Mc5r (melanocortin 5 receptor) - Rat Genome Database

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Gene: Mc5r (melanocortin 5 receptor) Rattus norvegicus
Analyze
Symbol: Mc5r
Name: melanocortin 5 receptor
RGD ID: 3058
Description: Enables hormone binding activity and melanocortin receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and regulation of metabolic process. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human MC5R (melanocortin 5 receptor); PARTICIPATES IN G protein mediated signaling pathway via Galphas family; melanocortin system pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; alpha-Zearalanol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MC5-R; melanocortin receptor 5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81864,185,013 - 64,190,054 (+)NCBIGRCr8
mRatBN7.21861,915,188 - 61,920,229 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1861,915,188 - 61,920,229 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1863,990,228 - 63,995,268 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01864,695,178 - 64,700,218 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01862,539,890 - 62,544,930 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01864,113,659 - 64,118,700 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1864,114,933 - 64,116,524 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01863,329,399 - 63,330,432 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41864,679,384 - 64,680,417 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11864,752,231 - 64,753,823 (-)NCBI
Celera1860,019,520 - 60,020,553 (+)NCBICelera
RH 3.4 Map18628.5RGD
RH 3.4 Map18628.4RGD
Cytogenetic Map18q12.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
plasma membrane  (IBA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Binding of alpha-melanocyte-stimulating hormone to its G-protein-coupled receptor on B-lymphocytes activates the Jak/STAT pathway. Buggy JJ Biochem J. 1998 Apr 1;331 ( Pt 1):211-6.
2. The melanocortin system in control of inflammation. Catania A, etal., ScientificWorldJournal. 2010 Sep 14;10:1840-53.
3. Linkage and association studies between the melanocortin receptors 4 and 5 genes and obesity-related phenotypes in the Quebec Family Study. Chagnon YC, etal., Mol Med. 1997 Oct;3(10):663-73.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Molecular cloning and characterization of the rat fifth melanocortin receptor. Griffon N, etal., Biochem Biophys Res Commun 1994 Apr 29;200(2):1007-14.
7. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
8. Melanocortin receptors in rat liver cells: change of gene expression and intracellular localization during acute-phase response. Malik IA, etal., Histochem Cell Biol. 2012 Mar;137(3):279-91. Epub 2011 Dec 20.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Evidence for a stimulatory action of melanin-concentrating hormone on luteinising hormone release involving MCH1 and melanocortin-5 receptors. Murray JF, etal., J Neuroendocrinol. 2006 Mar;18(3):157-67.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14660008   PMID:17531155   PMID:19329486   PMID:22643233  


