Muc2 (mucin 2, oligomeric mucus/gel-forming) - Rat Genome Database

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Gene: Muc2 (mucin 2, oligomeric mucus/gel-forming) Rattus norvegicus
Analyze
Symbol: Muc2
Name: mucin 2, oligomeric mucus/gel-forming
RGD ID: 3123
Description: Enables identical protein binding activity. Involved in several processes, including cellular response to tumor necrosis factor; response to bacterium; and response to vitamin A. Located in mucus layer. Used to study colitis; intestinal disease; and pneumonia. Biomarker of several diseases, including colonic disease (multiple); ischemia; liver cirrhosis; mucositis; and perinatal necrotizing enterocolitis. Human ortholog(s) of this gene implicated in asthma. Orthologous to human MUC2 (mucin 2, oligomeric mucus/gel-forming); PARTICIPATES IN Entamoebiasis pathway; INTERACTS WITH 2,4,6-trinitrobenzenesulfonic acid; bisphenol A; chlorpyrifos.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AABR07006030.1; HH-Muc; intestinal mucin-2; LOC682800; LOC682824; MLP; MUC-2; mucin 2; mucin-2; similar to Intestinal mucin-like protein (MLP)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81206,225,775 - 206,261,280 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1206,229,035 - 206,261,280 (+)EnsemblGRCr8
mRatBN7.21196,799,494 - 196,831,740 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1196,799,517 - 196,831,756 (+)EnsemblmRatBN7.2
Rnor_6.01214,663,929 - 214,693,197 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1214,664,537 - 214,693,043 (+)NCBIrn6Rnor6.0
Rnor_5.01221,581,822 - 221,611,451 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera1194,430,946 - 194,458,668 (+)NCBICelera
Celera1194,458,772 - 194,461,359 (+)NCBICelera
Cytogenetic Map1q41NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1,8-cineole  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2-palmitoylglycerol  (ISO)
4,4'-sulfonyldiphenol  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aflatoxin M1  (ISO)
all-trans-4-hydroxyretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
amphotericin B  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
benzylpenicillin  (ISO)
biochanin A  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cannabidiol  (ISO)
carmustine  (ISO)
chlorothalonil  (ISO)
chlorpyrifos  (EXP)
cholic acid  (EXP)
clodronic acid  (ISO)
copper(II) sulfate  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diisononyl phthalate  (ISO)
disodium selenite  (ISO)
dodecanoic acid  (ISO)
enilconazole  (ISO)
erythromycin A  (ISO)
ethyl methanesulfonate  (ISO)
ethylparaben  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
genistein  (ISO)
Lafutidine  (EXP)
lipopolysaccharide  (ISO)
loxoprofen  (EXP)
mercury atom  (ISO)
mercury(0)  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
microcystin-LR  (EXP)
Muraglitazar  (EXP)
N-nitrosodiethylamine  (EXP)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
phenobarbital  (EXP)
pirinixic acid  (EXP)
potassium dichromate  (ISO)
procymidone  (ISO)
quercetin  (ISO)
sodium arsenite  (ISO)
sulfasalazine  (EXP)
Sunset Yellow FCF  (ISO)
T-2 toxin  (ISO)
Tesaglitazar  (EXP)
triptonide  (ISO)
troglitazone  (EXP,ISO)
valproic acid  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Pathogenesis of colloid (pure mucinous) carcinoma of exocrine organs: Coupling of gel-forming mucin (MUC2) production with altered cell polarity and abnormal cell-stroma interaction may be the key factor in the morphogenesis and indolent behavior of colloid carcinoma in the breast and pancreas. Adsay NV, etal., Am J Surg Pathol. 2003 May;27(5):571-8.
2. Intestinal anti-inflammatory activity of hydroalcoholic extracts of Phlomis purpurea L. and Phlomis lychnitis L. in the trinitrobenzenesulphonic acid model of rat colitis. Algieri F, etal., J Ethnopharmacol. 2013 Apr 19;146(3):750-9. doi: 10.1016/j.jep.2013.01.041. Epub 2013 Feb 7.
