The following Strains have been annotated to Prlr


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 25 17 17 23 5
Low 3 3 15 8 16 8 8 8 40 12 30 9 8
Below cutoff 12 9 8 3 8 1 30 4 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001034111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB071022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC092133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L48060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M19304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M34083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M57668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M74152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U07567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U34730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z83758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000080786   ⟹   ENSRNOP00000072948
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl259,134,588 - 59,306,557 (+)Ensembl
Rnor_6.0 Ensembl260,131,776 - 60,308,152 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000080974   ⟹   ENSRNOP00000074428
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl259,172,057 - 59,324,718 (+)Ensembl
Rnor_6.0 Ensembl260,169,517 - 60,325,692 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000084624   ⟹   ENSRNOP00000073622
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl259,182,484 - 59,319,599 (+)Ensembl
Rnor_6.0 Ensembl260,180,215 - 60,325,671 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000099452   ⟹   ENSRNOP00000081286
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl259,182,484 - 59,323,442 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000110246   ⟹   ENSRNOP00000081145
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl259,182,484 - 59,324,218 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000116300   ⟹   ENSRNOP00000082145
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl259,288,838 - 59,306,559 (+)Ensembl
RefSeq Acc Id: NM_001034111   ⟹   NP_001029283
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2259,134,588 - 59,306,557 (+)NCBI
Rnor_6.0260,131,776 - 60,308,152 (+)NCBI
Rnor_5.0284,360,850 - 84,554,681 (-)NCBI
RGSC_v3.4259,507,966 - 59,701,221 (+)RGD
Celera259,365,234 - 59,534,658 (-)NCBI
Sequence:
RefSeq Acc Id: NM_012630   ⟹   NP_036762
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2259,182,484 - 59,324,712 (+)NCBI
Rnor_6.0260,180,215 - 60,325,686 (+)NCBI
Rnor_5.0284,360,850 - 84,554,681 (-)NCBI
RGSC_v3.4259,507,966 - 59,701,221 (+)RGD
Celera259,347,111 - 59,486,679 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039101745   ⟹   XP_038957673
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2259,270,506 - 59,316,685 (+)NCBI
RefSeq Acc Id: XM_039101746   ⟹   XP_038957674
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2259,134,147 - 59,316,685 (+)NCBI
RefSeq Acc Id: XM_039101747   ⟹   XP_038957675
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2259,166,190 - 59,316,685 (+)NCBI
RefSeq Acc Id: XM_039101748   ⟹   XP_038957676
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2259,213,756 - 59,316,685 (+)NCBI
RefSeq Acc Id: XM_039101749   ⟹   XP_038957677
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2259,166,190 - 59,316,685 (+)NCBI
RefSeq Acc Id: XM_039101750   ⟹   XP_038957678
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2259,213,756 - 59,316,685 (+)NCBI
RefSeq Acc Id: XM_039101751   ⟹   XP_038957679
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2259,270,511 - 59,324,367 (+)NCBI
RefSeq Acc Id: XM_039101752   ⟹   XP_038957680
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2259,168,868 - 59,324,719 (+)NCBI
RefSeq Acc Id: XM_039101753   ⟹   XP_038957681
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2259,134,150 - 59,324,367 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001029283 (Get FASTA)   NCBI Sequence Viewer  
  NP_036762 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957673 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957674 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957675 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957676 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957677 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957678 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957679 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957680 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957681 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41937 (Get FASTA)   NCBI Sequence Viewer  
  AAA41938 (Get FASTA)   NCBI Sequence Viewer  
  AAA41946 (Get FASTA)   NCBI Sequence Viewer  
  AAA61784 (Get FASTA)   NCBI Sequence Viewer  
  AAA79273 (Get FASTA)   NCBI Sequence Viewer  
  AAA79274 (Get FASTA)   NCBI Sequence Viewer  
  AAA92053 (Get FASTA)   NCBI Sequence Viewer  
  AAH92133 (Get FASTA)   NCBI Sequence Viewer  
  CAB06043 (Get FASTA)   NCBI Sequence Viewer  
  EDL82998 (Get FASTA)   NCBI Sequence Viewer  
  EDL82999 (Get FASTA)   NCBI Sequence Viewer  
  EDL83000 (Get FASTA)   NCBI Sequence Viewer  
  EDL83001 (Get FASTA)   NCBI Sequence Viewer  
  EDL83002 (Get FASTA)   NCBI Sequence Viewer  
  EDL83003 (Get FASTA)   NCBI Sequence Viewer  
  EDL83004 (Get FASTA)   NCBI Sequence Viewer  
  EDL83005 (Get FASTA)   NCBI Sequence Viewer  
  EDL83006 (Get FASTA)   NCBI Sequence Viewer  
  EDL83007 (Get FASTA)   NCBI Sequence Viewer  
  EDL83008 (Get FASTA)   NCBI Sequence Viewer  
