Pctp (phosphatidylcholine transfer protein) - Rat Genome Database

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Gene: Pctp (phosphatidylcholine transfer protein) Rattus norvegicus
Analyze
Symbol: Pctp
Name: phosphatidylcholine transfer protein
RGD ID: 3276
Description: Predicted to enable phosphatidylcholine binding activity and phosphatidylcholine transporter activity. Predicted to be involved in negative regulation of cold-induced thermogenesis and phospholipid transport. Predicted to act upstream of or within cholesterol metabolic process. Predicted to be located in cytoplasm. Orthologous to human PCTP (phosphatidylcholine transfer protein); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: PC-TP; stAR-related lipid transfer protein 2; stARD2; START domain-containing protein 2
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21074,808,887 - 74,856,260 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1074,808,887 - 74,849,867 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1079,424,875 - 79,465,710 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01078,929,821 - 78,970,657 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01074,404,137 - 74,444,999 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01077,491,445 - 77,537,268 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1077,491,454 - 77,512,032 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01077,353,593 - 77,394,532 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41078,400,328 - 78,420,774 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11078,414,697 - 78,435,144 (-)NCBI
Celera1073,699,943 - 73,741,523 (-)NCBICelera
RH 3.4 Map10707.0RGD
Cytogenetic Map10q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP,ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
buspirone  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
capsaicin  (ISO)
CGP 52608  (ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
doxorubicin  (ISO)
fipronil  (EXP)
folic acid  (ISO)
furan  (EXP)
gentamycin  (EXP)
glycine betaine  (EXP)
inulin  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
isotretinoin  (ISO)
ketoconazole  (EXP)
L-ethionine  (EXP)
L-methionine  (ISO)
leflunomide  (EXP)
lithocholic acid  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
nitrofen  (EXP)
omeprazole  (EXP)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (EXP,ISO)
pravastatin  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
raloxifene  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium dodecyl sulfate  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
tamoxifen  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP)
tetracycline  (ISO)
thioacetamide  (EXP)
topotecan  (EXP)
trichloroethene  (EXP,ISO)
triphenyl phosphate  (EXP)
trovafloxacin  (EXP)
valproic acid  (ISO)
zaragozic acid A  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Mice lacking Pctp /StarD2 exhibit increased adaptive thermogenesis and enlarged mitochondria in brown adipose tissue. Kang HW, etal., J Lipid Res. 2009 Nov;50(11):2212-21. doi: 10.1194/jlr.M900013-JLR200. Epub 2009 Jun 6.
4. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Cloning and gene structure of rat phosphatidylcholine transfer protein, Pctp. Wu MK, etal., Gene 1999 Jul 22;235(1-2):111-20.
Additional References at PubMed
PMID:8645232   PMID:12055623   PMID:12477932   PMID:15489334   PMID:15845870  


Genomics

Comparative Map Data
Pctp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21074,808,887 - 74,856,260 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1074,808,887 - 74,849,867 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1079,424,875 - 79,465,710 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01078,929,821 - 78,970,657 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01074,404,137 - 74,444,999 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01077,491,445 - 77,537,268 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1077,491,454 - 77,512,032 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01077,353,593 - 77,394,532 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41078,400,328 - 78,420,774 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11078,414,697 - 78,435,144 (-)NCBI
Celera1073,699,943 - 73,741,523 (-)NCBICelera
RH 3.4 Map10707.0RGD
Cytogenetic Map10q26NCBI
PCTP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381755,751,051 - 55,852,715 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1755,751,051 - 55,842,830 (+)EnsemblGRCh38hg38GRCh38
GRCh371753,828,412 - 53,900,498 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361751,183,355 - 51,209,747 (+)NCBINCBI36Build 36hg18NCBI36
Build 341751,183,448 - 51,209,733NCBI
Celera1750,290,127 - 50,316,517 (+)NCBICelera
Cytogenetic Map17q22NCBI
HuRef1749,187,946 - 49,214,609 (+)NCBIHuRef
CHM1_11753,893,255 - 53,919,657 (+)NCBICHM1_1
T2T-CHM13v2.01756,627,170 - 56,721,145 (+)NCBIT2T-CHM13v2.0
Pctp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391189,873,370 - 89,893,720 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1189,873,491 - 89,893,720 (-)EnsemblGRCm39 Ensembl
GRCm381189,982,544 - 90,002,894 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1189,982,665 - 90,002,894 (-)EnsemblGRCm38mm10GRCm38
MGSCv371189,844,731 - 89,864,208 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361189,800,687 - 89,818,955 (-)NCBIMGSCv36mm8
Celera1199,590,697 - 99,613,489 (-)NCBICelera
Cytogenetic Map11CNCBI
cM Map1154.7NCBI
PCTP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11776,740,464 - 76,834,711 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01749,834,065 - 49,928,134 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11754,696,803 - 54,770,248 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1754,696,803 - 54,770,244 (+)Ensemblpanpan1.1panPan2
PCTP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1930,725,209 - 30,749,891 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl930,724,157 - 30,853,803 (+)EnsemblCanFam3.1canFam3CanFam3.1
Pctp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560230,146,046 - 30,172,180 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364906,902,957 - 6,929,098 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364906,902,959 - 6,929,051 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PCTP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11232,043,841 - 32,089,977 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PCTP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11637,558,590 - 37,638,721 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1637,614,222 - 37,638,120 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660778,404,683 - 8,475,624 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pctp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479510,972,933 - 10,998,944 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479510,972,998 - 11,000,163 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pctp
350 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:161
Count of miRNA genes:118
Interacting mature miRNAs:134
Transcripts:ENSRNOT00000003295
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)104944455181709989Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104944455181709989Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)106134527681714865Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
61402Niddm3Non-insulin dependent diabetes mellitus QTL 34.58blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)106134541382564856Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
2298481Eau9Experimental allergic uveoretinitis QTL 90.0169uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)106592723382565079Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
2289982Bp303Blood pressure QTL 303arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)107345299275632053Rat
724555Bp150Blood pressure QTL 1500.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107345299278210622Rat
12880053Cm104Cardiac mass QTL 1040.009heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)107345299283463334Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)107437208484007272Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat

Markers in Region
D10Rat151  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21074,814,820 - 74,815,039 (+)MAPPERmRatBN7.2
Rnor_6.01077,497,382 - 77,497,600NCBIRnor6.0
Rnor_5.01077,359,530 - 77,359,748UniSTSRnor5.0
RGSC_v3.41078,406,258 - 78,406,475RGDRGSC3.4
RGSC_v3.41078,406,259 - 78,406,477UniSTSRGSC3.4
RGSC_v3.11078,420,575 - 78,420,916RGD
Celera1073,705,875 - 73,706,093UniSTS
RH 2.0 Map10788.2RGD
SHRSP x BN Map1053.0RGD
Cytogenetic Map10q26UniSTS
D10Chm97  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21074,813,780 - 74,813,976 (+)MAPPERmRatBN7.2
Rnor_6.01077,496,344 - 77,496,537NCBIRnor6.0
Rnor_5.01077,358,492 - 77,358,685UniSTSRnor5.0
RGSC_v3.41078,405,221 - 78,405,414UniSTSRGSC3.4
Celera1073,704,837 - 73,705,030UniSTS
Cytogenetic Map10q26UniSTS
RH129093  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21074,808,980 - 74,809,195 (+)MAPPERmRatBN7.2
Rnor_6.01077,491,544 - 77,491,758NCBIRnor6.0
Rnor_5.01077,353,692 - 77,353,906UniSTSRnor5.0
RGSC_v3.41078,400,421 - 78,400,635UniSTSRGSC3.4
Celera1073,700,037 - 73,700,251UniSTS
Cytogenetic Map10q26UniSTS
RH142213  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21074,809,217 - 74,809,379 (+)MAPPERmRatBN7.2
Rnor_6.01077,491,781 - 77,491,942NCBIRnor6.0
Rnor_5.01077,353,929 - 77,354,090UniSTSRnor5.0
RGSC_v3.41078,400,658 - 78,400,819UniSTSRGSC3.4
Celera1073,700,274 - 73,700,435UniSTS
RH 3.4 Map10707.0UniSTS
Cytogenetic Map10q26UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 12 47 41 17 41 6 35 31 11
Low 31 10 2 8 11 68 10 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000003295   ⟹   ENSRNOP00000003295
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1074,808,887 - 74,829,320 (-)Ensembl
Rnor_6.0 Ensembl1077,491,454 - 77,512,032 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000095165   ⟹   ENSRNOP00000093865
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1074,808,887 - 74,849,867 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000103306   ⟹   ENSRNOP00000079674
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1074,808,887 - 74,829,320 (-)Ensembl
RefSeq Acc Id: NM_001322798   ⟹   NP_001309727
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21074,808,887 - 74,849,867 (-)NCBI
Rnor_6.01077,491,450 - 77,532,428 (-)NCBI
Celera1073,699,943 - 73,741,523 (-)NCBI
Sequence:
RefSeq Acc Id: NM_017225   ⟹   NP_058921
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21074,808,887 - 74,829,320 (-)NCBI
Rnor_6.01077,491,450 - 77,511,881 (-)NCBI
Rnor_5.01077,353,593 - 77,394,532 (-)NCBI
RGSC_v3.41078,400,328 - 78,420,774 (-)RGD
Celera1073,699,943 - 73,720,367 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006247125   ⟹   XP_006247187
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21074,808,887 - 74,829,355 (-)NCBI
Rnor_6.01077,491,445 - 77,511,915 (-)NCBI
Rnor_5.01077,353,593 - 77,394,532 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008767982   ⟹   XP_008766204
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21074,808,887 - 74,849,883 (-)NCBI
Rnor_6.01077,491,445 - 77,532,462 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008767983   ⟹   XP_008766205
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21074,808,887 - 74,856,260 (-)NCBI
Rnor_6.01077,491,450 - 77,537,268 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039085770   ⟹   XP_038941698
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21074,808,887 - 74,856,260 (-)NCBI
RefSeq Acc Id: XM_039085771   ⟹   XP_038941699
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21074,808,887 - 74,856,260 (-)NCBI
RefSeq Acc Id: NP_058921   ⟸   NM_017225
- Peptide Label: isoform 1
- UniProtKB: Q9Z2N9 (UniProtKB/Swiss-Prot),   P53809 (UniProtKB/Swiss-Prot),   A6HI08 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247187   ⟸   XM_006247125
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZP06 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008766204   ⟸   XM_008767982
- Peptide Label: isoform X2
- UniProtKB: A6HI09 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008766205   ⟸   XM_008767983
- Peptide Label: isoform X2
- UniProtKB: A6HI09 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001309727   ⟸   NM_001322798
- Peptide Label: isoform 2
- UniProtKB: A0A8I6AL88 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000003295   ⟸   ENSRNOT00000003295
RefSeq Acc Id: XP_038941699   ⟸   XM_039085771
- Peptide Label: isoform X2
- UniProtKB: A6HI09 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038941698   ⟸   XM_039085770
- Peptide Label: isoform X2
- UniProtKB: A6HI09 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000093865   ⟸   ENSRNOT00000095165
RefSeq Acc Id: ENSRNOP00000079674   ⟸   ENSRNOT00000103306
Protein Domains
START

