Myc (MYC proto-oncogene, bHLH transcription factor) - Rat Genome Database

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Gene: Myc (MYC proto-oncogene, bHLH transcription factor) Rattus norvegicus
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Symbol: Myc
Name: MYC proto-oncogene, bHLH transcription factor
RGD ID: 3130
Description: Enables DNA-binding transcription factor activity; double-stranded DNA binding activity; and sequence-specific DNA binding activity. Involved in several processes, including cellular response to lipid; cellular response to organonitrogen compound; and regulation of nucleobase-containing compound metabolic process. Located in cytoplasm and nucleolus. Used to study artery disease (multiple); hepatocellular carcinoma; leiomyoma; osteoporosis; and prostatic hypertrophy. Biomarker of breast cancer; carcinoma (multiple); obesity; polycystic kidney disease; and prolactinoma. Human ortholog(s) of this gene implicated in several diseases, including angiosarcoma; carcinoma (multiple); demyelinating disease; hematologic cancer (multiple); and prostate cancer (multiple). Orthologous to human MYC (MYC proto-oncogene, bHLH transcription factor); PARTICIPATES IN ceramide signaling pathway; interleukin-2 signaling pathway; interleukin-6 signaling pathway; INTERACTS WITH (+)-schisandrin B; (-)-epigallocatechin 3-gallate; (R)-noradrenaline.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: Avian myelocytomatosis viral (v-myc) oncogene homolog; c-myc; MGC105490; mMyc; myc proto-oncogene protein; myelocytomatosis oncogene; myelocytomatosis viral oncogene homolog; myelocytomatosis viral oncogene homolog (avian); proto-oncogene c-Myc; RNCMYC; transcription factor p64; v-myc avian myelocytomatosis viral oncogene homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   W-Tg(MT2A-Myc)1Ys   W-Tg(MT2A-Myc)2Ys  
Candidate Gene For: Lnnr1 Hcas1 Ept7 Teswt1
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2793,593,705 - 93,598,633 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl793,593,705 - 93,598,630 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx795,416,828 - 95,421,746 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0797,619,124 - 97,624,042 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0797,498,652 - 97,503,571 (+)NCBIRnor_WKY
Rnor_6.07102,586,313 - 102,591,240 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7102,586,313 - 102,591,240 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07103,157,452 - 103,162,379 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4798,953,142 - 98,958,060 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1798,987,371 - 98,992,287 (+)NCBI
Celera790,263,903 - 90,268,823 (+)NCBICelera
Cytogenetic Map7q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Aberrant Crypt Foci  (IDA)
acute kidney failure  (ISO)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
acute promyelocytic leukemia  (ISO)
adenocarcinoma  (ISO)
Alcoholic Liver Diseases  (ISO)
angiosarcoma  (ISO)
Animal Disease Models  (ISO)
autosomal dominant polycystic kidney disease  (ISO)
autosomal recessive polycystic kidney disease  (ISO)
B-lymphoblastic leukemia/lymphoma  (ISO)
breast cancer  (IEP,ISO,ISS)
Breast Neoplasms  (IDA,ISO)
Burkitt lymphoma  (ISO)
carcinoma  (ISO)
Cardiomegaly  (IDA)
Carotid Artery Injuries  (IDA,IEP,IMP)
Chromosome Breakage  (ISO)
chronic lymphocytic leukemia  (ISO)
clear cell renal cell carcinoma  (ISO)
cleft lip  (ISO)
cleft palate  (ISO)
Colonic Neoplasms  (IDA,ISO)
Colorectal Neoplasms  (ISO)
coronary restenosis  (IDA)
COVID-19  (ISO)
demyelinating disease  (ISO)
diffuse large B-cell lymphoma  (ISO)
disease of cellular proliferation  (ISO)
Disease Progression  (ISO)
Ductal Carcinoma  (ISO)