3. New therapeutic strategy for amino acid medicine: prophylactic and healing promoting effect of monosodium glutamate against NSAID-induced enteropathy. Amagase K, etal., J Pharmacol Sci. 2012;118(2):131-7. Epub 2012 Jan 27.
4. Bacterial population and innate immunity-related genes in rat gastrointestinal tract are altered by vitamin A-deficient diet. Amit-Romach E, etal., J Nutr Biochem. 2009 Jan;20(1):70-7. Epub 2008 May 20.
5. N-linked oligosaccharides play a role in disulphide-dependent dimerization of intestinal mucin Muc2. Bell SL, etal., Biochem J 2003 Aug 1;373(Pt 3):893-900.
6. Altered Innate Defenses in the Neonatal Gastrointestinal Tract in Response to Colonization by Neuropathogenic Escherichia coli. Birchenough GM, etal., Infect Immun. 2013 Sep;81(9):3264-75. doi: 10.1128/IAI.00268-13. Epub 2013 Jun 24.
7. Homeostasis and function of goblet cells during rotavirus infection in mice. Boshuizen JA, etal., Virology. 2005 Jul 5;337(2):210-21.
8. Mucinous nonneoplastic cyst of the pancreas: apomucin phenotype distinguishes this entity from intraductal papillary mucinous neoplasm. Cao W, etal., Hum Pathol. 2010 Apr;41(4):513-21. Epub 2009 Dec 1.
9. Phenotypic alterations of mucins and cytokeratins during gallbladder carcinogenesis. Chang HJ, etal., Pathol Int. 2004 Aug;54(8):576-84.
10. Breakdown of mucin as barrier to digestive enzymes in the ischemic rat small intestine. Chang M, etal., PLoS One. 2012;7(6):e40087. doi: 10.1371/journal.pone.0040087. Epub 2012 Jun 29.
11. Therapeutic effects of rectal administration of muscovite on experimental colitis in rats. Chen Y, etal., J Gastroenterol Hepatol. 2009 May;24(5):912-9. Epub 2009 Feb 9.
12. A Decoy Oligonucleotide to NF-kappaB Delivered through Inhalable Particles Prevents LPS-Induced Rat Airway Inflammation. De Stefano D, etal., Am J Respir Cell Mol Biol. 2013 Aug;49(2):288-95. doi: 10.1165/rcmb.2012-0473OC.
13. Tumor necrosis factor-alpha and Muc2 mucin play major roles in disease onset and progression in dextran sodium sulphate-induced colitis. Dharmani P, etal., PLoS One. 2011;6(9):e25058. doi: 10.1371/journal.pone.0025058. Epub 2011 Sep 19.
14. Alterations of the ocular surface epithelial mucins 1, 2, 4 and the tear functions in patients with atopic keratoconjunctivitis. Dogru M, etal., Clin Exp Allergy. 2006 Dec;36(12):1556-65.
15. Leptin modulates the expression of secreted and membrane-associated mucins in colonic epithelial cells by targeting PKC, PI3K, and MAPK pathways. El Homsi M, etal., Am J Physiol Gastrointest Liver Physiol. 2007 Jul;293(1):G365-73. Epub 2007 May 10.
16. Intrauterine growth restriction alters postnatal colonic barrier maturation in rats. Fanca-Berthon P, etal., Pediatr Res. 2009 Jul;66(1):47-52. doi: 10.1203/PDR.0b013e3181a2047e.
17. Mucin production and composition is altered in dextran sulfate sodium-induced colitis in rats. Faure M, etal., Dig Dis Sci. 2003 Jul;48(7):1366-73.
