Npy1r (neuropeptide Y receptor Y1) - Rat Genome Database

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Gene: Npy1r (neuropeptide Y receptor Y1) Rattus norvegicus
Symbol: Npy1r
Name: neuropeptide Y receptor Y1
RGD ID: 3198
Description: Predicted to enable neuropeptide binding activity; pancreatic polypeptide receptor activity; and peptide YY receptor activity. Involved in several processes, including positive regulation of vasoconstriction; regulation of presynaptic cytosolic calcium ion concentration; and regulation of secretion by cell. Located in axon and synaptic vesicle. Is active in glutamatergic synapse; neuronal dense core vesicle; and presynaptic membrane. Used to study anxiety disorder; childhood absence epilepsy; depressive disorder; and hypertension. Biomarker of obesity and visual epilepsy. Orthologous to human NPY1R (neuropeptide Y receptor Y1); INTERACTS WITH 17beta-estradiol; 1D-myo-inositol 1,4,5-trisphosphate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: FC5; MGC109393; Neuropepetide Y1 Receptor; neuropeptide Y receptor type 1; neuropeptide Y1 receptor; NPY-1; NPY1-R
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81627,804,416 - 27,814,070 (-)NCBIGRCr8
mRatBN7.21623,037,788 - 23,047,330 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1623,037,789 - 23,046,759 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1626,400,898 - 26,409,918 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01629,835,589 - 29,844,607 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01625,766,507 - 25,775,523 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01624,779,480 - 24,789,131 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1624,779,477 - 24,788,740 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01624,663,045 - 24,672,508 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41624,747,183 - 24,756,507 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11624,748,298 - 24,749,803 (-)NCBI
Celera1623,162,089 - 23,171,059 (-)NCBICelera
Cytogenetic Map16p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
1D-myo-inositol 1,4,5-trisphosphate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2-methyl-4-chlorophenoxybutyric acid  (EXP)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
ammonium acetate  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cantharidin  (ISO)
capsaicin  (EXP)
carbon nanotube  (ISO)
chrysene  (ISO)
coumestrol  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cyromazine  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
Diallyl sulfide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
Enterolactone  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP)
fluoxetine  (EXP)
genistein  (EXP,ISO)
ifosfamide  (ISO)
ketamine  (EXP)
lead diacetate  (EXP)
medroxyprogesterone acetate  (ISO)
mercury dichloride  (EXP)
methamphetamine  (ISO)
methylmercury chloride  (ISO)
morphine  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
O-methyleugenol  (ISO)
panobinostat  (ISO)
pentobarbital  (ISO)
perfluorohexanesulfonic acid  (ISO)
phenylmercury acetate  (ISO)
phenylpropanolamine  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
picrotoxin  (EXP)
pioglitazone  (ISO)
pirimicarb  (EXP)
progesterone  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
tetraphene  (ISO)
thiram  (EXP)
titanium dioxide  (ISO)
tribromoethanol  (ISO)
trichostatin A  (ISO)
trifluoroacetic acid  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
zearalenone  (ISO)
ziram  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function


References - curated
# Reference Title Reference Citation
1. NPY modulates epinephrine-induced leukocytosis via Y-1 and Y-5 receptor activation in vivo: sympathetic co-transmission during leukocyte mobilization. Bedoui S, etal., J Neuroimmunol 2002 Nov;132(1-2):25-33.
2. The antidepressant effects of running and escitalopram are associated with levels of hippocampal NPY and Y1 receptor but not cell proliferation in a rat model of depression. Bjornebekk A, etal., Hippocampus. 2010 Jul;20(7):820-8. doi: 10.1002/hipo.20683.
3. The effect of cardiac ischemic preconditioning on rat left ventricular gene expression profile. Canatan H Cell Biochem Funct. 2007 Jun 11;.
4. Alteration of NPY and Y1 receptor in dorsomedial and ventromedial areas of hypothalamus in anorectic tumor-bearing rats. Chance WT, etal., Peptides. 2007 Feb;28(2):295-301. Epub 2007 Jan 17.
5. NPY stimulates cholesterol synthesis acutely by activating the SREBP2-HMGCR pathway through the Y1 and Y5 receptors in murine hepatocytes. Chen F, etal., Life Sci. 2020 Dec 1;262:118478. doi: 10.1016/j.lfs.2020.118478. Epub 2020 Sep 22.
