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Gene: Mas1 (MAS1 proto-oncogene, G protein-coupled receptor) Rattus norvegicus

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Symbol:

Mas1

Name:

MAS1 proto-oncogene, G protein-coupled receptor

RGD ID:

3049

Description:

Predicted to enable angiotensin receptor activity and peptide binding activity. Involved in several processes, including hippocampus development; male gonad development; and regulation of primary metabolic process. Located in cell surface. Used to study glaucoma and hypertension. Biomarker of chronic kidney disease; congestive heart failure; dilated cardiomyopathy; and primary biliary cholangitis. Orthologous to human MAS1 (MAS1 proto-oncogene, G protein-coupled receptor); PARTICIPATES IN angiotensin (1-7) signaling pathway; renin-angiotensin cascade pathway; INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

angiotensin-(1-7) receptor; c-mas; MAS proto-oncogene; Mas-related G protein-coupled receptor a; MAS1 oncogene; Mgra; proto-oncogene Mas

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Allele / Splice:

Mas1^em1Mcwi

Genetic Models:

SS-Mas1^em1Mcwi

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	50,428,064 - 50,459,537 (+)	NCBI		GRCr8
mRatBN7.2	1	47,879,956 - 47,911,500 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	47,880,309 - 47,911,709 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	48,571,963 - 48,603,158 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	54,557,771 - 54,588,840 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	48,647,488 - 48,678,679 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	48,076,761 - 48,108,218 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	48,077,033 - 48,108,216 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	51,644,462 - 51,675,365 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	42,154,786 - 42,185,750 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	42,157,730 - 42,188,693 (+)	NCBI
Celera	1	43,680,754 - 43,711,122 (+)	NCBI		Celera
RH 3.4 Map	1	544.2	RGD
Cytogenetic Map	1	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome (ISO)

Alveolar Bone Loss (IEP)

chronic kidney disease (IEP)

congestive heart failure (IEP)

dilated cardiomyopathy (IEP)

Experimental Diabetes Mellitus (IEP)

Experimental Liver Cirrhosis (IEP)

glaucoma (IMP)

hypertension (IMP)

Prenatal Exposure Delayed Effects (IEP)

primary biliary cholangitis (IEP)

thrombosis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (EXP)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

6-propyl-2-thiouracil (EXP)

Ac-Ser-Asp-Lys-Pro-OH (ISO)

aldehydo-D-glucose (EXP,ISO)

ammonium chloride (EXP)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (EXP,ISO)

Benzo[k]fluoranthene (ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (ISO)

Candesartan cilexetil (EXP)

captopril (EXP,ISO)

chlorpyrifos (EXP)

choline (ISO)

clozapine (EXP)

cyclosporin A (ISO)

D-glucose (EXP,ISO)

decabromodiphenyl ether (EXP)

dimethylarsinic acid (ISO)

diminazene diaceturate (ISO)

ethanol (EXP,ISO)

fentanyl (EXP)

folic acid (ISO)

genistein (ISO)

glucose (EXP,ISO)

glycidol (EXP)

glyphosate (ISO)

goralatide (ISO)

haloperidol (EXP)

hydralazine (ISO)

indoxyl sulfate (EXP)

isoprenaline (EXP)

ketamine (EXP)

L-methionine (ISO)

lipopolysaccharide (EXP,ISO)

lipoxin A4 (ISO)

losartan (ISO)

N-methylnicotinate (EXP,ISO)

olmesartan (EXP)

oltipraz (EXP,ISO)

paracetamol (ISO)

paraquat (EXP)

PCB138 (ISO)

perindopril (EXP)

pirinixic acid (ISO)

pregabalin (EXP)

rotenone (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

streptozocin (ISO)

tamoxifen (ISO)

telmisartan (EXP,ISO)

tert-butyl hydroperoxide (ISO)

tetrachloroethene (ISO)

tetrachloromethane (EXP)

trichloroethene (EXP,ISO)

triptonide (ISO)

valproic acid (ISO)

zearalenone (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenylate cyclase-activating G protein-coupled receptor signaling pathway (ISO)

angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure (ISO)

cellular response to peptide hormone stimulus (IEP)

