Ppara (peroxisome proliferator activated receptor alpha) - Rat Genome Database

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Gene: Ppara (peroxisome proliferator activated receptor alpha) Rattus norvegicus
Symbol: Ppara
Name: peroxisome proliferator activated receptor alpha
RGD ID: 3369
Description: Enables several functions, including MDM2/MDM4 family protein binding activity; NFAT protein binding activity; and enzyme binding activity. Involved in several processes, including behavioral response to nicotine; cellular response to fructose stimulus; and negative regulation of cell growth involved in cardiac muscle cell development. Predicted to be located in nucleoplasm. Used to study hepatocellular carcinoma; hypertension; hypertensive encephalopathy; and periodontitis. Biomarker of alcoholic hepatitis; hydrocephalus; hypertension; obesity; and steatotic liver disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; hepatocellular carcinoma; lipid metabolism disorder; and myocardial infarction. Orthologous to human PPARA (peroxisome proliferator activated receptor alpha); PARTICIPATES IN eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; hepatitis C pathway; INTERACTS WITH (+)-catechin; (+)-schisandrin B; (3-phenoxyphenyl)methanol.
Type: protein-coding
Previously known as: nuclear receptor subfamily 1 group C member 1; peroxisome proliferator-activated receptor alpha; PPAR; PPAR-alpha
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.27116,832,405 - 116,900,878 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7116,832,756 - 116,895,346 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7118,583,352 - 118,646,124 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07120,808,966 - 120,871,752 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07120,778,539 - 120,841,315 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07126,618,872 - 126,687,282 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7126,619,196 - 126,681,752 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07126,330,559 - 126,397,441 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47123,729,774 - 123,807,090 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17123,764,003 - 123,841,320 (+)NCBI
Celera7113,125,201 - 113,187,404 (+)NCBICelera
RH 3.4 Map7922.4RGD
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
abdominal obesity-metabolic syndrome  (ISO)
acute kidney tubular necrosis  (ISO)
Alcoholic Fatty Liver  (ISO)
alcoholic hepatitis  (IEP)
Alcoholic Liver Diseases  (ISO)
Alzheimer's disease  (ISO)
Animal Mammary Neoplasms  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
atopic dermatitis  (ISO)
Brain Injuries  (IDA)
Cachexia  (ISO)
carcinoma  (ISO)
Cardiomegaly  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chronic Hepatitis C  (IEP,ISO)
colitis  (ISO)
coronary artery disease  (ISO)
Crohn's disease  (ISO)
cystic fibrosis  (ISO)
Diabetic Cardiomyopathies  (IDA)
disease of cellular proliferation  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Dyslipidemias  (ISO)
end stage renal disease  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Mammary Neoplasms  (ISO)
familial hyperlipidemia  (ISO)
genetic disease  (ISO)
hepatocellular carcinoma  (IAGP)
Hepatomegaly  (ISO)
hydrocephalus  (IEP)
Hyperapobetalipoproteinemia  (ISO)
Hyperlipoproteinemias  (ISO)
hypertension  (IEP,IMP,ISO)
hypertensive encephalopathy  (IDA)
Hypertensive Nephropathy  (IDA)
Hypertriglyceridemia  (ISO)
hypoglycemia  (ISO)
Hypoxia  (IEP)
Inflammation  (ISO)
Insulin Resistance  (ISO)
intellectual disability  (ISO)
kidney disease  (ISO)
Left Ventricular Hypertrophy  (ISO)
lipid metabolism disorder  (ISO)
Liver Neoplasms  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (IEP,ISO)
Multiple Organ Failure  (ISO)
muscular disease  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
obesity  (IEP,ISO)