Endometrial Neoplasms  (ISO)
esophageal carcinoma  (ISO)
Esophageal Neoplasms  (IDA)
Experimental Diabetes Mellitus  (IEP)
Experimental Liver Cirrhosis  (ISO)
Experimental Liver Neoplasms  (IEP,ISO)
Experimental Mammary Neoplasms  (ISO)
fatty liver disease  (ISO)
glioblastoma  (ISO)
Hemorrhagic Shock  (IDA)
hepatitis C  (ISO)
hepatocellular carcinoma  (IDA,IEP,ISO)
Hodgkin's lymphoma  (ISO)
hyperparathyroidism  (ISO)
hypertrophic cardiomyopathy  (ISO)
Kidney Reperfusion Injury  (IEP)
Left Ventricular Hypertrophy  (ISO)
leiomyoma  (IDA)
liver cirrhosis  (ISO)
Liver Injury  (IEP)
Liver Neoplasms  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
Lung Reperfusion Injury  (IEP)
lung small cell carcinoma  (ISO)
medulloblastoma  (ISO)
Merkel cell carcinoma  (ISO)
myelodysplastic syndrome  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
nephroblastoma  (ISO)
neuroblastoma  (ISO)
neuroectodermal tumor  (ISO)
non-Hodgkin lymphoma  (ISO)
obesity  (IEP)
osteoporosis  (IDA)
osteosarcoma  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
pancreatic carcinoma  (ISS)
polycystic kidney disease  (IEP,ISO)
polycystic kidney disease 1  (ISO)
primary ovarian insufficiency  (ISO)
prolactinoma  (IEP)
prostate adenocarcinoma  (ISO)
prostate cancer  (ISO)
prostate carcinoma in situ  (ISO)
prostatic hypertrophy  (IDA)
Prostatic Neoplasms  (ISO)
pulmonary hypertension  (IDA)
renal cell carcinoma  (IEP,ISO)
renal fibrosis  (ISO)
rhabdoid cancer  (ISO)
skin melanoma  (ISO)
Sporadic Papillary Renal Cell Carcinoma  (ISO)
squamous cell carcinoma  (ISO)
Stomach Neoplasms  (ISO)
thyroid gland cancer  (ISO)
thyroid gland papillary carcinoma  (ISO)
Transplant Rejection  (IMP)
trichorhinophalangeal syndrome type I  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-epicatechin-3-O-gallate  (ISO)
(+)-schisandrin B  (EXP)
(-)-anisomycin  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(-)-selegiline  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(R)-lipoic acid  (ISO)
(R)-noradrenaline  (EXP)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-colchicine  (EXP)
(S)-nicotine  (ISO)
1'-acetoxychavicol acetate  (ISO)
1,1-dichloroethene  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dichlorobenzene  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
1,4-dichlorobenzene  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
1-nitropyrene  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
1D-myo-inositol 1,4,5-trisphosphate  (EXP)
2'-(4-ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-D  (ISO)
2,4-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-butoxyethanol  (ISO)
2-hydroxy-17beta-estradiol  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methyl-2-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propanoic acid  (EXP)
2-nitrofluorene  (EXP)
2-nitrotoluene  (EXP)
26-hydroxycholesterol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3'-diindolylmethane  (ISO)
3-aminobenzamide  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP,ISO)
4-hydroxy-17beta-estradiol  (ISO)
4-Hydroxy-N-desmethyltamoxifen  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-bromo-2'-deoxyuridine  (ISO)
5-fluorouracil  (ISO)
5-nitroso-8-quinolinol  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
7beta-aminocephalosporanic acid  (ISO)
8-Br-cAMP  (ISO)
8-bromo-3',5'-cyclic GMP  (ISO)
acetaldehyde  (ISO)
acetohydrazide  (ISO)
acetylleucyl-leucyl-norleucinal  (ISO)
acetylsalicylic acid  (EXP,ISO)
aconitine  (EXP,ISO)
acrolein  (ISO)
acrylamide  (ISO)
actinomycin D  (EXP,ISO)
adenosine  (ISO)
Aeroplysinin 1  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
AH23848  (ISO)
alachlor  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
allethrin  (ISO)
alpha-hexachlorocyclohexane  (EXP)
