P2ry1 (purinergic receptor P2Y1) - Rat Genome Database

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Gene: P2ry1 (purinergic receptor P2Y1) Rattus norvegicus
Analyze
Symbol: P2ry1
Name: purinergic receptor P2Y1
RGD ID: 3242
Description: Enables several functions, including A1 adenosine receptor binding activity; G protein-coupled purinergic nucleotide receptor activity; and adenyl ribonucleotide binding activity. Involved in several processes, including positive regulation of phosphate metabolic process; purinergic nucleotide receptor signaling pathway; and regulation of secretion by cell. Located in several cellular components, including basolateral plasma membrane; postsynaptic density; and postsynaptic membrane. Is active in glutamatergic synapse and presynaptic active zone membrane. Used to study impotence. Orthologous to human P2RY1 (purinergic receptor P2Y1); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ATP receptor; P2 purinoreceptor subclass 2Y; P2y; P2Y ATP receptor 1; P2Y purinoceptor 1; P2y1; purinergic receptor P2Y, G-protein coupled 1; purinergic receptor P2Y, G-protein coupled, 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82147,391,661 - 147,397,870 (+)NCBIGRCr8
mRatBN7.22145,241,975 - 145,248,186 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2145,241,849 - 145,248,457 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2151,917,488 - 151,923,701 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02150,001,941 - 150,008,136 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02144,634,335 - 144,640,530 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02151,314,818 - 151,320,312 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2151,314,818 - 151,320,319 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02170,730,012 - 170,735,506 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42150,460,361 - 150,465,855 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12150,410,323 - 150,415,818 (+)NCBI
Celera2139,634,729 - 139,640,224 (+)NCBICelera
Cytogenetic Map2q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,6-dinitrotoluene  (EXP)
3'-O-(4-Benzoyl)benzoyl ATP  (ISO)
3'-phospho-5'-adenylyl sulfate  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP,ISO)
3-methylcholanthrene  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-bromo-2'-deoxyuridine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
ATP  (EXP,ISO)
avobenzone  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
butan-1-ol  (EXP,ISO)
butanal  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
decabromodiphenyl ether  (EXP)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
dichloroacetic acid  (ISO)
dorsomorphin  (ISO)
flutamide  (EXP)
folic acid  (ISO)
furan  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
glycidol  (EXP)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
nickel atom  (ISO)
Nonylphenol  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentanal  (ISO)
phencyclidine  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
rottlerin  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
sulfadimethoxine  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP,ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (IDA)
blood vessel diameter maintenance  (IMP)
cellular response to organic cyclic compound  (ISO)
cellular response to purine-containing compound  (ISO,ISS)
eating behavior  (IMP)
establishment of localization in cell  (ISO)
G protein-coupled adenosine receptor signaling pathway  (IDA)
G protein-coupled purinergic nucleotide receptor signaling pathway  (IDA)
G protein-coupled receptor signaling pathway  (IDA)
glial cell migration  (IMP)
microglial cell activation  (IMP)
monoatomic ion transport  (ISO)
negative regulation of norepinephrine secretion  (IDA)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IBA,ISO,ISS,TAS)
platelet activation  (IEA)
positive regulation of cytosolic calcium ion concentration  (IDA,IMP)
positive regulation of ERK1 and ERK2 cascade  (IDA)
positive regulation of hormone secretion  (IDA)
positive regulation of inositol trisphosphate biosynthetic process  (IDA)
positive regulation of monoatomic ion transport  (ISO)
positive regulation of penile erection  (IDA)
positive regulation of protein phosphorylation  (IDA)
positive regulation of transcription by RNA polymerase II  (IDA)
protein localization to plasma membrane  (IDA)
regulation of cell shape  (ISO,ISS)
regulation of presynaptic cytosolic calcium ion concentration  (EXP,IDA,IEP)
regulation of synaptic vesicle exocytosis  (EXP,IDA,IEP)
relaxation of muscle  (IEA)
response to growth factor  (IEP)
response to mechanical stimulus  (IMP)
signal transduction involved in regulation of gene expression  (IDA)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Abundant and dynamic expression of G protein-coupled P2Y receptors in mammalian development. Cheung KK, etal., Dev Dyn. 2003 Oct;228(2):254-66.