18. Gene expression profile and genomic alterations in colonic tumours induced by 1,2-dimethylhydrazine (DMH) in rats. Femia AP, etal., BMC Cancer. 2010 May 11;10:194. doi: 10.1186/1471-2407-10-194.
19. K-ras mutations and mucin profile in preneoplastic lesions and colon tumors induced in rats by 1,2-dimethylhydrazine. Femia AP, etal., Int J Cancer. 2008 Jan 1;122(1):117-23.
20. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
21. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
22. Mucin gene deficiency in mice impairs host resistance to an enteric parasitic infection. Hasnain SZ, etal., Gastroenterology. 2010 May;138(5):1763-71. doi: 10.1053/j.gastro.2010.01.045. Epub 2010 Feb 4.
23. Tumor necrosis factor-alpha induces the aberrant expression of mucus core protein-2 in non-neoplastic biliary epithelial cells via the upregulation of CDX2 in chronic cholangitis. Ikeda H, etal., Hepatol Res. 2008 Oct;38(10):1006-17. Epub 2008 May 27.
24. Interaction of Toll-like receptors with bacterial components induces expression of CDX2 and MUC2 in rat biliary epithelium in vivo and in culture. Ikeda H, etal., Lab Invest. 2007 Jun;87(6):559-71. Epub 2007 Apr 9.
25. Aberrant expression of CDX2 is closely related to the intestinal metaplasia and MUC2 expression in intraductal papillary neoplasm of the liver in hepatolithiasis. Ishikawa A, etal., Lab Invest. 2004 May;84(5):629-38.
26. Differences in the expression of mucins in various forms of cystitis glandularis. Jankovic Velickovic L, etal., Pathol Res Pract. 2007;203(9):653-8. Epub 2007 Jul 30.
27. Bifidobacterium bifidum improves intestinal integrity in a rat model of necrotizing enterocolitis. Khailova L, etal., Am J Physiol Gastrointest Liver Physiol. 2009 Aug 27.
28. Altered mucin gene expression in stone-containing intrahepatic bile ducts and cholangiocarcinomas. Lee KT and Liu TS, Dig Dis Sci. 2001 Oct;46(10):2166-72.
29. Localization and up-regulation of mucin (MUC2) gene expression in human nasal biopsies of patients with cystic fibrosis. Li D, etal., J Pathol. 1997 Mar;181(3):305-10.
30. Fate of goblet cells in experimental colitis. Makkink MK, etal., Dig Dis Sci. 2002 Oct;47(10):2286-97.
31. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
32. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
33. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
34. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
35. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
36. Milk casein-based diet containing TGF-beta controls the inflammatory reaction in the HLA-B27 transgenic rat model. Schiffrin EJ, et al., JPEN J Parenter Enteral Nutr. 2005 Jul-Aug;29(4 Suppl):S141-8; discussion S149-50, S184-8.
37. Temporal analysis of goblet cells and mucin gene expression in murine models of allergic asthma. Shahzeidi S, etal., Exp Lung Res. 2003 Dec;29(8):549-65.
38. Irinotecan-induced mucositis is associated with changes in intestinal mucins. Stringer AM, etal., Cancer Chemother Pharmacol. 2008 Nov 8.
39. CDX2, COX2 and MUC2 expressions in Barrett's esophagus: can they be useful in determination of the dysplasia? Turkmen IC, etal., Turk Patoloji Derg. 2012;28(3):251-8. doi: 10.5146/tjpath.2012.01132.
40. Polymorphism of human mucin genes in chest disease: possible significance of MUC2. Vinall LE, etal., Am J Respir Cell Mol Biol. 2000 Nov;23(5):678-86.
41. [Effects of platelet activating factor receptor antagonist in intestinal mucin-2 during endotoxemia on young rats]. Wang LJ and Sun M, Zhonghua Er Ke Za Zhi. 2008 Sep;46(9):680-3.
