P2rx7 (purinergic receptor P2X 7) - Rat Genome Database

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Gene: P2rx7 (purinergic receptor P2X 7) Rattus norvegicus
Symbol: P2rx7
Name: purinergic receptor P2X 7
RGD ID: 3241
Description: Enables several functions, including ATP binding activity; extracellularly ATP-gated monoatomic cation channel activity; and metal ion binding activity. Involved in several processes, including ATP export; bleb assembly; and positive regulation of macromolecule metabolic process. Located in several cellular components, including bleb; nuclear envelope; and terminal bouton. Part of protein-containing complex. Orthologous to human P2RX7 (purinergic receptor P2X 7); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; 17beta-estradiol.
Type: protein-coding
Previously known as: ATP receptor; LOC108352449; P2X purinoceptor 7; P2X purinoceptor 7-like; P2X7 purinoceptor; P2Z receptor; purinergic receptor P2X, ligand-gated ion channel, 7; purinergic receptor P2X7
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: P2rx7em8Mcwi   P2rx7em12Mcwi   P2rx7em10Mcwi   P2rx7em13Mcwi   P2rx7em1Tja  
Genetic Models: SS-P2rx7em12Mcwi SS-P2rx7em10Mcwi PCK-P2rx7em8Mcwi SS-P2rx7em13Mcwi WKY-P2rx7em1Tja
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81239,550,531 - 39,594,984 (-)NCBIGRCr8
mRatBN7.21233,889,709 - 33,934,168 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1233,879,745 - 33,934,619 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1235,064,139 - 35,106,383 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01235,675,576 - 35,717,824 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01234,727,868 - 34,770,118 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01239,353,613 - 39,396,042 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1239,353,613 - 39,396,042 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01241,804,060 - 41,808,755 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01241,242,368 - 41,284,797 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41235,074,025 - 35,117,152 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11234,937,412 - 34,980,540 (-)NCBI
Celera1235,564,374 - 35,607,476 (-)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(+)-schisandrin B  (EXP)
(R)-adrenaline  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-diaminotoluene  (ISO)
2-hydroxypropanoic acid  (ISO)
3'-O-(4-Benzoyl)benzoyl ATP  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acid  (ISO)
adenosine 5'-[gamma-thio]triphosphate  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
apigenin  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
avobenzone  (ISO)
azetidine  (ISO)
barium(0)  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
berberine  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
C60 fullerene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
calmidazolium  (ISO)
carbon nanotube  (ISO)
carrageenan  (EXP)
casticin  (ISO)
choline  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP)
dextran sulfate  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (EXP,ISO)
diethyl maleate  (EXP)
dimethyl sulfoxide  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
ethidium  (ISO)
etoposide  (ISO)
folic acid  (ISO)
FR900359  (ISO)
furan  (EXP)
gamma-aminobutyric acid  (EXP)
genistein  (ISO)
ginsenoside C-K  (ISO)
ginsenoside Rd  (ISO)
glucose  (EXP)
graphene oxide  (ISO)
hexadecanoic acid  (EXP)
iron atom  (ISO)
iron(0)  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP)
lipopolysaccharide  (ISO)
melittin  (ISO)
metformin  (EXP)
methoxychlor  (EXP)
N(4)-hydroxycytidine  (ISO)
N-nitrosodiethylamine  (ISO)
nevirapine  (EXP)
nickel atom  (ISO)
oleic acid  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenformin  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pinostrobin  (ISO)
poly(I:C)  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
protein kinase inhibitor  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
suramin  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thioacetamide  (EXP,ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
Triptolide  (EXP)
triptonide  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
vincristine  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic signaling pathway  (IDA)
ATP export  (IMP)
bleb assembly  (IDA,ISO)
calcium ion transmembrane transport  (IBA,IEA)
calcium ion transport  (ISO)
cell morphogenesis  (ISO)
cell surface receptor signaling pathway  (IBA,IDA)
