Pik3r1 (phosphoinositide-3-kinase regulatory subunit 1) - Rat Genome Database

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Gene: Pik3r1 (phosphoinositide-3-kinase regulatory subunit 1) Rattus norvegicus
Symbol: Pik3r1
Name: phosphoinositide-3-kinase regulatory subunit 1
RGD ID: 3329
Description: Enables several functions, including 1-phosphatidylinositol-3-kinase regulator activity; calmodulin binding activity; and enzyme binding activity. Contributes to 1-phosphatidylinositol-3-kinase activity. Involved in several processes, including regulation of protein metabolic process; response to steroid hormone; and transmembrane receptor protein tyrosine kinase signaling pathway. Part of phosphatidylinositol 3-kinase complex. Used to study hypertension and portal hypertension. Biomarker of hepatocellular carcinoma; hypertension; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including SHORT syndrome; agammaglobulinemia 7; astroblastoma; endometrial cancer (multiple); and immunodeficiency 36. Orthologous to human PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1); PARTICIPATES IN insulin signaling pathway; E-cadherin signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; phosphatidylinositol 3-kinase p85 alpha; phosphatidylinositol 3-kinase regulatory subunit alpha; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha); phosphoinositide 3-kinase p85; Phosphoinositide 3-kinase p85 (other splicing variants: p55 and p50); Phosphoinositide 3-kinase regulatory subunit polypeptide 1 (p85 alpha); Phosphoinositide 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha); phosphoinositide-3-kinase, regulatory subunit 1 (alpha); PI3-kinase p85 subunit alpha; PI3-kinase regulatory subunit alpha; PI3-kinase subunit p85-alpha; PI3K regulatory subunit alpha; PI3KA; ptdIns-3-kinase p85-alpha; ptdIns-3-kinase regulatory subunit alpha; ptdIns-3-kinase regulatory subunit p85-alpha
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Bp115
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8234,612,946 - 34,697,660 (-)NCBIGRCr8
mRatBN7.2232,878,942 - 32,963,668 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl232,882,032 - 32,963,631 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx240,014,126 - 40,099,015 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0238,073,343 - 38,158,218 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0232,921,198 - 33,006,089 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0231,742,326 - 31,826,882 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl231,745,088 - 31,826,867 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0250,891,225 - 50,965,217 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4232,602,673 - 32,675,350 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1232,523,041 - 32,595,719 (-)NCBI
Celera228,878,690 - 28,948,863 (-)NCBICelera
RH 3.4 Map2111.0RGD
Cytogenetic Map2q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (EXP)
1-monopalmitoylglycerol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,5-hexanedione  (ISO)
2-butoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
4-nitroquinoline N-oxide  (ISO)
4-tert-butylphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
9-cis-retinoic acid  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
albuterol  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
amphotericin B  (ISO)
angelicin  (ISO)
anthocyanin  (EXP)
antimonite  (ISO)
arecoline  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atazanavir sulfate  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bexarotene  (ISO)
bilirubin IXalpha  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
capsaicin  (ISO)
capsazepine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
celastrol  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chitosan  (ISO)
chlorogenic acid  (ISO)
chromium atom  (ISO)
ciguatoxin CTX1B  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
cobalt dichloride  (ISO)
coenzyme Q10  (EXP)
conjugated linoleic acid  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
daunorubicin  (ISO)
deoxycholic acid  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
Di-n-octyl phthalate  (ISO)
diallyl trisulfide  (EXP)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
diethyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
disodium selenite  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
emodin  (EXP)
endosulfan  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
eugenol  (EXP,ISO)
ferulic acid  (ISO)
folic acid  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
formoterol fumarate  (ISO)
fructose  (EXP)
fulvestrant  (EXP)
furan  (EXP)
Garcinol  (ISO)
gedunin  (ISO)
geldanamycin  (ISO)
geraniol  (EXP)
Gingerenone A  (ISO)
glucose  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hesperidin  (EXP)
HU-308  (EXP)
hydrazines  (ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
inulin  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
iron(2+) sulfate (anhydrous)  (EXP)
isoprenaline  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (EXP)
lactulose  (EXP)
lead diacetate  (EXP)
lead(0)  (ISO)
linsidomine  (ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
maculosin  (ISO)
melatonin  (ISO)
melphalan  (ISO)
mercury atom  (EXP)
mercury(0)  (EXP)
metformin  (EXP,ISO)
methamphetamine  (ISO)
methidathion  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (EXP)
mevinphos  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
naringin  (ISO)
nefazodone  (ISO)
Neferine  (EXP,ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
Nonylphenol  (EXP)
Nookatone  (EXP)
obeticholic acid  (ISO)
olanzapine  (ISO)
oxybenzone  (ISO)
ozone  (EXP,ISO)
paeoniflorin  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
pirinixic acid  (ISO)
procyanidin B1  (ISO)
propiconazole  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
quercitrin  (ISO)
rac-1-monopalmitoylglycerol  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
retinyl acetate  (ISO)
rivastigmine  (EXP)
rotenone  (EXP,ISO)
ruthenium red  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
streptozocin  (EXP,ISO)
succimer  (ISO)
swainsonine  (ISO)
tamoxifen  (ISO)
Tanshinone I  (EXP)
taraxasterol  (ISO)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrathiomolybdate(2-)  (ISO)
thiazolidinediones  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trans-caffeic acid  (ISO)