42. Diagnostic value of mucins (MUC1, MUC2 and MUC5AC) expression profile in endoscopic ultrasound-guided fine-needle aspiration specimens of the pancreas. Wang Y, etal., Int J Cancer. 2007 Dec 15;121(12):2716-22.
43. Expression of MUC2 and MUC4 proteins and cytokines: early markers of intestinal graft rejection. Wasserberg N, etal., Transplantation. 2003 Apr 27;75(8):1249-55.
44. Expulsion of the gastrointestinal cestode, Hymenolepis diminuta by tolerant rats: evidence for mediation by a Th2 type immune enhanced goblet cell hyperplasia, increased mucin production and secretion. Webb RA, etal., Parasite Immunol. 2007 Jan;29(1):11-21.
45. Intestinal microbiota and innate immunity-related gene alteration in cirrhotic rats with liver transplantation. Xie YR, etal., Transplant Proc. 2011 Dec;43(10):3973-9. doi: 10.1016/j.transproceed.2011.08.113.
46. Altered expression of goblet cell- and mucin glycosylation-related genes in the intestinal epithelium during infection with the nematode Nippostrongylus brasiliensis in rat. Yamauchi J, etal., APMIS. 2006 Apr;114(4):270-8.
47. The rat IgGFcgammaBP and Muc2 C-terminal domains and TFF3 in two intestinal mucus layers bind together by covalent interaction. Yu H, etal., PLoS One. 2011;6(5):e20334. doi: 10.1371/journal.pone.0020334. Epub 2011 May 23.
Additional References at PubMed
PMID:1371999   PMID:8027037   PMID:9512496   PMID:11352827   PMID:11872843   PMID:12082013   PMID:16973917   PMID:17058067   PMID:17203232   PMID:18806221   PMID:19411636   PMID:19431205  
PMID:19432394   PMID:22162748   PMID:22242189   PMID:22683765   PMID:23173170   PMID:26850552   PMID:29469038   PMID:29599128   PMID:30480410   PMID:35082322   PMID:37249555  


Genomics

Comparative Map Data
Muc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81206,225,775 - 206,261,280 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1206,229,035 - 206,261,280 (+)EnsemblGRCr8
mRatBN7.21196,799,494 - 196,831,740 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1196,799,517 - 196,831,756 (+)EnsemblmRatBN7.2
Rnor_6.01214,663,929 - 214,693,197 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1214,664,537 - 214,693,043 (+)NCBIrn6Rnor6.0
Rnor_5.01221,581,822 - 221,611,451 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera1194,430,946 - 194,458,668 (+)NCBICelera
Celera1194,458,772 - 194,461,359 (+)NCBICelera
Cytogenetic Map1q41NCBI
MUC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38111,074,874 - 1,110,508 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl111,074,875 - 1,110,511 (+)Ensemblhg38GRCh38
GRCh37111,074,874 - 1,104,416 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,064,902 - 1,094,419 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34111,064,874 - 1,094,416NCBI
Cytogenetic Map11p15.5NCBI
HuRef11897,783 - 932,205 (+)NCBIHuRef
CHM1_1111,073,796 - 1,103,733 (+)NCBICHM1_1
T2T-CHM13v2.0111,144,674 - 1,182,053 (+)NCBIT2T-CHM13v2.0
Muc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397141,276,583 - 141,308,428 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7141,276,583 - 141,308,430 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm387141,690,340 - 141,754,691 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7141,690,340 - 141,754,693 (+)Ensemblmm10GRCm38
MGSCv377148,930,517 - 148,940,598 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv377148,876,261 - 148,890,250 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367141,553,920 - 141,565,981 (+)NCBIMGSCv36mm8
Celera7141,484,086 - 141,510,531 (+)NCBICelera
Cytogenetic Map7F5NCBI
cM Map787.1NCBI
Muc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547611,108,826 - 11,135,697 (-)Ensembl
ChiLan1.0NW_00495547611,108,826 - 11,135,697 (-)NCBIChiLan1.0ChiLan1.0
MUC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v293,487,647 - 3,523,891 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1112,698,364 - 2,735,182 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0111,106,716 - 1,144,489 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1111,143,625 - 1,180,798 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl111,143,625 - 1,169,741 (+)EnsemblpanPan2panpan1.1
MUC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11845,416,347 - 45,438,226 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
