Mbl1 (mannose binding lectin 1) - Rat Genome Database

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Gene: Mbl1 (mannose binding lectin 1) Rattus norvegicus
Symbol: Mbl1
Name: mannose binding lectin 1
RGD ID: 3055
Description: Enables several functions, including calcium-dependent carbohydrate binding activity; mannose binding activity; and phosphatidylinositol-4-phosphate binding activity. Involved in complement activation, lectin pathway and protein homotrimerization. Located in extracellular space. Orthologous to human MBL1P (mannose binding lectin 1, pseudogene); PARTICIPATES IN coagulation cascade pathway; complement system pathway; phagocytosis pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
Previously known as: mannan-binding protein; mannose binding lectin (A); mannose binding lectin 1, protein A; mannose binding lectin 2, protein C; Mannose binding protein A serum; Mannose binding protein A, serum; mannose-binding lectin (protein A) 1; mannose-binding protein A; MBP-A; Mbpa; Mlb1
RGD Orthologs
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21617,029,146 - 17,035,187 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1617,029,118 - 17,035,174 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1617,093,376 - 17,099,473 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01618,221,699 - 18,227,754 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01617,146,274 - 17,152,371 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01618,736,154 - 18,742,193 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1618,736,154 - 18,742,193 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01618,604,750 - 18,610,789 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41617,591,820 - 17,597,859 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11617,591,817 - 17,597,857 (+)NCBI
Celera1617,254,917 - 17,260,956 (+)NCBICelera
RH 3.4 Map16167.5RGD
Cytogenetic Map16p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Resistance of MBL gene-knockout mice to experimental systemic aspergillosis. Clemons KV, etal., Immunol Lett. 2010 Feb 16;128(2):105-7. doi: 10.1016/j.imlet.2009.12.021. Epub 2010 Jan 12.
2. The mannose-binding lectin-pathway is involved in complement activation in the course of renal ischemia-reperfusion injury. de Vries B, etal., Am J Pathol. 2004 Nov;165(5):1677-88.
3. Exon structure of a mannose-binding protein gene reflects its evolutionary relationship to the asialoglycoprotein receptor and nonfibrillar collagens. Drickamer K and McCreary V, J Biol Chem 1987 Feb 25;262(6):2582-9.
4. Mannose-binding proteins isolated from rat liver contain carbohydrate-recognition domains linked to collagenous tails. Complete primary structures and homology with pulmonary surfactant apoprotein. Drickamer K, etal., J Biol Chem 1986 May 25;261(15):6878-87.
5. Protection from inflammatory disease in insulin resistance: the role of mannan-binding lectin. Fernandez-Real JM, etal., Diabetologia. 2006 Oct;49(10):2402-11. Epub 2006 Aug 29.
6. Mannan-binding lectin modulates the response to HSV-2 infection. Gadjeva M, etal., Clin Exp Immunol. 2004 Nov;138(2):304-11.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Impaired secretion of rat mannose-binding protein resulting from mutations in the collagen-like domain. Heise CT, etal., J Immunol. 2000 Aug 1;165(3):1403-9.
9. Inhibition of mannose-binding lectin reduces postischemic myocardial reperfusion injury. Jordan JE, etal., Circulation. 2001 Sep 18;104(12):1413-8.
10. A novel type of binding specificity to phospholipids for rat mannose-binding proteins isolated from serum and liver. Kuroki Y, etal., FEBS Lett. 1997 Sep 8;414(2):387-92.
11. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
12. The mannose-binding lectin pathway is a significant contributor to reperfusion injury in the type 2 diabetic heart. La Bonte LR, etal., Diab Vasc Dis Res. 2009 Jul;6(3):172-80.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Near-planar solution structures of mannose-binding lectin oligomers provide insight on activation of lectin pathway of complement. Miller A, etal., J Biol Chem. 2012 Feb 3;287(6):3930-45. doi: 10.1074/jbc.M111.320341. Epub 2011 Dec 13.
15. Involvement of mannose-binding lectin in the pathogenesis of Kawasaki disease-like murine vasculitis. Nakamura A, etal., Clin Immunol. 2014 Jul;153(1):64-72. doi: 10.1016/j.clim.2014.03.019. Epub 2014 Apr 8.
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. Structural analysis of monosaccharide recognition by rat liver mannose-binding protein. Ng KK, etal., J Biol Chem. 1996 Jan 12;271(2):663-74.
18. Orientation of bound ligands in mannose-binding proteins. Implications for multivalent ligand recognition. Ng KK, etal., J Biol Chem. 2002 May 3;277(18):16088-95. doi: 10.1074/jbc.M200493200. Epub 2002 Feb 15.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. GOA pipeline RGD automated data pipeline
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
23. Engineering novel complement activity into a pulmonary surfactant protein. Venkatraman Girija U, etal., J Biol Chem. 2010 Apr 2;285(14):10546-52. doi: 10.1074/jbc.M109.097493. Epub 2010 Jan 29.