Genomics

Comparative Map Data
Mc5r
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81864,185,013 - 64,190,054 (+)NCBIGRCr8
mRatBN7.21861,915,188 - 61,920,229 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1861,915,188 - 61,920,229 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1863,990,228 - 63,995,268 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01864,695,178 - 64,700,218 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01862,539,890 - 62,544,930 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01864,113,659 - 64,118,700 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1864,114,933 - 64,116,524 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01863,329,399 - 63,330,432 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41864,679,384 - 64,680,417 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11864,752,231 - 64,753,823 (-)NCBI
Celera1860,019,520 - 60,020,553 (+)NCBICelera
RH 3.4 Map18628.5RGD
RH 3.4 Map18628.4RGD
Cytogenetic Map18q12.1NCBI
MC5R
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381813,824,149 - 13,827,323 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1813,824,149 - 13,827,323 (+)EnsemblGRCh38hg38GRCh38
GRCh371813,824,148 - 13,827,322 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361813,815,765 - 13,816,742 (+)NCBINCBI36Build 36hg18NCBI36
Build 341813,815,764 - 13,816,742NCBI
Celera1813,706,729 - 13,708,047 (+)NCBICelera
Cytogenetic Map18p11.21NCBI
HuRef1813,778,780 - 13,780,099 (+)NCBIHuRef
CHM1_11813,824,630 - 13,825,948 (+)NCBICHM1_1
T2T-CHM13v2.01813,986,528 - 13,989,701 (+)NCBIT2T-CHM13v2.0
Mc5r
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391868,469,811 - 68,475,517 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1868,470,575 - 68,475,517 (+)EnsemblGRCm39 Ensembl
GRCm381868,336,744 - 68,342,446 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1868,337,596 - 68,342,446 (+)EnsemblGRCm38mm10GRCm38
MGSCv371868,497,257 - 68,499,365 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361868,462,972 - 68,465,092 (+)NCBIMGSCv36mm8
Celera1869,645,563 - 69,647,671 (+)NCBICelera
Cytogenetic Map18E2NCBI
cM Map1841.46NCBI
Mc5r
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955402283,388 - 286,884 (-)NCBIChiLan1.0ChiLan1.0
MC5R
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21724,217,275 - 24,222,385 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1189,907,321 - 9,914,981 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v018495,561 - 501,555 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1182,668,281 - 2,669,586 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl182,668,394 - 2,669,371 (-)Ensemblpanpan1.1panPan2
MC5R
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1124,429,331 - 24,433,212 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha125,410,285 - 25,414,162 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0124,326,030 - 24,331,495 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl124,328,811 - 24,329,788 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1124,381,249 - 24,385,125 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0124,267,632 - 24,271,507 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0124,538,879 - 24,544,347 (-)NCBIUU_Cfam_GSD_1.0
Mc5r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049443,972,966 - 3,976,952 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366263,202,346 - 3,204,477 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366263,203,437 - 3,204,743 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MC5R
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl696,322,422 - 96,323,339 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1696,322,276 - 96,323,795 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2689,672,688 - 89,674,974 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MC5R
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11872,263,016 - 72,268,436 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1872,264,815 - 72,265,792 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605047,330,875 - 47,334,183 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Mc5r
22 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:124
Count of miRNA genes:103
Interacting mature miRNAs:110
Transcripts:ENSRNOT00000022364
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
1298072Cia26Collagen induced arthritis QTL 263.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)185470976983828827Rat
1300125Rf26Renal function QTL 263.2urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)185253986365844950Rat
631834Sach3Saccharin preference QTL 33.90.01consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)185880568763636873Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184334502283828827Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184664067583828827Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184664067583828827Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)185971241776477814Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)182979296574792965Rat
1331770Bp234Blood pressure QTL 2343.807arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185979647871893566Rat
2300177Bmd65Bone mineral density QTL 6519.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
2301969Bp324Blood pressure QTL 3244.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185971241776477814Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183135940883218561Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)185253976376104388Rat
724542Kidm2Kidney mass QTL 22.6kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)185917211583828827Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183819245583192455Rat
2293658Bmd23Bone mineral density QTL 237.30.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)185146473363636873Rat
1359020Ppulsi2Prepulse inhibition QTL 22.71prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)185229287573997283Rat
2312600Bp341Blood pressure QTL 3410.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185933040970263868Rat
1331752Bw27Body weight QTL 272.963body mass (VT:0001259)body weight (CMO:0000012)185229287565845095Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)182979296574792965Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182979296574792965Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)185253976376104388Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)185253976376104388Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)184852004483828827Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)185253976376104388Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)185253976376104388Rat
61384Bp48Blood pressure QTL 4819.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186062231177209844Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185253976376104388Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)185253976376104388Rat
6903353Bp353Blood pressure QTL 3532.8arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)185979647883828827Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185146473383218561Rat
6903356Bp354Blood pressure QTL 3544.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185979647883828827Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183587072380870723Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184664067583828827Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)185253976369140759Rat
738005Anxrr11Anxiety related response QTL 113.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)183003981375039813Rat
2300157Bmd66Bone mineral density QTL 6613.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183139332077209694Rat
1358193Emca2Estrogen-induced mammary cancer QTL 21.6mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)181800759963571040Rat
2293704Bss35Bone structure and strength QTL 354.590.0002femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)182896485373964853Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182557098570570985Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181179151863636873Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)182979296574792965Rat
1600375Mcs22Mammary carcinoma susceptibility QTL 223.3mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)185253976363933058Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)184852004483828827Rat
631675Iddm15Insulin dependent diabetes mellitus QTL 15urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)186062231177209844Rat
1598826Anxrr20Anxiety related response QTL 203.04body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)184143297183828827Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183135940870263868Rat
7411719Strs5Sensitivity to stroke QTL 59.4cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)184999995865845095Rat

