Col4a5<sup>em1Matsu</sup> (collagen type IV alpha 5 chain; CRISPR/Cas9 induced mutant 1, Matsu) - Rat Genome Database

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Gene: Col4a5em1Matsu (collagen type IV alpha 5 chain; CRISPR/Cas9 induced mutant 1, Matsu) Rattus norvegicus
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Symbol: Col4a5em1Matsu
Name: collagen type IV alpha 5 chain; CRISPR/Cas9 induced mutant 1, Matsu
RGD ID: 329969888
Description: Genome editing was performed using the rGONAD method to produce three different genome mutations thus different in protein expression predication. The genetic background is WKY/NCrlCrlj (Charles River Laboratories Japan) (RGD:61119). Tandem STOP codons were designed to integrate into 27 bases after the first ATG in the rat Col4a5 gene This em1 mutant carries a premature stop coden after 9 amino acids due to the insertion of a 20 bp stop codon.
ASSOCIATED WITH decreased body weight; decreased creatinine clearance; increased blood urea nitrogen level; ASSOCIATED WITH Hematuria; proteinuria
Type: allele  of Col4a5  
Previously known as: Col4a5^[em1Matsu]
Is Marker For: Strains:   WKY-Col4a5em1Matsu  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


Disease Annotations     Click to see Annotation Detail View
Hematuria  (IMP)
proteinuria  (IMP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Creation of X-linked Alport syndrome rat model with Col4a5 deficiency. Namba M, etal., Sci Rep. 2021 Oct 21;11(1):20836. doi: 10.1038/s41598-021-00354-y.

Genomics


Related Rat Strains
The following Strains have been annotated to Col4a5em1Matsu


Expression


Sequence

Nucleotide Sequences


Additional Information