Nedd8 (NEDD8 ubiquitin like modifier) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Nedd8 (NEDD8 ubiquitin like modifier) Rattus norvegicus
Analyze
Symbol: Nedd8
Name: NEDD8 ubiquitin like modifier
RGD ID: 3158
Description: Predicted to enable protein tag activity and ubiquitin protein ligase binding activity. Involved in cellular response to camptothecin and protein neddylation. Is active in postsynapse. Orthologous to human NEDD8 (NEDD8 ubiquitin like modifier); PARTICIPATES IN neddylation pathway; p53 signaling pathway; proteasome degradation pathway involving cullin-dependent ubiquitin ligases; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CDK8; MGC105320; neddylin; neural precursor cell expressed, developmentally down-regulated 8; neural precursor cell expressed, developmentally down-regulated gene 8; ubiquitin-like protein Nedd8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81533,123,505 - 33,135,522 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1533,123,505 - 33,135,522 (-)EnsemblGRCr8
mRatBN7.21529,153,556 - 29,165,575 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1529,153,556 - 29,166,160 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1530,999,240 - 31,011,260 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01532,146,461 - 32,158,481 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01530,388,805 - 30,400,824 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01534,340,607 - 34,352,673 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1534,340,607 - 34,352,673 (-)Ensemblrn6Rnor6.0
Rnor_5.01538,230,806 - 38,242,650 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41533,797,457 - 33,820,624 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1528,729,741 - 28,741,968 (-)NCBICelera
RGSC_v3.11533,813,156 - 33,836,123 (-)NCBI
Cytogenetic Map15p13NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
cytosol  (IEA,ISO)
glutamatergic synapse  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO)
postsynapse  (IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Synaptic control of DNA methylation involves activity-dependent degradation of DNMT3A1 in the nucleus. Bayraktar G, etal., Neuropsychopharmacology. 2020 Nov;45(12):2120-2130. doi: 10.1038/s41386-020-0780-2. Epub 2020 Jul 29.
2. Expression of VACM-1/cul5 mutant in endothelial cells induces MAPK phosphorylation and maspin degradation and converts cells to the angiogenic phenotype. Buchwalter A, etal., Microvasc Res. 2008 Mar;75(2):155-68. Epub 2007 Sep 4.
3. APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain. Chen Y, etal., J Cell Biol. 2003 Oct 13;163(1):27-33.
4. Cullin-based ubiquitin ligase and its control by NEDD8-conjugating system. Chiba T and Tanaka K, Curr Protein Pept Sci 2004 Jun;5(3):177-84.
5. NEDD8 protein is involved in ubiquitinated inclusion bodies. Dil Kuazi A, etal., J Pathol 2003 Feb;199(2):259-66.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Comparative expressed-sequence-tag analysis of differential gene expression profiles in PC-12 cells before and after nerve growth factor treatment. Lee NH, etal., Proc Natl Acad Sci U S A 1995 Aug 29;92(18):8303-7.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. Zhang QG, etal., Proc Natl Acad Sci U S A. 2011 Aug 30;108(35):E617-24. doi: 10.1073/pnas.1104391108. Epub 2011 Aug 1.
Additional References at PubMed
PMID:9125149   PMID:10500095   PMID:12215427   PMID:12477932   PMID:15489334   PMID:15694336   PMID:20458337   PMID:22871113   PMID:23376485  


Genomics

Comparative Map Data
Nedd8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81533,123,505 - 33,135,522 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1533,123,505 - 33,135,522 (-)EnsemblGRCr8
mRatBN7.21529,153,556 - 29,165,575 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1529,153,556 - 29,166,160 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1530,999,240 - 31,011,260 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01532,146,461 - 32,158,481 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01530,388,805 - 30,400,824 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01534,340,607 - 34,352,673 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1534,340,607 - 34,352,673 (-)Ensemblrn6Rnor6.0
Rnor_5.01538,230,806 - 38,242,650 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41533,797,457 - 33,820,624 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1528,729,741 - 28,741,968 (-)NCBICelera
RGSC_v3.11533,813,156 - 33,836,123 (-)NCBI
Cytogenetic Map15p13NCBI
NEDD8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381424,216,857 - 24,232,367 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1424,216,857 - 24,232,367 (-)Ensemblhg38GRCh38
GRCh371424,686,063 - 24,701,573 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361423,755,897 - 23,771,416 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341423,755,911 - 23,771,412NCBI
Celera144,550,695 - 4,566,214 (-)NCBICelera
Cytogenetic Map14q12NCBI
HuRef144,801,062 - 4,816,345 (-)NCBIHuRef
CHM1_11424,684,707 - 24,700,199 (-)NCBICHM1_1
T2T-CHM13v2.01418,415,233 - 18,430,739 (-)NCBIT2T-CHM13v2.0
Nedd8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391455,899,720 - 55,909,337 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1455,899,720 - 55,909,581 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381455,662,263 - 55,671,880 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1455,662,263 - 55,672,124 (-)Ensemblmm10GRCm38
MGSCv371456,281,104 - 56,290,743 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361454,616,338 - 54,625,977 (-)NCBIMGSCv36mm8
Celera1453,467,340 - 53,476,979 (-)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.19NCBI
Nedd8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540936,173,533 - 36,182,444 (+)Ensembl
ChiLan1.0NW_00495540936,173,533 - 36,182,444 (+)NCBIChiLan1.0ChiLan1.0
NEDD8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21525,571,077 - 25,586,644 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11424,787,569 - 24,803,136 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0144,993,011 - 5,008,620 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11423,117,271 - 23,132,249 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1423,117,271 - 23,132,249 (-)EnsemblpanPan2panpan1.1
NEDD8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.184,202,621 - 4,213,090 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl84,202,621 - 4,213,049 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha84,124,303 - 4,134,768 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.084,313,388 - 4,323,857 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl84,313,388 - 4,323,818 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.184,003,790 - 4,014,244 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.084,065,590 - 4,076,046 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.084,327,911 - 4,338,370 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nedd8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864036,050,496 - 36,058,043 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936722331,136 - 338,496 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936722331,116 - 338,496 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NEDD8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl775,070,161 - 75,085,899 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1775,069,947 - 75,085,905 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2780,340,870 - 80,353,291 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NEDD8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1241,199,974 - 1,215,079 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603612,884,384 - 12,899,520 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nedd8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248208,319,832 - 8,329,748 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248208,319,763 - 8,329,748 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Nedd8
49 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:48
Count of miRNA genes:40
Interacting mature miRNAs:47
Transcripts:ENSRNOT00000064916
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152024860037896129Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)152788577486257085Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat

Markers in Region
RH129220  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21529,153,591 - 29,153,782 (+)MAPPERmRatBN7.2
Rnor_6.01534,340,643 - 34,340,833NCBIRnor6.0
Rnor_5.01538,230,842 - 38,231,032UniSTSRnor5.0
RGSC_v3.41533,797,493 - 33,797,683UniSTSRGSC3.4
Celera1528,729,777 - 28,729,967UniSTS
Cytogenetic Map15p13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000064916   ⟹   ENSRNOP00000061284
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1533,123,505 - 33,135,522 (-)Ensembl
mRatBN7.2 Ensembl1529,153,557 - 29,165,611 (-)Ensembl
Rnor_6.0 Ensembl1534,340,607 - 34,352,673 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000080232   ⟹   ENSRNOP00000073032
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1534,340,872 - 34,342,373 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104192   ⟹   ENSRNOP00000091841
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1529,153,556 - 29,166,160 (-)Ensembl
RefSeq Acc Id: NM_138878   ⟹   NP_620233
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,123,505 - 33,135,522 (-)NCBI
mRatBN7.21529,153,556 - 29,165,575 (-)NCBI
Rnor_6.01534,340,607 - 34,352,673 (-)NCBI
Rnor_5.01538,230,806 - 38,242,650 (-)NCBI
RGSC_v3.41533,797,457 - 33,820,624 (-)RGD
Celera1528,729,741 - 28,741,968 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_620233 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC64189 (Get FASTA)   NCBI Sequence Viewer  
  AAH84728 (Get FASTA)   NCBI Sequence Viewer  
  EDM14262 (Get FASTA)   NCBI Sequence Viewer  
  EDM14263 (Get FASTA)   NCBI Sequence Viewer  
  EDM14264 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000061284
  ENSRNOP00000061284.1
GenBank Protein Q71UE8 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_620233   ⟸   NM_138878
- UniProtKB: Q71UE8 (UniProtKB/Swiss-Prot),   A6KH34 (UniProtKB/TrEMBL),   A0A8I6AG01 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073032   ⟸   ENSRNOT00000080232
Ensembl Acc Id: ENSRNOP00000061284   ⟸   ENSRNOT00000064916
Ensembl Acc Id: ENSRNOP00000091841   ⟸   ENSRNOT00000104192
Protein Domains
Ubiquitin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q71UE8-F1-model_v2 AlphaFold Q71UE8 1-81 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699681
Promoter ID:EPDNEW_R10204
Type:initiation region
Name:Nedd8_1
Description:neural precursor cell expressed, developmentally down-regulated8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10205  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01534,352,482 - 34,352,542EPDNEW
RGD ID:13699682
Promoter ID:EPDNEW_R10205
Type:initiation region
Name:Nedd8_2
Description:neural precursor cell expressed, developmentally down-regulated8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10204  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01534,352,714 - 34,352,774EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3158 AgrOrtholog
BioCyc Gene G2FUF-13699 BioCyc
Ensembl Genes ENSRNOG00000019895 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000064916 ENTREZGENE
  ENSRNOT00000064916.3 UniProtKB/Swiss-Prot
Gene3D-CATH Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7315541 IMAGE-MGC_LOAD
InterPro Nedd8-like UniProtKB/Swiss-Prot
  Ubiquitin UniProtKB/Swiss-Prot
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot
  Ubiquitin_CS UniProtKB/Swiss-Prot
  Ubiquitin_dom UniProtKB/Swiss-Prot
  Ubiquitin_ubiquitin-like UniProtKB/Swiss-Prot
KEGG Report rno:25490 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105320 IMAGE-MGC_LOAD
NCBI Gene 25490 ENTREZGENE
PANTHER UBIQUITIN UniProtKB/Swiss-Prot
Pfam ubiquitin UniProtKB/Swiss-Prot
PhenoGen Nedd8 PhenoGen
PRINTS UBIQUITIN UniProtKB/Swiss-Prot
PROSITE UBIQUITIN_1 UniProtKB/Swiss-Prot
  UBIQUITIN_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019895 RatGTEx
SMART UBQ UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54236 UniProtKB/Swiss-Prot
UniProt A0A8I6AG01 ENTREZGENE, UniProtKB/TrEMBL
  A6KH33_RAT UniProtKB/TrEMBL
  A6KH34 ENTREZGENE, UniProtKB/TrEMBL
  NEDD8_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-08 Nedd8  NEDD8 ubiquitin like modifier  Nedd8  neural precursor cell expressed, developmentally down-regulated 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Nedd8  neural precursor cell expressed, developmentally down-regulated 8  Nedd8  neural precursor cell expressed, developmentally down-regulated gene 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Nedd8  Neural precursor cell expressed, developmentally down-regulated gene 8      Symbol and Name status set to approved 70586 APPROVED