Mat1a (methionine adenosyltransferase 1A) - Rat Genome Database

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Gene: Mat1a (methionine adenosyltransferase 1A) Rattus norvegicus
Symbol: Mat1a
Name: methionine adenosyltransferase 1A
RGD ID: 3050
Description: Enables several functions, including adenyl ribonucleotide binding activity; magnesium ion binding activity; and methionine adenosyltransferase activity. Involved in S-adenosylmethionine biosynthetic process and protein-containing complex assembly. Located in nuclear matrix. Human ortholog(s) of this gene implicated in hypermethioninemia. Orthologous to human MAT1A (methionine adenosyltransferase 1A); PARTICIPATES IN methionine cycle/metabolic pathway; cysteine and methionine metabolic pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AdoMet; adoMet synthase 1; adoMet synthetase 1; MAT 1; MAT-I/III; methionine adenosyltransferase 1; methionine adenosyltransferase I, alpha; methionine adenosyltransferase I/III; MGC108563; S - adenosylmethionine synthetase; S-adenosylmethionine synthase isoform type-1; S-adenosylmethionine synthetase isoform type-1; SADE; SAS
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21616,983,084 - 17,001,284 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1616,983,022 - 17,001,274 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1617,047,431 - 17,066,101 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01618,174,001 - 18,192,511 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01617,100,335 - 17,119,005 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01618,690,649 - 18,709,135 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1618,690,246 - 18,709,133 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01618,560,492 - 18,578,747 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41617,548,582 - 17,563,989 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11617,548,582 - 17,562,884 (+)NCBI
Celera1617,208,280 - 17,226,582 (+)NCBICelera
Cytogenetic Map16p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-nitrofluorene  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-methylcholanthrene  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
Benoxacor  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
buspirone  (EXP)
butanal  (ISO)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
carmustine  (ISO)
cerium trichloride  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chrysene  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
copper(II) sulfate  (ISO)
coumarin  (EXP)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dichloroacetic acid  (ISO)
dimethyl sulfoxide  (ISO)
endosulfan  (EXP)
ethyl methanesulfonate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
furan  (EXP)
inulin  (ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
Muraglitazar  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
nitrofen  (EXP)
O-methyleugenol  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
piperonyl butoxide  (EXP)
potassium dichromate  (ISO)
propanal  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
streptozocin  (ISO)
tamoxifen  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
trichloroethene  (EXP)
troglitazone  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Analysis of the 5' non-coding region of rat liver S-adenosylmethionine synthetase mRNA and comparison of the Mr deduced from the cDNA sequence and the purified enzyme. Alvarez L, etal., FEBS Lett 1991 Sep 23;290(1-2):142-6.
2. Characterization of rat liver-specific methionine adenosyltransferase gene promoter. Role of distal upstream cis-acting elements in the regulation of the transcriptional activity. Alvarez L, etal., J Biol Chem 1997 Sep 5;272(36):22875-83.
3. Dominant inheritance of isolated hypermethioninemia is associated with a mutation in the human methionine adenosyltransferase 1A gene. Chamberlin ME, etal., Am J Hum Genet. 1997 Mar;60(3):540-6.
4. Aminooxy analogues of spermidine as inhibitors of spermine synthase and substrates of hepatic polyamine acetylating activity. Eloranta TO, etal., J Biochem. 1990 Oct;108(4):593-8.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. The crystal structure of tetrameric methionine adenosyltransferase from rat liver reveals the methionine-binding site. Gonzalez B, etal., J Mol Biol. 2000 Jul 7;300(2):363-75.
8. Crystal structures of methionine adenosyltransferase complexed with substrates and products reveal the methionine-ATP recognition and give insights into the catalytic mechanism. Gonzalez B, etal., J Mol Biol. 2003 Aug 8;331(2):407-16.
9. Isolation of a cDNA encoding the rat liver S-adenosylmethionine synthetase. Horikawa S, etal., Eur J Biochem 1989 Oct 1;184(3):497-501.
10. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
11. Proteomics reveal a concerted upregulation of methionine metabolic pathway enzymes, and downregulation of carbonic anhydrase-III, in betaine supplemented ethanol-fed rats. Kharbanda KK, etal., Biochem Biophys Res Commun. 2009 Apr 17;381(4):523-7. doi: 10.1016/j.bbrc.2009.02.082. Epub 2009 Feb 23.
