Prkg2 (protein kinase cGMP-dependent 2)

	Submit Data \| Help \| Video Tutorials \| News \| Publications \| Download \| REST API \| Citing RGD \| Contact
	Search RGD Grant Resources Citing RGD About Us Contact Us Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease Find Models new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive Pathways Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
	Advanced Search (OLGA)

Gene: Prkg2 (protein kinase cGMP-dependent 2) Rattus norvegicus

Analyze

Symbol:

Prkg2

Name:

protein kinase cGMP-dependent 2

RGD ID:

3401

Description:

Enables cGMP-dependent protein kinase activity and identical protein binding activity. Involved in several processes, including negative regulation of chloride transport; peptidyl-serine autophosphorylation; and positive regulation of chondrocyte differentiation. Located in nuclear membrane. Human ortholog(s) of this gene implicated in acromesomelic dysplasia-4 and spondylometaphyseal dysplasia. Orthologous to human PRKG2 (protein kinase cGMP-dependent 2); PARTICIPATES IN long term depression; INTERACTS WITH 17beta-estradiol 3-benzoate; 3,4-methylenedioxymethamphetamine; 3-chloropropane-1,2-diol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

CGK 2; cGK2; cGKII; cGMP dependent protein kinase type II; cGMP-dependent protein kinase 2; cGMP-dependent protein kinase II; GDPKII; protein kinase cGMP- dependent type 2; protein kinase, cGMP- dependent, type 2; protein kinase, cGMP- dependent, type II; protein kinase, cGMP-dependent, type II; type II cGMP-dependent protein kinase

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PRKG2 (protein kinase cGMP-dependent 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Prkg2 (protein kinase, cGMP-dependent, type II)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Prkg2 (protein kinase cGMP-dependent 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PRKG2 (protein kinase cGMP-dependent 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PRKG2 (protein kinase cGMP-dependent 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Prkg2 (protein kinase cGMP-dependent 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PRKG2 (protein kinase cGMP-dependent 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PRKG2 (protein kinase cGMP-dependent 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Prkg2 (protein kinase cGMP-dependent 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Prkg2 (protein kinase, cGMP-dependent, type II)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	PRKG2 (protein kinase cGMP-dependent 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	prkg2 (protein kinase cGMP-dependent 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	egl-4	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	for	Alliance	DIOPT (Ensembl Compara\|InParanoid\|PANTHER\|SonicParanoid)

Is Marker For:

Strains: KMI/Tky

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	14	10,559,882 - 10,668,479 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	10,559,882 - 10,666,888 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	10,540,037 - 10,640,477 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	14	11,839,852 - 11,940,298 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	14	10,529,813 - 10,630,458 (+)	NCBI	Rnor_WKY
Rnor_6.0	14	12,217,121 - 12,313,616 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	12,218,553 - 12,315,229 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	12,159,378 - 12,255,994 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	11,888,101 - 12,005,547 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	11,888,100 - 12,005,547 (+)	NCBI
Celera	14	10,666,687 - 10,755,836 (+)	NCBI		Celera
Cytogenetic Map	14	p22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acromesomelic dysplasia-4 (ISO)

Dwarfism (IAGP)

genetic disease (ISO)

Kabuki Syndrome 1 (ISO)

Spondylometaphyseal Dysplasia Pagnamenta Type (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol 3-benzoate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

3,4-methylenedioxymethamphetamine (EXP)

3-chloropropane-1,2-diol (EXP)

4-nitrophenol (ISO)

6-propyl-2-thiouracil (EXP)

7,9-dihydro-1H-purine-2,6,8(3H)-trione (ISO)

aldehydo-D-glucose (ISO)

ammonium chloride (EXP)

antirheumatic drug (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (EXP)

carbon nanotube (ISO)

CGP 52608 (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

clofibrate (ISO)

copper atom (EXP,ISO)

copper(0) (EXP,ISO)

crocidolite asbestos (ISO)

D-glucose (ISO)

dexamethasone (ISO)

dextran sulfate (ISO)

diclofenac (ISO)

ethanol (ISO)

fenvalerate (EXP)

glucose (ISO)

lead(0) (ISO)

lead(2+) (ISO)

lipopolysaccharide (ISO)

methylphenidate (ISO)