trans-cinnamic acid  (ISO)
tremolite asbestos  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
tyrphostin AG 1478  (ISO)
uranium atom  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin E  (ISO)
wortmannin  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
B cell differentiation  (IEA,ISO)
cellular response to fatty acid  (IEP)
cellular response to insulin stimulus  (IEP,ISO,ISS)
cellular response to UV  (IEA,ISO)
cytokine-mediated signaling pathway  (ISO)
extrinsic apoptotic signaling pathway via death domain receptors  (IEA,ISO)
glucose metabolic process  (IMP)
growth hormone receptor signaling pathway  (IEA,ISO)
insulin receptor signaling pathway  (IBA,IEA,IMP,ISO,ISS)
insulin-like growth factor receptor signaling pathway  (IEA,IMP,ISO,ISS)
interleukin-18-mediated signaling pathway  (IEA,ISO)
intracellular glucose homeostasis  (IEA,ISO,ISS)
intrinsic apoptotic signaling pathway in response to DNA damage  (IEA,ISO)
myeloid leukocyte migration  (IEA,ISO)
negative regulation of apoptotic process  (IEA,ISO,ISS)
negative regulation of blood pressure  (IMP)
negative regulation of cell adhesion  (ISO)
negative regulation of cell-cell adhesion  (IMP)
negative regulation of cell-matrix adhesion  (IEA,ISO)
negative regulation of heart rate  (IMP)
negative regulation of muscle cell apoptotic process  (IMP)
negative regulation of osteoclast differentiation  (IEA,ISO)
negative regulation of proteolysis  (IMP)
negative regulation of smooth muscle cell proliferation  (IMP)
negative regulation of stress fiber assembly  (IEA,ISO)
osteoclast differentiation  (IEA,ISO)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
phosphatidylinositol metabolic process  (IDA)
phosphatidylinositol phosphate biosynthetic process  (IBA,IEA,ISS)
phosphatidylinositol-3-phosphate biosynthetic process  (IEA)
positive regulation of cell migration  (IMP)
positive regulation of endoplasmic reticulum unfolded protein response  (IEA,ISO,ISS)
positive regulation of filopodium assembly  (IEA,ISO)
positive regulation of focal adhesion disassembly  (IEA,ISO)
positive regulation of gene expression  (IMP)
positive regulation of lamellipodium assembly  (IEA,ISO)
positive regulation of leukocyte migration  (IEA,ISO)
positive regulation of myoblast differentiation  (IMP)
positive regulation of protein import into nucleus  (IEA,ISO,ISS)
positive regulation of protein phosphorylation  (IMP)
positive regulation of RNA splicing  (IEA,ISO,ISS)
positive regulation of smooth muscle cell proliferation  (IEA,ISO)
positive regulation of synapse assembly  (IDA)
positive regulation of transcription by RNA polymerase II  (IEA,ISO,ISS)
positive regulation of tumor necrosis factor production  (IEA,ISO)
protein import into nucleus  (IEA,ISO)
protein stabilization  (IEA,ISO,ISS)
regulation of protein localization to plasma membrane  (IEA,ISO)
regulation of stress fiber assembly  (ISO)
regulation of toll-like receptor 4 signaling pathway  (IEA,ISO)
response to amino acid  (IEP)
response to cAMP  (IDA)
response to dexamethasone  (IEP)
response to endoplasmic reticulum stress  (IEA,ISO,ISS)
response to estradiol  (IEP)
response to ethanol  (IEP)
response to fatty acid  (IEP)
response to fructose  (IEP)
response to glucocorticoid  (IDA)
response to growth factor  (IEP)
response to insulin  (IDA)
response to iron(II) ion  (IEP)
response to nutrient  (IEP)
response to progesterone  (IEP)
response to testosterone  (IEP)
response to xenobiotic stimulus  (IEP)
response to yeast  (IEP)
transcription by RNA polymerase II  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acute myeloid leukemia pathway   (IEA)
aldosterone signaling pathway  (IEA)
apoptotic cell death pathway  (IEA)
B cell receptor signaling pathway  (IEA)
ceramide signaling pathway  (IEA)
Chagas disease pathway  (IEA)
chemokine mediated signaling pathway  (IEA)
chronic myeloid leukemia pathway   (IEA)
colorectal cancer pathway  (IEA)
E-cadherin signaling pathway   (ISO)
endometrial cancer pathway  (IEA)
Entamoebiasis pathway  (IEA)
ephrin - ephrin receptor bidirectional signaling axis   (ISO)
epidermal growth factor/neuregulin signaling pathway  (IEA,ISO)
erythropoietin signaling pathway   (ISO)
FasL mediated signaling pathway  (ISO)
Fc epsilon receptor mediated signaling pathway  (IEA,ISO)
Fc gamma receptor mediated signaling pathway  (IEA)
fibroblast growth factor signaling pathway  (ISO)
glioma pathway  (IEA)
granulocyte-macrophage colony-stimulating factor signaling pathway   (ISO)
Hedgehog signaling pathway  (ISO)
hepatitis C pathway  (IEA)
influenza A pathway   (IEA)
insulin signaling pathway  (IDA,IEA,ISO)
insulin-like growth factor signaling pathway   (ISO)
interleukin-1 signaling pathway  (ISO)
interleukin-2 signaling pathway  (ISO)
interleukin-23 signaling pathway  (ISO)
interleukin-3 signaling pathway  (ISO)
interleukin-4 signaling pathway  (ISO)
interleukin-5 signaling pathway   (ISO)
interleukin-6 signaling pathway   (ISO)
Jak-Stat signaling pathway  (IEA)
measles pathway  (IEA)
melanoma pathway   (IEA)
mTOR signaling pathway  (IEA)
N-cadherin signaling pathway  (ISO)
neurotrophic factor signaling pathway   (IEA)
non-small cell lung carcinoma pathway   (IEA)
nuclear factor kappa B signaling pathway   (ISO)
pancreatic cancer pathway  (IEA)
phosphatidylinositol 3-kinase class I signaling pathway  (ISO)
phosphatidylinositol 3-kinase signaling pathway   (IEA)
phosphatidylinositol 3-kinase-Akt signaling pathway  (ISO)
phosphoinositide metabolic pathway  (ISO)
platelet-derived growth factor signaling pathway   (ISO)
prostate cancer pathway   (IEA)
Reelin signaling pathway   (ISO)
renal cell carcinoma pathway   (IEA)
scatter factor/hepatocyte growth factor signaling pathway  (ISO)
small cell lung carcinoma pathway  (IEA)
T cell receptor signaling pathway   (IEA)
Toll-like receptor signaling pathway  (IEA)
toxoplasmosis pathway   (IEA)
Trail mediated signaling pathway   (ISO)
type 2 diabetes mellitus pathway  (IEA)
type II interferon signaling pathway   (ISO)
vascular endothelial growth factor signaling pathway  (IEA,ISO)


References - curated
# Reference Title Reference Citation
1. Dexamethasone suppresses antigen-induced activation of phosphatidylinositol 3-kinase and downstream responses in mast cells. Andrade MV, etal., J Immunol. 2004 Jun 15;172(12):7254-62.