cell volume homeostasis  (ISO)
cellular response to dsRNA  (ISO)
cellular response to organic cyclic compound  (ISO)
ceramide biosynthetic process  (ISO)
collagen metabolic process  (ISO)
defense response to Gram-positive bacterium  (ISO)
establishment of localization in cell  (ISO)
excitatory postsynaptic potential  (IEA)
extrinsic apoptotic signaling pathway  (IDA,ISO)
gamma-aminobutyric acid secretion  (ISO)
gene expression  (ISO)
glutamate secretion  (ISO)
homeostasis of number of cells within a tissue  (ISO)
inflammatory response  (ISO)
lymphocyte apoptotic process  (ISO)
MAPK cascade  (ISO)
membrane depolarization  (IDA,ISO)
membrane protein ectodomain proteolysis  (ISO)
mitochondrial depolarization  (ISO)
mitochondrion organization  (ISO)
monoatomic cation transport  (ISO)
NAD transport  (ISO)
negative regulation of bone resorption  (ISO)
negative regulation of cell volume  (ISO)
negative regulation of MAPK cascade  (ISO)
neuronal action potential  (IDA)
phagolysosome assembly  (ISO)
phospholipid transfer to membrane  (ISO)
phospholipid translocation  (ISO)
plasma membrane organization  (ISO)
plasma membrane phospholipid scrambling  (ISO)
pore complex assembly  (IDA,IMP,ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of bleb assembly  (ISO)
positive regulation of bone mineralization  (ISO)
positive regulation of calcium ion transport into cytosol  (ISO)
positive regulation of cytoskeleton organization  (IDA)
positive regulation of gamma-aminobutyric acid secretion  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of glutamate secretion  (ISO)
positive regulation of glycolytic process  (ISO)
positive regulation of interleukin-1 alpha production  (ISO)
positive regulation of interleukin-1 beta production  (IDA,IMP,ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of lymphocyte apoptotic process  (ISO)
positive regulation of macrophage cytokine production  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of mitochondrial depolarization  (ISO)
positive regulation of monoatomic ion transmembrane transport  (ISO)
positive regulation of ossification  (ISO)
positive regulation of prostaglandin secretion  (ISO)
positive regulation of protein phosphorylation  (IDA,ISO)
positive regulation of protein secretion  (ISO)
positive regulation of T cell apoptotic process  (ISO)
positive regulation of T cell mediated cytotoxicity  (ISO)
programmed cell death  (ISO)
prostaglandin secretion  (ISO)
protein catabolic process  (ISO)
protein processing  (ISO)
protein secretion  (ISO)
purinergic nucleotide receptor signaling pathway  (IEA,ISO)
reactive oxygen species metabolic process  (ISO)
regulation of presynaptic dense core granule exocytosis  (EXP,IDA)
regulation of sodium ion transport  (IDA)
release of sequestered calcium ion into cytosol  (ISO)
response to ATP  (IDA,IEA,ISO)
response to bacterium  (ISO)
response to calcium ion  (ISO)
response to electrical stimulus  (ISO)
response to fluid shear stress  (ISO)
response to lipopolysaccharide  (ISO)
response to mechanical stimulus  (ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (ISO)
response to xenobiotic stimulus  (ISO)
response to zinc ion  (ISO)
sensory perception of pain  (ISO)
skeletal system morphogenesis  (ISO)
synaptic vesicle exocytosis  (ISO)
T cell apoptotic process  (ISO)
T cell homeostasis  (ISO)
T cell mediated cytotoxicity  (ISO)
T cell proliferation  (ISO)
vesicle budding from membrane  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References - curated
# Reference Title Reference Citation
1. Differential role of extracellular histidines in copper, zinc, magnesium and proton modulation of the P2X7 purinergic receptor. Acuna-Castillo C, etal., J Neurochem. 2007 Apr;101(1):17-26.
2. Knockout of P2rx7 purinergic receptor attenuates cyst growth in a rat model of ARPKD. Arkhipov SN, etal., Am J Physiol Renal Physiol. 2019 Oct 21. doi: 10.1152/ajprenal.00395.2019.
3. An ATP-gated ion channel at the cell nucleus. Atkinson L, etal., Nature 2002 Nov 7;420(6911):42.
4. P2X7 receptors activate protein kinase D and p42/p44 mitogen-activated protein kinase (MAPK) downstream of protein kinase C. Bradford MD and Soltoff SP, Biochem J 2002 Sep 15;366(Pt 3):745-55.
5. Pharmacological characterization of P2X7 receptors in rat peritoneal cells. Chen YW, etal., Inflamm Res. 2005 Mar;54(3):119-26.
6. P2X7 receptors in neurohypophysial terminals: evidence for their role in arginine-vasopressin secretion. Cuadra AE, etal., J Cell Physiol. 2014 Mar;229(3):333-42. doi: 10.1002/jcp.24453.