periodontitis  (IDA)
Phelan-McDermid syndrome  (ISO)
Prenatal Exposure Delayed Effects  (IEP)
Prostatic Neoplasms  (ISO)
proteinuria  (ISO)
Reperfusion Injury  (IDA,ISO)
schizophrenia  (ISS)
Sepsis  (ISO)
steatotic liver disease  (IEP,ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(+)-schisandrin B  (EXP)
(+)-taxifolin  (ISO)
(-)-Arctigenin  (ISO)
(-)-matairesinol  (ISO)
(1->4)-beta-D-glucan  (ISO)
(3-phenoxyphenyl)methanol  (EXP)
(9E,11E)-octadecadienoic acid  (ISO)
(R)-carnitine  (EXP)
(R)-lipoic acid  (EXP)
(R)-noradrenaline  (EXP)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-naringenin  (EXP,ISO)
(S)-nicotine  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dichloropropan-2-ol  (ISO)
1,4-bis(2-ethylhexyl) sulfosuccinate  (ISO)
1,4-dichlorobenzene  (ISO)
1-benzofuran  (ISO)
1-chloro-2,4,6-trinitrobenzene  (ISO)
1-naphthol  (EXP)
1-naphthyl isothiocyanate  (ISO)
11-deoxycorticosterone  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2'-Dihydroxy-4-methoxybenzophenone  (ISO)
2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9-hexadecafluorononanoic acid  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-D  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-arachidonoylglycerol  (EXP)
2-deoxy-D-glucose  (ISO)
2-Ethylhexanoic acid  (EXP,ISO)
2-methyl-2-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propanoic acid  (EXP,ISO)
25-hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5'-triiodo-L-thyronine  (EXP)
3,3',5'-triiodothyronine  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (EXP,ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-hydroxybutyric acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
3-methylcholanthrene  (EXP)
3-phenoxybenzoic acid  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-(2-chloroethyl)-4-methylthiazole  (ISO)
5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
7-ketocholesterol  (ISO)
8-Br-cAMP  (ISO)
9-cis,11-trans-octadecadienoic acid  (EXP)
9-cis-retinoic acid  (ISO)
acadesine  (EXP)
acetaldehyde  (EXP,ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (EXP)
alcohol  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
allopurinol  (EXP,ISO)
alpha-linolenic acid  (EXP,ISO)
alpha-naphthoflavone  (ISO)
amiodarone  (EXP,ISO)
amlexanox  (ISO)
ammonium chloride  (EXP)
anandamide  (ISO)
angiotensin II  (EXP)
Ankaflavin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apigenin  (ISO)
arachidonic acid  (ISO)
arachidonoyl-CoA  (ISO)
Arctiin  (ISO)
aristolochic acid A  (ISO)
aristolochic acids  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
aspartame  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (EXP,ISO)
atrazine  (ISO)
atropine  (ISO)
avobenzone  (ISO)
benzalkonium chloride  (ISO)
benzamides  (ISO)
benzo[a]pyrene  (EXP,ISO)
Benzo[k]fluoranthene  (ISO)
Benzyl parahydroxybenzoate  (EXP)
berberine  (ISO)
beta-carotene  (ISO)
beta-naphthoflavone  (EXP,ISO)
bezafibrate  (EXP,ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol F  (ISO)
bisphenol F diglycidyl ether  (ISO)
bleomycin A2  (ISO)
boron atom  (EXP)
budesonide  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (EXP)
butyric acid  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
Calphostin C  (EXP)
cannabidiol  (ISO)
cannabidiolic acid  (ISO)
cannabigerol  (ISO)
cannabigerolic acid  (ISO)
capsaicin  (ISO)
carbamazepine  (EXP)
carbaryl  (EXP)
carbon dioxide  (ISO)
carbon nanotube  (ISO)
carvedilol  (EXP)
cefuroxime  (ISO)
celecoxib  (ISO)
cerivastatin  (ISO)
chenodeoxycholic acid  (EXP,ISO)
CHIR 99021  (ISO)
chitosan  (EXP)
chlorothalonil  (ISO)
chlorpyrifos  (EXP)
cholesterol  (ISO)
cholic acid  (ISO)
choline  (EXP,ISO)
chromium atom  (ISO)
chrysin  (ISO)
ciglitazone  (ISO)
ciguatoxin CTX1B  (ISO)
ciprofibrate  (EXP,ISO)
cisplatin  (EXP,ISO)
citronellol  (ISO)
Clinofibrate  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP,ISO)
Clofop  (ISO)