2. Syndapin I and endophilin I bind overlapping proline-rich regions of dynamin I: role in synaptic vesicle endocytosis. Anggono V and Robinson PJ, J Neurochem. 2007 Aug;102(3):931-43. Epub 2007 Apr 16.
3. Candidate gene association study in type 2 diabetes indicates a role for genes involved in beta-cell function as well as insulin action. Barroso I, etal., PLoS Biol. 2003 Oct;1(1):E20. Epub 2003 Oct 13.
4. In vivo leptin infusion impairs insulin and leptin signalling in liver and hypothalamus. Benomar Y, etal., Mol Cell Endocrinol. 2005 Oct 20;242(1-2):59-66.
5. Met, metastasis, motility and more. Birchmeier C, etal., Nat Rev Mol Cell Biol. 2003 Dec;4(12):915-25.
6. PDGF- and insulin/IGF-1-specific distinct modes of class IA PI 3-kinase activation in normal rat retinas and RGC-5 retinal ganglion cells. Biswas SK, etal., Invest Ophthalmol Vis Sci. 2008 Aug;49(8):3687-98. Epub 2008 Apr 17.
7. Phosphatidylinositol 3-kinase interacts with the adaptor protein Dab1 in response to Reelin signaling and is required for normal cortical lamination. Bock HH, etal., J Biol Chem 2003 Oct 3;278(40):38772-9. Epub 2003 Jul 25.
8. Transduction pathways regulating the trophic effects of Saccharomyces boulardii in rat intestinal mucosa. Buts JP and De Keyser N, Scand J Gastroenterol. 2010;45(2):175-85.
9. Oncogenic Ras signals through activation of both phosphoinositide 3-kinase and Rac1 to induce c-Jun NH2-terminal kinase-mediated, caspase-independent cell death. Byun JY, etal., Mol Cancer Res. 2009 Sep;7(9):1534-42. Epub 2009 Sep 1.
10. MicroRNA-542-3p Suppresses Tumor Cell Invasion via Targeting AKT Pathway in Human Astrocytoma. Cai J, etal., J Biol Chem. 2015 Oct 9;290(41):24678-88. doi: 10.1074/jbc.M115.649004. Epub 2015 Aug 18.
11. Integrated genomic characterization of endometrial carcinoma. Cancer Genome Atlas Research Network, etal., Nature. 2013 May 2;497(7447):67-73. doi: 10.1038/nature12113.
12. Gas6-axl receptor signaling is regulated by glucose in vascular smooth muscle cells. Cavet ME, etal., Arterioscler Thromb Vasc Biol. 2008 May;28(5):886-91. Epub 2008 Feb 21.
13. Dilinoleoyl-phosphatidic acid mediates reduced IRS-1 tyrosine phosphorylation in rat skeletal muscle cells and mouse muscle. Cazzolli R, etal., Diabetologia. 2007 Aug;50(8):1732-42. Epub 2007 Jun 26.
14. Signal transduction of the protective effect of insulin like growth factor-1 on adriamycin-induced apoptosis in cardiac muscle cells. Chae HJ, etal., Arch Pharm Res. 2004 Mar;27(3):324-33.
15. High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability. Cheung LW, etal., Cancer Discov. 2011 Jul;1(2):170-85. doi: 10.1158/2159-8290.CD-11-0039. Epub 2011 Jun 7.
16. EGF-ERBB signalling: towards the systems level. Citri A and Yarden Y, Nat Rev Mol Cell Biol. 2006 Jul;7(7):505-16.
17. Phosphoinositide-3-kinase activation controls synaptogenesis and spinogenesis in hippocampal neurons. Cuesto G, etal., J Neurosci. 2011 Feb 23;31(8):2721-33. doi: 10.1523/JNEUROSCI.4477-10.2011.
18. Potential role of growth hormone in impairment of insulin signaling in skeletal muscle, adipose tissue, and liver of rats chronically treated with arginine. de Castro Barbosa T, etal., Endocrinology. 2009 May;150(5):2080-6. Epub 2008 Dec 23.
19. Focal adhesion kinase as a RhoA-activable signaling scaffold mediating Akt activation and cardiomyocyte protection. Del Re DP, etal., J Biol Chem. 2008 Dec 19;283(51):35622-9. Epub 2008 Oct 14.
20. Protein-tyrosine phosphatase-1B negatively regulates insulin signaling in l6 myocytes and Fao hepatoma cells. Egawa K, etal., J Biol Chem. 2001 Mar 30;276(13):10207-11. Epub 2001 Jan 2.
21. Tissue- and fibre-specific modifications of insulin-signalling molecules in cardiac and skeletal muscle of diabetic rats. Ekladous D, etal., Clin Exp Pharmacol Physiol. 2008 Aug;35(8):971-8. Epub 2008 Apr 21.
22. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Engelman JA, etal., Nat Rev Genet. 2006 Aug;7(8):606-19.
23. Induced expression of MMP-9 in C6 glioma cells is inhibited by PDGF via a PI 3-kinase-dependent pathway. Esteve PO, etal., Biochem Biophys Res Commun 2002 Aug 30;296(4):864-9.