G protein-coupled receptor signaling pathway (IBA,IEA,ISO)

hippocampus development (IEP)

male gonad development (IEP)

negative regulation of protein phosphorylation (IMP)

phospholipase C-activating angiotensin-activated signaling pathway (ISO)

positive regulation of canonical NF-kappaB signal transduction (ISO)

positive regulation of cell population proliferation (IDA,IMP)

positive regulation of DNA replication (IDA)

positive regulation of inositol phosphate biosynthetic process (IDA)

regulation of inflammatory response (ISO)

response to activity (IEP)

response to gonadotropin (IEP)

response to peptide hormone (IEP)

response to xenobiotic stimulus (IEP)

signal transduction (IEA)

spermatogenesis (IMP)

Cellular Component

cell surface (IDA)

membrane (IEA)

plasma membrane (IBA,IEA,ISO)

Molecular Function

angiotensin receptor activity (IBA,ISO)

G protein-coupled peptide receptor activity (ISO)

G protein-coupled receptor activity (IEA,ISO)

peptide binding (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

angiotensin (1-7) signaling pathway (IMP,ISO)

renin-angiotensin cascade pathway (IEA,ISO,TAS)

References

References - curated

#	Reference Title	Reference Citation
1.	Candesartan cilexetil protects from cardiac myosin induced cardiotoxicity via reduction of endoplasmic reticulum stress and apoptosis in rats: involvement of ACE2-Ang (1-7)-mas axis.	Arumugam S, etal., Toxicology. 2012 Jan 27;291(1-3):139-45. doi: 10.1016/j.tox.2011.11.008. Epub 2011 Nov 23.
2.	Telmisartan Prevents Alveolar Bone Loss by Decreasing the Expression of Osteoclasts Markers in Hypertensive Rats With Periodontal Disease.	Brito VGB, etal., Front Pharmacol. 2020 Nov 11;11:579926. doi: 10.3389/fphar.2020.579926. eCollection 2020.
3.	Chronic infusion of angiotensin receptor antagonists in the hypothalamic paraventricular nucleus prevents hypertension in a rat model of sleep apnea.	da Silva AQ, etal., Brain Res. 2011 Jan 12;1368:231-8. Epub 2010 Oct 30.
4.	Selective increase of angiotensin(1-7) and its receptor in hearts of spontaneously hypertensive rats subjected to physical training.	Filho AG, etal., Exp Physiol. 2008 May;93(5):589-98.
5.	Antiglaucomatous effects of the activation of intrinsic Angiotensin-converting enzyme 2.	Foureaux G, etal., Invest Ophthalmol Vis Sci. 2013 Jun 21;54(6):4296-306. doi: 10.1167/iovs.12-11427.
6.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
8.	Upregulation of hepatic angiotensin-converting enzyme 2 (ACE2) and angiotensin-(1-7) levels in experimental biliary fibrosis.	Herath CB, etal., J Hepatol. 2007 Sep;47(3):387-95. Epub 2007 Apr 2.
9.	Maternal Tryptophan Supplementation Protects Adult Rat Offspring against Hypertension Programmed by Maternal Chronic Kidney Disease: Implication of Tryptophan-Metabolizing Microbiome and Aryl Hydrocarbon Receptor.	Hsu CN, etal., Int J Mol Sci. 2020 Jun 26;21(12):4552. doi: 10.3390/ijms21124552.
10.	Upregulation Of Angiotensin Converting Enzyme 2 In Hepatic Fibrosis By Angiotensin Converting Enzyme Inhibitors: An In Vivo And In Vitro Study.	Huang ML, etal., Clin Exp Pharmacol Physiol. 2009 Sep 28.
11.	High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence.	Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