cobalt dichloride  (EXP,ISO)
conjugated linoleic acid  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
cortisol  (ISO)
cyanamide  (EXP)
cyanocob(III)alamin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (EXP,ISO)
cypermethrin  (ISO)
cyproconazole  (ISO)
D-glucose  (EXP,ISO)
D-penicillamine  (ISO)
dapagliflozin  (EXP)
daunorubicin  (EXP)
decabromodiphenyl ether  (ISO)
dehydroepiandrosterone  (EXP,ISO)
dehydroepiandrosterone sulfate  (ISO)
deoxycholic acid  (ISO)
Deoxyschizandrin  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
Di-n-decyl phthalate  (ISO)
Di-n-hexyl phthalate  (ISO)
Di-n-octyl phthalate  (ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
diclofop-methyl  (ISO)
diethyl maleate  (EXP)
diethyl phthalate  (ISO)
difenoconazole  (ISO)
diheptyl phthalate  (ISO)
dihydroartemisinin  (EXP,ISO)
diisobutyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
Dimethyl phthalate  (ISO)
dimethyl sulfoxide  (ISO)
Diosbulbin B  (ISO)
dioscin  (EXP,ISO)
dioxygen  (ISO)
dipentyl phthalate  (ISO)
dipropyl phthalate  (ISO)
disodium selenite  (ISO)
diuron  (ISO)
dodecanoic acid  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
elemental boron  (EXP)
elemental selenium  (ISO)
enalapril  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
farnesol  (ISO)
fenofibrate  (EXP,ISO)
fenoprofen  (ISO)
fentin chloride  (EXP)
flufenamic acid  (ISO)
fluoxetine  (EXP)
fluvastatin  (ISO)
folic acid  (EXP,ISO)
folpet  (ISO)
fomepizole  (EXP)
fructose  (EXP,ISO)
fucoxanthin  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
gadolinium trichloride  (EXP)
gamma-aminobutyric acid  (ISO)
gamma-linolenic acid  (ISO)
gedunin  (ISO)
gemcitabine  (ISO)
gemfibrozil  (EXP,ISO)
gentamycin  (EXP)
geraniol  (EXP,ISO)
geranylgeraniol  (ISO)
ginsenoside Rf  (ISO)
glucagon  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glycine betaine  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (ISO)
gossypetin  (ISO)
gramine  (ISO)
griseofulvin  (ISO)
guggulsterone  (EXP,ISO)
GW 4064  (EXP,ISO)
GW 501516  (ISO)
GW 6471  (EXP,ISO)
GW 7647  (EXP,ISO)
HET0016  (EXP)
hexadecanoic acid  (EXP,ISO)
hydrazine  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroxytyrosol  (ISO)
ibuprofen  (EXP,ISO)
icariin  (ISO)
idebenone  (EXP)
Ile(5)-angiotensin II  (EXP)
imidacloprid  (ISO)
indometacin  (EXP,ISO)
inulin  (ISO)
isoniazide  (ISO)
isoprenaline  (EXP,ISO)
isosilybin  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP)
L-methionine  (EXP,ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
leukotriene B4  (ISO)
levofloxacin  (ISO)
linalool  (ISO)
linoleic acid  (EXP,ISO)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (ISO)
losartan  (EXP)
LY294002  (ISO)
lycopene  (ISO)
malathion  (ISO)
malonyl-CoA  (ISO)
mangiferin  (ISO)
mechlorethamine  (ISO)
MeIQx  (ISO)
melatonin  (EXP,ISO)
meldonium  (ISO)
mercury dichloride  (EXP,ISO)
Mesaconitine  (EXP)
metformin  (EXP,ISO)
methapyrilene  (EXP)
methiocarb  (EXP)
methotrexate  (ISO)
methoxsalen  (EXP)
methylparaben  (EXP)
metoprolol  (EXP)
mevalonic acid  (ISO)
miquelianin  (EXP)
monascin  (ISO)
mono(2-ethyl-5-oxohexyl) phthalate  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monocrotophos  (EXP)
monoethyl phthalate  (ISO)
monohexyl phthalate  (ISO)
Monomethyl phthalate  (ISO)
monooctyl phthalate  (ISO)
monosodium L-glutamate  (EXP,ISO)
Muraglitazar  (EXP,ISO)
myricetin  (EXP)
myristoyl-CoA  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-beta-D-glucosamine  (ISO)
N-acetyl-D-glucosamine  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
N-phenylthiourea  (ISO)
nafenopin  (EXP,ISO)
naphthalene  (ISO)
naproxen  (EXP)
naringin  (ISO)
nefazodone  (ISO)
nicotine  (EXP)
nicotinic acid  (EXP,ISO)
nimesulide  (ISO)
nitric oxide  (EXP,ISO)
nitrites  (ISO)
nitrofen  (EXP)
NMN zwitterion  (ISO)
nonanoic acid  (ISO)
norathyriol  (ISO)
NS-398  (EXP,ISO)