24. Soybean diet alters the insulin-signaling pathway in the liver of rats recovering from early-life malnutrition. Feres NH, etal., Nutrition. 2010 Apr;26(4):441-8. Epub 2009 Oct 31.
25. Involvement of JAK2 upstream of the PI 3-kinase in cell-cell adhesion regulation by gastrin. Ferrand A, etal., Exp Cell Res. 2004 Dec 10;301(2):128-38.
26. Acidosis impairs insulin receptor substrate-1-associated phosphoinositide 3-kinase signaling in muscle cells: consequences on proteolysis. Franch HA, etal., Am J Physiol Renal Physiol. 2004 Oct;287(4):F700-6. Epub 2004 May 25.
27. Coordinate regulation of catecholamine uptake by rab3 and phosphoinositide 3-kinase. Francis SC, etal., J Biol Chem 2002 Mar 8;277(10):7816-23.
28. Structural organization and alternative splicing of the murine phosphoinositide 3-kinase p85 alpha gene. Fruman DA, etal., Genomics 1996 Oct 1;37(1):113-21.
29. Selective loss of gastrointestinal mast cells and impaired immunity in PI3K-deficient mice. Fukao T, etal., Nat Immunol 2002 Mar;3(3):295-304.
30. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
31. The Met tyrosine kinase receptor in development and cancer. Gentile A, etal., Cancer Metastasis Rev. 2008 Mar;27(1):85-94.
32. Regulation of the phosphoinositide-3 kinase and mitogen-activated protein kinase signaling pathways by progesterone and its reduced metabolites in the rat brain. Guerra-Araiza C, etal., J Neurosci Res. 2009 Feb;87(2):470-81.
33. The Modulation of Vascular ATP-Sensitive K+ Channel Function via the Phosphatidylinositol 3-Kinase-Akt Pathway Activated by Phenylephrine. Haba M, etal., J Pharmacol Exp Ther. 2010 Aug;334(2):673-8. Epub 2010 Jun 2.
34. Dose-dependent effects of alcohol on insulin signaling: partial explanation for biphasic alcohol impact on human health. He L, etal., Mol Endocrinol. 2007 Oct;21(10):2541-50. Epub 2007 Jul 10.
35. A comprehensive analysis of transcript signatures of the phosphatidylinositol-3 kinase/protein kinase B signal-transduction pathway in prostate cancer. Hellwinkel OJ, etal., BJU Int. 2008 Jun;101(11):1454-60. Epub 2008 Mar 11.
36. Phosphoinositide 3-kinases as a common platform for multi-hormone signaling. Hirsch E, etal., J Endocrinol. 2007 Aug;194(2):243-56.
37. The regulatory subunit of PDE6 interacts with PACSIN in photoreceptors. Houdart F, etal., Mol Vis. 2005 Dec 9;11:1061-70.
38. A novel 55-kDa regulatory subunit for phosphatidylinositol 3-kinase structurally similar to p55PIK Is generated by alternative splicing of the p85alpha gene. Inukai K, etal., J Biol Chem 1996 Mar 8;271(10):5317-20.
39. p85alpha gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase (PI 3-Kinase), p50alpha, p55alpha, and p85alpha, with different PI 3-kinase activity elevating responses to insulin. Inukai K, etal., J Biol Chem 1997 Mar 21;272(12):7873-82.
40. MicroRNA-Related Polymorphisms in PI3K/Akt/mTOR Pathway Genes Are Predictive of Limited-Disease Small Cell Lung Cancer Treatment Outcomes. Jiang W, etal., Biomed Res Int. 2017;2017:6501385. doi: 10.1155/2017/6501385. Epub 2017 Feb 9.
41. Insulin-like growth factors require phosphatidylinositol 3-kinase to signal myogenesis: dominant negative p85 expression blocks differentiation of L6E9 muscle cells. Kaliman P, etal., Mol Endocrinol. 1998 Jan;12(1):66-77.
42. Platelet-derived growth factor-BB-mediated activation of Akt suppresses smooth muscle-specific gene expression through inhibition of mitogen-activated protein kinase and redistribution of serum response factor. Kaplan-Albuquerque N, etal., J Biol Chem. 2003 Oct 10;278(41):39830-8. Epub 2003 Jul 25.
43. Activation of eNOS in rat portal hypertensive gastric mucosa is mediated by TNF-alpha via the PI 3-kinase-Akt signaling pathway. Kawanaka H, etal., Hepatology. 2002 Feb;35(2):393-402.
44. Effects of eicosapentaenoic acid on synaptic plasticity, fatty acid profile and phosphoinositide 3-kinase signaling in rat hippocampus and differentiated PC12 cells. Kawashima A, etal., J Nutr Biochem. 2010 Apr;21(4):268-77. Epub 2009 Apr 14.
45. Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse. Kerouz NJ, etal., J Clin Invest. 1997 Dec 15;100(12):3164-72.
46. Insulin signaling through insulin receptor substrate 1 and 2 in normal liver development. Khamzina L, etal., Gastroenterology 2003 Aug;125(2):572-85.
47. Protein kinase C-delta mediates neuronal apoptosis in the retinas of diabetic rats via the Akt signaling pathway. Kim YH, etal., Diabetes. 2008 Aug;57(8):2181-90. Epub 2008 Apr 28.
48. Epidermal growth factor-induced phosphatidylinositol 3-kinase activation and DNA synthesis. Identification of Grb2-associated binder 2 as the major mediator in rat hepatocytes. Kong M, etal., J Biol Chem. 2000 Nov 17;275(46):36035-42.
49. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
50. Modulating Toll-like receptor mediated signaling by (1-->3)-beta-D-glucan rapidly induces cardioprotection. Li C, etal., Cardiovasc Res 2004 Feb 15;61(3):538-47.