6. Neuropeptide Y-Y1 receptor antisense oligodeoxynucleotide increases the infarct volume after middle cerebral artery occlusion in rats. Cheung RT and Cechetto DF, Neuroscience. 2000;98(4):771-7.
7. Expression of neuropeptide Y and its receptors Y1 and Y2 in the rat heart and its supplying autonomic and spinal sensory ganglia in experimentally induced diabetes. Chottova Dvorakova M, etal., Neuroscience. 2008 Feb 19;151(4):1016-28. doi: 10.1016/j.neuroscience.2007.07.069. Epub 2007 Dec 8.
8. Molecular cloning of a novel G protein-coupled receptor that may belong to the neuropeptide receptor family. Eva C, etal., FEBS Lett 1990 Oct 1;271(1-2):81-4.
9. Neuropeptide Y1 and Y5 receptors mediate the effects of neuropeptide Y on the hypothalamic-pituitary-thyroid axis. Fekete C, etal., Endocrinology 2002 Dec;143(12):4513-9.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Neuropeptide Y inhibits capsaicin-sensitive nociceptors via a Y1-receptor-mediated mechanism. Gibbs J, etal., Neuroscience. 2004;125(3):703-9.
12. Neuropeptide Y modulates effects of bradykinin and prostaglandin E2 on trigeminal nociceptors via activation of the Y1 and Y2 receptors. Gibbs JL, etal., Br J Pharmacol. 2007 Jan;150(1):72-9. Epub 2006 Dec 4.
13. Ultrastructural localization of neuropeptide Y Y1 receptors in the rat medial nucleus tractus solitarius: relationships with neuropeptide Y or catecholamine neurons. Glass MJ, etal., J Neurosci Res. 2002 Mar 15;67(6):753-65.
14. Physiological role of neuropeptide Y in the regulation of the ascending phase of the peristaltic reflex. Grider JR and Langdon LE, Am J Physiol Gastrointest Liver Physiol. 2003 Dec;285(6):G1139-46. Epub 2003 Aug 14.
15. Estrogen Induces Neuropeptide Y (NPY) Y1 receptor gene expression and responsiveness to NPY in gonadotrope-enriched pituitary cell cultures. Hill JW, etal., Endocrinology. 2004 May;145(5):2283-90. Epub 2004 Jan 15.
16. Neuropeptide y and neuropeptide y y5 receptor interaction restores impaired growth potential of aging bone marrow stromal cells. Igura K, etal., Rejuvenation Res. 2011 Aug;14(4):393-403. doi: 10.1089/rej.2010.1129. Epub 2011 May 19.
17. Infusion of neuropeptide Y into CA3 region of hippocampus produces antidepressant-like effect via Y1 receptor. Ishida H, etal., Hippocampus. 2007;17(4):271-80.
18. Electroconvulsive stimuli selectively affect behavior and neuropeptide Y (NPY) and NPY Y(1) receptor gene expressions in hippocampus and hypothalamus of Flinders Sensitive Line rat model of depression. Jiménez-Vasquez PA, etal., Eur Neuropsychopharmacol. 2007 Mar;17(4):298-308. doi: 10.1016/j.euroneuro.2006.06.011. Epub 2006 Aug 9.
19. Differential regulation of mRNAs for neuropeptide Y and its receptor subtypes in widespread areas of the rat limbic system during kindling epileptogenesis. Kopp J, etal., Brain Res Mol Brain Res. 1999 Sep 8;72(1):17-29.
20. Obesity and mild hyperinsulinemia found in neuropeptide Y-Y1 receptor-deficient mice. Kushi A, etal., Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15659-64.
21. Genetic variations in genes of the stress response pathway are associated with prolonged abstinence from heroin. Levran O, etal., Pharmacogenomics. 2018 Mar;19(4):333-341. doi: 10.2217/pgs-2017-0179. Epub 2018 Feb 21.
22. A 3' UTR SNP rs885863, a cis-eQTL for the circadian gene VIPR2 and lincRNA 689, is associated with opioid addiction. Levran O, etal., PLoS One. 2019 Nov 5;14(11):e0224399. doi: 10.1371/journal.pone.0224399. eCollection 2019.
