Pparg (peroxisome proliferator-activated receptor gamma) - Rat Genome Database

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Gene: Pparg (peroxisome proliferator-activated receptor gamma) Rattus norvegicus
Symbol: Pparg
Name: peroxisome proliferator-activated receptor gamma
RGD ID: 3371
Description: Enables several functions, including DNA-binding transcription factor activity; nuclear estrogen receptor binding activity; and protein phosphatase binding activity. Involved in several processes, including negative regulation of biosynthetic process; positive regulation of cell differentiation; and response to vitamin. Acts upstream of or within negative regulation of cardiac muscle hypertrophy in response to stress; negative regulation of connective tissue replacement involved in inflammatory response wound healing; and positive regulation of adiponectin secretion. Located in cytosol; nucleus; and perinuclear region of cytoplasm. Used to study several diseases, including acute kidney failure; artery disease (multiple); pancreatitis; polycystic kidney disease; and transient cerebral ischemia. Biomarker of several diseases, including alcoholic cardiomyopathy; diabetic encephalopathy; hyperandrogenism; obesity; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); end stage renal disease; lipodystrophy (multiple); obesity; and type 2 diabetes mellitus. Orthologous to human PPARG (peroxisome proliferator activated receptor gamma); PARTICIPATES IN DNA modification pathway; Wnt signaling, non-canonical pathway; eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; INTERACTS WITH (+)-catechin; (+)-schisandrin B; (25R)-cholest-5-ene-3beta,26-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: nuclear receptor subfamily 1 group C member 3; peroxisome proliferator activated receptor gamma; peroxisome proliferator activated receptor, gamma; peroxisome proliferator activator receptor gamma; peroxisome proliferator activator receptor, gamma; PPAR-gamma; PPARgamma2
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Ppargem1Mcwi   Ppargm1Kyo  
Genetic Models: F344-Ppargm1Kyo SS-Ppargem1Mcwi
Is Marker For: QTLs:   Coreg2  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.24148,423,102 - 148,548,471 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl4148,423,194 - 148,548,468 (+)Ensembl
Rnor_6.04147,274,055 - 147,399,383 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4147,274,107 - 147,399,380 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04210,562,928 - 210,688,585 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44151,492,220 - 151,617,331 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14151,796,047 - 151,862,171 (+)NCBI
Celera4137,316,681 - 137,440,473 (+)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)