alpha-naphthoflavone  (EXP)
alpha-pinene  (ISO)
amifostine  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
ammonium hexachloroplatinate  (ISO)
amsacrine  (ISO)
androstane  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aprepitant  (ISO)
aristolochic acid  (ISO)
arsenic acid  (EXP,ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
Asimicin  (ISO)
aspartame  (ISO)
atorvastatin calcium  (ISO)
atrazine  (ISO)
Azaspiracid  (ISO)
bathocuproine disulfonic acid  (ISO)
benazepril  (EXP)
benzamide  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzoates  (ISO)
benzoic acid  (ISO)
benzylpenicillin  (ISO)
berberine  (EXP)
beryllium difluoride  (ISO)
beryllium sulfate  (EXP)
betulin  (ISO)
betulinic acid  (ISO)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bleomycin A5  (ISO)
bortezomib  (ISO)
bromobenzene  (EXP)
bromochloroacetic acid  (EXP)
bromodichloromethane  (EXP,ISO)
bromoform  (ISO)
bucladesine  (ISO)
budesonide  (ISO)
bufalin  (ISO)
busulfan  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (ISO)
butyric acid  (EXP,ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
caffeine  (EXP,ISO)
calcein am  (ISO)
calcitriol  (ISO)
calcium dichloride  (EXP)
calmidazolium  (ISO)
camptothecin  (ISO)
cannabidiol  (EXP,ISO)
capsaicin  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbofuran  (EXP,ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
carboplatin  (ISO)
carvedilol  (EXP)
catechol  (ISO)
celastrol  (ISO)
celecoxib  (ISO)
CGP 52608  (ISO)
chalcone  (ISO)
chelerythrine  (ISO)
CHIR 99021  (ISO)
chlorambucil  (ISO)
Chlorodibromomethane  (ISO)
chloroform  (EXP,ISO)
chlorohydrocarbon  (ISO)
chloropicrin  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
Cholestane-3,5,6-triol  (EXP)
choline  (ISO)
chromium(6+)  (ISO)
ciglitazone  (ISO)
ciguatoxin CTX1B  (ISO)
Cinobufagin  (ISO)
cisplatin  (ISO)
clofarabine  (ISO)
clofibrate  (EXP,ISO)
clotrimazole  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (EXP,ISO)
crocin-1  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyanamide  (EXP)
cycloheximide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyproterone acetate  (EXP)
D-glucose  (EXP,ISO)
daidzein  (ISO)
DDE  (ISO)
DDT  (EXP,ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
Destruxin B  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diarylheptanoid  (ISO)
diazinon  (EXP,ISO)
dibenziodolium  (ISO)
dibenzoylmethane  (ISO)
dibromoacetic acid  (ISO)
Dibromoacetonitrile  (EXP)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
diclofenac  (EXP,ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
diethylstilbestrol  (EXP,ISO)
dihydroartemisinin  (ISO)
Dimaprit  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (ISO)
diosgenin  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (EXP,ISO)
emodin  (EXP)
endosulfan  (ISO)
enzalutamide  (ISO)
epichlorohydrin  (ISO)
epoxiconazole  (ISO)
erlotinib hydrochloride  (ISO)
erythromycin estolate  (EXP)
estra-1,3,5(10)-triene-3,16beta-diol  (EXP)
estriol  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
eugenol  (ISO)
everolimus  (ISO)
Evodiamine  (ISO)
fenofibrate  (EXP,ISO)
fenthion  (ISO)
fipronil  (EXP)
fluoranthene  (ISO)
fluoxetine  (ISO)
flusilazole  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fructose  (ISO)
fucoidan  (ISO)
fulvestrant  (EXP,ISO)
furan  (EXP,ISO)
gamma-aminobutyric acid  (EXP)
gamma-hexachlorocyclohexane  (EXP)
gamma-linolenic acid  (ISO)
gamma-tocopherol  (ISO)
gefitinib  (ISO)
gemcitabine  (ISO)
gemfibrozil  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glucaric acid  (ISO)
glucose  (EXP,ISO)
glutathione  (EXP,ISO)
Glutethimide  (EXP)
glycerol  (ISO)
glycidol  (EXP)
glycine betaine  (EXP)
glyphosate  (ISO)
guanosine  (ISO)