51. LncRNA MALAT1 mediates proliferation of LPS treated-articular chondrocytes by targeting the miR-146a-PI3K/Akt/mTOR axis. Li H, etal., Life Sci. 2020 Aug 1;254:116801. doi: 10.1016/j.lfs.2019.116801. Epub 2019 Aug 28.
52. Oroxin B Induces Apoptosis by Down-Regulating MicroRNA-221 Resulting in the Inactivation of the PTEN/PI3K/AKT Pathway in Liver Cancer. Li N, etal., Molecules. 2019 Nov 30;24(23). pii: molecules24234384. doi: 10.3390/molecules24234384.
53. PIK3R1 negatively regulates the epithelial-mesenchymal transition and stem-like phenotype of renal cancer cells through the AKT/GSK3ß/CTNNB1 signaling pathway. Lin Y, etal., Sci Rep. 2015 Mar 11;5:8997. doi: 10.1038/srep08997.
54. Genetic variability in the insulin signalling pathway may contribute to the risk of late onset Alzheimer's disease. Liolitsa D, etal., J Neurol Neurosurg Psychiatry. 2002 Sep;73(3):261-6.
55. Hepatic ischemia-reperfusion induces insulin resistance via down-regulation during the early steps in insulin signaling in rats. Liu C, etal., Transplant Proc. 2008 Dec;40(10):3330-4.
56. Myricetin, a naturally occurring flavonol, ameliorates insulin resistance induced by a high-fructose diet in rats. Liu IM, etal., Life Sci. 2007 Nov 10;81(21-22):1479-88. Epub 2007 Oct 2.
57. Association of PI3K-Akt signaling pathway with digitalis-induced hypertrophy of cardiac myocytes. Liu L, etal., Am J Physiol Cell Physiol. 2007 Nov;293(5):C1489-97. Epub 2007 Aug 29.
58. Insulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteins. Liu YF, etal., J Biol Chem. 2001 Apr 27;276(17):14459-65. Epub 2001 Jan 29.
59. Phosphatidylinositol 3-kinase/Akt signaling stimulates colonic mucosal cell survival during aging. Majumdar AP and Du J, Am J Physiol Gastrointest Liver Physiol. 2006 Jan;290(1):G49-55. Epub 2005 Aug 25.
60. Estrogen receptor protein interaction with phosphatidylinositol 3-kinase leads to activation of phosphorylated Akt and extracellular signal-regulated kinase 1/2 in the same population of cortical neurons: a unified mechanism of estrogen action. Mannella P and Brinton RD, J Neurosci. 2006 Sep 13;26(37):9439-47.
61. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
62. Chronic 17beta-estradiol treatment improves skeletal muscle insulin signaling pathway components in insulin resistance associated with aging. Moreno M, etal., Age (Dordr). 2010 Mar;32(1):1-13. Epub 2009 May 22.
63. Rapamycin inhibits multiple stages of c-Neu/ErbB2 induced tumor progression in a transgenic mouse model of HER2-positive breast cancer. Mosley JD, etal., Mol Cancer Ther. 2007 Aug;6(8):2188-97.
64. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
65. Tyrosine kinase and phosphatidylinositol 3-kinase activation are required for cyclic adenosine 3',5'-monophosphate-dependent potentiation of deoxyribonucleic acid synthesis induced by insulin-like growth factor-I in FRTL-5 cells. Nedachi T, etal., Endocrinology. 2000 Jul;141(7):2429-38.
66. Analysis of expression profile of gene encoding proteins of signal cascades activated by insulin-like growth factors in colorectal cancer. Nowakowska-Zajdel E, etal., Int J Immunopathol Pharmacol. 2011 Jul-Sep;24(3):781-7.
67. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
68. Maternal and postweaning diet interaction alters hypothalamic gene expression and modulates response to a high-fat diet in male offspring. Page KC, etal., Am J Physiol Regul Integr Comp Physiol. 2009 Oct;297(4):R1049-57. Epub 2009 Aug 5.
69. Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance of early postreceptor insulin signaling events in skeletal muscle. Patti ME, etal., Diabetes. 1999 Aug;48(8):1562-71.
70. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
71. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
72. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
73. Selective modulation of the CAP/Cbl pathway in the adipose tissue of high fat diet treated rats. Prada PO, etal., FEBS Lett. 2006 Sep 4;580(20):4889-94. Epub 2006 Aug 10.
74. Gene expression profiles of adipose tissue of obese rats after central administration of neuropeptide Y-Y5 receptor antisense oligodeoxynucleotides by cDNA microarrays. Qiu J, etal., Peptides. 2008 Nov;29(11):2052-60. Epub 2008 Jul 4.
75. Differential reelin-induced enhancement of NMDA and AMPA receptor activity in the adult hippocampus. Qiu S, etal., J Neurosci. 2006 Dec 13;26(50):12943-55.
76. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
77. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
78. Src-dependent association of Cas and p85 phosphatidylinositol 3'-kinase in v-crk-transformed cells. Riggins RB, etal., Mol Cancer Res 2003 Apr;1(6):428-37.
79. p68 Sam is a substrate of the insulin receptor and associates with the SH2 domains of p85 PI3K. Sanchez-Margalet V and Najib S, FEBS Lett. 1999 Jul 23;455(3):307-10.
80. Insulin resistance in human preeclamptic placenta is mediated by serine phosphorylation of insulin receptor substrate-1 and -2. Scioscia M, etal., J Clin Endocrinol Metab. 2006 Feb;91(2):709-17. Epub 2005 Dec 6.
81. Caveolin-1 facilitates mechanosensitive protein kinase B (Akt) signaling in vitro and in vivo. Sedding DG, etal., Circ Res. 2005 Apr 1;96(6):635-42. Epub 2005 Feb 24.
82. Dephosphorylation of Akt in C6 cells grown in serum-free conditions corresponds with redistribution of p85/PI3K to the nucleus. Sephton CF and Mousseau DD, J Neurosci Res. 2008 Feb 15;86(3):675-82.