ROS_Cfam_1.01846,091,348 - 46,116,933 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.11845,539,151 - 45,565,262 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01845,119,185 - 45,145,631 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01845,857,452 - 45,883,423 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Muc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947806,466 - 835,556 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493681660,499 - 91,628 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493681660,499 - 91,628 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MUC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2689,364 - 710,330 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.12689,363 - 719,542 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22140 - 7,521 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MUC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11893,554 - 926,854 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603898,020,755 - 98,058,827 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Muc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476621,493,125 - 21,522,535 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Muc2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v127,769,003 - 7,801,010 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Muc2
275 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1177339686222339686Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1181059071226059071Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1181059071226059071Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1182039247227039247Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1183564652228564652Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1193964073238964073Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1181059071226059071Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1165278545210278545Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1181059071226059071Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1194575422239575422Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1168063662213063662Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1193400541238400541Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1159894717207261263Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1163992710208992710Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1182535316227535316Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1181059071226059071Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1181059071226059071Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1202543537247543537Rat
1359018Hrtrt20Heart rate QTL 203.08heart pumping trait (VT:2000009)heart rate (CMO:0000002)1194786607207590403Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1162753891207753891Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1205674651250674651Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1203300512229359342Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1180739993225739993Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1191190115223964326Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631260Tcas2Tongue tumor susceptibility QTL 24.93tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1201915593208479939Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1178547286206690557Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
1300168Bp170Blood pressure QTL 1702.76arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1192995199237995199Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1201464383246464383Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1203675682248675682Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1205674651250674651Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1185979875230979875Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1197807365233480676Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1193400541238400541Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1202851915223964440Rat
6480783Insul19Insulin level QTL 194.33blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1203300512213659238Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1165707719210707719Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1191260175236260175Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2325727Pia41Pristane induced arthritis QTL 41joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1188241285233241285Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
7 13 40 57 115 79 10 37 29 32 11 11

Sequence