guggulsterone  (ISO)
GW 4064  (ISO)
GW 7647  (ISO)
harmine  (ISO)
hemin  (ISO)
heparin  (EXP,ISO)
hesperetin  (EXP)
hexachlorophene  (ISO)
hexamethylene diisocyanate  (ISO)
hexanal  (ISO)
Honokiol  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxamic acid  (ISO)
indirubin  (ISO)
indole-3-methanol  (EXP)
indometacin  (EXP,ISO)
ionomycin  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
iron(III) nitrilotriacetate  (EXP)
isoprenaline  (EXP,ISO)
ketamine  (EXP)
KT 5823  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lead nitrate  (ISO)
leflunomide  (ISO)
letrozole  (ISO)
limonene  (EXP,ISO)
linalool  (ISO)
linuron  (EXP)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (EXP,ISO)
losartan  (EXP)
lupeol  (ISO)
LY294002  (ISO)
m-xylene  (EXP)
mancozeb  (EXP,ISO)
maneb  (ISO)
masoprocol  (ISO)
Matrine  (ISO)
mebendazole  (ISO)
memantine  (ISO)
menadione  (ISO)
mercury atom  (ISO)
mercury dichloride  (EXP)
mercury(0)  (ISO)
meso-tetrakis(N-methyl-4-pyridyl)porphine(4+)  (ISO)
mestranol  (EXP)
metformin  (EXP,ISO)
methamphetamine  (EXP)
methapyrilene  (EXP)
methotrexate  (ISO)
methoxyacetic acid  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylmercury chloride  (EXP,ISO)
methylseleninic acid  (ISO)
metoprolol  (EXP)
microcystin-LR  (ISO)
mifepristone  (ISO)
mitoxantrone  (ISO)
ML-7  (ISO)
monensin A  (EXP)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
myricetin  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-bis(2-hydroxypropyl)nitrosamine  (EXP)
N,N-dimethylaniline  (ISO)
N-(6-acetamidohexyl)acetamide  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (EXP,ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (EXP,ISO)
N-methylnicotinate  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nafenopin  (EXP)
naloxone  (EXP)
naphthalene  (ISO)
naphthalenes  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nickel subsulfide  (ISO)
nickel sulfate  (EXP,ISO)
niclosamide  (EXP,ISO)
nicotinamide  (ISO)
nicotine  (ISO)
nifedipine  (ISO)
nitrofurazone  (EXP)
nitroprusside  (ISO)
Nodularin  (ISO)
NS-398  (ISO)
o-anisidine  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
oleanolic acid  (EXP,ISO)
oridonin  (ISO)
ortho-Aminoazotoluene  (ISO)
ouabain  (ISO)
oxaliplatin  (ISO)
oxidopamine  (EXP)
ozone  (EXP,ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
PD 0325901  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
pevonedistat  (ISO)
phenethyl isothiocyanate  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenol  (ISO)
phenylhydrazine  (ISO)
phenytoin  (ISO)
PhIP  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
phorone  (EXP)
phosgene  (ISO)
picene  (ISO)
pinosylvin  (ISO)
piperonyl butoxide  (EXP,ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (EXP)
platycodin D  (ISO)
poly(I:C)  (ISO)
ponatinib  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
promegestone  (ISO)
promethazine  (EXP)
propiconazole  (ISO)
propylparaben  (ISO)
prostaglandin D2  (EXP)
prostaglandin E2  (EXP,ISO)
pterostilbene  (ISO)
puerarin  (ISO)
putrescine  (EXP)
pyrrolidine dithiocarbamate  (ISO)
pyrvinium  (ISO)
quartz  (ISO)
quercetin  (ISO)
quinacrine  (ISO)
quinapril hydrochloride  (EXP)
quinidine  (EXP)
quinolone  (ISO)
quizartinib  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
ranitidine  (EXP)
reactive oxygen species  (ISO)
Rebamipide  (EXP)
reserpine  (ISO)
resveratrol  (EXP,ISO)
ribavirin  (ISO)
riboflavin  (ISO)
ritonavir  (ISO)
rotenone  (EXP,ISO)
royal jelly  (ISO)
ruxolitinib  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
saccharin  (ISO)
Salinomycin  (ISO)
salvianolic acid B  (ISO)
SB 431542  (ISO)
Securinine  (ISO)
selenium atom  (EXP,ISO)
selumetinib  (ISO)
serpentine asbestos  (ISO)