7. Coupling of two pools of P2X7 receptors to distinct intracellular signaling pathways in rat submandibular gland. Garcia-Marcos M, etal., J Lipid Res. 2006 Apr;47(4):705-14. Epub 2006 Jan 16.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. P2X(7) receptors in rat parotid acinar cells: formation of large pores. Gibbons SJ, etal., J Auton Pharmacol 2001 Aug;21(4):181-90.
10. Evidence for functional P2X4/P2X7 heteromeric receptors. Guo C, etal., Mol Pharmacol. 2007 Dec;72(6):1447-56. Epub 2007 Sep 4.
11. Presence of diverse functional P2X receptors in rat cerebellar synaptic terminals. Hervas C, etal., Biochem Pharmacol. 2005 Sep 1;70(5):770-85.
12. P2X7 receptors stimulate AKT phosphorylation in astrocytes. Jacques-Silva MC, etal., Br J Pharmacol. 2004 Apr;141(7):1106-17. Epub 2004 Mar 15.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Extracellular ATP causes ROCK I-dependent bleb formation in P2X7-transfected HEK293 cells. Morelli A, etal., Mol Biol Cell. 2003 Jul;14(7):2655-64. Epub 2003 Apr 4.
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. Homotrimeric complexes are the dominant assembly state of native P2X7 subunits. Nicke A, Biochem Biophys Res Commun. 2008 Dec 19;377(3):803-8. doi: 10.1016/j.bbrc.2008.10.042. Epub 2008 Oct 18.
17. P2X7 receptors on osteoblasts couple to production of lysophosphatidic acid: a signaling axis promoting osteogenesis. Panupinthu N, etal., J Cell Biol. 2008 Jun 2;181(5):859-71. doi: 10.1083/jcb.200708037.
18. Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor. Pelegrin P and Surprenant A, EMBO J. 2006 Nov 1;25(21):5071-82. Epub 2006 Oct 12.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. The pannexin 1 channel activates the inflammasome in neurons and astrocytes. Silverman WR, etal., J Biol Chem. 2009 Jul 3;284(27):18143-51. Epub 2009 May 5.
24. The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7). Surprenant A, etal., Science 1996 May 3;272(5262):735-8.
Additional References at PubMed
PMID:9038151   PMID:10395640   PMID:11016935   PMID:11489964   PMID:11544318   PMID:11707406   PMID:12055263   PMID:12107182   PMID:12370338   PMID:12496266   PMID:12551918   PMID:12649594  
PMID:12677010   PMID:12684872   PMID:12747800   PMID:12783957   PMID:12783958   PMID:12850289   PMID:14706788   PMID:14715932   PMID:14761980   PMID:15024749   PMID:15184050   PMID:15228593  
PMID:15240711   PMID:15254086   PMID:15290894   PMID:15312787   PMID:15331634   PMID:15456831   PMID:15496477   PMID:15550367   PMID:15640761   PMID:15713258   PMID:15777864   PMID:15905573  
PMID:15914561   PMID:15937334   PMID:15964665   PMID:15978588   PMID:16038985   PMID:16116196   PMID:16198349   PMID:16269410   PMID:16325464   PMID:16338906   PMID:16455971   PMID:16493071  
PMID:16635480   PMID:16969386   PMID:17082644   PMID:17135244   PMID:17240370   PMID:17286969   PMID:17306762   PMID:17448897   PMID:17540539   PMID:17624242   PMID:17632323   PMID:17803959  
PMID:18039556   PMID:18071294   PMID:18082965   PMID:18089587   PMID:18097031   PMID:18177631   PMID:18178317   PMID:18206860   PMID:18242779   PMID:18315565   PMID:18490713   PMID:18615736  
PMID:18782864   PMID:18804898   PMID:18848528   PMID:18942742   PMID:18942747   PMID:18946042   PMID:18977353   PMID:19084381   PMID:19218877   PMID:19304656   PMID:19309360   PMID:19321774  
PMID:19397270   PMID:19546214   PMID:19546221   PMID:19625689   PMID:19767540   PMID:19854240   PMID:20071613   PMID:20146080   PMID:20200324   PMID:20378545   PMID:20534165   PMID:20534852  
PMID:20554014   PMID:20649592   PMID:20673841   PMID:20739479   PMID:20817062   PMID:20829501   PMID:20848604   PMID:20939924   PMID:21073871   PMID:21162127   PMID:21185900   PMID:21205829  
PMID:21266468   PMID:21267638   PMID:21397667   PMID:21502139   PMID:21607877   PMID:21631954   PMID:21669492   PMID:21677150   PMID:21685263   PMID:21685341   PMID:21763757   PMID:21865551  
PMID:21907716   PMID:22078760   PMID:22286664   PMID:22314033   PMID:22372415   PMID:22473129   PMID:22774935   PMID:22814097   PMID:22898868   PMID:23089744   PMID:23106524   PMID:23123775  
PMID:23438872   PMID:23472093   PMID:23479225   PMID:23523696   PMID:23564500   PMID:23646980   PMID:23657251   PMID:23754120   PMID:23770274   PMID:23832015   PMID:23877788   PMID:23889535  
PMID:23907465   PMID:23990036   PMID:24091672   PMID:24114535   PMID:24146541   PMID:24533168   PMID:24610121   PMID:24746144   PMID:24895290   PMID:24922070   PMID:24961463   PMID:24989856  