2. Mechanically evoked reflex electrogenic chloride secretion in rat distal colon is triggered by endogenous nucleotides acting at P2Y1, P2Y2, and P2Y4 receptors. Christofi FL, etal., J Comp Neurol. 2004 Jan 26;469(1):16-36.
3. TGF-beta and LPS modulate ADP-induced migration of microglial cells through P2Y1 and P2Y12 receptor expression. De Simone R, etal., J Neurochem. 2010 Oct;115(2):450-9. doi: 10.1111/j.1471-4159.2010.06937.x. Epub 2010 Aug 30.
4. Regulation of rat hepatocyte function by P2Y receptors: focus on control of glycogen phosphorylase and cyclic AMP by 2-methylthioadenosine 5'-diphosphate. Dixon CJ, etal., J Pharmacol Exp Ther. 2004 Oct;311(1):334-41. Epub 2004 May 19.
5. Polarized expression and function of P2Y ATP receptors in rat bile duct epithelia. Dranoff JA, etal., Am J Physiol Gastrointest Liver Physiol 2001 Oct;281(4):G1059-67.
6. P2 receptor-mediated stimulation of the PI3-K/Akt-pathway in vivo. Franke H, etal., Glia. 2009 Aug 1;57(10):1031-45.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Purinergic receptor expression in the regeneration epidermis in a rat model of normal and delayed wound healing. Greig AV, etal., Exp Dermatol. 2003 Dec;12(6):860-71.
10. Management of erectile function by penile purinergic p2 receptors in the diabetic rat. Gur S, etal., J Urol. 2009 May;181(5):2375-82. Epub 2009 Mar 19.
11. Extracellular ATP or ADP induce chemotaxis of cultured microglia through Gi/o-coupled P2Y receptors. Honda S, etal., J Neurosci. 2001 Mar 15;21(6):1975-82.
12. Comparison of P2 receptor subtypes producing dilation in rat intracerebral arterioles. Horiuchi T, etal., Stroke. 2003 Jun;34(6):1473-8. Epub 2003 May 1.
13. Enhanced food intake after stimulation of hypothalamic P2Y1 receptors in rats: modulation of feeding behaviour by extracellular nucleotides. Kittner H, etal., Eur J Neurosci. 2006 Oct;24(7):2049-56.
14. Mitochondrial localization of P2Y1, P2Y2 and P2Y12 receptors in rat astrocytes and glioma C6 cells. Krzeminski P, etal., Brain Res Bull. 2007 Mar 30;71(6):587-92. Epub 2006 Dec 22.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Age-related changes in P2 receptor mRNA of rat cerebral arteries. Miao LY, etal., Exp Gerontol. 2001 Dec;37(1):67-79.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. Complementary role of extracellular ATP and adenosine in ischemic preconditioning in the rat heart. Ninomiya H, etal., Am J Physiol Heart Circ Physiol 2002 May;282(5):H1810-20.
19. The P2Y(1) and P2Y(12) receptors mediate autoinhibition of transmitter release in sympathetic innervated tissues. Quintas C, etal., Neurochem Int. 2009 Dec;55(7):505-13. Epub 2009 May 15.
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Dual presynaptic control by ATP of glutamate release via facilitatory P2X1, P2X2/3, and P2X3 and inhibitory P2Y1, P2Y2, and/or P2Y4 receptors in the rat hippocampus. Rodrigues RJ, etal., J Neurosci. 2005 Jul 6;25(27):6286-95.
24. ATP induces synaptic gene expressions in cortical neurons: transduction and transcription control via P2Y1 receptors. Siow NL, etal., Mol Pharmacol. 2010 Dec;78(6):1059-71. doi: 10.1124/mol.110.066506. Epub 2010 Sep 16.
25. Role of purinergic P2Y1 receptors in regulation of vasopressin and oxytocin secretion. Song Z, etal., Am J Physiol Regul Integr Comp Physiol. 2009 Aug;297(2):R478-84. Epub 2009 Jun 10.
26. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
27. Cloning of rat and mouse P2Y purinoceptors. Tokuyama Y, etal., Biochem Biophys Res Commun 1995 Jun 6;211(1):211-8.
28. Expression and function of P2Y receptors on Muller cells of the postnatal rat retina. Wurm A, etal., Glia. 2009 Nov 15;57(15):1680-90.
29. Inhibitory, facilitatory, and excitatory effects of ATP and purinergic receptor agonists on the activity of rat cutaneous nociceptors in vitro. Yajima H, etal., Neurosci Res. 2005 Apr;51(4):405-16. Epub 2005 Jan 20.
30. Agonist-promoted heteromeric oligomerization between adenosine A(1) and P2Y(1) receptors in living cells. Yoshioka K, etal., FEBS Lett. 2002 Jul 17;523(1-3):147-51.
31. Hetero-oligomerization of adenosine A1 receptors with P2Y1 receptors in rat brains. Yoshioka K, etal., FEBS Lett. 2002 Nov 6;531(2):299-303.
32. Heteromeric association creates a P2Y-like adenosine receptor. Yoshioka K, etal., Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7617-22. Epub 2001 Jun 5.
Additional References at PubMed
PMID:9442040   PMID:12629523   PMID:12799304   PMID:12850289   PMID:14564529   PMID:14645457   PMID:14729222   PMID:15103469   PMID:15172882   PMID:15494980   PMID:15528188   PMID:15574734  
PMID:15670583   PMID:15914557   PMID:16336659   PMID:16624826   PMID:16643864   PMID:16882655   PMID:16944453   PMID:17598884   PMID:17869006   PMID:18072286   PMID:18174215   PMID:18384646  
PMID:18627435   PMID:18668152   PMID:18756525   PMID:18841035   PMID:19196799   PMID:19223012   PMID:19396875   PMID:19906120   PMID:20570683   PMID:20720114   PMID:21487414   PMID:21540076  
PMID:21879346   PMID:22065011   PMID:22349022   PMID:22759594   PMID:23382103   PMID:23479225   PMID:23753413   PMID:24048730   PMID:24401144   PMID:24687862   PMID:24733747   PMID:24857820  
PMID:24879869   PMID:24998877   PMID:25027332   PMID:25449358   PMID:25526634   PMID:25822790   PMID:26743169   PMID:27318677   PMID:28153540   PMID:28154160   PMID:28974901   PMID:29463792  
PMID:31689490   PMID:33848220   PMID:34166321   PMID:35907034   PMID:38043889  


Genomics

Comparative Map Data
P2ry1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82147,391,661 - 147,397,870 (+)NCBIGRCr8
mRatBN7.22145,241,975 - 145,248,186 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2145,241,849 - 145,248,457 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2151,917,488 - 151,923,701 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02150,001,941 - 150,008,136 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02144,634,335 - 144,640,530 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02151,314,818 - 151,320,312 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2151,314,818 - 151,320,319 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02170,730,012 - 170,735,506 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42150,460,361 - 150,465,855 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12150,410,323 - 150,415,818 (+)NCBI
Celera2139,634,729 - 139,640,224 (+)NCBICelera
Cytogenetic Map2q31NCBI
P2RY1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383152,835,131 - 152,841,439 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3152,835,131 - 152,841,439 (+)EnsemblGRCh38hg38GRCh38
GRCh373152,552,920 - 152,559,228 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363154,035,426 - 154,038,535 (+)NCBINCBI36Build 36hg18NCBI36
Build 343154,035,433 - 154,038,539NCBI
Celera3150,971,424 - 150,974,533 (+)NCBICelera
Cytogenetic Map3q25.2NCBI
HuRef3149,943,255 - 149,946,364 (+)NCBIHuRef
CHM1_13152,516,451 - 152,519,560 (+)NCBICHM1_1
T2T-CHM13v2.03155,605,520 - 155,611,828 (+)NCBIT2T-CHM13v2.0
P2ry1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39360,910,206 - 60,916,403 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl360,910,216 - 60,916,403 (+)EnsemblGRCm39 Ensembl
GRCm38361,002,785 - 61,008,982 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl361,002,795 - 61,008,982 (+)EnsemblGRCm38mm10GRCm38
MGSCv37360,806,717 - 60,812,901 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36361,090,724 - 61,096,908 (+)NCBIMGSCv36mm8
Celera360,703,955 - 60,710,141 (+)NCBICelera
Cytogenetic Map3E1NCBI
cM Map329.24NCBI
P2ry1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554484,366,706 - 4,372,626 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554484,366,706 - 4,372,626 (+)NCBIChiLan1.0ChiLan1.0
P2RY1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22150,726,644 - 150,733,886 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13150,731,389 - 150,738,619 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03149,859,748 - 149,865,873 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13157,426,423 - 157,432,339 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3157,426,692 - 157,427,813 (+)Ensemblpanpan1.1panPan2