83. Mechanism for differential effect of protein-tyrosine phosphatase 1B on Akt versus mitogen-activated protein kinase in 3T3-L1 adipocytes. Shimizu S, etal., Endocrinology. 2002 Dec;143(12):4563-9.
84. The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance. Taniguchi CM, etal., Mol Cell Biol. 2007 Apr;27(8):2830-40. Epub 2007 Feb 5.
85. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
86. Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase. Terauchi Y, etal., Nat Genet 1999 Feb;21(2):230-5.
87. Differential regulation of vascular smooth muscle and endothelial cell proliferation in vitro and in vivo by cAMP/PKA-activated p85alphaPI3K. Torella D, etal., Am J Physiol Heart Circ Physiol. 2009 Dec;297(6):H2015-25. Epub 2009 Sep 25.
88. Shootin1: A protein involved in the organization of an asymmetric signal for neuronal polarization. Toriyama M, etal., J Cell Biol. 2006 Oct 9;175(1):147-57.
89. EV71 induces COX-2 expression via c-Src/PDGFR/PI3K/Akt/p42/p44 MPAK/AP-1 and NF-kappaB in rat brain astrocytes. Tung WH, etal., J Cell Physiol. 2010 Mar 23.
90. Both p110alpha and p110beta isoforms of phosphatidylinositol 3-OH-kinase are required for insulin signalling in the hypothalamus. Tups A, etal., J Neuroendocrinol. 2010 Jun;22(6):534-42. Epub 2010 Mar 2.
91. Activation of phosphoinositide-3 kinase/Akt pathway by FeSO4 in rat cerebral cortex synaptic endings. Uranga RM, etal., J Neurosci Res. 2007 Oct;85(13):2924-32.
92. PIK3R1 (p85a) is somatically mutated at high frequency in primary endometrial cancer. Urick ME, etal., Cancer Res. 2011 Jun 15;71(12):4061-7. doi: 10.1158/0008-5472.CAN-11-0549. Epub 2011 Apr 8.
93. Survival kinase genes present prognostic significance in glioblastoma. Varghese RT, etal., Oncotarget. 2016 Mar 4. doi: 10.18632/oncotarget.7917.
94. GABAA receptor-associated phosphoinositide 3-kinase is required for insulin-induced recruitment of postsynaptic GABAA receptors. Vetiska SM, etal., Neuropharmacology. 2007 Jan;52(1):146-55. Epub 2006 Aug 4.
95. Modulating serine palmitoyl transferase (SPT) expression and activity unveils a crucial role in lipid-induced insulin resistance in rat skeletal muscle cells. Watson ML, etal., Biochem J. 2009 Feb 1;417(3):791-801.
96. Dual inhibitory roles of geldanamycin on the c-Jun NH2-terminal kinase 3 signal pathway through suppressing the expression of mixed-lineage kinase 3 and attenuating the activation of apoptosis signal-regulating kinase 1 via facilitating the activation of Akt in ischemic brain injury. Wen XR, etal., Neuroscience. 2008 Oct 15;156(3):483-97. Epub 2008 Aug 12.
97. Gene expression profiling of lung adenocarcinoma in Xuanwei, China. Wu H, etal., Eur J Cancer Prev. 2016 Nov;25(6):508-17. doi: 10.1097/CEJ.0000000000000214.
98. REDD1 is a major target of testosterone action in preventing dexamethasone-induced muscle loss. Wu Y, etal., Endocrinology. 2010 Mar;151(3):1050-9. Epub 2009 Dec 23.
99. Subtoxic N-methyl-D-aspartate delayed neuronal death in ischemic brain injury through TrkB receptor- and calmodulin-mediated PI-3K/Akt pathway activation. Xu J, etal., Hippocampus. 2007;17(7):525-37.
100. Garlic Oil Suppressed Nitrosodiethylamine-Induced Hepatocarcinoma in Rats by Inhibiting PI3K-AKT-NF-κB Pathway. Zhang CL, etal., Int J Biol Sci. 2015 Apr 25;11(6):643-51. doi: 10.7150/ijbs.10785. eCollection 2015.
101. Reduced cardiotropic response to insulin in spontaneously hypertensive rats: role of peroxisome proliferator-activated receptor-gamma-initiated signaling. Zhang H, etal., J Hypertens. 2008 Mar;26(3):560-9.
102. Chronic blockade of phosphatidylinositol 3-kinase in the nucleus tractus solitarii is prohypertensive in the spontaneously hypertensive rat. Zubcevic J, etal., Hypertension. 2009 Jan;53(1):97-103. Epub 2008 Nov 17.
Additional References at PubMed
PMID:7537849   PMID:7539611   PMID:7541045   PMID:7782332   PMID:8183574   PMID:8402898   PMID:8440175   PMID:8550620   PMID:8628286   PMID:8781294   PMID:9415395   PMID:9748281  
PMID:9791008   PMID:10572067   PMID:10860857   PMID:12408866   PMID:12594288   PMID:12960006   PMID:14699157   PMID:15039234   PMID:15192701   PMID:15488758   PMID:15845362   PMID:15858065  
PMID:16043515   PMID:16569213   PMID:16717100   PMID:16960657   PMID:17053831   PMID:17242187   PMID:18417706   PMID:18828053   PMID:19298529   PMID:19689064   PMID:19946888   PMID:20042608  
PMID:20348923   PMID:20348926   PMID:20624904   PMID:20669351   PMID:21321938   PMID:21671003   PMID:21704119   PMID:21788123   PMID:22341695   PMID:23793062   PMID:24057979   PMID:24090963  
PMID:24907397   PMID:25048263   PMID:25217619   PMID:25667086   PMID:26657864   PMID:33215443  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8234,612,946 - 34,697,660 (-)NCBIGRCr8
mRatBN7.2232,878,942 - 32,963,668 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl232,882,032 - 32,963,631 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx240,014,126 - 40,099,015 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0238,073,343 - 38,158,218 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0232,921,198 - 33,006,089 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0231,742,326 - 31,826,882 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl231,745,088 - 31,826,867 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0250,891,225 - 50,965,217 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4232,602,673 - 32,675,350 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1232,523,041 - 32,595,719 (-)NCBI
Celera228,878,690 - 28,948,863 (-)NCBICelera
RH 3.4 Map2111.0RGD
Cytogenetic Map2q12NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38568,215,756 - 68,301,821 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl568,215,740 - 68,301,821 (+)EnsemblGRCh38hg38GRCh38
GRCh37567,511,584 - 67,597,649 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36567,558,218 - 67,633,405 (+)NCBINCBI36Build 36hg18NCBI36
Build 34567,622,250 - 67,633,403NCBI
Celera564,520,829 - 64,597,175 (+)NCBICelera
Cytogenetic Map5q13.1NCBI
HuRef564,468,818 - 64,555,164 (+)NCBIHuRef
CHM1_1567,511,846 - 67,597,747 (+)NCBICHM1_1
T2T-CHM13v2.0569,037,928 - 69,124,117 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3913101,817,269 - 101,904,725 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13101,817,071 - 101,904,725 (-)EnsemblGRCm39 Ensembl
GRCm3813101,680,761 - 101,768,217 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13101,680,563 - 101,768,217 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713102,450,716 - 102,538,172 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613102,781,018 - 102,792,904 (-)NCBIMGSCv36mm8
Celera13105,285,857 - 105,373,612 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1353.92NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554461,020,043 - 1,098,820 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554461,020,707 - 1,098,327 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v2445,620,454 - 45,705,861 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1543,777,000 - 43,859,488 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0545,701,219 - 45,786,652 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1547,268,477 - 47,350,960 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl547,267,286 - 47,350,960 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1253,447,802 - 53,527,563 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl253,448,286 - 53,524,970 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha250,408,936 - 50,489,628 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0253,951,256 - 54,032,010 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl253,960,673 - 54,031,993 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1251,011,708 - 51,092,420 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0251,791,194 - 51,871,863 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0252,678,736 - 52,759,442 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024407213192,252,011 - 192,336,736 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364801,188,183 - 1,273,537 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364801,188,408 - 1,273,210 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1646,511,521 - 46,523,609 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11646,434,757 - 46,523,626 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21650,135,837 - 50,148,434 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1464,321,296 - 64,406,188 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl464,321,078 - 64,406,519 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604913,008,003 - 13,093,192 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248151,289,997 - 1,369,610 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248151,290,106 - 1,376,961 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Pik3r1
473 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:273
Count of miRNA genes:99
Interacting mature miRNAs:113
Transcripts:ENSRNOT00000025687, ENSRNOT00000065301, ENSRNOT00000075057
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631682Bp115Blood pressure QTL 1154.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2137410502Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2141244106Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777242804738Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)21185206249003364Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22691781781754745Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
1331764Bp205Blood pressure QTL 2053.476arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22699957143154682Rat
1643006Pain1Pain QTL 13.630.005mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)22699957148268661Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22715716072157160Rat
1300160Hrtrt3Heart rate QTL 33.62heart pumping trait (VT:2000009)absolute change in heart rate (CMO:0000534)22997159351729300Rat
10755434Coatc7Coat color QTL 70.04794coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23064806575648065Rat
731179Mamtr3Mammary tumor resistance QTL 30.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)23237377043665178Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2232,882,781 - 32,882,865 (+)MAPPERmRatBN7.2
Rnor_6.0231,746,164 - 31,746,247NCBIRnor6.0
Rnor_5.0250,895,063 - 50,895,146UniSTSRnor5.0
RGSC_v3.4232,602,472 - 32,602,555UniSTSRGSC3.4
Celera228,878,489 - 28,878,572UniSTS
Cytogenetic Map2q12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2232,885,090 - 32,885,351 (+)MAPPERmRatBN7.2
Rnor_6.0231,748,473 - 31,748,733NCBIRnor6.0
Rnor_5.0250,897,372 - 50,897,632UniSTSRnor5.0
