HMGA2 (high mobility group AT-hook 2) - Rat Genome Database

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Gene: HMGA2 (high mobility group AT-hook 2) Pan paniscus
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Symbol: HMGA2
Name: high mobility group AT-hook 2
RGD ID: 32727344
Description: ENCODES a protein that exhibits 5'-deoxyribose-5-phosphate lyase activity (ortholog); C2H2 zinc finger domain binding (ortholog); cAMP response element binding (ortholog); INVOLVED IN adipose tissue development (ortholog); adrenal gland development (ortholog); astrocyte differentiation (ortholog); PARTICIPATES IN Ras mediated signaling pathway; ASSOCIATED WITH Birth Weight (ortholog); disease of cellular proliferation (ortholog); Hamartoma (ortholog); FOUND IN male germ cell nucleus (ortholog); nuclear chromosome (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: high mobility group protein HMGI-C
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21028,400,118 - 28,548,065 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11228,396,888 - 28,538,621 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01222,954,946 - 23,096,623 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adipose tissue development  (ISO)
adrenal gland development  (ISO)
astrocyte differentiation  (ISO)
base-excision repair  (ISO)
cell population proliferation  (ISO)
cell proliferation in forebrain  (ISO)
chondrocyte differentiation  (ISO)
chondrocyte proliferation  (ISO)
endodermal cell differentiation  (ISO)
epithelial to mesenchymal transition  (ISO)
epithelial tube branching involved in lung morphogenesis  (ISO)
fat cell differentiation  (ISO)
fat pad development  (ISO)
fibroblast proliferation  (ISO)
heterochromatin formation  (ISO)
intracellular signal transduction  (ISO)
lung epithelium development  (ISO)
male gonad development  (ISO)
mesenchymal cell differentiation  (ISO)
mesodermal cell differentiation  (ISO)
mesodermal-endodermal cell signaling  (ISO)
multicellular organism growth  (ISO)
negative regulation by host of viral transcription  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of astrocyte differentiation  (ISO)
negative regulation of cellular senescence  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of double-strand break repair via nonhomologous end joining  (ISO)
negative regulation of intracellular steroid hormone receptor signaling pathway  (ISO)
negative regulation of receptor signaling pathway via JAK-STAT  (ISO)
negative regulation of single stranded viral RNA replication via double stranded DNA intermediate  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of Wnt signaling pathway  (ISO)
oncogene-induced cell senescence  (ISO)
pituitary gland development  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cell proliferation in bone marrow  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of epithelial cell proliferation involved in lung morphogenesis  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of multicellular organism growth  (ISO)
positive regulation of protein serine/threonine kinase activity  (ISO)
positive regulation of stem cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
regulation of cell cycle process  (ISO)
regulation of DNA-templated transcription  (ISO)
regulation of growth hormone secretion  (ISO)
regulation of peptide hormone secretion  (ISO)
regulation of stem cell population maintenance  (ISO)
response to virus  (ISO)
somatic stem cell population maintenance  (ISO)
spermatogenesis  (ISO)
stem cell differentiation  (ISO)
stem cell proliferation  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
HMGA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21028,400,118 - 28,548,065 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11228,396,888 - 28,538,621 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01222,954,946 - 23,096,623 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
HMGA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381265,824,460 - 65,966,291 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1265,824,460 - 65,966,291 (+)EnsemblGRCh38hg38GRCh38
GRCh371266,218,240 - 66,360,071 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361264,504,507 - 64,646,338 (+)NCBINCBI36Build 36hg18NCBI36
Build 341264,504,457 - 64,646,266NCBI
Celera1265,883,845 - 66,025,902 (+)NCBICelera
Cytogenetic Map12q14.3NCBI
HuRef1263,271,242 - 63,413,086 (+)NCBIHuRef
CHM1_11266,185,507 - 66,327,350 (+)NCBICHM1_1
T2T-CHM13v2.01265,803,963 - 65,945,820 (+)NCBIT2T-CHM13v2.0
Hmga2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910120,197,173 - 120,312,374 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10120,197,180 - 120,312,374 (-)EnsemblGRCm39 Ensembl
GRCm3810120,361,268 - 120,476,469 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10120,361,275 - 120,476,469 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710119,798,331 - 119,913,991 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610119,764,721 - 119,880,028 (-)NCBIMGSCv36mm8
Celera10122,723,179 - 122,838,757 (-)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1067.94NCBI
Hmga2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8757,762,710 - 57,884,555 (-)NCBIGRCr8
mRatBN7.2755,877,145 - 55,998,813 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl755,880,112 - 55,994,784 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx757,786,495 - 57,901,148 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0759,989,707 - 60,104,351 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0759,767,092 - 59,881,753 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0765,159,944 - 65,275,408 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl765,159,944 - 65,275,408 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0765,375,936 - 65,490,635 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4759,638,555 - 59,753,791 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1759,659,284 - 59,774,521 (-)NCBI
Celera752,634,133 - 52,748,501 (-)NCBICelera
Cytogenetic Map7q22NCBI
Hmga2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545812,493,790 - 12,624,805 (+)NCBIChiLan1.0ChiLan1.0
HMGA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1108,348,101 - 8,491,435 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha108,278,957 - 8,424,016 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0108,459,176 - 8,604,625 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl108,459,180 - 8,601,880 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1108,335,596 - 8,480,987 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0108,581,865 - 8,727,080 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0108,703,471 - 8,848,741 (+)NCBIUU_Cfam_GSD_1.0
Hmga2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494550,151,774 - 50,166,701 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365453,944,419 - 4,064,193 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365453,944,419 - 3,958,289 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HMGA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1530,188,521 - 30,329,635 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2533,375,397 - 33,516,455 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HMGA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11161,509,114 - 61,655,633 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037184,069,350 - 184,211,090 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hmga2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248022,337,464 - 2,467,990 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248022,337,344 - 2,468,757 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


RefSeq Acc Id: XM_034935503   ⟹   XP_034791394
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21028,400,118 - 28,548,065 (-)NCBI
NHGRI_mPanPan11228,396,888 - 28,538,183 (-)NCBI
Mhudiblu_PPA_v01222,954,946 - 23,095,890 (-)NCBI
RefSeq Acc Id: XM_034935505   ⟹   XP_034791396
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21028,523,211 - 28,548,065 (-)NCBI
NHGRI_mPanPan11228,519,967 - 28,538,601 (-)NCBI
Mhudiblu_PPA_v01223,077,916 - 23,096,592 (-)NCBI
Protein Sequences
Protein RefSeqs XP_034791394 (Get FASTA)   NCBI Sequence Viewer  
  XP_034791396 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_034791394   ⟸   XM_034935503
- Peptide Label: isoform X1
RefSeq Acc Id: XP_034791396   ⟸   XM_034935505
- Peptide Label: isoform X2


Additional Information

Database Acc Id Source(s)
NCBI Gene HMGA2 ENTREZGENE