N,N-diethyl-m-toluamide (EXP)

palytoxin (ISO)

permethrin (EXP)

phenobarbital (ISO)

pirinixic acid (ISO)

potassium dichromate (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sotorasib (ISO)

streptozocin (ISO)

tadalafil (ISO)

titanium dioxide (ISO)

trametinib (ISO)

trichloroethene (EXP)

trimellitic anhydride (ISO)

triptonide (ISO)

trovafloxacin (ISO)

valproic acid (ISO)

vanadium atom (ISO)

vanadium(0) (ISO)

venlafaxine hydrochloride (EXP)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular hypotonic response (ISO)

circadian regulation of gene expression (ISO)

circadian rhythm (ISO)

negative regulation of cell volume (ISO)

negative regulation of chloride transport (IDA)

peptidyl-serine autophosphorylation (IDA)

positive regulation of chondrocyte differentiation (IGI)

positive regulation of protein localization (IGI)

protein localization to plasma membrane (IMP)

protein phosphorylation (ISO,TAS)

signal transduction (ISO)

Cellular Component

apical plasma membrane (IEA)

membrane (IDA)

nuclear membrane (IDA)

plasma membrane (ISO)

Molecular Function

ATP binding (IEA)

cGMP binding (IEA)

cGMP-dependent protein kinase activity (IDA,ISO)

identical protein binding (IPI)

mitogen-activated protein kinase binding (ISO,ISS)

protein binding (ISO)

protein serine kinase activity (ISO,ISS)

Molecular Pathway Annotations Click to see Annotation Detail View

long term depression (IEA)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal bone healing (IAGP)

abnormal endochondral bone ossification (IAGP)

abnormal long bone hypertrophic chondrocyte zone (IAGP)

decreased body length (IAGP)

decreased body weight (IAGP)

decreased retroperitoneal fat pad weight (IAGP)

increased long bone epiphyseal plate size (IAGP)

postnatal growth retardation (IAGP)

short tail (IAGP)

small neurocranium (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Cyclic GMP-dependent protein kinase II is a molecular switch from proliferation to hypertrophic differentiation of chondrocytes.	Chikuda H, etal., Genes Dev. 2004 Oct 1;18(19):2418-29. doi: 10.1101/gad.1224204.
2.	Guanylyl cyclase and protein kinase G mediate nitric oxide suppression of 5-lipoxygenase metabolism in rat alveolar macrophages.	Coffey MJ, etal., Biochim Biophys Acta. 2008 Jun-Jul;1781(6-7):299-305. doi: 10.1016/j.bbalip.2008.04.005. Epub 2008 Apr 24.
3.	ICln159 folds into a pleckstrin homology domain-like structure. Interaction with kinases and the splicing factor LSm4.	Fürst J, etal., J Biol Chem. 2005 Sep 2;280(35):31276-82. Epub 2005 May 19.
4.	Inhibition of cGMP-dependent protein kinase II by its own splice isoform.	Gambaryan S, etal., Biochem Biophys Res Commun 2002 May 24;293(5):1438-44.
5.	cGMP-dependent protein kinase type II regulates basal level of aldosterone production by zona glomerulosa cells without increasing expression of the steroidogenic acute regulatory protein gene.	Gambaryan S, etal., J Biol Chem 2003 Aug 8;278(32):29640-8. Epub 2003 May 29.
6.	Expression of type II cGMP-dependent protein kinase in rat kidney is regulated by dehydration and correlated with renin gene expression.	Gambaryan S, etal., J Clin Invest 1996 Aug 1;98(3):662-70.
7.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
9.	STa and cGMP stimulate CFTR translocation to the surface of villus enterocytes in rat jejunum and is regulated by protein kinase G.	Golin-Bisello F, etal., Am J Physiol Cell Physiol. 2005 Sep;289(3):C708-16. Epub 2005 May 4.
10.	Cloning, expression, and in situ localization of rat intestinal cGMP-dependent protein kinase II.	Jarchau T, etal., Proc Natl Acad Sci U S A 1994 Sep 27;91(20):9426-30.
11.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
12.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
13.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
14.	Expression, purification, and characterization of the cGMP-dependent protein kinases I beta and II using the baculovirus system.	Pohler D, etal., FEBS Lett. 1995 Nov 6;374(3):419-25.
15.	GOA pipeline	RGD automated data pipeline
16.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
18.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
19.	Phenotypic characterization of the Komeda miniature rat Ishikawa, an animal model of dwarfism caused by a mutation in Prkg2.	Tsuchida A, etal., Comp Med. 2008 Dec;58(6):560-7.
20.	Autophosphorylation of cGMP-dependent protein kinase type II.	Vaandrager AB, etal., J Biol Chem 2003 Aug 1;278(31):28651-8. Epub 2003 May 22.
21.	Endogenous type II cGMP-dependent protein kinase exists as a dimer in membranes and can Be functionally distinguished from the type I isoforms.	Vaandrager AB, etal., J Biol Chem. 1997 May 2;272(18):11816-23.