P2RY1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12347,249,496 - 47,253,203 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2347,249,496 - 47,253,203 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2347,112,593 - 47,116,262 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02347,878,074 - 47,881,878 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2347,878,074 - 47,881,878 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12347,462,527 - 47,466,223 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02347,517,721 - 47,521,447 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02347,800,041 - 47,803,744 (+)NCBIUU_Cfam_GSD_1.0
P2ry1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560288,861,485 - 88,867,833 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936519866,208 - 872,393 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936519865,756 - 872,466 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
P2RY1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1392,991,152 - 92,997,700 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11392,991,150 - 92,997,702 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213101,032,051 - 101,038,362 (+)NCBISscrofa10.2Sscrofa10.2susScr3
P2RY1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11537,822,474 - 37,827,245 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604110,556,129 - 10,561,290 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
P2ry1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473030,471,610 - 30,476,941 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473030,470,894 - 30,478,269 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in P2ry1
38 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:582
Count of miRNA genes:266
Interacting mature miRNAs:341
Transcripts:ENSRNOT00000019305
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2102803808147803808Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2104559726149559726Rat
1581552Pur12Proteinuria QTL 125.190.0009urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)2112103657148076632Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1354594Despr10Despair related QTL 100.00000249locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2114654253159654253Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527185876470Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
5135226Leukc2Leukocyte quantity QTL 2eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)2118111229149559726Rat
1582257Gluco21Glucose level QTL 213.10.0035blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2118111229157142209Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2118189491163189491Rat
1358360Sradr2Stress Responsive Adrenal Weight QTL 210.24adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)2129164097152195315Rat
6907363Bp357Blood pressure QTL 3574.10.002arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2129540907174540907Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
12879841Cm87Cardiac mass QTL 870.026heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2142323368146786035Rat
12879842Cm88Cardiac mass QTL 880.042heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2142323368146786035Rat
12879843Am3Aortic mass QTL 30.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2142323368146786035Rat
12879844Kidm62Kidney mass QTL 620.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2142323368146786035Rat
7488933Bp368Blood pressure QTL 3680.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2142323368147803808Rat
1549828Bp258Blood pressure QTL 2580.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2142323368150650069Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2143657411190602963Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2143657569184114274Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat

Markers in Region
PMC123072P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22145,242,893 - 145,243,144 (+)MAPPERmRatBN7.2
Rnor_6.02151,315,704 - 151,315,954NCBIRnor6.0
Rnor_5.02170,730,898 - 170,731,148UniSTSRnor5.0
RGSC_v3.42150,461,247 - 150,461,497UniSTSRGSC3.4
Celera2139,635,616 - 139,635,866UniSTS
Cytogenetic Map2q31UniSTS
PMC34459P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22145,242,883 - 145,243,535 (+)MAPPERmRatBN7.2
Rnor_6.02151,315,694 - 151,316,345NCBIRnor6.0
Rnor_5.02170,730,888 - 170,731,539UniSTSRnor5.0
RGSC_v3.42150,461,237 - 150,461,888UniSTSRGSC3.4
Celera2139,635,606 - 139,636,257UniSTS