PMID:24997266   PMID:25127716   PMID:25239372   PMID:25288220   PMID:25526634   PMID:25527178   PMID:25549098   PMID:25605289   PMID:25651887   PMID:25682129   PMID:25712548   PMID:25836422  
PMID:25989529   PMID:26031379   PMID:26070527   PMID:26108066   PMID:26299340   PMID:26481422   PMID:26630943   PMID:26683661   PMID:26865268   PMID:26980524   PMID:26988236   PMID:27100355  
PMID:27107575   PMID:27118262   PMID:27215605   PMID:27235833   PMID:27301716   PMID:27363267   PMID:27431093   PMID:27720859   PMID:27738636   PMID:27810364   PMID:28039004   PMID:28039938  
PMID:28061416   PMID:28404593   PMID:28470940   PMID:28616989   PMID:28707031   PMID:28807217   PMID:29204447   PMID:29436679   PMID:29501771   PMID:29895988   PMID:29932348   PMID:30077925  
PMID:30170060   PMID:30248434   PMID:30582910   PMID:31202513   PMID:31894530   PMID:32155290   PMID:32187491   PMID:32348177   PMID:32668623   PMID:32952148   PMID:33182845   PMID:33407649  
PMID:33532039   PMID:33620697   PMID:33650080   PMID:34205953   PMID:34243066   PMID:34638832   PMID:34890016   PMID:34964926   PMID:35057643   PMID:35163829   PMID:35166175   PMID:35218450  
PMID:35239186   PMID:35388574   PMID:35605331   PMID:35907034   PMID:36115462   PMID:36282438   PMID:36328143   PMID:36375190   PMID:36430617   PMID:36945903   PMID:37021698  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81239,550,531 - 39,594,984 (-)NCBIGRCr8
mRatBN7.21233,889,709 - 33,934,168 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1233,879,745 - 33,934,619 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1235,064,139 - 35,106,383 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01235,675,576 - 35,717,824 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01234,727,868 - 34,770,118 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01239,353,613 - 39,396,042 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1239,353,613 - 39,396,042 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01241,804,060 - 41,808,755 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01241,242,368 - 41,284,797 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41235,074,025 - 35,117,152 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11234,937,412 - 34,980,540 (-)NCBI
Celera1235,564,374 - 35,607,476 (-)NCBICelera
Cytogenetic Map12q16NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh3812121,132,876 - 121,188,032 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12121,132,819 - 121,188,032 (+)EnsemblGRCh38hg38GRCh38
GRCh3712121,570,679 - 121,625,835 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612120,055,061 - 120,108,259 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412120,033,397 - 120,086,591NCBI
Celera12121,208,365 - 121,262,089 (+)NCBICelera
Cytogenetic Map12q24.31NCBI
HuRef12118,580,277 - 118,634,021 (+)NCBIHuRef
CHM1_112121,539,497 - 121,593,180 (+)NCBICHM1_1
T2T-CHM13v2.012121,123,629 - 121,178,800 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm395122,781,990 - 122,830,399 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5122,781,974 - 122,829,495 (+)EnsemblGRCm39 Ensembl
GRCm385122,643,927 - 122,692,336 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5122,643,911 - 122,691,432 (+)EnsemblGRCm38mm10GRCm38
MGSCv375123,093,920 - 123,141,441 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365122,904,528 - 122,952,049 (+)NCBIMGSCv36mm8
Celera5119,722,412 - 119,770,254 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map562.5NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554827,048,776 - 7,086,926 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554827,048,674 - 7,087,525 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v210129,218,528 - 129,272,802 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112129,214,900 - 129,269,176 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012118,731,761 - 118,786,039 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112122,102,888 - 122,154,068 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12122,102,888 - 122,154,068 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1267,928,863 - 7,983,956 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl267,940,985 - 7,983,740 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha268,105,749 - 8,148,516 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0268,197,891 - 8,242,043 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl268,197,292 - 8,242,044 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1268,159,088 - 