Plk1 (polo-like kinase 1) - Rat Genome Database

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Gene: Plk1 (polo-like kinase 1) Rattus norvegicus
Analyze
Symbol: Plk1
Name: polo-like kinase 1
RGD ID: 3352
Description: Predicted to enable several functions, including ATP binding activity; anaphase-promoting complex binding activity; and magnesium ion binding activity. Involved in polar body extrusion after meiotic divisions. Located in spindle midzone and spindle pole. Human ortholog(s) of this gene implicated in urinary bladder cancer. Orthologous to human PLK1 (polo like kinase 1); PARTICIPATES IN cell cycle pathway, mitotic; M phase pathway; INTERACTS WITH 1,3-dinitrobenzene; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Plk; PLK-1; polo-like kinase 1 (Drosophila); polo-like kinase homolog; polo-like kinase homolog (Drosophila); serine/threonine-protein kinase PLK1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21176,716,420 - 176,726,400 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1176,716,420 - 176,726,400 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1185,044,423 - 185,054,396 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01192,230,379 - 192,240,352 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01184,914,429 - 184,924,412 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01192,115,990 - 192,125,969 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1192,115,966 - 192,125,989 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01199,178,259 - 199,188,238 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41181,002,811 - 181,012,741 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11181,142,728 - 181,152,656 (+)NCBI
Celera1174,424,809 - 174,434,922 (+)NCBICelera
Cytogenetic Map1q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,3-dinitrobenzene  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-methoxyethanol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-D-glucosamine  (EXP,ISO)
beta-naphthoflavone  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
CGP 52608  (ISO)
Chloroacetonitrile  (ISO)
choline  (ISO)
chromium atom  (ISO)
ciprofloxacin  (EXP)
cis-caffeic acid  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
coumarin  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP,ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
diethyl maleate  (ISO)
dioxygen  (EXP,ISO)
doxorubicin  (ISO)
Echimidine  (ISO)
Enterolactone  (ISO)
enzalutamide  (ISO)
etoposide  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gemcitabine  (ISO)
genistein  (ISO)
geraniol  (ISO)
glucose  (ISO)
hydrogen peroxide  (ISO)
hydroxyurea  (ISO)
indole-3-methanol  (EXP)
irinotecan  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
Lasiocarpine  (ISO)
leflunomide  (EXP,ISO)
lucanthone  (ISO)
luteolin  (ISO)
menadione  (ISO)
methotrexate  (ISO)
methoxyacetic acid  (EXP)
methylseleninic acid  (ISO)
microcystin-LR  (ISO)
mitomycin C  (ISO)
monocrotaline  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
nocodazole  (ISO)
O-methyleugenol  (EXP,ISO)
ochratoxin A  (EXP,ISO)
oxaliplatin  (EXP)
oxcarbazepine  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
promethazine  (EXP)
propanal  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
riddelliine  (ISO)
rotenone  (EXP,ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
trans-caffeic acid  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
Triptolide  (EXP)
troglitazone  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
zaragozic acid A  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
centrosome cycle  (IEA,ISO,ISS)
double-strand break repair  (ISO)
double-strand break repair via alternative nonhomologous end joining  (IEA,ISO)
establishment of mitotic spindle orientation  (IEA,ISO)
establishment of protein localization  (IEA,ISO)
female meiosis chromosome segregation  (IEA,ISO)