Ensembl Acc Id: ENSRNOT00000075002   ⟹   ENSRNOP00000064975
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1206,229,035 - 206,261,280 (+)Ensembl
mRatBN7.2 Ensembl1196,799,517 - 196,831,756 (+)Ensembl
RefSeq Acc Id: NM_022174   ⟹   NP_071510
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81206,229,035 - 206,261,280 (+)NCBI
mRatBN7.21196,799,494 - 196,831,740 (+)NCBI
RefSeq Acc Id: XM_063280773   ⟹   XP_063136843
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81206,225,775 - 206,261,280 (+)NCBI
Protein Sequences
Protein RefSeqs NP_071510 (Get FASTA)   NCBI Sequence Viewer  
  XP_063136843 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA21655 (Get FASTA)   NCBI Sequence Viewer  
  AAB08481 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000064975
GenBank Protein P98089 (Get FASTA)   NCBI Sequence Viewer  
  Q62635 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Acc Id: ENSRNOP00000064975   ⟸   ENSRNOT00000075002
RefSeq Acc Id: NP_071510   ⟸   NM_022174
- Peptide Label: precursor
- UniProtKB: M0R6C7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063136843   ⟸   XM_063280773
- Peptide Label: isoform X1
- UniProtKB: M0R6C7 (UniProtKB/TrEMBL)
Protein Domains
CTCK   TIL   VWFC   VWFD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P98089-F1-model_v2 AlphaFold P98089 1-837 view protein structure
AF-Q62635-F1-model_v2 AlphaFold Q62635 1-1513 view protein structure
AF-M0R6C7-F1-model_v2 AlphaFold M0R6C7 1-2391 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3123 AgrOrtholog
BioCyc Gene G2FUF-56934 BioCyc
Ensembl Genes ENSRNOG00000046602 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000075002 ENTREZGENE
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot
  Laminin UniProtKB/Swiss-Prot
InterPro Cys_knot_C UniProtKB/Swiss-Prot
  Cystine-knot_cytokine UniProtKB/Swiss-Prot
  Glyco_hormone_CN UniProtKB/Swiss-Prot
  Mucin_vWF_Thrombospondin_sf UniProtKB/Swiss-Prot
  Ser_inhib-like_sf UniProtKB/Swiss-Prot
  TIL_dom UniProtKB/Swiss-Prot
  Unchr_dom_Cys-rich UniProtKB/Swiss-Prot
  VWF_dom UniProtKB/Swiss-Prot
  VWF_type-D UniProtKB/Swiss-Prot
  WxxW_domain UniProtKB/Swiss-Prot
NCBI Gene 24572 ENTREZGENE
PANTHER EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED UniProtKB/Swiss-Prot
  MUCIN-2 UniProtKB/Swiss-Prot
Pfam Cys_knot UniProtKB/Swiss-Prot
  Mucin2_WxxW UniProtKB/Swiss-Prot
  PF08742 UniProtKB/Swiss-Prot
  TIL UniProtKB/Swiss-Prot
  VWD UniProtKB/Swiss-Prot
  VWF UniProtKB/Swiss-Prot
PhenoGen Muc2 PhenoGen
PRINTS PRICHEXTENSN UniProtKB/Swiss-Prot
PROSITE CTCK_1 UniProtKB/Swiss-Prot
  CTCK_2 UniProtKB/Swiss-Prot
  EGF_1 UniProtKB/Swiss-Prot
  VWFC_1 UniProtKB/Swiss-Prot
  VWFC_2 UniProtKB/Swiss-Prot
  VWFD UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000046602 RatGTEx
SMART SM00041 UniProtKB/Swiss-Prot
  SM00832 UniProtKB/Swiss-Prot
  VWC UniProtKB/Swiss-Prot
  VWC_out UniProtKB/Swiss-Prot
  VWD UniProtKB/Swiss-Prot
Superfamily-SCOP FnI-like domain UniProtKB/Swiss-Prot
  SSF57567 UniProtKB/Swiss-Prot
UniProt M0R6C7 ENTREZGENE, UniProtKB/TrEMBL
  MUC2_RAT UniProtKB/Swiss-Prot
  MUC2L_RAT UniProtKB/Swiss-Prot
  P70598_RAT UniProtKB/TrEMBL
  P98089 ENTREZGENE
  Q62635 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Muc2  mucin 2, oligomeric mucus/gel-forming  AABR07006030.1    Data merged from RGD:15005079 737654 PROVISIONAL
2019-11-08 AABR07006030.1        Symbol and Name status set to provisional 45752 PROVISIONAL
2015-11-24 Muc2  mucin 2, oligomeric mucus/gel-forming  LOC682824  similar to Intestinal mucin-like protein (MLP)  Data merged from RGD:1594023 737654 APPROVED
2015-11-24 Muc2  mucin 2, oligomeric mucus/gel-forming  Muc2  mucin 2, oligomeric mucus/gel-forming  Type changed (type changed from [null] to [protein-coding]) 629549 APPROVED
2013-03-29 Muc2  mucin 2, oligomeric mucus/gel-forming  LOC682800  similar to Mucin-2 precursor (Intestinal mucin 2)  Data merged from RGD:1594045 737654 PROVISIONAL
2008-08-29 Muc2  mucin 2, oligomeric mucus/gel-forming  Muc2  mucin 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC682824  similar to Intestinal mucin-like protein (MLP)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC682800  similar to Mucin-2 precursor (Intestinal mucin 2)      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Muc2  Mucin 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_protein the N-glycan found at position N9 plays an important role in the stability of dimer formation 724404