Enables phosphatidylinositol 3-kinase binding activity and platelet-derived growth factor receptor activity. Involved in several processes, including metanephros development; positive regulation of Rho protein signal transduction; and regulation of apoptotic process. Located in several cellular components, including apical plasma membrane; cell surface; and nucleus. Used to study extrahepatic cholestasis; middle cerebral artery infarction; and prostate cancer. Biomarker of hypertension; metabolic dysfunction-associated steatohepatitis; oligohydramnios; and sciatic neuropathy. Human ortholog(s) of this gene implicated in basal ganglia calcification; glioblastoma; infantile myofibromatosis; myeloproliferative neoplasm; and renal cell carcinoma. Orthologous to human PDGFRB (platelet derived growth factor receptor beta); PARTICIPATES IN platelet-derived growth factor signaling pathway; sphingosine 1-phosphate signaling pathway; calcium/calcium-mediated signaling pathway; INTERACTS WITH (+)-dihydromyricetin; (-)-epigallocatechin 3-gallate; (R,R,R)-alpha-tocopherol.
epigallocatechin gallate inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB mRNA] and epigallocatechin gallate inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB protein]
[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of PDGFRB mRNA and [alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of PDGFRB protein
bisindolylmaleimide I inhibits the reaction [Leukotriene D4 results in increased phosphorylation of and results in increased activity of PDGFRB protein]
[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of PDGFRB mRNA more ...
[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in decreased expression of PDGFRB mRNA and [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of PDGFRB mRNA
[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in decreased expression of PDGFRB mRNA and [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of PDGFRB mRNA
[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of PDGFRB mRNA and [alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of PDGFRB protein
[bisphenol A co-treated with Genistein] results in decreased methylation of PDGFRB gene and [bisphenol A co-treated with Genistein] results in increased methylation of PDGFRB gene
[Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of PDGFRB protein
[Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of PDGFRB protein
Chondroitin Sulfates promotes the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of PDGFRB protein] and Genistein inhibits the reaction [Chondroitin Sulfates promotes the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of PDGFRB protein]]
[Potassium Dichromate results in increased abundance of chromium hexavalent ion] which results in increased expression of PDGFRB mRNA and SHH protein affects the reaction [[Potassium Dichromate results in increased abundance of chromium hexavalent ion] which results in increased expression of PDGFRB mRNA]
[Chelating Agents binds to Copper] which results in decreased expression of PDGFRB mRNA and [Disulfiram binds to Copper] which results in increased expression of PDGFRB mRNA
[Chelating Agents binds to Copper] which results in decreased expression of PDGFRB mRNA and [Disulfiram binds to Copper] which results in increased expression of PDGFRB mRNA
[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of PDGFRB mRNA
[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of PDGFRB mRNA more ...
Oxygen deficiency results in increased expression of and results in increased activity of PDGFRB protein and rosiglitazone inhibits the reaction [Oxygen deficiency results in increased expression of and results in increased activity of PDGFRB protein]
[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of PDGFRB mRNA and [alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of PDGFRB protein
[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of PDGFRB mRNA
[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of PDGFRB mRNA
[bisphenol A co-treated with Genistein] results in decreased methylation of PDGFRB gene and [bisphenol A co-treated with Genistein] results in increased methylation of PDGFRB gene
Genistein inhibits the reaction [Chondroitin Sulfates promotes the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of PDGFRB protein]]
tetramethylpyrazine inhibits the reaction [Hydrogen Peroxide results in increased expression of PDGFRB mRNA] and tetramethylpyrazine inhibits the reaction [Hydrogen Peroxide results in increased expression of PDGFRB protein]
[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of PDGFRB mRNA and [alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of PDGFRB protein
Cysteine inhibits the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein] and Cysteine inhibits the reaction [Thioacetamide results in increased expression of PDGFRB protein]
Methionine inhibits the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein] and Methionine inhibits the reaction [Thioacetamide results in increased expression of PDGFRB protein]
[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in decreased expression of PDGFRB mRNA and [manganese chloride results in increased abundance of Manganese] which results in decreased expression of PDGFRB mRNA
[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in decreased expression of PDGFRB mRNA and [manganese chloride results in increased abundance of Manganese] which results in decreased expression of PDGFRB mRNA
[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in decreased expression of PDGFRB mRNA and [manganese chloride results in increased abundance of Manganese] which results in decreased expression of PDGFRB mRNA
olmesartan inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB protein] and olmesartan inhibits the reaction [Fish Oils inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB protein]]
[Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of PDGFRB mRNA and [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of PDGFRB mRNA
[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of PDGFRB mRNA and [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of PDGFRB mRNA
[Potassium Dichromate results in increased abundance of chromium hexavalent ion] which results in increased expression of PDGFRB mRNA and SHH protein affects the reaction [[Potassium Dichromate results in increased abundance of chromium hexavalent ion] which results in increased expression of PDGFRB mRNA]
resveratrol inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PDGFRB protein] and resveratrol inhibits the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]
Buthionine Sulfoximine inhibits the reaction [Acetylcysteine inhibits the reaction [Copper Sulfate results in increased expression of PDGFRB mRNA]] and Buthionine Sulfoximine inhibits the reaction [Acetylcysteine inhibits the reaction [Copper Sulfate results in increased expression of PDGFRB protein]]
[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of PDGFRB mRNA
[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in decreased expression of PDGFRB mRNA and [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of PDGFRB mRNA
tetramethylpyrazine inhibits the reaction [Hydrogen Peroxide results in increased expression of PDGFRB mRNA] and tetramethylpyrazine inhibits the reaction [Hydrogen Peroxide results in increased expression of PDGFRB protein]
NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB mRNA]] more ...
[Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of PDGFRB protein
[Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of PDGFRB protein
[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of PDGFRB mRNA and [alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of PDGFRB protein
[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of PDGFRB mRNA and [alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of PDGFRB protein
[Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of PDGFRB protein
Stimulated activation of platelet-derived growth factor receptor in vivo in balloon-injured arteries: a link between angiotensin II and intimal thickening.
High glucose-induced upregulation of Rho/Rho-kinase via platelet-derived growth factor receptor-beta increases migration of aortic smooth muscle cells.
Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta.
Effects of ribozyme targeting platelet-derived growth factor receptor beta subunit gene on the proliferation and apoptosis of hepatic stellate cells in vitro.
Quantitative trait loci disposing for both experimental arthritis and encephalomyelitis in the DA rat; impact on severity of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis and antibody isotype pattern.
Sequential in-office vitreous aspirates demonstrate vitreous matrix metalloproteinase 9 levels correlate with the amount of subretinal fluid in eyes with wet age-related macular degeneration.
Estrogen-induced smooth muscle cell growth is regulated by tuberin and associated with altered activation of platelet-derived growth factor receptor-beta and ERK-1/2.
Successive activation of the platelet-derived growth factor beta receptor and platelet-derived growth factor B genes correlates with the genesis of human choriocarcinoma.
Inhibition of PDGF beta-receptor tyrosine phosphorylation and its downstream intracellular signal transduction in rat aortic vascular smooth muscle cells by kaempferol.
Better-surviving liver grafts by the injection of anti-CD2 antibody: the important roles of host CD8+ and CD2+CD28+ T cells in chronic graft rejection and beta type platelet-derived growth factor receptor (PDGFR-beta) expression on apoptotic liver grafts.
Ligand-independent trans-activation of the platelet-derived growth factor receptor by reactive oxygen species requires protein kinase C-delta and c-Src.
Functional blockade of platelet-derived growth factor receptor-beta but not of receptor-alpha prevents vascular smooth muscle cell accumulation in fibrous cap lesions in apolipoprotein E-deficient mice.
The effect of acute rejection and cyclosporin A-treatment on induction of platelet-derived growth factor and its receptors during the development of chronic rat renal allograft rejection.
Melittin, a major bioactive component of bee venom toxin, inhibits PDGF receptor beta-tyrosine phosphorylation and downstream intracellular signal transduction in rat aortic vascular smooth muscle cells.
Prenatal exposure to estrogenic compounds alters the expression pattern of platelet-derived growth factor receptors alpha and beta in neonatal rat testis: identification of gonocytes as targets of estrogen exposure.
[A preliminary study on the changes of expression of PDGF-beta, PDGFR-beta, TGF-beta 1, TGFR, bFGF and its relationship with the wound age in wound healing]
Identification and distribution of a novel platelet-derived growth factor receptor beta variant: effect of retinoic acid and involvement in cell differentiation.
The antihypertensive agent hydralazine reduced extracellular matrix synthesis and liver fibrosis in nonalcoholic steatohepatitis exacerbated by hypertension.
Enhancement of glomerular platelet-derived growth factor beta-receptor tyrosine phosphorylation in hypertensive rats and its inhibition by calcium channel blocker.
autophosphorylates and binds to downstream proteins linking cell surface message to the nucleus, required for the activation of mitogen-activated protein kinases when mediated by platelet-derived growht factor -BB but not required during tyrosine phosphor