12. S-adenosylmethionine in liver health, injury, and cancer. Lu SC and Mato JM, Physiol Rev. 2012 Oct;92(4):1515-42. doi: 10.1152/physrev.00047.2011.
13. Changes in methionine adenosyltransferase and S-adenosylmethionine homeostasis in alcoholic rat liver. Lu SC, etal., Am J Physiol Gastrointest Liver Physiol. 2000 Jul;279(1):G178-85.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Recombinant rat liver S-adenosyl-L-methionine synthetase tetramers and dimers are in equilibrium. Mingorance J, etal., Int J Biochem Cell Biol 1997 Mar;29(3):485-91.
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. Conformational signals in the C-terminal domain of methionine adenosyltransferase I/III determine its nucleocytoplasmic distribution. Reytor E, etal., FASEB J. 2009 Oct;23(10):3347-60. doi: 10.1096/fj.09-130187. Epub 2009 Jun 4.
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:10601859   PMID:10677294   PMID:12477932   PMID:12496263   PMID:15489334   PMID:20102719   PMID:22213190   PMID:22318685   PMID:23425511   PMID:25416956   PMID:27548429   PMID:34948004  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21616,983,084 - 17,001,284 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1616,983,022 - 17,001,274 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1617,047,431 - 17,066,101 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01618,174,001 - 18,192,511 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01617,100,335 - 17,119,005 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01618,690,649 - 18,709,135 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1618,690,246 - 18,709,133 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01618,560,492 - 18,578,747 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41617,548,582 - 17,563,989 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11617,548,582 - 17,562,884 (+)NCBI
Celera1617,208,280 - 17,226,582 (+)NCBICelera
Cytogenetic Map16p14NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381080,271,820 - 80,289,658 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1080,271,820 - 80,289,658 (-)EnsemblGRCh38hg38GRCh38
GRCh371082,031,576 - 82,049,414 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361082,021,556 - 82,039,414 (-)NCBINCBI36Build 36hg18NCBI36
Build 341082,021,556 - 82,039,230NCBI
Celera1076,021,909 - 76,039,786 (-)NCBICelera
Cytogenetic Map10q22.3NCBI
HuRef1075,874,785 - 75,892,650 (-)NCBIHuRef
CHM1_11082,314,612 - 82,332,492 (-)NCBICHM1_1
T2T-CHM13v2.01081,140,919 - 81,158,757 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391440,826,969 - 40,846,385 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1440,826,992 - 40,846,369 (+)EnsemblGRCm39 Ensembl
GRCm381441,105,012 - 41,124,428 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1441,105,035 - 41,124,412 (+)EnsemblGRCm38mm10GRCm38
MGSCv371441,918,670 - 41,937,701 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361440,014,094 - 40,033,125 (+)NCBIMGSCv36mm8
Celera1437,265,428 - 37,284,459 (+)NCBICelera
Cytogenetic Map14BNCBI
cM Map1422.36NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_004955510281,331 - 300,985 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955510283,860 - 300,991 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan11092,248,370 - 92,268,054 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01076,677,815 - 76,697,512 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11080,280,063 - 80,298,302 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1080,280,063 - 80,298,291 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1429,450,857 - 29,467,251 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl429,452,601 - 29,466,929 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha429,575,218 - 29,592,037 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0429,753,050 - 29,769,565 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl429,753,057 - 29,769,102 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1429,622,538 - 29,639,457 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0429,825,220 - 29,841,704 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0430,179,220 - 30,195,966 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440721351,267,381 - 51,283,984 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936716126,574 - 143,155 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936716126,628 - 142,986 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1482,107,390 - 82,127,049 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11482,109,405 - 82,126,487 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21488,716,155 - 88,733,936 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1951,540,162 - 51,558,076 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl951,540,162 - 51,558,576 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604811,863,034 - 11,882,962 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248416,843,741 - 6,862,683 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248416,843,725 - 6,864,700 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Mat1a
171 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:196
