Enables several functions, including DNA binding activity; histone acetyltransferase binding activity; and transcription coactivator binding activity. Involved in several processes, including nuclear receptor-mediated corticosteroid signaling pathway; positive regulation of transcription by RNA polymerase II; and response to mineralocorticoid. Located in cytoplasm and nucleus. Is active in glutamatergic synapse; postsynaptic density, intracellular component; and presynaptic active zone cytoplasmic component. Used to study alcohol use disorder; morphine dependence; and polycystic ovary syndrome. Biomarker of alcohol dependence; fetal alcohol spectrum disorder; obesity; and steatotic liver disease. Human ortholog(s) of this gene implicated in autosomal dominant pseudohypoaldosteronism type 1 and pseudohypoaldosteronism. Orthologous to human NR3C2 (nuclear receptor subfamily 3 group C member 2); PARTICIPATES IN aldosterone signaling pathway; amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; INTERACTS WITH (+)-schisandrin B; (S)-nicotine; 11-deoxycorticosterone.
[Progesterone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with Estradiol] results in increased expression of NR3C2 protein more ...
Metribolone binds to and results in decreased activity of NR3C2 protein and Metribolone inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]
[diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate co-treated with bis(2-propylheptyl)phthalate co-treated with bisphenol A co-treated with 3 more ...
[diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate co-treated with bis(2-propylheptyl)phthalate co-treated with bisphenol A co-treated with 3 more ...
[diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate co-treated with bis(2-propylheptyl)phthalate co-treated with bisphenol A co-treated with 3 more ...
acephate inhibits the reaction [Aldosterone affects the localization of NR3C2 protein] and acephate inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]
alachlor inhibits the reaction [Aldosterone affects the localization of NR3C2 protein] and alachlor inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]
Aldosterone inhibits the reaction [TSG101 protein binds to NR3C2 protein] and FR 180204 inhibits the reaction [Aldosterone results in increased phosphorylation of NR3C2 protein]
[cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of NR3C2 protein
[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of NR3C2 mRNA
Atrazine metabolite inhibits the reaction [Aldosterone affects the localization of NR3C2 protein] and Atrazine metabolite inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]
bifenthrin inhibits the reaction [Aldosterone affects the localization of NR3C2 protein] and bifenthrin inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]
[diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate co-treated with bis(2-propylheptyl)phthalate co-treated with bisphenol A co-treated with 3 more ...
[bisphenol A co-treated with Fulvestrant] results in increased methylation of NR3C2 gene and bisphenol A inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]
[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of NR3C2 mRNA
[diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate co-treated with bis(2-propylheptyl)phthalate co-treated with bisphenol A co-treated with 3 more ...
[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of NR3C2 mRNA
[Diethylnitrosamine co-treated with Dietary Fats co-treated with Canrenoic Acid co-treated with isoquercitrin analog] results in increased expression of NR3C2 mRNA
[cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of NR3C2 protein
cypermethrin inhibits the reaction [Aldosterone affects the localization of NR3C2 protein] and cypermethrin inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]
[cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of NR3C2 protein
Dichlorodiphenyl Dichloroethylene inhibits the reaction [Aldosterone affects the localization of NR3C2 protein] and Dichlorodiphenyl Dichloroethylene inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]
[diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate co-treated with bis(2-propylheptyl)phthalate co-treated with bisphenol A co-treated with 3 more ...
DDT inhibits the reaction [Aldosterone affects the localization of NR3C2 protein] and DDT inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]
[diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate co-treated with bis(2-propylheptyl)phthalate co-treated with bisphenol A co-treated with 3 more ...
[diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate co-treated with bis(2-propylheptyl)phthalate co-treated with bisphenol A co-treated with 3 more ...
[diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate co-treated with bis(2-propylheptyl)phthalate co-treated with bisphenol A co-treated with 3 more ...
Dimethoate inhibits the reaction [Aldosterone affects the localization of NR3C2 protein] and Dimethoate inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]
Angiotensin-Converting Enzyme Inhibitors results in decreased expression of NR3C2 mRNA and Angiotensin-Converting Enzyme Inhibitors results in decreased expression of NR3C2 protein
[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of NR3C2 mRNA
[cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of NR3C2 protein
[fipronil co-treated with DEET] results in decreased expression of NR3C2 mRNA and fipronil inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]
[Fludrocortisone binds to and results in increased activity of NR3C2 protein] which results in decreased abundance of Hydrocortisone and [Fludrocortisone binds to and results in increased activity of NR3C2 protein] which results in decreased expression of POMC protein
[Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of NR3C2 mRNA and [Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of NR3C2 protein
Methoxychlor inhibits the reaction [Aldosterone affects the localization of NR3C2 protein] and Methoxychlor inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]
[Diethylnitrosamine co-treated with Dietary Fats co-treated with Canrenoic Acid co-treated with isoquercitrin analog] results in increased expression of NR3C2 mRNA
[Air Pollutants results in increased abundance of Ozone] which results in decreased expression of NR3C2 mRNA and [Ozone co-treated with Chlorine] results in decreased expression of NR3C2 mRNA
[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of NR3C2 mRNA
Permethrin inhibits the reaction [Aldosterone affects the localization of NR3C2 protein] and Permethrin inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]
[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NR3C2 mRNA
[Progesterone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with Estradiol] results in increased expression of NR3C2 protein more ...
[Diethylnitrosamine co-treated with Dietary Fats co-treated with Canrenoic Acid co-treated with isoquercitrin analog] results in increased expression of NR3C2 mRNA
[Diethylnitrosamine co-treated with Dietary Fats co-treated with Canrenoic Acid co-treated with isoquercitrin analog] results in increased expression of NR3C2 mRNA
Spironolactone inhibits the reaction [Aldosterone affects the ubiquitination of NR3C2 protein] and Spironolactone inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]
terbutylazine inhibits the reaction [Aldosterone affects the localization of NR3C2 protein] and terbutylazine inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]
[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NR3C2 mRNA
Zineb inhibits the reaction [Aldosterone affects the localization of NR3C2 protein] and Zineb inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]
A relationship between the aldosterone-mineralocorticoid receptor pathway and alcohol drinking: preliminary translational findings across rats, monkeys and humans.
Interactive effects of prenatal alcohol exposure and chronic stress in adulthood on anxiety-like behavior and central stress-related receptor mRNA expression: Sex- and time-dependent effects.
Differential impacts of mineralocorticoid receptor antagonist potassium canrenoate on liver and renal changes in high fat diet-mediated early hepatocarcinogenesis model rats.