8,201,849 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0268,217,646 - 8,260,409 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0268,174,038 - 8,216,804 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024405118156,329,671 - 156,378,094 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365583,108,283 - 3,149,765 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365583,106,819 - 3,149,689 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1431,415,193 - 31,476,472 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11431,415,188 - 31,476,502 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21433,281,108 - 33,340,508 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.111116,505,975 - 116,560,151 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11116,529,346 - 116,563,059 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037128,519,187 - 128,586,099 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462474721,725,395 - 21,759,453 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474721,725,813 - 21,768,123 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in P2rx7
525 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:379
Count of miRNA genes:219
Interacting mature miRNAs:262
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121363552335682913Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121555082638478808Rat
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961088935682913Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121983578938193007Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
70169Eae13Experimental allergic encephalomyelitis QTL 130.032nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)122413920236638073Rat
1556747Calcic1Intracellular calcium level QTL 13.6platelet calcium amount (VT:0010500)platelet intracellular calcium level (CMO:0000922)122806443340130419Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)122806443345899022Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)122806443346669029Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)122806455740218380Rat
631829Alc6Alcohol consumption QTL 64.7consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)122860752637691617Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123210317445899022Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21233,930,009 - 33,930,145 (+)MAPPERmRatBN7.2
Rnor_6.01239,391,951 - 39,392,086NCBIRnor6.0
Rnor_5.01241,280,706 - 41,280,841UniSTSRnor5.0
RGSC_v3.41235,113,061 - 35,113,196UniSTSRGSC3.4
Celera1235,603,384 - 35,603,519UniSTS
RH 3.4 Map12606.2UniSTS
Cytogenetic Map12q16UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21233,930,008 - 33,930,142 (+)MAPPERmRatBN7.2
Rnor_6.01239,391,950 - 39,392,083NCBIRnor6.0
Rnor_5.01241,280,705 - 41,280,838UniSTSRnor5.0
RGSC_v3.41235,113,060 - 35,113,193UniSTSRGSC3.4
Celera1235,603,383 - 35,603,516UniSTS
Cytogenetic Map12q16UniSTS

Genetic Models
This gene P2rx7 is modified in the following models/strains:


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 1 19 19 19 10 6 11
Low 2 42 36 20 19 20 8 9 54 29 34 8
Below cutoff 1 2 2 2 2 10 6 1


RefSeq Acc Id: ENSRNOT00000001746   ⟹   ENSRNOP00000001746
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1233,890,989 - 33,926,169 (-)Ensembl
Rnor_6.0 Ensembl1239,353,613 - 39,396,042 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079201   ⟹   ENSRNOP00000071169
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1233,890,790 - 33,934,101 (-)Ensembl
Rnor_6.0 Ensembl1239,355,056 - 39,388,021 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000100996   ⟹   ENSRNOP00000097073
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1233,890,989 - 33,928,291 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000113768   ⟹   ENSRNOP00000087262
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1233,879,745 - 33,934,101 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000114333   ⟹   ENSRNOP00000097214
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1233,915,432 - 33,934,101 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000119858   ⟹   ENSRNOP00000094617
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1233,890,989 - 33,934,619 (-)Ensembl
RefSeq Acc Id: NM_019256   ⟹   NP_062129
Rat AssemblyChrPosition (strand)Source
GRCr81239,551,811 - 39,594,922 (-)NCBI
mRatBN7.21233,890,989 - 33,934,101 (-)NCBI
Rnor_6.01239,353,613 - 39,396,042 (-)NCBI
Rnor_5.01241,242,368 - 41,284,797 (-)NCBI
RGSC_v3.41235,074,025 - 35,117,152 (-)RGD