Markers in Region
RH142200  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21861,916,479 - 61,916,660 (+)MAPPERmRatBN7.2
Rnor_6.01864,114,951 - 64,115,131NCBIRnor6.0
Rnor_5.01863,329,212 - 63,329,392UniSTSRnor5.0
RGSC_v3.41864,680,424 - 64,680,604UniSTSRGSC3.4
Celera1860,019,333 - 60,019,513UniSTS
RH 3.4 Map18628.5UniSTS
Cytogenetic Map18q12.1UniSTS
RH94550  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21861,917,854 - 61,918,026 (+)MAPPERmRatBN7.2
Rnor_6.01864,116,326 - 64,116,497NCBIRnor6.0
Rnor_5.01863,330,587 - 63,330,758UniSTSRnor5.0
RGSC_v3.41864,679,058 - 64,679,229UniSTSRGSC3.4
Celera1860,020,708 - 60,020,879UniSTS
Cytogenetic Map18q12.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 11 8 69 63 62 33 18 33 6 101 49 49 5 38 29

Sequence


Ensembl Acc Id: ENSRNOT00000022364   ⟹   ENSRNOP00000022364
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1861,915,188 - 61,920,229 (+)Ensembl
Rnor_6.0 Ensembl1864,114,933 - 64,116,524 (+)Ensembl
RefSeq Acc Id: NM_013182   ⟹   NP_037314
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81864,185,013 - 64,190,054 (+)NCBI
mRatBN7.21861,915,188 - 61,920,229 (+)NCBI
Rnor_6.01864,115,138 - 64,116,171 (+)NCBI
Rnor_5.01863,329,399 - 63,330,432 (+)NCBI
RGSC_v3.41864,679,384 - 64,680,417 (-)RGD
Celera1860,019,520 - 60,020,553 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_037314 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41577 (Get FASTA)   NCBI Sequence Viewer  
  EDM14757 (Get FASTA)   NCBI Sequence Viewer  
  EDM14758 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000022364.3
  ENSRNOP00055014424
  ENSRNOP00060012283
  ENSRNOP00065032501
GenBank Protein P35345 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037314   ⟸   NM_013182
- UniProtKB: P35345 (UniProtKB/Swiss-Prot),   A6IXX6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022364   ⟸   ENSRNOT00000022364
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35345-F1-model_v2 AlphaFold P35345 1-325 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3058 AgrOrtholog
BioCyc Gene G2FUF-7103 BioCyc
Ensembl Genes ENSRNOG00000016685 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055010584 UniProtKB/Swiss-Prot
  ENSRNOG00060009340 UniProtKB/Swiss-Prot
  ENSRNOG00065023401 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000022364.5 UniProtKB/Swiss-Prot
  ENSRNOT00055017915 UniProtKB/Swiss-Prot
  ENSRNOT00060015752 UniProtKB/Swiss-Prot
  ENSRNOT00065039984 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MC3-5R UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  Melancort_rcpt_5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Melcrt_ACTH_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25726 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MELANOCORTIN RECEPTOR 5 UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mc5r PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MCRFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MELNOCORTINR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MELNOCORTN5R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016685 RatGTEx
  ENSRNOG00055010584 RatGTEx
  ENSRNOG00060009340 RatGTEx
  ENSRNOG00065023401 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6IXX6 ENTREZGENE, UniProtKB/TrEMBL
  MC5R_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Mc5r  Melanocortin 5 receptor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process causes an increase in cAMP accumulation 729030
gene_protein 325 amino acids 729030