12.	The role of angiotensin-(1-7) receptor Mas in spermatogenesis in mice and rats.	Leal MC, etal., J Anat. 2009 May;214(5):736-43.
13.	The mas proto-oncogene is developmentally regulated in the rat central nervous system.	Martin KA, etal., Brain Res Dev Brain Res. 1992 Jul 24;68(1):75-82.
14.	Expression of the mouse and rat mas proto-oncogene in the brain and peripheral tissues.	Metzger R, etal., FEBS Lett. 1995 Jan 2;357(1):27-32.
15.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
16.	Renal ACE and ACE2 expression in early diabetic rats.	Moon JY, etal., Nephron Exp Nephrol. 2008;110(1):e8-e16. Epub 2008 Aug 4.
17.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
18.	Indoxyl sulfate downregulates expression of Mas receptor via OAT3/AhR/Stat3 pathway in proximal tubular cells.	Ng HY, etal., PLoS One. 2014 Mar 10;9(3):e91517. doi: 10.1371/journal.pone.0091517. eCollection 2014.
19.	Gonadotropin Stimulation Increases the Expression of Angiotensin-(1-7) and Mas Receptor in the Rat Ovary.	Pereira VM, etal., Reprod Sci. 2009 Aug 24.
20.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
21.	The renin-angiotensin system: peptides and enzymes beyond angiotensin II.	Reudelhuber TL Curr Opin Nephrol Hypertens. 2005 Mar;14(2):155-9.
22.	A place in our hearts for the lowly angiotensin 1-7 peptide?	Reudelhuber TL Hypertension. 2006 May;47(5):811-5. Epub 2006 Mar 6.
23.	GOA pipeline	RGD automated data pipeline
24.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
25.	Comprehensive gene review and curation	RGD comprehensive gene curation
26.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
27.	Angiotensin-(1-7) inhibits growth of cardiac myocytes through activation of the mas receptor.	Tallant EA, etal., Am J Physiol Heart Circ Physiol. 2005 Oct;289(4):H1560-6. Epub 2005 Jun 10.
28.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
29.	Reduction in renal ACE2 expression in subtotal nephrectomy is ameliorated with ACE inhibition.	Velkoska E, etal., Clin Sci (Lond). 2009 Aug 21.
30.	Sustained long term potentiation and anxiety in mice lacking the Mas protooncogene.	Walther T, etal., J Biol Chem 1998 May 8;273(19):11867-73.
31.	Effects of angiotensin II on proximal tubular cells stably transfected with the c-mas oncogene.	Wolf G and Neilson EG, Am J Physiol. 1992 Nov;263(5 Pt 2):F931-8.
32.	Counteraction between angiotensin II and angiotensin-(1-7) via activating angiotensin type I and Mas receptor on rat renal mesangial cells.	Xue H, etal., Regul Pept. 2012 Aug 20;177(1-3):12-20. doi: 10.1016/j.regpep.2012.04.002. Epub 2012 May 1.
33.	Characterization of the rat mas oncogene and its high-level expression in the hippocampus and cerebral cortex of rat brain.	Young D, etal., Proc Natl Acad Sci U S A 1988 Jul;85(14):5339-42.
34.	Regulation of angiotensin-(1-7) and angiotensin II type 1 receptor by telmisartan and losartan in adriamycin-induced rat heart failure.	Zong WN, etal., Acta Pharmacol Sin. 2011 Nov;32(11):1345-50. doi: 10.1038/aps.2011.96. Epub 2011 Oct 3.
35.	Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family.	Zylka MJ, etal., Proc Natl Acad Sci U S A 2003 Aug 19;100(17):10043-8. Epub 2003 Aug 8.