24. Interaction of mannose-binding protein with associated serine proteases: effects of naturally occurring mutations. Wallis R and Dodd RB, J Biol Chem 2000 Oct 6;275(40):30962-9.
25. Dominant effects of mutations in the collagenous domain of mannose-binding protein. Wallis R J Immunol 2002 May 1;168(9):4553-8.
26. Decoupling of carbohydrate binding and MASP-2 autoactivation in variant mannose-binding lectins associated with immunodeficiency. Wallis R, etal., J Immunol. 2005 Nov 15;175(10):6846-51.
27. Mannose-binding lectin is a regulator of inflammation that accompanies myocardial ischemia and reperfusion injury. Walsh MC, etal., J Immunol. 2005 Jul 1;175(1):541-6.
28. Activation of the lectin pathway by natural IgM in a model of ischemia/reperfusion injury. Zhang M, etal., J Immunol. 2006 Oct 1;177(7):4727-34.
Additional References at PubMed
PMID:1436090   PMID:1721241   PMID:3584121   PMID:7704532   PMID:9922165   PMID:12477932   PMID:14724269   PMID:15060079   PMID:15148336   PMID:15489334   PMID:21866632   PMID:22879370  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21617,029,146 - 17,035,187 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1617,029,118 - 17,035,174 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1617,093,376 - 17,099,473 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01618,221,699 - 18,227,754 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01617,146,274 - 17,152,371 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01618,736,154 - 18,742,193 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1618,736,154 - 18,742,193 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01618,604,750 - 18,610,789 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41617,591,820 - 17,597,859 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11617,591,817 - 17,597,857 (+)NCBI
Celera1617,254,917 - 17,260,956 (+)NCBICelera
RH 3.4 Map16167.5RGD
Cytogenetic Map16p14NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381079,920,178 - 79,923,119 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1079,920,178 - 79,923,119 (+)EnsemblGRCh38hg38GRCh38
GRCh371081,679,934 - 81,682,875 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361081,669,914 - 81,672,855 (+)NCBINCBI36Build 36hg18NCBI36
Build 341081,669,913 - 81,672,855NCBI
Celera1075,670,857 - 75,673,805 (+)NCBICelera
Cytogenetic Map10q22.3NCBI
HuRef1075,522,689 - 75,525,630 (+)NCBIHuRef
CHM1_11081,962,581 - 81,965,522 (+)NCBICHM1_1
T2T-CHM13v2.01080,789,562 - 80,792,503 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391440,873,413 - 40,885,861 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1440,873,415 - 40,881,558 (+)EnsemblGRCm39 Ensembl
GRCm381441,151,456 - 41,163,904 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1441,151,458 - 41,159,601 (+)EnsemblGRCm38mm10GRCm38
MGSCv371441,964,745 - 41,972,248 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361440,060,169 - 40,067,672 (+)NCBIMGSCv36mm8
Celera1437,311,454 - 37,318,966 (+)NCBICelera
Cytogenetic Map14BNCBI
cM Map1422.36NCBI


Variants in Mbl1
24 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:426
Count of miRNA genes:149
Interacting mature miRNAs:163
Transcripts:ENSRNOT00000015723, ENSRNOT00000072985
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
61372Bp40Blood pressure QTL 402.2blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)16422773017696785Rat
631517Scl9Serum cholesterol level QTL 93.3blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)161572643321034895Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21617,033,876 - 17,034,023 (+)MAPPERmRatBN7.2
Rnor_6.01618,740,885 - 18,741,029NCBIRnor6.0
Rnor_5.01618,609,481 - 18,609,625UniSTSRnor5.0
RGSC_v3.41617,596,550 - 17,596,695RGDRGSC3.4
RGSC_v3.41617,596,551 - 17,596,695UniSTSRGSC3.4
RGSC_v3.11617,596,548 - 17,596,693RGD
Celera1617,259,648 - 17,259,792UniSTS
Cytogenetic Map16p14UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21617,033,869 - 17,034,109 (+)MAPPERmRatBN7.2
Rnor_6.01618,740,878 - 18,741,115NCBIRnor6.0
Rnor_5.01618,609,474 - 18,609,711UniSTSRnor5.0
RGSC_v3.41617,596,543 - 17,596,781RGDRGSC3.4
RGSC_v3.41617,596,544 - 17,596,781UniSTSRGSC3.4
RGSC_v3.11617,596,541 - 17,596,779RGD
Celera1617,259,641 - 17,259,878UniSTS
RH 3.4 Map16171.9RGD
RH 3.4 Map16171.9UniSTS
Cytogenetic Map16p14UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21617,033,783 - 17,034,077 (+)MAPPERmRatBN7.2
Rnor_6.01618,740,792 - 18,741,083NCBIRnor6.0
Rnor_5.01618,609,388 - 18,609,679UniSTSRnor5.0
RGSC_v3.41617,596,457 - 17,596,749RGDRGSC3.4
RGSC_v3.41617,596,458 - 17,596,749UniSTSRGSC3.4
RGSC_v3.11617,596,455 - 17,596,747RGD
Celera1617,259,555 - 17,259,846UniSTS
SHRSP x BN Map165.64UniSTS
SHRSP x BN Map165.64RGD
FHH x ACI Map1612.1799RGD
Cytogenetic Map16p14UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21617,034,959 - 17,035,087 (+)MAPPERmRatBN7.2