G2/M transition of mitotic cell cycle  (IEA,ISO,ISS)
homologous chromosome segregation  (IEA,ISO)
microtubule bundle formation  (IEA,ISO,ISS)
mitotic cell cycle  (ISO,ISS)
mitotic cytokinesis  (IEA,ISO,ISS)
mitotic G2 DNA damage checkpoint signaling  (IEA,ISO,ISS)
mitotic sister chromatid segregation  (IEA,ISO,ISS)
mitotic spindle assembly checkpoint signaling  (IEA,ISO,ISS)
mitotic spindle organization  (IBA)
negative regulation of apoptotic process  (IEA,ISO,ISS)
negative regulation of transcription by RNA polymerase II  (IEA,ISO,ISS)
nuclear membrane disassembly  (IEA,ISO,ISS)
phosphorylation  (IEA)
polar body extrusion after meiotic divisions  (IMP)
positive regulation of peptidyl-threonine phosphorylation  (IEA,ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IEA,ISO,ISS)
positive regulation of proteolysis  (ISO)
protein destabilization  (IEA,ISO)
protein localization to chromatin  (IEA,ISO,ISS)
protein localization to nuclear envelope  (IEA,ISO,ISS)
protein localization to organelle  (ISO)
protein ubiquitination  (IEA,ISO)
regulation of cytokinesis  (IEA,ISO)
regulation of mitotic cell cycle  (ISO)
regulation of mitotic metaphase/anaphase transition  (ISO)
regulation of mitotic spindle assembly  (IEA,ISO)
regulation of protein localization to cell cortex  (IEA,ISO)
synaptonemal complex disassembly  (IEA,ISO)

Cellular Component
centriolar satellite  (IEA,ISO)
centriole  (IEA,ISO)
centrosome  (IBA,ISO,ISS)
chromatin  (IEA,ISO)
chromosome, centromeric region  (ISO)
condensed chromosome, centromeric region  (ISO)
cytoplasm  (IBA)
kinetochore  (IBA,ISO,ISS)
microtubule cytoskeleton  (ISO)
midbody  (IEA,ISO,ISS)
mitotic spindle pole  (IEA,ISO)
nucleus  (IBA,ISO,ISS)
outer kinetochore  (IEA,ISO)
spindle  (ISO,ISS)
spindle microtubule  (IEA,ISO)
spindle midzone  (IDA,IEA,ISO)
spindle pole  (IBA,IDA,ISO)
synaptonemal complex  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Characterization of Polo-like kinase-1 in rat oocytes and early embryos implies its functional roles in the regulation of meiotic maturation, fertilization, and cleavage. Fan HY, etal., Mol Reprod Dev 2003 Jul;65(3):318-29.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Influence of neuroendocrine tumor cells on proliferation in prostatic carcinoma. Grobholz R, etal., Hum Pathol. 2005 May;36(5):562-70.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Intravesical administration of small interfering RNA targeting PLK-1 successfully prevents the growth of bladder cancer. Nogawa M, etal., J Clin Invest. 2005 Apr;115(4):978-85. Epub 2005 Mar 10.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. Reactome: A Knowledgebase of Biological Processes Reactome
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Roles of polo-like kinase 1 in the assembly of functional mitotic spindles. Sumara I, etal., Curr Biol. 2004 Oct 5;14(19):1712-22.
14. High expression levels of cyclin B1 and Polo-like kinase 1 in ectopic endometrial cells associated with abnormal cell cycle regulation of endometriosis. Tang L, etal., Fertil Steril. 2008 Mar 17.
15. Ciprofloxacin-mediated cell proliferation inhibition and G2/M cell cycle arrest in rat tendon cells. Tsai WC, etal., Arthritis Rheum. 2008 Jun;58(6):1657-63.
16. The peptidyl-prolyl isomerase Pin1 regulates cytokinesis through Cep55. van der Horst A and Khanna KK, Cancer Res. 2009 Aug 15;69(16):6651-9. doi: 10.1158/0008-5472.CAN-09-0825. Epub 2009 Jul 28.
17. Polo-like kinase isoform expression is a prognostic factor in ovarian carcinoma. Weichert W, etal., Br J Cancer. 2004 Feb 23;90(4):815-21.
18. Polo-like kinase isoforms in breast cancer: expression patterns and prognostic implications. Weichert W, etal., Virchows Arch. 2005 Apr;446(4):442-50. Epub 2005 Mar 23.
19. Overexpression of polo-like kinase 1 (PLK1) and chromosomal instability in bladder cancer. Yamamoto Y, etal., Oncology. 2006;70(3):231-7. Epub 2006 Jul 6.