RGSC_v3.4232,604,781 - 32,605,041UniSTSRGSC3.4
Celera228,880,798 - 28,881,058UniSTS
RH 3.4 Map2111.0UniSTS
Cytogenetic Map2q12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2232,938,036 - 32,938,203 (+)MAPPERmRatBN7.2
Rnor_6.0231,801,324 - 31,801,490NCBIRnor6.0
Rnor_5.0250,950,223 - 50,950,389UniSTSRnor5.0
RGSC_v3.4232,660,025 - 32,660,191UniSTSRGSC3.4
Celera228,933,723 - 28,933,889UniSTS
RH 3.4 Map2111.7UniSTS
Cytogenetic Map2q12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2232,882,774 - 32,882,958 (+)MAPPERmRatBN7.2
Rnor_6.0231,746,157 - 31,746,340NCBIRnor6.0
Rnor_5.0250,895,056 - 50,895,239UniSTSRnor5.0
RGSC_v3.4232,602,465 - 32,602,648UniSTSRGSC3.4
Celera228,878,482 - 28,878,665UniSTS
Cytogenetic Map2q12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2232,932,877 - 32,933,030 (+)MAPPERmRatBN7.2
Rnor_6.0231,796,258 - 31,796,410NCBIRnor6.0
Rnor_5.0250,945,157 - 50,945,309UniSTSRnor5.0
RGSC_v3.4232,654,435 - 32,654,587UniSTSRGSC3.4
Celera228,928,588 - 28,928,740UniSTS
RH 3.4 Map279.0UniSTS
Cytogenetic Map2q12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2232,936,486 - 32,936,606 (+)MAPPERmRatBN7.2
Rnor_6.0231,799,867 - 31,799,986NCBIRnor6.0
Rnor_5.0250,948,766 - 50,948,885UniSTSRnor5.0
RGSC_v3.4232,658,584 - 32,658,703UniSTSRGSC3.4
RGSC_v3.4232,658,044 - 32,658,163UniSTSRGSC3.4
Celera228,932,197 - 28,932,316UniSTS
RH 3.4 Map2111.4UniSTS
Cytogenetic Map2q12UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 34 53 37 19 37 8 9 74 35 34 11 8
Low 9 4 4 4 2 7
Below cutoff


RefSeq Acc Id: ENSRNOT00000025687   ⟹   ENSRNOP00000025687
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl232,882,032 - 32,963,631 (-)Ensembl
Rnor_6.0 Ensembl231,745,088 - 31,826,867 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000075057   ⟹   ENSRNOP00000067155
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl232,882,790 - 32,892,458 (-)Ensembl
Rnor_6.0 Ensembl231,746,365 - 31,753,528 (-)Ensembl
RefSeq Acc Id: NM_013005   ⟹   NP_037137
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr8234,612,946 - 34,697,660 (-)NCBI
mRatBN7.2232,878,942 - 32,963,668 (-)NCBI
Rnor_6.0231,746,365 - 31,816,385 (-)NCBI
Rnor_5.0250,891,225 - 50,965,217 (-)NCBI
RGSC_v3.4232,602,673 - 32,675,350 (-)RGD
Celera228,878,690 - 28,948,863 (-)RGD
RefSeq Acc Id: XM_006231868   ⟹   XP_006231930
Rat AssemblyChrPosition (strand)Source
GRCr8234,612,946 - 34,625,119 (-)NCBI
mRatBN7.2232,882,983 - 32,891,084 (-)NCBI
Rnor_6.0231,742,326 - 31,754,521 (-)NCBI
Rnor_5.0250,891,225 - 50,965,217 (-)NCBI
RefSeq Acc Id: XM_008760659   ⟹   XP_008758881
Rat AssemblyChrPosition (strand)Source
GRCr8234,612,946 - 34,631,725 (-)NCBI
mRatBN7.2232,878,942 - 32,894,171 (-)NCBI
Rnor_6.0231,742,326 - 31,758,165 (-)NCBI
RefSeq Acc Id: NP_037137   ⟸   NM_013005
- UniProtKB: Q63790 (UniProtKB/Swiss-Prot),   Q63787 (UniProtKB/Swiss-Prot),   P70544 (UniProtKB/Swiss-Prot),   O55085 (UniProtKB/Swiss-Prot),   F1LNG5 (UniProtKB/TrEMBL),   A6I5C4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231930   ⟸   XM_006231868
- Peptide Label: isoform X1
- UniProtKB: M0RC47 (UniProtKB/TrEMBL),   A6I5C6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008758881   ⟸   XM_008760659
- Peptide Label: isoform X2
- UniProtKB: A6I5C5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000067155   ⟸   ENSRNOT00000075057
RefSeq Acc Id: ENSRNOP00000025687   ⟸   ENSRNOT00000025687
Protein Domains
Rho-GAP   SH2   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63787-F1-model_v2 AlphaFold Q63787 1-724 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13691115
Promoter ID:EPDNEW_R1640
Type:initiation region
Description:phosphoinositide-3-kinase regulatory subunit 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.0231,826,844 - 31,826,904EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3329 AgrOrtholog
BioCyc Gene G2FUF-54609 BioCyc
BioCyc Pathway PWY-6352 [3-phosphoinositide biosynthesis] BioCyc
BioCyc Pathway Image PWY-6352 BioCyc
Ensembl Genes ENSRNOG00000018903 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025687 ENTREZGENE
  ENSRNOT00000025687.8 UniProtKB/TrEMBL
  ENSRNOT00000075057.2 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.10.555.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 Domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ISH2_PIK3R1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_P85_iSH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_p85alpha_SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3kinase_P85_cSH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3kinase_P85_nSH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGAP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25513 UniProtKB/Swiss-Prot
  PI3K21B, ISOFORM B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PI3K_P85_iSH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_2 UniProtKB/TrEMBL
PhenoGen Pik3r1 PhenoGen
  SH2DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018903 RatGTEx
SMART RhoGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC228818
  P85A_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary O55085 UniProtKB/Swiss-Prot
  P70544 UniProtKB/Swiss-Prot
  Q63790 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-30 Pik3r1  phosphoinositide-3-kinase regulatory subunit 1  Pik3r1  phosphoinositide-3-kinase, regulatory subunit 1 (alpha)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-09 Pik3r1  phosphoinositide-3-kinase, regulatory subunit 1 (alpha)  Pik3r1  phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-14 Pik3r1  phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)  Pik3r1  phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2001-05-08 Pik3r1  Phosphoinositide 3-kinase p85      Name withdrawn, does not match Human and Mouse nomenclature 62408 WITHDRAWN
2001-05-08 Pik3r1  Phosphoinositide 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)      Name changed to reflect Human and Mouse nomenclature 62408 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains SH2 domains 729673
gene_expression expressed in hepatic, brain and renal tissues 729673
gene_function activation is strongly induced by insulin 729673
gene_function activation is required for insulin-stimulated glucose transport and insulin-dependent p70S6K activation 68289
gene_function phosphorylates a variety of lipids and proteins to activate specific signaling cascades 729503
gene_homology alternative splice product of 55 kDa, p55alpha, has homology to p55 gamma (Pik3r3) 68289
gene_physical_interaction tyrosine kinase receptor binding 729673
gene_physical_interaction binds to and is stimulated by phosphorylated substrates 729673
gene_physical_interaction binds to insulin receptor 729673
gene_physical_interaction forms a heterodimer with the p110 catalytic subunit 729673
gene_regulation regulatory subunit of holoprotein p85 729673
gene_transcript three splice variants, p85, p55 and p50 68289