  P05710 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_036762   ⟸   NM_012630
- Peptide Label: isoform b precursor
- UniProtKB: P05710 (UniProtKB/Swiss-Prot),   Q58DZ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001029283   ⟸   NM_001034111
- Peptide Label: isoform a precursor
- UniProtKB: P05710 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072948   ⟸   ENSRNOT00000080786
RefSeq Acc Id: ENSRNOP00000073622   ⟸   ENSRNOT00000084624
RefSeq Acc Id: ENSRNOP00000074428   ⟸   ENSRNOT00000080974
RefSeq Acc Id: XP_038957674   ⟸   XM_039101746
- Peptide Label: isoform X1
- UniProtKB: Q64274 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038957681   ⟸   XM_039101753
- Peptide Label: isoform X2
- UniProtKB: Q58DZ7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957675   ⟸   XM_039101747
- Peptide Label: isoform X1
- UniProtKB: Q64274 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038957677   ⟸   XM_039101749
- Peptide Label: isoform X1
- UniProtKB: Q64274 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038957680   ⟸   XM_039101752
- Peptide Label: isoform X2
- UniProtKB: Q58DZ7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957676   ⟸   XM_039101748
- Peptide Label: isoform X1
- UniProtKB: Q64274 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038957678   ⟸   XM_039101750
- Peptide Label: isoform X1
- UniProtKB: Q64274 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038957673   ⟸   XM_039101745
- Peptide Label: isoform X1
- UniProtKB: Q64274 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038957679   ⟸   XM_039101751
- Peptide Label: isoform X2
- UniProtKB: Q58DZ7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000081145   ⟸   ENSRNOT00000110246
RefSeq Acc Id: ENSRNOP00000081286   ⟸   ENSRNOT00000099452
RefSeq Acc Id: ENSRNOP00000082145   ⟸   ENSRNOT00000116300
Protein Domains
EpoR_lig-bind   Fibronectin type-III

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P05710-F1-model_v2 AlphaFold P05710 1-610 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691181
Promoter ID:EPDNEW_R1706
Type:initiation region
Name:Prlr_1
Description:prolactin receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0260,180,256 - 60,180,316EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3407 AgrOrtholog
BioCyc Gene G2FUF-54086 BioCyc
Ensembl Genes ENSRNOG00000057557 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000072948 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOP00000073622 ENTREZGENE
  ENSRNOP00000073622.2 UniProtKB/TrEMBL
  ENSRNOP00000074428 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOP00000081145.1 UniProtKB/TrEMBL
  ENSRNOP00000081286.1 UniProtKB/TrEMBL
  ENSRNOP00000082145.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000080786 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOT00000080974 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOT00000084624 ENTREZGENE
  ENSRNOT00000084624.2 UniProtKB/TrEMBL
  ENSRNOT00000099452.1 UniProtKB/TrEMBL
  ENSRNOT00000110246.1 UniProtKB/TrEMBL
  ENSRNOT00000116300.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7310645 IMAGE-MGC_LOAD
InterPro FN3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth/epo_recpt_lig-bind UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Long_hematopoietin_rcpt_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRLR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24684 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105486 IMAGE-MGC_LOAD
NCBI Gene 24684 ENTREZGENE
PANTHER PTHR23036:SF86 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EpoR_lig-bind UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  fn3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Prlr PhenoGen
PROSITE FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEMATOPO_REC_L_F1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K488_RAT UniProtKB/TrEMBL
  A0A0G2K600_RAT UniProtKB/TrEMBL
  A0A0G2K813_RAT UniProtKB/TrEMBL
  A0A8I5ZRL2_RAT UniProtKB/TrEMBL
  A0A8I5ZSH8_RAT UniProtKB/TrEMBL
  A0A8I5ZWH3_RAT UniProtKB/TrEMBL
  P05710 ENTREZGENE, UniProtKB/Swiss-Prot
  Q58DZ7 ENTREZGENE, UniProtKB/TrEMBL
  Q64274 ENTREZGENE
  Q7M037_RAT UniProtKB/TrEMBL
UniProt Secondary Q62832 UniProtKB/Swiss-Prot
  Q63451 UniProtKB/Swiss-Prot
  Q63479 UniProtKB/Swiss-Prot
  Q63723 UniProtKB/Swiss-Prot
  Q64274 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Prlr  prolactin receptor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expression levels increased during pregnancy and lactating periods 625741
gene_expression expressed in the brain, liver and mammary gland 625741
gene_expression expressed in the uterine stromal cell line (UIII) 625741
gene_product member of type-1 cytokine receptor superfamily 625741
gene_regulation expression in brain is controlled by the promoter for the E1(4) first exon 625741
gene_regulation expression changed during estrous cycle; may be regulated by PRL or steroid hormones 729535
gene_transcript putative transcription factor-binding sites such as CCAAT, Sp1, and glucocorticoid-responsive elements were observed in the upstream regions 625741
gene_transcript the E1(4) first exon consists of two variants, a longer cDNA containing a 243 bp sequence and a shorter variant lacking 139 bp at the 5' end 625741
gene_transcript unlike variants using exons E1(1), E1(2) and E1(3), transcripts which utilize E1(4) lack the usual second exon and are instead spliced to join E1(4) with the third exon 625741