Additional References at PubMed
PMID:8991084   PMID:12477932   PMID:12524548   PMID:12639966   PMID:12939256   PMID:15148369   PMID:15678101   PMID:16885022   PMID:17146433   PMID:17351640   PMID:17461553   PMID:17495026  
PMID:17617734   PMID:18174154   PMID:18195732   PMID:18331714   PMID:18378770   PMID:18477460   PMID:18615013   PMID:18662541   PMID:19160488   PMID:19468300   PMID:19468302   PMID:19473992  
PMID:19596235   PMID:19707596   PMID:20577264   PMID:20679239   PMID:21041660   PMID:21111234   PMID:21399614   PMID:21637952   PMID:21931181   PMID:22249248   PMID:22405274   PMID:22621898  
PMID:22701722   PMID:22854038   PMID:23354166   PMID:23455478   PMID:23509069   PMID:24157919   PMID:25395579   PMID:25533956   PMID:26192437   PMID:27579920   PMID:27979967   PMID:31081105  
PMID:34115550  


Genomics

Comparative Map Data
Plk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21176,716,420 - 176,726,400 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1176,716,420 - 176,726,400 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1185,044,423 - 185,054,396 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01192,230,379 - 192,240,352 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01184,914,429 - 184,924,412 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01192,115,990 - 192,125,969 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1192,115,966 - 192,125,989 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01199,178,259 - 199,188,238 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41181,002,811 - 181,012,741 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11181,142,728 - 181,152,656 (+)NCBI
Celera1174,424,809 - 174,434,922 (+)NCBICelera
Cytogenetic Map1q36NCBI
PLK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381623,678,889 - 23,690,367 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1623,677,656 - 23,690,367 (+)EnsemblGRCh38hg38GRCh38
GRCh371623,690,210 - 23,701,688 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361623,597,702 - 23,609,189 (+)NCBINCBI36Build 36hg18NCBI36
Build 341623,597,701 - 23,609,191NCBI
Celera1622,468,373 - 22,479,857 (+)NCBICelera
Cytogenetic Map16p12.2NCBI
HuRef1621,779,829 - 21,791,312 (+)NCBIHuRef
CHM1_11624,701,920 - 24,713,407 (+)NCBICHM1_1
T2T-CHM13v2.01623,954,691 - 23,966,171 (+)NCBIT2T-CHM13v2.0
Plk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397121,758,658 - 121,769,107 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7121,758,662 - 121,769,096 (+)EnsemblGRCm39 Ensembl
GRCm387122,159,435 - 122,169,884 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7122,159,439 - 122,169,873 (+)EnsemblGRCm38mm10GRCm38
MGSCv377129,302,951 - 129,313,389 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367121,950,641 - 121,961,011 (+)NCBIMGSCv36mm8
Celera7122,049,692 - 122,060,205 (+)NCBICelera
Cytogenetic Map7F2NCBI
cM Map765.52NCBI
Plk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554932,206,353 - 2,217,231 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554932,206,353 - 2,217,231 (+)NCBIChiLan1.0ChiLan1.0
PLK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11629,600,211 - 29,620,577 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01614,420,972 - 14,432,821 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11623,928,773 - 23,940,779 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1623,928,773 - 23,940,779 (+)Ensemblpanpan1.1panPan2
PLK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1622,165,338 - 22,176,847 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl622,165,338 - 22,176,441 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha623,732,161 - 23,743,926 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0622,309,120 - 22,320,926 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl622,309,120 - 22,341,941 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1622,112,754 - 22,124,540 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0622,014,857 - 22,026,662 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0622,410,301 - 22,422,125 (-)NCBIUU_Cfam_GSD_1.0
Plk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344120,223,455 - 120,234,564 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365018,321,305 - 8,332,424 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365018,321,415 - 8,332,414 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl322,537,831 - 22,552,380 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1322,537,814 - 22,550,901 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PLK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1521,388,957 - 21,408,574 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl521,396,204 - 21,410,718 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660688,388,349 - 8,407,454 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247828,811,616 - 8,826,749 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247828,811,593 - 8,823,060 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Plk1