sertraline  (ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sirtinol  (EXP)
sodium arsenite  (EXP,ISO)
sodium chromate  (ISO)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (EXP)
Soman  (EXP,ISO)
sorafenib  (ISO)
staurosporine  (ISO)
styrene oxide  (ISO)
SU6656  (ISO)
succimer  (ISO)
succinic acid  (ISO)
sulfates  (ISO)
sulforaphane  (ISO)
sulfur dioxide  (EXP)
sulindac  (EXP,ISO)
sunitinib  (ISO)
tacrolimus hydrate  (EXP,ISO)
taiwanin C  (ISO)
tamibarotene  (ISO)
tamoxifen  (EXP,ISO)
Tanshinone I  (ISO)
taurocholic acid  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
teniposide  (ISO)
terbufos  (ISO)
terbutylazine  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thapsigargin  (ISO)
theaflavin  (ISO)
theophylline  (EXP,ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
thiophenes  (ISO)
thiram  (ISO)
thymidine  (ISO)
thymol  (ISO)
thymol sulfate(1-)  (ISO)
thymoquinone  (ISO)
tiazofurine  (ISO)
titanium dioxide  (ISO)
tocopherol  (ISO)
toxaphene  (ISO)
trametinib  (ISO)
trans-chalcone  (ISO)
trans-pinosylvin  (ISO)
Tributyltin oxide  (ISO)
trichloroacetic acid  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (EXP,ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tubastatin A  (ISO)
tunicamycin  (ISO)
undecane  (EXP)
urethane  (ISO)
uridine  (ISO)
valproic acid  (EXP,ISO)
vemurafenib  (ISO)
vincaleukoblastine  (EXP,ISO)
vincristine  (EXP,ISO)
vinyl carbamate  (ISO)
vorinostat  (EXP,ISO)
WIN 55212-2  (ISO)
WR-1065  (ISO)
xanthohumol  (EXP)
zearalenone  (ISO)
zerumbone  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acinar cell proliferation  (ISO)
activation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
amino acid transport  (IMP)
B cell apoptotic process  (ISO)
branching involved in ureteric bud morphogenesis  (ISO,ISS)
canonical Wnt signaling pathway involved in negative regulation of apoptotic process  (ISO)
canonical Wnt signaling pathway involved in positive regulation of apoptotic process  (ISO)
cell population proliferation  (IMP,ISO)
cellular iron ion homeostasis  (ISO,ISS)
cellular response to angiotensin  (IEP)
cellular response to arsenite(3-)  (IEP)
cellular response to carbohydrate stimulus  (IEP)
cellular response to cycloheximide  (IEP)
cellular response to cytokine stimulus  (IEP)
cellular response to dimethyl sulfoxide  (IEP)
cellular response to DNA damage stimulus  (ISO,ISS)
cellular response to endothelin  (IEP)
cellular response to epidermal growth factor stimulus  (IEP)
cellular response to estrogen stimulus  (IEP)
cellular response to fibroblast growth factor stimulus  (IEP)
cellular response to growth hormone stimulus  (IEP)
cellular response to hydrostatic pressure  (IEP)
cellular response to hypoxia  (ISO)
cellular response to insulin stimulus  (IEP)
cellular response to interferon-alpha  (ISO)
cellular response to interleukin-1  (IEP)
cellular response to lectin  (IEP)
cellular response to organic cyclic compound  (IEP)
cellular response to phorbol 13-acetate 12-myristate  (IEP)
cellular response to platelet-derived growth factor stimulus  (IEP)
cellular response to prolactin  (IEP)
cellular response to putrescine  (IEP)
cellular response to retinoic acid  (IEP)
cellular response to testosterone stimulus  (IEP)
cellular response to type II interferon  (IEP)
cellular response to UV  (ISO)
cellular response to xenobiotic stimulus  (IEP,ISO)
chromatin remodeling  (ISO,ISS)
chromosome organization  (ISO,ISS)
detection of mechanical stimulus involved in sensory perception of sound  (ISO)
DNA-templated transcription  (IDA)
DNA-templated transcription initiation  (IDA)
ERK1 and ERK2 cascade  (ISO)
G0 to G1 transition  (IEP)
G1/S transition of mitotic cell cycle  (ISO,ISS)
glucose metabolic process  (IMP)
hypothalamus development  (IEP)