obeticholic acid  (EXP,ISO)
octadecanoic acid  (ISO)
octanoic acid  (ISO)
octocrylene  (ISO)
okadaic acid  (EXP,ISO)
olaparib  (ISO)
oleanolic acid  (ISO)
oleic acid  (EXP,ISO)
oleoyl ethanolamide  (ISO)
oleoyl-CoA  (ISO)
orotic acid  (EXP)
oroxylin A  (ISO)
osthole  (ISO)
oxazepam  (ISO)
oxybenzone  (ISO)
ozone  (EXP,ISO)
palmitoyl ethanolamide  (EXP)
palmitoyl-CoA  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parthenolide  (ISO)
penconazole  (ISO)
pentanal  (ISO)
pentane-2,3-dione  (EXP)
perfluorobutanesulfonic acid  (ISO)
perfluorobutyric acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (EXP,ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanesulfonamide  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoropentanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
permethrin  (ISO)
phenobarbital  (EXP,ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phthalic acid  (ISO)
phytanic acid  (ISO)
phytol  (ISO)
picoxystrobin  (ISO)
pinostrobin  (ISO)
pioglitazone  (EXP,ISO)
pirinixic acid  (EXP,ISO)
pitavastatin  (ISO)
pitavastatin(1-)  (ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
prochloraz  (ISO)
procymidone  (ISO)
propiconazole  (ISO)
propylparaben  (EXP)
propyzamide  (ISO)
Ptaquiloside  (ISO)
pterostilbene  (EXP,ISO)
puerarin  (ISO)
pyrazinecarboxamide  (EXP,ISO)
pyrethrins  (ISO)
Pyridostigmine bromide  (ISO)
pyridoxal 5'-phosphate  (EXP)
pyrimidifen  (ISO)
quercetin  (EXP,ISO)
quinoline  (ISO)
quizalofop-ethyl  (EXP)
raffinose  (ISO)
raspberry ketone  (ISO)
reactive oxygen species  (EXP)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rimonabant  (EXP)
rosmarinic acid  (ISO)
rotenone  (EXP,ISO)
rutin  (EXP)
saccharin  (ISO)
salicylamide  (ISO)
SB 431542  (ISO)
scopoletin  (EXP)
selenium atom  (ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (EXP)
sodium cholate  (ISO)
sodium dichromate  (EXP,ISO)
Sodium oleate  (ISO)
sphingosine 1-phosphate  (EXP)
spironolactone  (ISO)
stearoyl-CoA  (ISO)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP,ISO)
sucrose  (EXP,ISO)
Sudan III  (EXP,ISO)
sulfluramid  (ISO)
sulindac sulfide  (ISO)
sulindac sulfone  (ISO)
sunitinib  (ISO)
Sunset Yellow FCF  (ISO)
syringin  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
taurine  (ISO)
tauro-beta-muricholic acid  (ISO)
taurocholic acid  (ISO)
tauroursodeoxycholic acid  (ISO)
tectoridin  (ISO)
tectorigenin  (ISO)
tert-butyl ethyl ether  (EXP)
tert-butyl hydroperoxide  (EXP)
Tesaglitazar  (ISO)
testosterone  (ISO)
testosterone cypionate  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP,ISO)
tetradecanoic acid  (ISO)
tetramethylpyrazine  (ISO)
tetraphene  (ISO)
tetrathiomolybdate(2-)  (EXP)
theophylline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tolazoline  (ISO)
tolmetin  (ISO)
tomelukast  (ISO)
tributyl phosphate  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroacetic acid  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
Tris(2,3-dibromopropyl) phosphate  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
ubiquinones  (ISO)
urea  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
voriconazole  (EXP)
WIN 55212-2  (ISO)
wortmannin  (EXP)
zearalenone  (ISO)
zinc atom  (EXP,ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
behavioral response to nicotine  (IDA)
cell differentiation  (IBA)
cellular response to fructose stimulus  (IEP)
cellular response to starvation  (ISO)
circadian regulation of gene expression  (ISO,ISS)
enamel mineralization  (ISO)
epidermis development  (ISO)
fatty acid metabolic process  (IBA,IMP,ISO)
gluconeogenesis  (ISO)
heart development  (IEP)
hormone-mediated signaling pathway  (IBA)
intracellular receptor signaling pathway  (IEA)
lipoprotein metabolic process  (IMP)
negative regulation of appetite  (ISO,ISS)
negative regulation of blood pressure  (IMP)
negative regulation of cell growth involved in cardiac muscle cell development  (IMP)