Additional References at PubMed

PMID:12725729	PMID:14960318	PMID:15312652	PMID:15582712	PMID:15763176	PMID:15958724	PMID:17341596	PMID:17626895	PMID:18656450	PMID:22203739	PMID:23545413	PMID:24966379
PMID:28057484

Genomics

Comparative Map Data

Prkg2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	14	10,559,882 - 10,668,479 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	10,559,882 - 10,666,888 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	10,540,037 - 10,640,477 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	14	11,839,852 - 11,940,298 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	14	10,529,813 - 10,630,458 (+)	NCBI	Rnor_WKY
Rnor_6.0	14	12,217,121 - 12,313,616 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	12,218,553 - 12,315,229 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	12,159,378 - 12,255,994 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	11,888,101 - 12,005,547 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	11,888,100 - 12,005,547 (+)	NCBI
Celera	14	10,666,687 - 10,755,836 (+)	NCBI		Celera
Cytogenetic Map	14	p22	NCBI

PRKG2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	81,087,370 - 81,217,836 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	4	81,087,370 - 81,215,222 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	82,008,524 - 82,136,376 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	82,228,861 - 82,345,239 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	82,367,015 - 82,483,394	NCBI
Celera	4	79,302,549 - 79,418,932 (-)	NCBI		Celera
Cytogenetic Map	4	q21.21	NCBI
HuRef	4	77,753,401 - 77,870,008 (-)	NCBI		HuRef
CHM1_1	4	81,986,323 - 82,102,706 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	84,417,063 - 84,544,924 (-)	NCBI		T2T-CHM13v2.0

Prkg2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	99,077,632 - 99,185,042 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	99,077,632 - 99,185,210 (-)	Ensembl		GRCm39 Ensembl
GRCm38	5	98,929,773 - 99,037,375 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	98,929,773 - 99,037,351 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	99,358,792 - 99,466,098 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	99,171,570 - 99,277,381 (-)	NCBI		MGSCv36	mm8
Celera	5	96,252,278 - 96,360,518 (-)	NCBI		Celera
Cytogenetic Map	5	E3	NCBI
cM Map	5	48.35	NCBI

Prkg2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955433	5,286,153 - 5,491,924 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955433	5,286,594 - 5,387,571 (-)	NCBI	ChiLan1.0	ChiLan1.0

PRKG2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	4	48,836,953 - 48,960,383 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	48,836,953 - 48,960,383 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	4	42,987,217 - 43,114,993 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

PRKG2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	32	5,266,435 - 5,365,396 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	32	5,266,442 - 5,365,396 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	32	36,517,409 - 36,617,588 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	32	5,294,681 - 5,395,076 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	32	5,294,693 - 5,395,085 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	32	5,324,348 - 5,424,902 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	32	5,231,256 - 5,331,589 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	32	34,635,113 - 34,735,693 (+)	NCBI		UU_Cfam_GSD_1.0