in utero embryonic development  (IEP)
inner mitochondrial membrane organization  (IMP)
intrinsic apoptotic signaling pathway in response to DNA damage  (ISO)
lactic acid secretion  (IMP)
liver regeneration  (IEP)
MAPK cascade  (ISO,ISS)
middle ear morphogenesis  (ISO)
myoblast proliferation  (IEP)
myotube differentiation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cell death  (IMP)
negative regulation of cell division  (ISO,ISS)
negative regulation of fibroblast proliferation  (ISO)
negative regulation of gene expression  (IMP)
negative regulation of glucose import  (IMP)
negative regulation of monocyte differentiation  (ISO,ISS)
negative regulation of protein binding  (ISO)
negative regulation of stress-activated MAPK cascade  (ISO)
negative regulation of transcription by RNA polymerase II  (IMP,ISO)
NK T cell proliferation  (ISO)
ovarian follicle development  (IEP)
ovulation  (IEP)
pigmentation  (ISO)
positive regulation of acinar cell proliferation  (ISO)
positive regulation of apoptotic signaling pathway  (ISO)
positive regulation of ATP biosynthetic process  (IMP)
positive regulation of B cell apoptotic process  (ISO)
positive regulation of catalytic activity  (ISO)
positive regulation of cell cycle  (IMP)
positive regulation of cell population proliferation  (IGI,ISO)
positive regulation of cellular respiration  (IMP)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO,ISS)
positive regulation of DNA binding  (IMP)
positive regulation of DNA biosynthetic process  (ISO,ISS)
positive regulation of DNA methylation  (ISO)
positive regulation of DNA-templated transcription  (IDA,ISO,ISS)
positive regulation of epithelial cell proliferation  (ISO,ISS)
positive regulation of fibroblast proliferation  (IMP,ISO,ISS)
positive regulation of gene expression  (ISO)
positive regulation of glial cell proliferation  (IMP)
positive regulation of glycolytic process  (IMP)
positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator  (ISO)
positive regulation of mesenchymal cell proliferation  (ISO,ISS)
positive regulation of metanephric cap mesenchymal cell proliferation  (ISO,ISS)
positive regulation of miRNA transcription  (ISO)
positive regulation of mitochondrial membrane potential  (IMP)
positive regulation of oxidative phosphorylation  (IMP)
positive regulation of response to DNA damage stimulus  (ISO,ISS)
positive regulation of smooth muscle cell migration  (IMP)
positive regulation of smooth muscle cell proliferation  (IMP)
positive regulation of telomerase activity  (ISO)
positive regulation of transcription by RNA polymerase II  (IMP,ISO)
positive regulation of transcription initiation by RNA polymerase II  (ISO)
protein processing  (ISO)
protein-DNA complex disassembly  (ISO)
pyruvate transport  (IMP)
re-entry into mitotic cell cycle  (IMP)
regulation of apoptotic process  (ISO)
regulation of cell cycle process  (ISO)
regulation of DNA-templated transcription  (IDA,IEA,IMP,ISO,TAS)
regulation of gene expression  (ISO)
regulation of mitotic cell cycle  (IMP)
regulation of oxidative phosphorylation  (IMP)
regulation of somatic stem cell population maintenance  (ISO,ISS)
regulation of telomere maintenance  (ISO,ISS)
regulation of transcription by RNA polymerase II  (IBA)
response to alkaloid  (ISO)
response to estradiol  (IEP)
response to ethanol  (IEP)
response to gamma radiation  (ISO,ISS)
response to human chorionic gonadotropin  (IEP)
response to radiation  (ISO)
response to wounding  (IEP)
response to xenobiotic stimulus  (ISO)
skeletal muscle cell differentiation  (ISO)
skeletal system morphogenesis  (ISO)
transcription by RNA polymerase II  (IDA,ISO)
transformation of host cell by virus  (IMP)
Wnt signaling pathway  (ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype