Mep1b (meprin A subunit beta) - Rat Genome Database

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Gene: Mep1b (meprin A subunit beta) Rattus norvegicus
Analyze
Symbol: Mep1b
Name: meprin A subunit beta
RGD ID: 3081
Description: Enables metalloendopeptidase activity. Predicted to be involved in inflammatory response and proteolysis. Predicted to be located in plasma membrane. Predicted to be part of meprin A complex. Orthologous to human MEP1B (meprin A subunit beta); INTERACTS WITH 17beta-estradiol; 3-chloropropane-1,2-diol; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: endopeptidase-2; LOC100911405; LOC102554362; meprin; meprin 1 beta; meprin A beta; meprin A subunit beta-like; meprin B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81812,641,041 - 12,667,759 (+)NCBIGRCr8
mRatBN7.21812,366,126 - 12,392,840 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1812,365,289 - 12,392,840 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1812,549,574 - 12,575,989 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01813,337,224 - 13,363,645 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01812,608,782 - 12,635,267 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01815,063,159 - 15,090,877 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1815,063,079 - 15,089,988 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01814,847,661 - 14,874,235 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1812,357,847 - 12,384,551 (+)NCBICelera
RH 3.4 Map18131.4RGD
Cytogenetic Map18p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
extracellular region  (IEA)
membrane  (IEA,ISO)
meprin A complex  (IEA,ISO)
plasma membrane  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Probing the active sites and mechanisms of rat metalloproteases meprin A and B. Bertenshaw GP, etal., Biol Chem 2002 Jul-Aug;383(7-8):1175-83.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Combined genealogical, mapping, and expression approaches to identify spontaneously hypertensive rat hypertension candidate genes. Hinojos CA, etal., Hypertension 2005 Apr;45(4):698-704. Epub 2005 Feb 14.
5. Cloning a rat meprin cDNA reveals the enzyme is a heterodimer. Johnson GD and Hersh LB, J Biol Chem 1992 Jul 5;267(19):13505-12.
6. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
13. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:8407940   PMID:8760356   PMID:8939981   PMID:9288916   PMID:12093806   PMID:12399461   PMID:15695509   PMID:18509531   PMID:18786924   PMID:22988105   PMID:23716698   PMID:27180358  