42 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:307
Count of miRNA genes:191
Interacting mature miRNAs:217
Transcripts:ENSRNOT00000025629
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1136830018181830018Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164747424209747424Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1164747558181133855Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1166532971191278129Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169112897197261052Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1169112897197261052Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
61326Eae6Experimental allergic encephalomyelitis QTL 65.3body mass (VT:0001259)change in body weight (CMO:0002045)1172949660181830018Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1174133260196383668Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat

Markers in Region
D1Got398  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21176,714,884 - 176,715,005 (+)MAPPERmRatBN7.2
Rnor_6.01192,114,455 - 192,114,575NCBIRnor6.0
Rnor_5.01199,176,724 - 199,176,844UniSTSRnor5.0
RGSC_v3.41181,001,276 - 181,001,396UniSTSRGSC3.4
Celera1174,423,274 - 174,423,394UniSTS
Cytogenetic Map1q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 26 28 22 13 22 43 20 35
Low 14 22 13 6 13 3 6 31 14 6 11 3
Below cutoff 3 7 6 6 5 5 1 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000025629   ⟹   ENSRNOP00000025629
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1176,716,420 - 176,726,400 (+)Ensembl
Rnor_6.0 Ensembl1192,115,966 - 192,125,989 (+)Ensembl
RefSeq Acc Id: NM_017100   ⟹   NP_058796
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21176,716,420 - 176,726,400 (+)NCBI
Rnor_6.01192,115,990 - 192,125,969 (+)NCBI
Rnor_5.01199,178,259 - 199,188,238 (+)NCBI
RGSC_v3.41181,002,811 - 181,012,741 (+)RGD
Celera1174,424,809 - 174,434,922 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_058796 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA18885 (Get FASTA)   NCBI Sequence Viewer  
  AAH83926 (Get FASTA)   NCBI Sequence Viewer  
  EDM17560 (Get FASTA)   NCBI Sequence Viewer  
  EDM17561 (Get FASTA)   NCBI Sequence Viewer  
  Q62673 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_058796   ⟸   NM_017100
- UniProtKB: Q62673 (UniProtKB/Swiss-Prot),   Q5XHX4 (UniProtKB/Swiss-Prot),   F1LNH6 (UniProtKB/Swiss-Prot),   A0A140TAD2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000025629   ⟸   ENSRNOT00000025629
Protein Domains
POLO box   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62673-F1-model_v2 AlphaFold Q62673 1-603 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3352 AgrOrtholog
BioCyc Gene G2FUF-57546 BioCyc
Ensembl Genes ENSRNOG00000018815 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000025629 ENTREZGENE
  ENSRNOP00000025629.6 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025629 ENTREZGENE
  ENSRNOT00000025629.8 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1120.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7135428 IMAGE-MGC_LOAD
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLK1_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POLO_box_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POLO_box_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POLO_box_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POLO_box_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25515 UniProtKB/Swiss-Prot
MGC_CLONE MGC:95329 IMAGE-MGC_LOAD
NCBI Gene 25515 ENTREZGENE
PANTHER SERINE/THREONINE-PROTEIN KINASE PLK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE PLK1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POLO_box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Plk1 PhenoGen
PROSITE POLO_BOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Polo-box domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A140TAD2 ENTREZGENE, UniProtKB/TrEMBL
  A6I8W9_RAT UniProtKB/TrEMBL
  A6I8X0_RAT UniProtKB/TrEMBL
  F1LNH6 ENTREZGENE
  PLK1_RAT UniProtKB/Swiss-Prot
  Q5XHX4 ENTREZGENE
  Q62673 ENTREZGENE
UniProt Secondary F1LNH6 UniProtKB/Swiss-Prot
  Q5XHX4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Plk1  polo-like kinase 1  Plk1  polo-like kinase 1 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Plk1  polo-like kinase 1 (Drosophila)  Plk  polo-like kinase homolog (Drosophila)  Symbol and Name updated 1299863 APPROVED
2002-11-06 Plk  polo-like kinase homolog (Drosophila)    Polo-like kinase homolog  Name updated 625702 APPROVED
2002-06-10 Plk  Polo-like kinase homolog      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localizes to the nucleus, spindle pole during M-phase and anaphase and after fertilization to actively assembling microtubules. 1304387
gene_process involved in a regulatory role in microtubule assembly during oocyte meiotic maturation, fertilization, and early embryonic mitosis 1304387