23. Stress-related genes and heroin addiction: a role for a functional FKBP5 haplotype. Levran O, etal., Psychoneuroendocrinology. 2014 Jul;45:67-76. doi: 10.1016/j.psyneuen.2014.03.017. Epub 2014 Apr 6.
24. Of mice and men: neuropeptide Y and its receptors are associated with atherosclerotic lesion burden and vulnerability. Li L, etal., J Cardiovasc Transl Res. 2011 Jun;4(3):351-62. doi: 10.1007/s12265-011-9271-5. Epub 2011 Apr 6.
25. Gene Expression Changes in Glutamate and GABA-A Receptors, Neuropeptides, Ion Channels, and Cholesterol Synthesis in the Periaqueductal Gray Following Binge-Like Alcohol Drinking by Adolescent Alcohol-Preferring (P) Rats. McClintick JN, etal., Alcohol Clin Exp Res. 2016 May;40(5):955-68. doi: 10.1111/acer.13056. Epub 2016 Apr 8.
26. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
27. Central neuropeptide Y signaling ameliorates N(omega)-nitro-L-arginine methyl ester hypertension in the rat through a Y1 receptor mechanism. Michalkiewicz M, etal., Hypertension 2005 Apr;45(4):780-5. Epub 2005 Feb 7.
28. Role of neuropeptide Y Y(1) and Y(2) receptors on behavioral despair in a rat model of depression with co-morbid anxiety. Morales-Medina JC, etal., Neuropharmacology. 2012 Jan;62(1):200-8. doi: 10.1016/j.neuropharm.2011.06.030. Epub 2011 Jul 23.
29. Neuropeptide Y suppresses absence seizures in a genetic rat model primarily through effects on Y receptors. Morris MJ, etal., Eur J Neurosci. 2007 Feb;25(4):1136-43.
30. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
31. The neuropeptide Y receptors, Y1 and Y2, are transiently and differentially expressed in the developing cerebellum. Neveu I, etal., Neuroscience 2002;113(4):767-77.
32. Association between neuropeptide Y gene and its receptor Y1 gene and methamphetamine dependence. Okahisa Y, etal., Psychiatry Clin Neurosci. 2009 Jun;63(3):417-22. doi: 10.1111/j.1440-1819.2009.01961.x.
33. Gene expression in the neuropeptide Y system during ethanol withdrawal kindling in rats. Olling JD, etal., Alcohol Clin Exp Res. 2010 Mar 1;34(3):462-70. doi: 10.1111/j.1530-0277.2009.01110.x. Epub 2009 Dec 17.
34. Complex plastic changes in the neuropeptide Y system during ethanol intoxication and withdrawal in the rat brain. Olling JD, etal., J Neurosci Res. 2009 Aug 1;87(10):2386-97. doi: 10.1002/jnr.22049.
35. Polymorphisms in Stress-Related Genes Are Associated with Reduced Cocaine Abuse and Longer Retention in Methadone Maintenance Treatment for Opioid Use Disorder. Peles E, etal., Eur Addict Res. 2021;27(3):198-205. doi: 10.1159/000511898. Epub 2020 Nov 26.
36. An immunohistochemical marker for Wallerian degeneration of fibers in the central and peripheral nervous system. Pesini P, etal., Brain Res. 1999 May 15;828(1-2):41-59.
37. Characterization of NPY receptors mediating contraction in rat intramyocardial coronary arteries. Prieto D, etal., Regul Pept. 1998 Sep 25;75-76:155-60.
38. Further evidence for the association of GAL, GALR1 and NPY1R variants with opioid dependence. Randesi M, etal., Pharmacogenomics. 2020 Aug;21(13):903-917. doi: 10.2217/pgs-2020-0045. Epub 2020 Aug 6.
39. GOA pipeline RGD automated data pipeline
40. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
41. Comprehensive gene review and curation RGD comprehensive gene curation
42. Medial prefrontal cortex neuropeptide Y modulates binge-like ethanol consumption in C57BL/6J mice. Robinson SL, etal., Neuropsychopharmacology. 2019 May;44(6):1132-1140. doi: 10.1038/s41386-018-0310-7. Epub 2019 Jan 7.