Prkg2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	6,966,547 - 7,070,004 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936749	900,208 - 991,891 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PRKG2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	136,755,469 - 136,852,906 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	136,754,698 - 136,854,589 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	146,048,858 - 146,148,011 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PRKG2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	29,511,796 - 29,629,943 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	29,511,380 - 29,618,330 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	8,011,684 - 8,129,346 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Prkg2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624757	9,798,808 - 9,906,517 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624757	9,799,777 - 9,904,825 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Prkg2
1620 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	56
Count of miRNA genes:	44
Interacting mature miRNAs:	54
Transcripts:	ENSRNOT00000003237
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2300159	Bmd61	Bone mineral density QTL 61	5.3	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	14	1	26541967	Rat
2300183	Bmd60	Bone mineral density QTL 60	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	14	1	26541967	Rat
619619	Rf4	Renal disease susceptibility QTL 4	4.1	0.002	urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	14	1	32754612	Rat
634352	Apr6	Acute phase response QTL 6	3.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	14	1	41131407	Rat
71115	Niddm15	Non-insulin dependent diabetes mellitus QTL 15	4.8		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	14	1217606	11030812	Rat
70204	Niddm20	Non-insulin dependent diabetes mellitus QTL 20	5.1	0.000008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	1217606	16960180	Rat
2293089	Iddm31	Insulin dependent diabetes mellitus QTL 31	4.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	3813074	18274691	Rat
2293089	Iddm31	Insulin dependent diabetes mellitus QTL 31	4.7		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	14	3813074	18274691	Rat
1300114	Srn2	Serum renin concentration QTL 2	3.27		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	14	3813074	21217635	Rat
70195	Mcs8	Mammary carcinoma susceptibility QTL 8	4.28		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	14	3813074	24531477	Rat
1331740	Bw26	Body weight QTL 26	3.028		body mass (VT:0001259)	body weight (CMO:0000012)	14	3813074	30767156	Rat
1581500	Renag1	Renal agenesis QTL 1			kidney development trait (VT:0000527)	percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)	14	8170668	68298175	Rat
1358296	Ael3	Aortic elastin QTL 3	3.7	0.00051	aorta elastin amount (VT:0003905)	aortic elastin	14	8267090	53267090	Rat
2302045	Pia39	Pristane induced arthritis QTL 39	4.9	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G2a level (CMO:0002116)	14	8267090	53267090	Rat
731183	Pia20	Pristane induced arthritis QTL 20	3.55		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	14	9088978	39057237	Rat

Markers in Region

D14Got16

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	10,654,327 - 10,654,483 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	12,301,002 - 12,301,157	NCBI	Rnor6.0
Rnor_5.0	14	12,243,454 - 12,243,609	UniSTS	Rnor5.0
RGSC_v3.4	14	11,992,408 - 11,992,564	RGD	RGSC3.4
RGSC_v3.4	14	11,992,409 - 11,992,564	UniSTS	RGSC3.4
RGSC_v3.1	14	11,992,408 - 11,992,564	RGD
Celera	14	10,743,200 - 10,743,355	UniSTS
RH 2.0 Map	14	178.6	RGD
Cytogenetic Map	14	p22	UniSTS

BE120376

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	10,571,897 - 10,572,086 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	12,218,561 - 12,218,749	NCBI	Rnor6.0
Rnor_5.0	14	12,160,818 - 12,161,006	UniSTS	Rnor5.0
RGSC_v3.4	14	11,889,541 - 11,889,729	UniSTS	RGSC3.4
Celera	14	10,668,115 - 10,668,303	UniSTS
Cytogenetic Map	14	p22	UniSTS

RH137660

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	10,666,550 - 10,666,727 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	12,313,279 - 12,313,455	NCBI	Rnor6.0
Rnor_5.0	14	12,255,657 - 12,255,833	UniSTS	Rnor5.0
RGSC_v3.4	14	12,005,210 - 12,005,386	UniSTS	RGSC3.4
Celera	14	10,755,499 - 10,755,675	UniSTS
Cytogenetic Map	14	p22	UniSTS

Related Rat Strains

The following Strains have been annotated to Prkg2

KMI/Tky

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	2		7						3		1
Low	1	10	5	4		4	5	5	71	35	29	5	5
Below cutoff		31	15	7	17	7	3	6			8	5	3

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_013012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039091638	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474022	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000248	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	Z36276	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000003237 ⟹ ENSRNOP00000003237

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	10,559,882 - 10,666,888 (+)	Ensembl
Rnor_6.0 Ensembl	14	12,218,553 - 12,315,229 (+)	Ensembl

RefSeq Acc Id:

NM_013012 ⟹ NP_037144

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	14	10,559,882 - 10,666,918 (+)	NCBI
Rnor_6.0	14	12,217,121 - 12,313,616 (+)	NCBI
Rnor_5.0	14	12,159,378 - 12,255,994 (+)	NCBI
RGSC_v3.4	14	11,888,101 - 12,005,547 (+)	RGD
Celera	14	10,666,687 - 10,755,836 (+)	RGD

Sequence:

show sequence

CGTTGCTGTCGATCGCTGGAAGCTGGAGTTACAGGTTCCTGAGCAACATGGGAAATGGTTCAGT
GAAACCCAAGCATTCGAAGCACCCAGACGGCCAGTCAGGGAACCTCAGCAATGAAGCCCTGCGG
AGCAAAGTGGCAGAGCTGGAGCGCGAGGTGAAGAGGAAGGATGCAGAACTTCAGGAGCGCGAGT
ACCACCTGAAGGAGCTTCGGGAGCAGCTAGCTAAGCAGACCGTGGCCATTGCGGAGCTCACCGA
GGAGCTGCAGAGCAAGTGCATCCAGCTGAACAAGCTGCAGGATGTTATCCACGTGCAGGGAGGA
AGCCCACTGCAGGCCTCTCCCGACAAAGTGCCTCTGGATGTTCACCGCAAGACCTCAGGCTTGG
TCTCCCTCCACAGCAGGAGGGGGGCGAAGGCTGGAGTGTCTGCAGAGCCCACAAGCCGGACCTA
TGACCTCAACAAGCCCCCTGAGTTCTCCTTTGAGAAAGCGAGGGTCAGGAAGGATTCCAGTGAG
AAAAAACTTATCACAGACGCCCTGAATAAGAACCAGTTTCTGAAGAGACTGGATCCGCAGCAGA
TCAAAGACATGGTGGAATGCATGTACGGGAGAAACTATCAACAGGGCAGTTACATCGTTAAGCA
AGGGGAACCTGGAAACCACATCTTTGTGCTGGCCGAGGGTAGACTGGAGGTGTTCCAAGGAGAG
AAATTGCTGTCGTCCATCCCAATGTGGACCACGTTTGGGGAGCTGGCTATTTTGTATAATTGTA
CGCGGACTGCCTCTGTGAAAGCTATTACCAATGTTAAAACTTGGGCTCTCGATAGAGAGGTTTT
CCAGAACATTATGAGGAGAACAGCGCAAGCCAGGGATGAGGAATACAGAAACTTCCTCAGAAGT
GTCTCCTTGTTGAAGAATTTACCTGAAGACAAACTAACCAAGATTATTGACTGCTTGGAAGTGG
AATACTATGACAAAGGAGATTATATCATCAGAGAAGGAGAGGAAGGGAGCACCTTTTTCATCTT
GGCAAAAGGAAAGGTGAAAGTCACACAGAGCACAGAGGGCCATGATCAGCCACAGTTGATCAAA
ACACTGCAGAAAGGAGAGTACTTTGGAGAAAAGGCTCTGATCAGTGATGATGTCAGATCGGCCA
ATATAATCGCGGAAGAAAATGATGTCGCATGCCTCGTGATCGACCGAGAAACATTCAACCAAAC
TGTCGGGACATTTGATGAACTCCAAAAATACCTTGAGGGGTATGTGGCCACCCTGAACCGTGAC
GATGAAAAGAGACACGCAAAGCGCTCCATGTCTAGCTGGAAGTTGTCCAAAGCCCTTTCTCTGG
AGATGATTCAGCTGAAAGAGAAGGTGGCCAGATTCTCCTCAACCTCCCCATTCCAGAACCTTGA
GATTATCGCAACACTGGGCGTTGGTGGGTTCGGAAGAGTGGAGCTTGTTAAAGTTAAAAATGAG
AACATCGCTTTTGCCATGAAGTGTATAAGGAAGAAGCACATTGTTGACACTAAACAGCAGGAAC
ATGTCTACTCCGAGAAGAGGATCCTGGAGGAGCTGTGTTCTCCCTTCATCGTGAAATTGTATCG
TACTTTCAAGGACAATAAATACGTATACATGCTTCTGGAGGCCTGCTTAGGTGGGGAGCTCTGG
AGTATATTAAGGGACAGAGGCAGCTTCGATGAACCCACCTCCAAATTCTGTGTGGCCTGCGTGA
CAGAAGCATTCGATTATCTACACCGACTAGGCATTATCTACAGAGACCTGAAGCCAGAGAACTT
AATTCTGGATGCCGATGGCTACCTTAAGTTGGTTGACTTTGGATTCGCTAAGAAGATTGGCTCT
GGGCAGAAAACGTGGACATTCTGTGGGACTCCAGAGTATGTGGCCCCCGAGGTCATTCTTAACA
AAGGACATGACTTCAGTGTGGATTTCTGGTCCCTGGGGATTCTGGTCTATGAGCTTCTAACGGG
CAACCCTCCCTTTTCTGGGATAGACCAAATGATGACCTACAATTTGATTCTCAAAGGGATCGAG
AAAATGGATTTTCCTAGAAAGATAACAAGGCGACCCGAGGATTTGATCCGGAGGCTTTGCAGGC
AAAACCCAACAGAAAGGCTGGGGAACCTGAAGAATGGGATCAACGACATTAAGAAACACAGGTG
GTTAAACGGTTTCAATTGGGAGGGGTTGAAAGCACGGAGCCTTCCCTCACCTTTACGAAGAGAG
CTCAGTGGCCCCATAGATCACAGCTACTTTGACAAGTATCCTCCTGAAAAGGGGGTTCCTCCGG
ATGAAATGTCAGGCTGGGATAAGGACTTCTGACAGGAGAGAAACCGACGCCACCGTGGAAGAGG
ACCGTGAGGATCGGTGACACGATGCTGATTATCCCTCTCTTCAAAGCATTGTTAGATCTCCCGG
AAGACAATGGCAGAAAAGAAAACCCTGATAGACAGGGAAGGAGAGTGGCCGGATGTGGTTCTGA
ATGAGAATGTGTCCTTTAGATGCTGTGAATTATTCCTGTATTCCATTCTGTTCTTGTCTAAAGA
TGTCAAAGGTTGTTCCTTTCCATTTCCATGGTCCGATCCATTTTCGTTGGCATAGCACAGTTTT
CTCTCAAATCGGTTTCTCCCTCCAAATCAAACTCTCCTGCCTAGAATCCTAATAATATTAATAT
GGCTTTTGTTCTCGAGCACCTAAGTTATCCAGATAGAAGGAAGACTACAGAACAACGTTAGAAG
AATCACTCCAGGGCTCAGCAGACACCAGGGACTTCCTCCTCCGATTGTGGTTTCCAGACATCTT
GGGAAGTCAATAGAAGACCATGAATTTTATTTTCTTTCAACTTACAGATACACTAATATATTTT
TCGATGTTATTGAAGCAAAAGGAAACATTTGGATATTAATGAGTAGTGCCAGTTACTAAAGAAG
GCCAGTCAATCAAATCAGATAATCATATCAGTTTTCGACAGCAACG