Rnor_6.01618,741,966 - 18,742,093NCBIRnor6.0
Rnor_5.01618,610,562 - 18,610,689UniSTSRnor5.0
RGSC_v3.41617,597,632 - 17,597,759UniSTSRGSC3.4
Celera1617,260,729 - 17,260,856UniSTS
RH 3.4 Map16167.5UniSTS
Cytogenetic Map16p14UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21617,034,959 - 17,035,174 (+)MAPPERmRatBN7.2
Rnor_6.01618,741,966 - 18,742,180NCBIRnor6.0
Rnor_5.01618,610,562 - 18,610,776UniSTSRnor5.0
RGSC_v3.41617,597,632 - 17,597,846UniSTSRGSC3.4
Celera1617,260,729 - 17,260,943UniSTS
RH 3.4 Map16166.71UniSTS
Cytogenetic Map16p14UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 37 37 37 4
Low 7 4 2 4 2 2 1 9 8 11 2
Below cutoff 6 12 16 3 3 24 8 10 3


RefSeq Acc Id: ENSRNOT00000015723   ⟹   ENSRNOP00000015723
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1617,029,118 - 17,035,174 (+)Ensembl
Rnor_6.0 Ensembl1618,736,154 - 18,742,193 (+)Ensembl
RefSeq Acc Id: NM_012599   ⟹   NP_036731
Rat AssemblyChrPosition (strand)Source
mRatBN7.21617,029,146 - 17,035,187 (+)NCBI
Rnor_6.01618,736,154 - 18,742,193 (+)NCBI
Rnor_5.01618,604,750 - 18,610,789 (+)NCBI
RGSC_v3.41617,591,820 - 17,597,859 (+)RGD
Celera1617,254,917 - 17,260,956 (+)RGD
RefSeq Acc Id: XM_039094193   ⟹   XP_038950121
Rat AssemblyChrPosition (strand)Source
mRatBN7.21617,031,627 - 17,035,185 (+)NCBI
Protein Sequences
Protein RefSeqs NP_036731 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950121 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA98781 (Get FASTA)   NCBI Sequence Viewer  
  AAH88159 (Get FASTA)   NCBI Sequence Viewer  
  EDL90868 (Get FASTA)   NCBI Sequence Viewer  
  EDL90869 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000015723
GenBank Protein P19999 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036731   ⟸   NM_012599
- Peptide Label: precursor
- UniProtKB: P19999 (UniProtKB/Swiss-Prot),   A6K9L8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000015723   ⟸   ENSRNOT00000015723
RefSeq Acc Id: XP_038950121   ⟸   XM_039094193
- Peptide Label: isoform X1
- UniProtKB: A6K9L9 (UniProtKB/TrEMBL)
Protein Domains
C-type lectin   Collagen-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P19999-F1-model_v2 AlphaFold P19999 1-238 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13699976
Promoter ID:EPDNEW_R10498
Type:initiation region
Description:mannose-binding lectin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01618,736,135 - 18,736,195EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3055 AgrOrtholog
BioCyc Gene G2FUF-11905 BioCyc
Ensembl Genes ENSRNOG00000011706 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015723 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C-type_lectin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Collagen UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Collectin_CTLD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTDL_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24548 UniProtKB/Swiss-Prot
Pfam Collagen UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lectin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mbl1 PhenoGen
  C_TYPE_LECTIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011706 RatGTEx
SMART CLECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP C-type lectin-like UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  Triple coiled coil domain of C-type lectins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC234245

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-08-13 Mbl1  mannose binding lectin 1  Mbl1  mannose-binding lectin (protein A) 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-11 Mbl1  mannose-binding lectin (protein A) 1  Mbl1  mannose binding lectin (A)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Mbl1  mannose binding lectin (A)  Mbl1  mannose binding lectin 1, protein A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-09-12 Mbl1  mannose binding lectin 1, protein A  Mlb1  mannose binding lectin 2, protein C  Symbol and Name updated 1299863 APPROVED
2003-04-09 Mlb1  mannose binding lectin 2, protein C  Mbpa  Mannose binding protein A, serum  Symbol and Name updated 629477 APPROVED
2002-06-10 Mbpa  Mannose binding protein A, serum      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease deficiency leads to increased susceptibility to infections 625609
gene_domains N-terminus collagenous and cystine rich domain disrupts the interactions with associated proteases 625609
gene_physical_interaction dimers bind with dimers of the serine proteases and the trimers and tetramers bind to multiple serine proteases 625609
gene_process involved in reducing susceptibility to infections caused by a wide range of pathogenic microorganisms 625609
gene_product member of the collecting family 625609
gene_product member of the collectin family 625609