43. Impact of intermittent voluntary ethanol consumption during adolescence on the expression of endocannabinoid system and neuroinflammatory mediators. Sanchez-Marin L, etal., Eur Neuropsychopharmacol. 2020 Apr;33:126-138. doi: 10.1016/j.euroneuro.2020.01.012. Epub 2020 Feb 10.
44. Neuropeptide Y Y1 receptors mediate morphine-induced reductions of natural killer cell activity. Saurer TB, etal., J Neuroimmunol. 2006 Aug;177(1-2):18-26. doi: 10.1016/j.jneuroim.2006.05.002.
45. Modulation of intracellular calcium changes and glutamate release by neuropeptide Y1 and Y2 receptors in the rat hippocampus: differential effects in CA1, CA3 and dentate gyrus. Silva AP, etal., J Neurochem. 2001 Oct;79(2):286-96. doi: 10.1046/j.1471-4159.2001.00560.x.
46. Antisense mRNA for NPY-Y1 receptor in the medial preoptic area increases prolactin secretion. Silveira NA and Franci CR, Braz J Med Biol Res. 1999 Sep;32(9):1161-5.
47. Differential roles for neuropeptide Y Y1 and Y5 receptors in anxiety and sedation. Sorensen G, etal., J Neurosci Res. 2004 Sep 1;77(5):723-9.
48. Central neuropeptide Y modulates binge-like ethanol drinking in C57BL/6J mice via Y1 and Y2 receptors. Sparrow AM, etal., Neuropsychopharmacology. 2012 May;37(6):1409-21. doi: 10.1038/npp.2011.327. Epub 2012 Jan 4.
49. Acute stress and alcohol exposure during adolescence result in an anxious phenotype in adulthood: Role of altered glutamate/endocannabinoid transmission mechanisms. Sánchez-Marín L, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2022 Mar 8;113:110460. doi: 10.1016/j.pnpbp.2021.110460. Epub 2021 Oct 22.
50. Ultrastructural Characterization of Corticotropin-Releasing Factor and Neuropeptide Y in the Rat Locus Coeruleus: Anatomical Evidence for Putative Interactions. Theisen CC, etal., Neuroscience. 2018 Aug 1;384:21-40. doi: 10.1016/j.neuroscience.2018.04.043. Epub 2018 May 22.
51. Influence of dehydration on the expression of neuropeptide Y Y1 receptors in hypothalamic magnocellular neurons. Urban JH, etal., Endocrinology. 2006 Sep;147(9):4122-31. Epub 2006 May 25.
52. Overexpression of NPY and Y2 receptors in epileptic brain tissue: an endogenous neuroprotective mechanism in temporal lobe epilepsy? Vezzani A and Sperk G, Neuropeptides. 2004 Aug;38(4):245-52.
53. Difference of NPY and its receptor gene expressions between obesity and obesity-resistant rats in response to high-fat diet. Wang C, etal., Horm Metab Res. 2007 Apr;39(4):262-7.
54. Activation of neuropeptide Y Y1 receptors inhibits glutamate release through reduction of voltage-dependent Ca2+ entry in the rat cerebral cortex nerve terminals: suppression of this inhibitory effect by the protein kinase C-dependent facilitatory pathway. Wang SJ, Neuroscience. 2005;134(3):987-1000. doi: 10.1016/j.neuroscience.2005.04.053.
55. Association study of 45 candidate genes in nicotine dependence in Han Chinese. Wei J, etal., Addict Behav. 2012 May;37(5):622-6. doi: 10.1016/j.addbeh.2012.01.009. Epub 2012 Jan 18.