Additional References at PubMed

PMID:12829792	PMID:15489334	PMID:16087780	PMID:16611642	PMID:17496218	PMID:18026570	PMID:19404405	PMID:21436210	PMID:22003054	PMID:22504011	PMID:22561450	PMID:22775972
PMID:22811473	PMID:23174757	PMID:23873801	PMID:23909597	PMID:24041943	PMID:24168260	PMID:24583173	PMID:24711523	PMID:24819472	PMID:24824997	PMID:24877125	PMID:24914635
PMID:24968411	PMID:25169953	PMID:25194129	PMID:25194138	PMID:25371522	PMID:25426615	PMID:25766467	PMID:25895850	PMID:26256416	PMID:26519026	PMID:27030624	PMID:27050934
PMID:27628189	PMID:27660028	PMID:27960152	PMID:28082260	PMID:28656296	PMID:28940861	PMID:29928987	PMID:31328772	PMID:31406138	PMID:31843339	PMID:32324784	PMID:32851948
PMID:33070664	PMID:34743271	PMID:35247425

Genomics

Comparative Map Data

Mas1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	50,428,064 - 50,459,537 (+)	NCBI		GRCr8
mRatBN7.2	1	47,879,956 - 47,911,500 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	47,880,309 - 47,911,709 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	48,571,963 - 48,603,158 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	54,557,771 - 54,588,840 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	48,647,488 - 48,678,679 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	48,076,761 - 48,108,218 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	48,077,033 - 48,108,216 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	51,644,462 - 51,675,365 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	42,154,786 - 42,185,750 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	42,157,730 - 42,188,693 (+)	NCBI
Celera	1	43,680,754 - 43,711,122 (+)	NCBI		Celera
RH 3.4 Map	1	544.2	RGD
Cytogenetic Map	1	q11	NCBI

MAS1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	159,888,787 - 159,917,447 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	159,890,988 - 159,917,447 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	160,312,020 - 160,338,479 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	160,247,964 - 160,249,098 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	160,298,384 - 160,299,519	NCBI
Celera	6	160,974,252 - 160,975,386 (+)	NCBI		Celera
Cytogenetic Map	6	q25.3	NCBI
HuRef	6	157,798,119 - 157,799,253 (+)	NCBI		HuRef
CHM1_1	6	160,590,238 - 160,591,372 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	161,134,461 - 161,165,992 (+)	NCBI		T2T-CHM13v2.0

Mas1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	13,056,981 - 13,087,037 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	13,059,966 - 13,087,030 (-)	Ensembl		GRCm39 Ensembl
GRCm38	17	12,838,841 - 12,868,150 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	12,841,079 - 12,868,143 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	13,033,871 - 13,061,009 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	12,684,009 - 12,711,075 (-)	NCBI		MGSCv36	mm8
Celera	17	12,872,985 - 12,900,041 (-)	NCBI		Celera
Cytogenetic Map	17	A1	NCBI
cM Map	17	8.69	NCBI

Mas1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955439	20,956,862 - 20,957,839 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955439	20,956,862 - 20,957,839 (-)	NCBI	ChiLan1.0	ChiLan1.0

MAS1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	179,989,640 - 180,015,684 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	177,894,549 - 177,920,364 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	157,774,098 - 157,799,983 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	162,785,263 - 162,802,530 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	162,801,416 - 162,802,393 (+)	Ensembl	panpan1.1		panPan2

MAS1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	49,090,041 - 49,105,244 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	49,090,041 - 49,105,244 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	49,931,512 - 49,946,711 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	49,272,721 - 49,299,228 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	49,274,155 - 49,289,356 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	49,156,624 - 49,171,810 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	49,028,114 - 49,043,315 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	49,643,019 - 49,658,218 (+)	NCBI		UU_Cfam_GSD_1.0