negative regulation of cholesterol storage  (IBA,ISO)
negative regulation of cytokine production involved in inflammatory response  (ISO)
negative regulation of glycolytic process  (ISO)
negative regulation of hepatocyte apoptotic process  (ISO)
negative regulation of inflammatory response  (IBA,ISO)
negative regulation of leukocyte cell-cell adhesion  (ISO)
negative regulation of macrophage derived foam cell differentiation  (ISO)
negative regulation of miRNA transcription  (ISO)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
negative regulation of protein binding  (IMP)
negative regulation of reactive oxygen species biosynthetic process  (ISO)
negative regulation of sequestering of triglyceride  (ISO)
negative regulation of transcription by RNA polymerase II  (IBA,ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
nitric oxide metabolic process  (IEP)
positive regulation of ATP biosynthetic process  (ISO)
positive regulation of DNA-templated transcription  (ISO,ISS)
positive regulation of fatty acid metabolic process  (IBA)
positive regulation of fatty acid oxidation  (ISO)
positive regulation of gluconeogenesis  (ISO)
positive regulation of lipid biosynthetic process  (ISO)
positive regulation of transcription by RNA polymerase II  (IBA,ISO)
regulation of cellular ketone metabolic process  (ISO)
regulation of circadian rhythm  (ISO,ISS)
regulation of DNA-templated transcription  (IDA)
regulation of fatty acid metabolic process  (ISO,TAS)
regulation of gene expression  (ISO)
regulation of lipid storage  (IEP)
response to ethanol  (IEP)
response to hypoxia  (IDA,IEP)
response to insulin  (IMP)
response to nutrient  (IEP)
response to organic cyclic compound  (IEP)
steroid hormone mediated signaling pathway  (IEA)
wound healing  (ISO)

Cellular Component
nucleoplasm  (IEA,ISO)
nucleus  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
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3. Histone acetylation and steroid receptor coactivator expression during clofibrate-induced rat hepatocarcinogenesis. Asano J, etal., Cancer Sci. 2010 Apr;101(4):869-75. Epub 2009 Dec 8.
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6. Arjunolic acid, a peroxisome proliferator-activated receptor α agonist, regresses cardiac fibrosis by inhibiting non-canonical TGF-β signaling. Bansal T, etal., J Biol Chem. 2017 Oct 6;292(40):16440-16462. doi: 10.1074/jbc.M117.788299. Epub 2017 Aug 18.
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9. WY-14643, a Potent Peroxisome Proliferator Activator Receptor-alpha PPAR-alpha Agonist Ameliorates the Inflammatory Process Associated to Experimental Periodontitis. Briguglio E, etal., PPAR Res. 2010;2010:193019. Epub 2010 Dec 27.
10. Polymorphism in the peroxisome proliferator-activated receptor alpha gene influences the risk for Alzheimer's disease. Brune S, etal., J Neural Transm. 2003 Sep;110(9):1041-50.
11. Combination therapy with fenofibrate, a peroxisome proliferator-activated receptor alpha agonist, and simvastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, on experimental traumatic brain injury. Chen XR, etal., J Pharmacol Exp Ther. 2008 Sep;326(3):966-74. Epub 2008 Jun 18.
12. Cloning and identification of rat deoxyuridine triphosphatase as an inhibitor of peroxisome proliferator-activated receptor alpha. Chu R, etal., J Biol Chem 1996 Nov 1;271(44):27670-6.
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15. Absence of peroxisome proliferators-activated receptors (PPAR)alpha enhanced the multiple organ failure induced by zymosan. Di Paola R, etal., Shock. 2006 Nov;26(5):477-84.
16. Inhibition of cytokine-induced matrix metalloproteinase 9 expression by peroxisome proliferator-activated receptor alpha agonists is indirect and due to a NO-mediated reduction of mRNA stability. Eberhardt W, etal., J Biol Chem 2002 Sep 6;277(36):33518-28.