Additional References at PubMed
PMID:9623984   PMID:10698177   PMID:11206547   PMID:12429884   PMID:12477932   PMID:12535945   PMID:12855401   PMID:12900925   PMID:14615027   PMID:14688445   PMID:15044185   PMID:15123022  
PMID:15295007   PMID:15544855   PMID:15576634   PMID:15623437   PMID:15690487   PMID:15720710   PMID:16051880   PMID:16448775   PMID:17463058   PMID:17510186   PMID:18323405   PMID:18535365  
PMID:19138726   PMID:19593212   PMID:19731317   PMID:20219870   PMID:20536577   PMID:21629996   PMID:22210742   PMID:22659471   PMID:22713926   PMID:22732442   PMID:23052195   PMID:23071607  
PMID:23074243   PMID:23179670   PMID:23548582   PMID:23825421   PMID:24225225   PMID:24444822   PMID:24779394   PMID:25241802   PMID:26330345   PMID:26490304   PMID:26666529   PMID:28239793  
PMID:28438668   PMID:29157796   PMID:30227410   PMID:30700376   PMID:31076578   PMID:31622603  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81627,804,416 - 27,814,070 (-)NCBIGRCr8
mRatBN7.21623,037,788 - 23,047,330 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1623,037,789 - 23,046,759 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1626,400,898 - 26,409,918 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01629,835,589 - 29,844,607 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01625,766,507 - 25,775,523 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01624,779,480 - 24,789,131 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1624,779,477 - 24,788,740 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01624,663,045 - 24,672,508 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41624,747,183 - 24,756,507 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11624,748,298 - 24,749,803 (-)NCBI
Celera1623,162,089 - 23,171,059 (-)NCBICelera
Cytogenetic Map16p14NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh384163,323,962 - 163,344,689 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4163,323,962 - 163,344,832 (-)EnsemblGRCh38hg38GRCh38
GRCh374164,245,114 - 164,253,748 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364164,464,567 - 164,473,198 (-)NCBINCBI36Build 36hg18NCBI36
Build 344164,602,721 - 164,611,353NCBI
Celera4161,577,336 - 161,585,966 (-)NCBICelera
Cytogenetic Map4q32.2NCBI
HuRef4159,999,060 - 160,008,005 (-)NCBIHuRef
CHM1_14164,221,563 - 164,230,393 (-)NCBICHM1_1
T2T-CHM13v2.04166,671,793 - 166,692,717 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39867,149,595 - 67,159,452 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl867,149,844 - 67,159,444 (+)EnsemblGRCm39 Ensembl
GRCm38866,697,149 - 66,706,800 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl866,697,192 - 66,706,792 (+)EnsemblGRCm38mm10GRCm38
MGSCv37869,221,321 - 69,230,697 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36869,632,837 - 69,635,097 (+)NCBIMGSCv36mm8
Celera869,251,576 - 69,260,940 (+)NCBICelera
Cytogenetic Map8B3.1NCBI
cM Map833.15NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495540341,681,728 - 41,694,020 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540341,681,834 - 41,693,094 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v23161,132,638 - 161,153,546 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14161,495,180 - 161,516,073 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04155,583,870 - 155,604,336 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14167,372,306 - 167,392,716 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4167,372,310 - 167,381,597 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11559,580,546 - 59,587,753 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1559,580,809 - 59,583,237 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1559,946,494 - 59,947,746 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01560,338,999 - 60,348,168 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1560,339,001 - 60,348,197 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11559,574,468 - 59,575,720 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01559,665,153 - 59,666,405 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01560,034,141 - 60,035,393 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494316,293,825 - 16,314,919 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365552,267,669 - 2,276,778 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365552,267,727 - 2,276,673 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl852,152,646 - 52,162,328 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1852,152,649 - 52,163,080 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2855,280,107 - 55,290,551 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.17109,774,700 - 109,794,543 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7109,774,918 - 109,776,905 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603789,580,043 - 89,600,565 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462475813,536,493 - 13,545,599 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475813,542,467 - 13,545,106 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Npy1r