Genomics

Comparative Map Data
Mep1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81812,641,041 - 12,667,759 (+)NCBIGRCr8
mRatBN7.21812,366,126 - 12,392,840 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1812,365,289 - 12,392,840 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1812,549,574 - 12,575,989 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01813,337,224 - 13,363,645 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01812,608,782 - 12,635,267 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01815,063,159 - 15,090,877 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1815,063,079 - 15,089,988 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01814,847,661 - 14,874,235 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1812,357,847 - 12,384,551 (+)NCBICelera
RH 3.4 Map18131.4RGD
Cytogenetic Map18p12NCBI
MEP1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381832,190,039 - 32,220,404 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1832,185,069 - 32,220,404 (+)EnsemblGRCh38hg38GRCh38
GRCh371829,770,002 - 29,800,367 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361828,023,985 - 28,054,365 (+)NCBINCBI36Build 36hg18NCBI36
Build 341828,023,985 - 28,054,362NCBI
Celera1826,576,994 - 26,607,343 (+)NCBICelera
Cytogenetic Map18q12.1NCBI
HuRef1826,626,575 - 26,656,944 (+)NCBIHuRef
CHM1_11829,697,554 - 29,727,904 (+)NCBICHM1_1
T2T-CHM13v2.01832,380,357 - 32,410,718 (+)NCBIT2T-CHM13v2.0
Mep1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391821,205,401 - 21,233,256 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1821,194,980 - 21,233,256 (+)EnsemblGRCm39 Ensembl
GRCm381821,072,344 - 21,100,199 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1821,061,923 - 21,100,199 (+)EnsemblGRCm38mm10GRCm38
MGSCv371821,230,845 - 21,258,700 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361821,215,354 - 21,243,199 (+)NCBIMGSCv36mm8
Celera1821,568,002 - 21,595,856 (+)NCBICelera
Cytogenetic Map18A2NCBI
cM Map1811.81NCBI
Mep1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540219,404,096 - 19,433,044 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540219,404,026 - 19,432,724 (+)NCBIChiLan1.0ChiLan1.0
MEP1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21749,554,834 - 49,605,537 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11835,247,431 - 35,288,816 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01825,396,288 - 25,427,530 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11828,991,439 - 29,021,928 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1828,991,439 - 29,021,928 (+)Ensemblpanpan1.1panPan2
MEP1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1757,456,414 - 57,476,238 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl757,456,530 - 57,478,337 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha756,888,238 - 56,911,333 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0757,436,320 - 57,459,609 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl757,436,464 - 57,459,701 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1757,114,830 - 57,136,681 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0757,132,324 - 57,155,413 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0757,429,048 - 57,452,158 (-)NCBIUU_Cfam_GSD_1.0
Mep1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494453,099,990 - 53,130,877 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366821,105,243 - 1,132,404 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366821,102,365 - 1,132,404 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MEP1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6116,015,021 - 116,049,791 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16116,015,021 - 116,049,796 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26108,695,842 - 108,729,740 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MEP1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11848,519,933 - 48,551,223 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1848,518,403 - 48,550,604 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605023,072,664 - 23,101,070 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mep1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624770757,711 - 806,330 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624770757,626 - 806,289 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mep1b
296 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:81
Count of miRNA genes:75
Interacting mature miRNAs:76
Transcripts:ENSRNOT00000074116
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301410Bp317Blood pressure QTL 3170.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181194427326548295Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)181194429959330563Rat
61382Bp46Blood pressure QTL 4618.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194179131393320Rat
8552968Pigfal19Plasma insulin-like growth factor 1 level QTL 1911.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)18125758124Rat
61388Bp2Blood pressure QTL 23.23arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)18135374722Rat
1331781Scl28Serum cholesterol level QTL 283.995blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)181194429924797117Rat
6903359Bp355Blood pressure QTL 3553.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194454459796478Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18518585840503530Rat
1331766Bp236Blood pressure QTL 2363.022arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181194429931359530Rat
70178EaezExperimental allergic encephalomyelitis QTL z2.4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)181235778612874620Rat
631264Scl22Serum cholesterol level QTL 226.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)181194179131393320Rat
12904680Bw189Body weight QTL 1890.019body mass (VT:0001259)body weight (CMO:0000012)181194427326548295Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181179151863636873Rat
1641910Colcr3Colorectal carcinoma resistance QTL 35.020.000007intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)18224947722066430Rat
12904693Am20Aortic mass QTL 200.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)181194427326548295Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
9589153Insul31Insulin level QTL 317.150.05blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)18142547119Rat
12904695Kidm73Kidney mass QTL 730.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)181194427326548295Rat
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18130558703Rat
12904689Cm128Cardiac mass QTL 1280.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)181194427326548295Rat
12904690Cm129Cardiac mass QTL 1290.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)181194427326548295Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134291613Rat
12904691Cm130Cardiac mass QTL 1300.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)181194427326548295Rat
9590248Scort10Serum corticosterone level QTL 1019.710.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)18125758124Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18420794160377792Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194429952293055Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134291613Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)181194429941122201Rat

Markers in Region
RH94561  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21812,392,705 - 12,392,805 (-)MAPPERmRatBN7.2
Rnor_6.01815,063,204 - 15,063,303NCBIRnor6.0
Rnor_5.01814,847,706 - 14,847,805UniSTSRnor5.0
Celera1812,384,417 - 12,384,516UniSTS
RH 3.4 Map18131.4UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 25
Low 1 4 2
Below cutoff 1 16 7 7 7 1 1 6 2 14 3 1