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P53809-F1-model_v2 AlphaFold P53809 1-214 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697585
Promoter ID:EPDNEW_R8109
Type:multiple initiation site
Name:Pctp_1
Description:phosphatidylcholine transfer protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01077,511,871 - 77,511,931EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3276 AgrOrtholog
BioCyc Gene G2FUF-23684 BioCyc
Ensembl Genes ENSRNOG00000002425 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055025831 UniProtKB/Swiss-Prot
  ENSRNOG00060025140 UniProtKB/Swiss-Prot
  ENSRNOG00065020122 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000003295 ENTREZGENE
  ENSRNOT00000003295.5 UniProtKB/Swiss-Prot
  ENSRNOT00000095165 ENTREZGENE
  ENSRNOT00000095165.1 UniProtKB/TrEMBL
  ENSRNOT00000103306 ENTREZGENE
  ENSRNOT00000103306.1 UniProtKB/TrEMBL
  ENSRNOT00055044574 UniProtKB/Swiss-Prot
  ENSRNOT00060043515 UniProtKB/Swiss-Prot
  ENSRNOT00065033947 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.530.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7113616 IMAGE-MGC_LOAD
InterPro STARD2_START UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  START-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  START_lipid-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29510 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93515 IMAGE-MGC_LOAD
NCBI Gene 29510 ENTREZGENE
PANTHER PHOSPHATIDYLCHOLINE TRANSFER PROTEIN UniProtKB/Swiss-Prot
  PHOSPHATIDYLCHOLINE TRANSFER PROTEIN UniProtKB/Swiss-Prot
  PHOSPHATIDYLCHOLINE TRANSFER PROTEIN UniProtKB/TrEMBL
  PHOSPHATIDYLCHOLINE TRANSFER PROTEIN UniProtKB/TrEMBL
Pfam START UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pctp PhenoGen
PROSITE START UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002425 RatGTEx
  ENSRNOG00055025831 RatGTEx
  ENSRNOG00060025140 RatGTEx
  ENSRNOG00065020122 RatGTEx
SMART START UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Bet v1-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZP06 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AL88 ENTREZGENE, UniProtKB/TrEMBL
  A6HI08 ENTREZGENE, UniProtKB/TrEMBL
  A6HI09 ENTREZGENE, UniProtKB/TrEMBL
  P53809 ENTREZGENE, UniProtKB/Swiss-Prot
  Q9Z2N9 ENTREZGENE
UniProt Secondary Q9Z2N9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Pctp  phosphatidylcholine transfer protein      Name updated 70584 APPROVED