MAS1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	7,527,861 - 7,528,838 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	7,527,566 - 7,542,110 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	9,326,523 - 9,339,701 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MAS1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	13	87,520,860 - 87,523,523 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	13	87,521,947 - 87,523,098 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	59,898,097 - 59,920,293 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mas1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624855	2,969,444 - 2,970,421 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624855	2,968,111 - 3,008,728 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Mas1
187 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	149
Count of miRNA genes:	121
Interacting mature miRNAs:	132
Transcripts:	ENSRNOT00000020100
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331732	Srn4	Serum renin concentration QTL 4	4.467		renin activity (VT:0005581)	plasma renin activity level (CMO:0000116)	1	35239598	78430678	Rat
2313059	Bss55	Bone structure and strength QTL 55	3.2	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	1	43284731	118944897	Rat
631688	Hcas2	Hepatocarcinoma susceptibility QTL 2	3	0.0001	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	5925874	115540829	Rat
1357397	Bw41	Body weight QTL 41	4.19	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	1	22340647	49361612	Rat
1358359	Sradr1	Stress Responsive Adrenal Weight QTL 1	4.74		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	30882023	123479925	Rat
1331792	Rf29	Renal function QTL 29	4.589		urine potassium amount (VT:0010539)	urine potassium level (CMO:0000128)	1	35239598	78430678	Rat
2313062	Bmd73	Bone mineral density QTL 73	3.9	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	1	11481312	82174945	Rat
8552900	Pigfal1	Plasma insulin-like growth factor 1 level QTL 1	7.4		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	1	34836858	79836858	Rat
1554320	Bmd1	Bone mineral density QTL 1	12.2	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	509108	86060548	Rat
1354643	Foco2	Food consumption QTL 2	7.17	0.0001	eating behavior trait (VT:0001431)	food intake rate (CMO:0000427)	1	33449848	78449848	Rat
2302059	Pia36	Pristane induced arthritis QTL 36	3.8	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	1	43333002	88333002	Rat
2313065	Bss67	Bone structure and strength QTL 67	3.1	0.0001	tibia area (VT:1000281)	tibia total energy absorbed before break (CMO:0001736)	1	11481312	82174945	Rat
7421626	Bp360	Blood pressure QTL 360		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	4393289	49393289	Rat
1357400	Bw62	Body weight QTL62	4.05		inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	1	22340647	67340647	Rat
1357401	Bw43	Body weight QTL 43	3.75		body mass (VT:0001259)	body weight (CMO:0000012)	1	22340647	49361612	Rat
2313069	Bss68	Bone structure and strength QTL 68	2.9	0.0001	tibia size trait (VT:0100001)	tibia total energy absorbed before break (CMO:0001736)	1	11481312	82174945	Rat
631495	Bp96	Blood pressure QTL 96	4.52		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	22340647	102268831	Rat
631494	Bp95	Blood pressure QTL 95	40	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	16206210	49268520	Rat
2313075	Bss66	Bone structure and strength QTL 66	3.4	0.0001	tibia length (VT:0004357)	tibia length (CMO:0000450)	1	11481312	82174945	Rat
5684998	Bss101	Bone structure and strength QTL 101	3.6		tibia strength trait (VT:1000284)	tibia ultimate force (CMO:0001734)	1	15431621	49361612	Rat
70225	Bp58	Blood pressure QTL 58	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	32356093	162846471	Rat
5684999	Bss102	Bone structure and strength QTL 102	5.5	7e-07	tibia strength trait (VT:1000284)	tibia stiffness (CMO:0001735)	1	15431621	49361612	Rat
2313072	Bss53	Bone structure and strength QTL 53	4.3	0.0001	tibia length (VT:0004357)	tibia length (CMO:0000450)	1	43284731	118944897	Rat
1300167	Hrtrt2	Heart rate QTL 2	4.35		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	11481312	75088344	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	32737458	199368955	Rat
2313078	Bss54	Bone structure and strength QTL 54	3.5	0.0001	tibia area (VT:1000281)	tibia midshaft cross-sectional area (CMO:0001717)	1	43284731	118944897	Rat
2313077	Bss69	Bone structure and strength QTL 69	3.5	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	1	11481312	82174945	Rat
1331778	Rf28	Renal function QTL 28	4.66		urine potassium amount (VT:0010539)	urine potassium excretion rate (CMO:0000761)	1	45803140	78430678	Rat
1578756	Iddm22	Insulin dependent diabetes mellitus QTL 22	2.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	11835181	56835181	Rat
631508	Sald1	Serum aldosterone level QTL 1	3.7		blood aldosterone amount (VT:0005346)	serum aldosterone level (CMO:0000487)	1	9856001	54856001	Rat
1331785	Rf27	Renal function QTL 27	4.643		urine sodium amount (VT:0006274)	urine sodium level (CMO:0000129)	1	28879780	78430678	Rat
1300172	Bp172	Blood pressure QTL 172	3.56		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	32737273	90665040	Rat
724520	Bp145	Blood pressure QTL 145	2.1	0.0024	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	20784828	65784828	Rat
2313094	Bss58	Bone structure and strength QTL 58	3.7	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	1	43284731	118944897	Rat
2313092	Bmd72	Bone mineral density QTL 72	2.5	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	1	11481312	82174945	Rat
2313099	Bss56	Bone structure and strength QTL 56	2.4	0.0001	tibia size trait (VT:0100001)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	1	43284731	118944897	Rat
2313098	Bmd70	Bone mineral density QTL 70	3.6	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	1	43284731	118944897	Rat
2313097	Bss70	Bone structure and strength QTL 70	3.5	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	1	11481312	82174945	Rat
9589820	Insglur3	Insulin/glucose ratio QTL 3	10.75	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	1	34836858	79836858	Rat
738020	Pia8	Pristane induced arthritis QTL 8	4.7		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	1	1	65833076	Rat
1354599	Bw29	Body weight QTL 29	3.46	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	1	33449848	78449848	Rat
2302038	Pia31	Pristane induced arthritis QTL 31	5.5	0.001	blood autoantibody amount (VT:0003725)	serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)	1	10992065	55992065	Rat
8552948	Pigfal11	Plasma insulin-like growth factor 1 level QTL 11	4.7		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	1	34836858	79836858	Rat
634353	Rends2	Renal damage susceptibility QTL 2		0.05	kidney blood vessel morphology trait (VT:0000530)	organ lesion measurement (CMO:0000677)	1	19333571	56983283	Rat
2313051	Bss57	Bone structure and strength QTL 57	3.7	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	1	43284731	118944897	Rat