Sequence


RefSeq Acc Id: ENSRNOT00000074116   ⟹   ENSRNOP00000063916
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1812,366,151 - 12,389,722 (+)Ensembl
Rnor_6.0 Ensembl1815,063,079 - 15,089,988 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000082044
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1812,140,400 - 12,146,683 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000118375   ⟹   ENSRNOP00000091050
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1812,365,289 - 12,392,840 (+)Ensembl
RefSeq Acc Id: NM_013183   ⟹   NP_037315
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81812,641,041 - 12,667,755 (+)NCBI
mRatBN7.21812,366,126 - 12,392,840 (+)NCBI
Rnor_6.01815,063,169 - 15,089,989 (-)NCBI
Rnor_5.01814,847,661 - 14,874,235 (-)NCBI
Celera1812,357,847 - 12,384,551 (+)RGD
Sequence:
RefSeq Acc Id: XM_063277123   ⟹   XP_063133193
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81812,641,047 - 12,667,759 (+)NCBI
RefSeq Acc Id: XM_063277124   ⟹   XP_063133194
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81812,656,190 - 12,667,759 (+)NCBI
RefSeq Acc Id: NP_037315   ⟸   NM_013183
- Peptide Label: precursor
- UniProtKB: Q642D0 (UniProtKB/Swiss-Prot),   P28826 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000063916   ⟸   ENSRNOT00000074116
RefSeq Acc Id: ENSRNOP00000091050   ⟸   ENSRNOT00000118375
RefSeq Acc Id: XP_063133193   ⟸   XM_063277123
- Peptide Label: isoform X1
- UniProtKB: Q642D0 (UniProtKB/Swiss-Prot),   P28826 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063133194   ⟸   XM_063277124
- Peptide Label: isoform X2
Protein Domains
EGF-like   MAM   MATH   Peptidase M12A

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P28826-F1-model_v2 AlphaFold P28826 1-704 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700653
Promoter ID:EPDNEW_R11177
Type:multiple initiation site
Name:Mep1b_1
Description:meprin A subunit beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01815,089,989 - 15,090,049EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3081 AgrOrtholog
BioCyc Gene G2FUF-8204 BioCyc
Ensembl Genes ENSRNOG00000049345 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000052995 Ensembl
  ENSRNOG00055018423 UniProtKB/Swiss-Prot
  ENSRNOG00060012398 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000074116.3 UniProtKB/TrEMBL
  ENSRNOT00000118375 ENTREZGENE
  ENSRNOT00000118375.1 UniProtKB/TrEMBL
  ENSRNOT00055031310 UniProtKB/Swiss-Prot
  ENSRNOT00060021094 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.120.200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7108543 IMAGE-MGC_LOAD
InterPro ConA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MATH/TRAF_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Meprin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M12A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_Metallo UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRAF-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRAF_MEP1_MATH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25727 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93578 IMAGE-MGC_LOAD
NCBI Gene 25727 ENTREZGENE
PANTHER DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10127:SF814 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Astacin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRAF-mep_MATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mep1b PhenoGen
PIRSF Meprin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS ASTACIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAMDOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ASTACIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAM_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_PROTEASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000049345 RatGTEx
  ENSRNOG00000052995 RatGTEx
  ENSRNOG00055018423 RatGTEx
  ENSRNOG00060012398 RatGTEx
SMART MAM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnMc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRAF domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC232892
UniProt A0A8I6GIQ4_RAT UniProtKB/TrEMBL
  A0A8L2QVK1_RAT UniProtKB/TrEMBL
  MEP1B_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q642D0 ENTREZGENE
UniProt Secondary Q642D0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Mep1b  meprin A subunit beta  LOC100911405  meprin A subunit beta-like  Data merged from RGD:6493229 737654 PROVISIONAL
2016-08-26 Mep1b  meprin A subunit beta  Mep1b  meprin 1 beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-07-29 LOC100911405  meprin A subunit beta-like  LOC102554362  meprin A subunit beta-like  Data merged from RGD:7695917 737654 PROVISIONAL
2013-12-18 LOC102554362  meprin A subunit beta-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2012-07-05 LOC100911405  meprin A subunit beta-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Mep1b  Meprin 1 beta      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expression is decreased 2.4 fold in SHR compared with WKY rats 1357414