Cytogenetic Map2q31UniSTS
BF405988  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22145,244,674 - 145,244,834 (+)MAPPERmRatBN7.2
Rnor_6.02151,317,482 - 151,317,641NCBIRnor6.0
Rnor_5.02170,732,676 - 170,732,835UniSTSRnor5.0
RGSC_v3.42150,463,025 - 150,463,184UniSTSRGSC3.4
Celera2139,637,394 - 139,637,553UniSTS
RH 3.4 Map2897.2UniSTS
Cytogenetic Map2q31UniSTS
BE117641  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22145,247,400 - 145,247,555 (+)MAPPERmRatBN7.2
Rnor_6.02151,320,208 - 151,320,362NCBIRnor6.0
Rnor_5.02170,735,402 - 170,735,556UniSTSRnor5.0
RGSC_v3.42150,465,751 - 150,465,905UniSTSRGSC3.4
Celera2139,640,120 - 139,640,274UniSTS
RH 3.4 Map2899.6UniSTS
Cytogenetic Map2q31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 2 8 8 2 8 8 10 2 5 8
Low 2 41 49 33 17 33 1 72 35 28 11
Below cutoff 3

Sequence


RefSeq Acc Id: ENSRNOT00000019305   ⟹   ENSRNOP00000019304
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2145,241,849 - 145,248,457 (+)Ensembl
Rnor_6.0 Ensembl2151,314,818 - 151,320,319 (+)Ensembl
RefSeq Acc Id: NM_012800   ⟹   NP_036932
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82147,391,661 - 147,397,870 (+)NCBI
mRatBN7.22145,241,975 - 145,248,186 (+)NCBI
Rnor_6.02151,314,818 - 151,320,312 (+)NCBI
Rnor_5.02170,730,012 - 170,735,506 (+)NCBI
RGSC_v3.42150,460,361 - 150,465,855 (+)RGD
Celera2139,634,729 - 139,640,224 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036932 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA91303 (Get FASTA)   NCBI Sequence Viewer  
  EDM14829 (Get FASTA)   NCBI Sequence Viewer  
  EDM14830 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000019304
  ENSRNOP00000019304.3
  ENSRNOP00055025706
  ENSRNOP00060006718
  ENSRNOP00065036870
GenBank Protein P49651 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036932   ⟸   NM_012800
- UniProtKB: P49651 (UniProtKB/Swiss-Prot),   A6JVM2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000019304   ⟸   ENSRNOT00000019305
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P49651-F1-model_v2 AlphaFold P49651 1-373 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691356
Promoter ID:EPDNEW_R1878
Type:multiple initiation site
Name:P2ry1_1
Description:purinergic receptor P2Y1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02151,314,785 - 151,314,845EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3242 AgrOrtholog
BioCyc Gene G2FUF-52953 BioCyc
Ensembl Genes ENSRNOG00000014232 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055018671 UniProtKB/Swiss-Prot
  ENSRNOG00060005357 UniProtKB/Swiss-Prot
  ENSRNOG00065026099 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000019305 ENTREZGENE
  ENSRNOT00000019305.5 UniProtKB/Swiss-Prot
  ENSRNOT00055031791 UniProtKB/Swiss-Prot
  ENSRNOT00060008899 UniProtKB/Swiss-Prot
  ENSRNOT00065044985 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P2Y1_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25265 ENTREZGENE
PANTHER P2Y PURINOCEPTOR 1 UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB P2RY1 RGD
PhenoGen P2ry1 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P2Y1PRNOCPTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P2YPURNOCPTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014232 RatGTEx
  ENSRNOG00055018671 RatGTEx
  ENSRNOG00060005357 RatGTEx
  ENSRNOG00065026099 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC213922
UniProt A6JVM2 ENTREZGENE, UniProtKB/TrEMBL
  A6JVM3_RAT UniProtKB/TrEMBL
  P2RY1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 P2ry1  purinergic receptor P2Y1  P2ry1  purinergic receptor P2Y, G-protein coupled, 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-01-14 P2ry1  purinergic receptor P2Y, G-protein coupled, 1  P2ry1  purinergic receptor P2Y, G-protein coupled 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 P2ry1  purinergic receptor P2Y, G-protein coupled 1    P2 purinoreceptor subclass 2Y  Name updated 625702 APPROVED
2002-06-10 P2ry1  P2 purinoreceptor subclass 2Y      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the apical plasma membrane and basolateral domains 628452
gene_expression mRNA present in holangiocytes, hepatocytes and epithelial cells 628452
gene_physical_interaction coupled with both pertussis toxin-sensitive Gi/Go and -insensitive Gq/G11 proteins 729533
gene_process mediates vasomotor responses, neurotransmission, platelet aggregation, and secretion 628452
gene_regulation activated mainly by ADP, to a lesser degree by ATP 628452