Count of miRNA genes:140
Interacting mature miRNAs:163
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
61372Bp40Blood pressure QTL 402.2blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)16422773017696785Rat
631517Scl9Serum cholesterol level QTL 93.3blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)161572643321034895Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21617,000,996 - 17,001,203 (+)MAPPERmRatBN7.2
Rnor_6.01618,708,848 - 18,709,054NCBIRnor6.0
Rnor_5.01618,578,460 - 18,578,666UniSTSRnor5.0
RGSC_v3.41617,563,702 - 17,563,908UniSTSRGSC3.4
Celera1617,226,295 - 17,226,501UniSTS
RH 3.4 Map16167.1UniSTS
Cytogenetic Map16p14UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21616,998,802 - 16,999,578 (+)MAPPERmRatBN7.2
Rnor_6.01618,706,654 - 18,707,429NCBIRnor6.0
Rnor_5.01618,576,266 - 18,577,041UniSTSRnor5.0
RGSC_v3.41617,561,508 - 17,562,283UniSTSRGSC3.4
Celera1617,224,101 - 17,224,876UniSTS
Cytogenetic Map16p14UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 22 22 22
Medium 12 11 11 2 2
Low 2 23 19 4 16 4 5 5 7 15 23 9 5
Below cutoff 1 20 4 4 3 4 3 4 27 15 9 3


RefSeq Acc Id: ENSRNOT00000015190   ⟹   ENSRNOP00000015190
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1616,983,022 - 17,001,274 (+)Ensembl
Rnor_6.0 Ensembl1618,690,649 - 18,709,133 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000081484   ⟹   ENSRNOP00000072105
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1618,690,246 - 18,709,121 (+)Ensembl
RefSeq Acc Id: NM_012860   ⟹   NP_036992
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.21616,983,084 - 17,001,284 (+)NCBI
Rnor_6.01618,690,649 - 18,709,135 (+)NCBI
Rnor_5.01618,560,492 - 18,578,747 (+)NCBI
RGSC_v3.41617,548,582 - 17,563,989 (+)RGD
Celera1617,208,280 - 17,226,582 (+)RGD
Protein Sequences
Protein RefSeqs NP_036992 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH89770 (Get FASTA)   NCBI Sequence Viewer  
  CAA33754 (Get FASTA)   NCBI Sequence Viewer  
  EDL90871 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000015190
GenBank Protein P13444 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036992   ⟸   NM_012860
- UniProtKB: Q5FVU2 (UniProtKB/Swiss-Prot),   P13444 (UniProtKB/Swiss-Prot),   F1LZ34 (UniProtKB/TrEMBL),   A6K9L6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072105   ⟸   ENSRNOT00000081484
RefSeq Acc Id: ENSRNOP00000015190   ⟸   ENSRNOT00000015190
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P13444-F1-model_v2 AlphaFold P13444 1-397 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13699971
Promoter ID:EPDNEW_R10495
Type:initiation region
Description:methionine adenosyltransferase 1A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Alternative Promoters:null; see alsoEPDNEW_R10496  
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01618,690,270 - 18,690,330EPDNEW
RGD ID:13699974
Promoter ID:EPDNEW_R10496
Type:multiple initiation site
Description:methionine adenosyltransferase 1A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Alternative Promoters:null; see alsoEPDNEW_R10495  
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01618,690,564 - 18,690,624EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3050 AgrOrtholog
BioCyc Gene G2FUF-11910 BioCyc
BioCyc Pathway METHIONINE-DEG1-PWY [L-methionine degradation I (to L-homocysteine)] BioCyc
  PWY-5041 [S-adenosyl-L-methionine salvage II] BioCyc
Ensembl Genes ENSRNOG00000011351 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015190 ENTREZGENE
  ENSRNOT00000015190.8 UniProtKB/TrEMBL
Gene3D-CATH 3.30.300.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ADOMET_SYNTHASE_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S-AdoMet_synt_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S-AdoMet_synt_central UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S-AdoMet_synt_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S-AdoMet_synthetase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S-AdoMet_synthetase_sfam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25331 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PANTHER PTHR11964 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam S-AdoMet_synt_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S-AdoMet_synt_M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S-AdoMet_synt_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mat1a PhenoGen
PIRSF MAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADOMET_SYNTHASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011351 RatGTEx
Superfamily-SCOP SSF55973 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC228124
UniProt Secondary Q5FVU2 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-10 Mat1a  methionine adenosyltransferase 1A  Mat1a  methionine adenosyltransferase I, alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2001-10-23 Mat1a  methionine adenosyltransferase I, alpha      Name updated to reflect Human and Mouse nomenclature 68913 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process is the major methyl group donor in cell metabolism 729300
gene_protein 397 amino acid residues and has a molecular mass of 43.697 kDa 728958