57 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:402
Count of miRNA genes:218
Interacting mature miRNAs:258
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21623,039,172 - 23,039,540 (+)MAPPERmRatBN7.2
Rnor_6.01624,780,864 - 24,781,231NCBIRnor6.0
Rnor_5.01624,664,429 - 24,664,796UniSTSRnor5.0
RGSC_v3.41624,748,567 - 24,748,934UniSTSRGSC3.4
Celera1623,163,473 - 23,163,840UniSTS
Cytogenetic Map16p14UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 15
Low 2 13 18 2 18 2 8 11 51 32 36 11 8
Below cutoff 1 24 14 14 1 14 4 3 3


RefSeq Acc Id: ENSRNOT00000018952   ⟹   ENSRNOP00000018952
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1623,037,789 - 23,046,759 (-)Ensembl
Rnor_6.0 Ensembl1624,779,477 - 24,788,740 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079412   ⟹   ENSRNOP00000068980
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1623,037,790 - 23,046,759 (-)Ensembl
Rnor_6.0 Ensembl1624,779,481 - 24,788,456 (-)Ensembl
RefSeq Acc Id: NM_001113357   ⟹   NP_001106828
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr81627,804,416 - 27,813,387 (-)NCBI
mRatBN7.21623,037,789 - 23,046,759 (-)NCBI
Rnor_6.01624,779,480 - 24,788,456 (-)NCBI
Rnor_5.01624,663,045 - 24,672,508 (-)NCBI
RGSC_v3.41624,747,183 - 24,756,507 (-)RGD
Celera1623,162,089 - 23,171,059 (-)RGD
RefSeq Acc Id: XM_006253024   ⟹   XP_006253086
Rat AssemblyChrPosition (strand)Source
GRCr81627,804,416 - 27,814,070 (-)NCBI
mRatBN7.21623,037,788 - 23,047,330 (-)NCBI
Rnor_6.01624,779,480 - 24,789,131 (-)NCBI
Rnor_5.01624,663,045 - 24,672,508 (-)NCBI
RefSeq Acc Id: XM_006253025   ⟹   XP_006253087
Rat AssemblyChrPosition (strand)Source
GRCr81627,804,416 - 27,814,070 (-)NCBI
mRatBN7.21623,037,788 - 23,047,330 (-)NCBI
Rnor_6.01624,779,480 - 24,789,131 (-)NCBI
Rnor_5.01624,663,045 - 24,672,508 (-)NCBI
RefSeq Acc Id: XM_063275269   ⟹   XP_063131339
Rat AssemblyChrPosition (strand)Source
GRCr81627,804,416 - 27,814,066 (-)NCBI
RefSeq Acc Id: NP_001106828   ⟸   NM_001113357
- UniProtKB: P21555 (UniProtKB/Swiss-Prot),   G3V7T1 (UniProtKB/TrEMBL),   A6KFL5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253087   ⟸   XM_006253025
- Peptide Label: isoform X1
- UniProtKB: P21555 (UniProtKB/Swiss-Prot),   G3V7T1 (UniProtKB/TrEMBL),   A6KFL5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253086   ⟸   XM_006253024
- Peptide Label: isoform X1
- UniProtKB: P21555 (UniProtKB/Swiss-Prot),   G3V7T1 (UniProtKB/TrEMBL),   A6KFL5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000068980   ⟸   ENSRNOT00000079412
RefSeq Acc Id: ENSRNOP00000018952   ⟸   ENSRNOT00000018952
RefSeq Acc Id: XP_063131339   ⟸   XM_063275269
- Peptide Label: isoform X2
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P21555-F1-model_v2 AlphaFold P21555 1-382 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3198 AgrOrtholog
BioCyc Gene G2FUF-11662 BioCyc
Ensembl Genes ENSRNOG00000014149 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00055003822 UniProtKB/Swiss-Prot
  ENSRNOG00060006596 UniProtKB/Swiss-Prot
  ENSRNOG00060016812 UniProtKB/Swiss-Prot
  ENSRNOG00065004987 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000018952 ENTREZGENE
  ENSRNOT00000018952.7 UniProtKB/TrEMBL
  ENSRNOT00000079412.2 UniProtKB/TrEMBL
  ENSRNOT00055006020 UniProtKB/Swiss-Prot
  ENSRNOT00060010805 UniProtKB/Swiss-Prot
  ENSRNOT00060028754 UniProtKB/Swiss-Prot
  ENSRNOT00065007293 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NPY1_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NPY_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29358 UniProtKB/TrEMBL
  PTHR24235:SF24 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Npy1r PhenoGen
  NRPEPTIDEY1R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NRPEPTIDEYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014149 RatGTEx
  ENSRNOG00055003822 RatGTEx
  ENSRNOG00060006596 RatGTEx
  ENSRNOG00060016812 RatGTEx
  ENSRNOG00065004987 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-11-06 Npy1r  neuropeptide Y receptor Y1    neuropeptide Y1 receptor  Name updated 625702 APPROVED
2002-06-10 Npy1r  neuropeptide Y1 receptor      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in thalamus, cerebral cortex and hippocampus 69907