17. Cholesterol ester transfer protein, interleukin-8, peroxisome proliferator activator receptor alpha, and Toll-like receptor 4 genetic variations and risk of incident nonfatal myocardial infarction and ischemic stroke. Enquobahrie DA, etal., Am J Cardiol. 2008 Jun 15;101(12):1683-8. Epub 2008 Apr 9.
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20. Dependence of peroxisome proliferator-activated receptor ligand-induced mitogen-activated protein kinase signaling on epidermal growth factor receptor transactivation. Gardner OS, etal., J Biol Chem. 2003 Nov 21;278(47):46261-9. Epub 2003 Sep 9.
21. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
22. Peroxisome proliferator-activated receptor {alpha} agonism prevents renal damage and the oxidative stress and inflammatory processes affecting the brains of stroke-prone rats. Gelosa P, etal., J Pharmacol Exp Ther. 2010 Nov;335(2):324-31. Epub 2010 Jul 29.
23. Peroxisome proliferator-activated receptor (PPAR) alpha and PPARbeta/delta, but not PPARgamma, modulate the expression of genes involved in cardiac lipid metabolism. Gilde AJ, etal., Circ Res 2003 Mar 21;92(5):518-24.
24. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
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26. Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor. Gottlicher M, etal., Proc Natl Acad Sci U S A 1992 May 15;89(10):4653-7.
27. Peroxisome proliferator-activated receptor-alpha agonists protect cortical neurons from inflammatory mediators and improve peroxisomal function. Gray E, etal., Eur J Neurosci. 2011 Apr;33(8):1421-32. doi: 10.1111/j.1460-9568.2011.07637.x. Epub 2011 Mar 7.
28. The ribosomal protein rpL11 associates with and inhibits the transcriptional activity of peroxisome proliferator-activated receptor-alpha. Gray JP, etal., Toxicol Sci. 2006 Feb;89(2):535-46. Epub 2005 Nov 9.
29. Pre-germinated brown rice extract ameliorates high-fat diet-induced metabolic syndrome. Hao CL, etal., J Food Biochem. 2019 Mar;43(3):e12769. doi: 10.1111/jfbc.12769. Epub 2019 Jan 13.
30. Efficacy of combined peroxisome proliferator-activated receptor-alpha ligand and glucocorticoid therapy in a murine model of atopic dermatitis. Hatano Y, etal., J Invest Dermatol. 2011 Sep;131(9):1845-52. doi: 10.1038/jid.2011.144. Epub 2011 Jun 2.
31. Evaluation of the role of peroxisome-proliferator-activated receptor alpha in the regulation of cardiac pyruvate dehydrogenase kinase 4 protein expression in response to starvation, high-fat feeding and hyperthyroidism. Holness MJ, etal., Biochem J 2002 Jun 15;364(Pt 3):687-94.
32. Maternal Exposure to Bisphenol A Combined with High-Fat Diet-Induced Programmed Hypertension in Adult Male Rat Offspring: Effects of Resveratrol. Hsu CN, etal., Int J Mol Sci. 2019 Sep 6;20(18):4382. doi: 10.3390/ijms20184382.
33. Sex difference in hepatic peroxisome proliferator-activated receptor alpha expression: influence of pituitary and gonadal hormones. Jalouli M, etal., Endocrinology 2003 Jan;144(1):101-9.
34. Peroxisome proliferator--activated receptor alpha gene regulates left ventricular growth in response to exercise and hypertension. Jamshidi Y, etal., Circulation. 2002 Feb 26;105(8):950-5.
35. Fenofibrate inhibits adipocyte hypertrophy and insulin resistance by activating adipose PPARalpha in high fat diet-induced obese mice. Jeong S and Yoon M, Exp Mol Med. 2009 Jun 30;41(6):397-405.
36. Glucocorticoid receptor (GR)-associated SMRT binding to C/EBPbeta TAD and Nrf2 Neh4/5: role of SMRT recruited to GR in GSTA2 gene repression. Ki SH, etal., Mol Cell Biol. 2005 May;25(10):4150-65.
37. Palmitoylethanolamide protects dentate gyrus granule cells via peroxisome proliferator-activated receptor-alpha. Koch M, etal., Neurotox Res. 2011 Feb;19(2):330-40. Epub 2010 Mar 11.
38. PPAR-alpha L162V polymorphism in human hepatocellular carcinoma. Koytak ES, etal., Turk J Gastroenterol. 2008 Dec;19(4):245-9.
39. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
40. Mutation screening of the PPARalpha gene in type 2 diabetes associated with coronary heart disease. Lacquemant C, etal., Diabetes Metab. 2000 Nov;26(5):393-401.
41. The PPAR-alpha agonist, Wy 14,643, improves metabolic indices, steatosis and ballooning in diabetic mice with NASH. Larter CZ, etal., J Gastroenterol Hepatol. 2011 Sep 19. doi: 10.1111/j.1440-1746.2011.06939.x.
42. PPARalpha activation inhibits endothelin-1-induced cardiomyocyte hypertrophy by prevention of NFATc4 binding to GATA-4. Le K, etal., Arch Biochem Biophys. 2012 Feb 1;518(1):71-8. Epub 2011 Dec 16.
43. Influence of peroxisome proliferator-activated receptor alpha agonists on the intracellular turnover and secretion of apolipoprotein (Apo) B-100 and ApoB-48. Linden D, etal., J Biol Chem 2002 Jun 21;277(25):23044-53.
44. Blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptors. Mascia P, etal., Biol Psychiatry. 2011 Apr 1;69(7):633-41.
45. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
46. Differential expression of stress response genes in the H-Tx rat model of congenital hydrocephalus. Morgan FW, etal., Brain Res Mol Brain Res. 2005 Aug 18;138(2):273-90.
47. Peroxisome proliferator-activated receptor alpha physically interacts with CCAAT/enhancer binding protein (C/EBPbeta) to inhibit C/EBPbeta-responsive alpha1-acid glycoprotein gene expression. Mouthiers A, etal., Mol Endocrinol. 2005 May;19(5):1135-46. doi: 10.1210/me.2004-0188. Epub 2005 Jan 20.
48. Amelioration of high fructose-induced metabolic derangements by activation of PPARalpha. Nagai Y, etal., Am J Physiol Endocrinol Metab 2002 May;282(5):E1180-90.
49. Skeletal Muscle Characteristics of Rats with Obesity, Diabetes, Hypertension, and Hyperlipidemia. Nagatomo F, etal., J Atheroscler Thromb. 2009 Sep 18.
50. Peroxisome proliferator-activated receptor alpha protects against alcohol-induced liver damage. Nakajima T, etal., Hepatology. 2004 Oct;40(4):972-80.
51. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
52. Tesaglitazar, a dual PPAR{alpha}/{gamma} agonist, ameliorates glucose and lipid intolerance in obese Zucker rats. Oakes ND, etal., Am J Physiol Regul Integr Comp Physiol. 2005 Oct;289(4):R938-46.
53. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
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55. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
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57. Peroxisome proliferator-activated receptor alpha (PPAR alpha) down-regulation in cystic fibrosis lymphocytes. Reynders V, etal., Respir Res. 2006 Jul 30;7:104.
58. GOA pipeline RGD automated data pipeline
59. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
60. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
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62. Reduced PPARalpha Expression is Associated With Decreased Survival and Increased Tissue Bacterial Load in Sepsis. Standage SW, etal., Shock. 2011 Nov 15.
63. Evidence for mitochondrial thioesterase 1 as a peroxisome proliferator-activated receptor-alpha-regulated gene in cardiac and skeletal muscle. Stavinoha MA, etal., Am J Physiol Endocrinol Metab. 2004 Nov;287(5):E888-95. Epub 2004 Aug 3.
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65. Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator. Surapureddi S, etal., Proc Natl Acad Sci U S A 2002 Sep 3;99(18):11836-41.
66. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
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75. Contemporaneous carrier-state of two or three "proatherosclerotic" variants of APOE, ICAM1, PPARA and PAI-1 genes differentiate CAD patients from healthy individuals. Zak I, etal., Clin Chim Acta. 2005 Dec;362(1-2):110-8. Epub 2005 Jul 25.
Additional References at PubMed
PMID:8041794   PMID:8828512   PMID:9113987   PMID:9488698   PMID:9626662   PMID:9748239   PMID:11514592   PMID:12015306   PMID:12065722   PMID:12083418   PMID:12118155   PMID:12354675  
PMID:12425954   PMID:12485431   PMID:12700342   PMID:12730403   PMID:12802337   PMID:12914523   PMID:12941763   PMID:12955147   PMID:12962497   PMID:14871557   PMID:15007068