Celera1235,564,374 - 35,607,476 (-)RGD
RefSeq Acc Id: XM_008769223   ⟹   XP_008767445
Rat AssemblyChrPosition (strand)Source
GRCr81239,550,531 - 39,589,389 (-)NCBI
mRatBN7.21233,889,709 - 33,926,819 (-)NCBI
Rnor_6.01239,353,685 - 39,388,253 (-)NCBI
RefSeq Acc Id: XM_039089304   ⟹   XP_038945232
Rat AssemblyChrPosition (strand)Source
GRCr81239,550,531 - 39,594,984 (-)NCBI
mRatBN7.21233,889,709 - 33,934,168 (-)NCBI
RefSeq Acc Id: XM_039089305   ⟹   XP_038945233
Rat AssemblyChrPosition (strand)Source
GRCr81239,550,531 - 39,589,389 (-)NCBI
mRatBN7.21233,889,709 - 33,926,820 (-)NCBI
RefSeq Acc Id: XM_039089306   ⟹   XP_038945234
Rat AssemblyChrPosition (strand)Source
GRCr81239,550,531 - 39,567,251 (-)NCBI
mRatBN7.21233,889,709 - 33,905,101 (-)NCBI
RefSeq Acc Id: NP_062129   ⟸   NM_019256
- UniProtKB: Q64663 (UniProtKB/Swiss-Prot),   A6J185 (UniProtKB/TrEMBL),   A6J184 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008767445   ⟸   XM_008769223
- Peptide Label: isoform X3
- UniProtKB: C8YIX5 (UniProtKB/TrEMBL),   A0A8I6ARA0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071169   ⟸   ENSRNOT00000079201
RefSeq Acc Id: ENSRNOP00000001746   ⟸   ENSRNOT00000001746
RefSeq Acc Id: XP_038945232   ⟸   XM_039089304
- Peptide Label: isoform X1
- UniProtKB: A6J184 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038945233   ⟸   XM_039089305
- Peptide Label: isoform X2
- UniProtKB: A0A8L2Q078 (UniProtKB/TrEMBL),   A0A8I6ARA0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038945234   ⟸   XM_039089306
- Peptide Label: isoform X4
RefSeq Acc Id: ENSRNOP00000094617   ⟸   ENSRNOT00000119858
RefSeq Acc Id: ENSRNOP00000087262   ⟸   ENSRNOT00000113768
RefSeq Acc Id: ENSRNOP00000097214   ⟸   ENSRNOT00000114333
RefSeq Acc Id: ENSRNOP00000097073   ⟸   ENSRNOT00000100996
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64663-F1-model_v2 AlphaFold Q64663 1-595 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13698652
Promoter ID:EPDNEW_R9165
Type:single initiation site
Description:purinergic receptor P2X 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01239,387,977 - 39,388,037EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3241 AgrOrtholog
BioCyc Gene G2FUF-19261 BioCyc
Ensembl Genes ENSRNOG00000001296 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001746.8 UniProtKB/TrEMBL
  ENSRNOT00000079201.2 UniProtKB/TrEMBL
  ENSRNOT00000100996.1 UniProtKB/TrEMBL
  ENSRNOT00000113768.1 UniProtKB/TrEMBL
  ENSRNOT00000114333.1 UniProtKB/TrEMBL
  ENSRNOT00000119858.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.490.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  atp-gated p2x4 ion channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro P2RX7_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P2X7_purinoceptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P2X_extracellular_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P2X_purnocptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29665 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10125:SF13 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam P2RX7_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P2X_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen P2rx7 PhenoGen
  P2XRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001296 RatGTEx
  A6J186_RAT UniProtKB/TrEMBL
  P2RX7_RAT UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 P2rx7  purinergic receptor P2X 7  LOC108352449  P2X purinoceptor 7-like  Data merged from RGD:11419895 737654 PROVISIONAL
2016-08-02 LOC108352449  P2X purinoceptor 7-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2016-02-11 P2rx7  purinergic receptor P2X 7  P2rx7  purinergic receptor P2X, ligand-gated ion channel, 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 P2rx7  purinergic receptor P2X, ligand-gated ion channel, 7       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the cytoplasm and nuclear envelope 628349
gene_expression protein presents only in the terminals of excitatory neurons but mRNA is also co-expressed in cells containing immunoreactivity for the potassium-channel subunit Kv3.1b 628349
gene_expression expressed in the hippocampus 628349
gene_function activate protein kinase D and p42/p44 mitogen-activated protein kinase (MAPK) downstream of protein kinase C 724658
gene_process may play a role in regulating nuclear Ca2+ concentration in response to cytoplasmic activity 628349
gene_product member of a family of ATP-binding receptors that are permeable to calcium 628349