hide sequence

RefSeq Acc Id:

XM_039091638 ⟹ XP_038947566

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	14	10,560,003 - 10,668,479 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_037144	(Get FASTA)	NCBI Sequence Viewer
	XP_038947566	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	CAA85284	(Get FASTA)	NCBI Sequence Viewer
	EDL99610	(Get FASTA)	NCBI Sequence Viewer
	EDL99611	(Get FASTA)	NCBI Sequence Viewer
	Q64595	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_037144 ⟸ NM_013012

- UniProtKB:

Q64595 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MGNGSVKPKHSKHPDGQSGNLSNEALRSKVAELEREVKRKDAELQEREYHLKELREQLAKQTVA
IAELTEELQSKCIQLNKLQDVIHVQGGSPLQASPDKVPLDVHRKTSGLVSLHSRRGAKAGVSAE
PTSRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDMVECMYGRNYQQG
SYIVKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNCTRTASVKAITNVKTWA
LDREVFQNIMRRTAQARDEEYRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEG
STFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVIDR
ETFNQTVGTFDELQKYLEGYVATLNRDDEKRHAKRSMSSWKLSKALSLEMIQLKEKVARFSSTS
PFQNLEIIATLGVGGFGRVELVKVKNENIAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCSPF
IVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRD
LKPENLILDADGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILV
YELLTGNPPFSGIDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGIND
IKKHRWLNGFNWEGLKARSLPSPLRRELSGPIDHSYFDKYPPEKGVPPDEMSGWDKDF

hide sequence

RefSeq Acc Id:

ENSRNOP00000003237 ⟸ ENSRNOT00000003237

RefSeq Acc Id:	XP_038947566 ⟸ XM_039091638
- Peptide Label:	isoform X1

Protein Domains

AGC-kinase C-terminal Protein kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q64595-F1-model_v2	AlphaFold	Q64595	1-762	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:3401	AgrOrtholog
BioCyc Gene	G2FUF-16367	BioCyc
Ensembl Genes	ENSRNOG00000002361	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSRNOP00000003237	ENTREZGENE
	ENSRNOP00000003237.2	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000003237	ENTREZGENE
	ENSRNOT00000003237.5	UniProtKB/Swiss-Prot
Gene3D-CATH	2.60.120.10	UniProtKB/Swiss-Prot
	Transferase(Phosphotransferase) domain 1	UniProtKB/Swiss-Prot
InterPro	AGC-kinase_C	UniProtKB/Swiss-Prot
	cGMP_dep_kinase	UniProtKB/Swiss-Prot
	cNMP-bd-like	UniProtKB/Swiss-Prot
	cNMP-bd_CS	UniProtKB/Swiss-Prot
	cNMP-bd_dom	UniProtKB/Swiss-Prot
	Kinase-like_dom_sf	UniProtKB/Swiss-Prot
	Prot_kinase_dom	UniProtKB/Swiss-Prot
	Protein_kinase_ATP_BS	UniProtKB/Swiss-Prot
	RmlC-like_jellyroll	UniProtKB/Swiss-Prot
	Ser/Thr_kinase_AS	UniProtKB/Swiss-Prot
	STKc_cGK	UniProtKB/Swiss-Prot
KEGG Report	rno:25523	UniProtKB/Swiss-Prot
NCBI Gene	25523	ENTREZGENE
PANTHER	CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE	UniProtKB/Swiss-Prot
	PTHR24353:SF24	UniProtKB/Swiss-Prot
Pfam	cNMP_binding	UniProtKB/Swiss-Prot
	Pkinase	UniProtKB/Swiss-Prot
PhenoGen	Prkg2	PhenoGen
PIRSF	cGMP-dep_kinase	UniProtKB/Swiss-Prot
PRINTS	CGMPKINASE	UniProtKB/Swiss-Prot
PROSITE	AGC_KINASE_CTER	UniProtKB/Swiss-Prot
	CNMP_BINDING_1	UniProtKB/Swiss-Prot
	CNMP_BINDING_2	UniProtKB/Swiss-Prot
	CNMP_BINDING_3	UniProtKB/Swiss-Prot
	PROTEIN_KINASE_ATP	UniProtKB/Swiss-Prot
	PROTEIN_KINASE_DOM	UniProtKB/Swiss-Prot
	PROTEIN_KINASE_ST	UniProtKB/Swiss-Prot
SMART	cNMP	UniProtKB/Swiss-Prot
	S_TK_X	UniProtKB/Swiss-Prot
	S_TKc	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF51206	UniProtKB/Swiss-Prot
	SSF56112	UniProtKB/Swiss-Prot
TIGR	TC234258
UniProt	KGP2_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-04-27	Prkg2	protein kinase cGMP-dependent 2	Prkg2	protein kinase, cGMP-dependent, type II	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Prkg2	protein kinase, cGMP-dependent, type II		protein kinase, cGMP- dependent, type II	Name updated	1299863	APPROVED
2002-06-10	Prkg2	protein kinase, cGMP- dependent, type 2			Symbol and Name status set to approved	70586	APPROVED
2001-10-24	Prkg2	protein kinase, cAMP- dependent, type II			Name updated to reflect Human and Mouse nomenclature	68913	APPROVED
2001-10-24	Prkg2	protein kinase, cGMP- dependent, type II			Name updated	68913	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in intestinal mucosa and in kidney juxtaglomerular cells, ascending thin limb of Henles loop, and brush border of proximal tubules	61502
gene_process	involved in the osmotic changes regulating granule swelling and exocytosis in intestinal brush border	61502
gene_process	may have a role in regulating renin release	61502

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

Mammalian Phenotype

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

Mammalian Phenotype