Markers in Region

BB276039

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	47,911,325 - 47,911,450 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	48,108,044 - 48,108,168	NCBI	Rnor6.0
Rnor_5.0	1	51,644,770 - 51,644,894	UniSTS	Rnor5.0
RGSC_v3.4	1	42,185,576 - 42,185,700	UniSTS	RGSC3.4
Celera	1	43,710,948 - 43,711,072	UniSTS
Cytogenetic Map	1	q11-q12	UniSTS

BF386436

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	47,891,940 - 47,892,149 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	48,088,663 - 48,088,871	NCBI	Rnor6.0
Rnor_5.0	1	51,663,532 - 51,663,740	UniSTS	Rnor5.0
RGSC_v3.4	1	42,166,411 - 42,166,619	UniSTS	RGSC3.4
Celera	1	43,691,652 - 43,691,860	UniSTS
RH 3.4 Map	1	539.4	UniSTS
Cytogenetic Map	1	q11-q12	UniSTS

RH94551

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	47,911,027 - 47,911,127 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	48,107,746 - 48,107,845	NCBI	Rnor6.0
Rnor_5.0	1	51,645,093 - 51,645,192	UniSTS	Rnor5.0
RGSC_v3.4	1	42,185,278 - 42,185,377	UniSTS	RGSC3.4
Celera	1	43,710,650 - 43,710,749	UniSTS
RH 3.4 Map	1	544.2	UniSTS
Cytogenetic Map	1	q11-q12	UniSTS

BF414744

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	47,911,011 - 47,911,185 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	48,107,730 - 48,107,903	NCBI	Rnor6.0
Rnor_5.0	1	51,645,035 - 51,645,208	UniSTS	Rnor5.0
RGSC_v3.4	1	42,185,262 - 42,185,435	UniSTS	RGSC3.4
Celera	1	43,710,634 - 43,710,807	UniSTS
RH 3.4 Map	1	563.3	UniSTS
Cytogenetic Map	1	q11-q12	UniSTS

Genetic Models

This gene Mas1 is modified in the following models/strains:

SS-Mas1^em1Mcwi

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	27	85	68	67	36	25	36	6	157	75	65	29	49	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_012757	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006227860	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017588807	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017588808	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039101408	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039101409	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039101416	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063281307	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063281312	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063281318	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063281319	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063281329	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC129234	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC078884	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474059	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HG426116	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	J03823	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000020100 ⟹ ENSRNOP00000020100

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	47,880,309 - 47,911,498 (+)	Ensembl
Rnor_6.0 Ensembl	1	48,077,033 - 48,108,216 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000104217 ⟹ ENSRNOP00000097396

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	47,900,582 - 47,911,709 (+)	Ensembl

RefSeq Acc Id:

NM_012757 ⟹ NP_036889

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	50,428,090 - 50,459,277 (+)	NCBI
mRatBN7.2	1	47,880,309 - 47,911,500 (+)	NCBI
Rnor_6.0	1	48,077,033 - 48,108,218 (+)	NCBI
Rnor_5.0	1	51,644,462 - 51,675,365 (-)	NCBI
RGSC_v3.4	1	42,154,786 - 42,185,750 (+)	RGD
Celera	1	43,680,754 - 43,711,122 (+)	RGD

Sequence:

show sequence

GGAGGAAGGCTGCCTGCATACTGGGAAGACCAGCCCACAGTTACCAGTTCTTCCGGCTTTCTGG
ATTCTCAAAGTCAGAAGGGGAACCCTGGGCTTTGGTGAAGCACTCGAGGCTCTCTTCCTGTGAT
CGACAATCAACATCTAGGACTGGGTAGAGTTGGTTCCAGGAGATGCTTCCATGAGAAACAGGAA
GGGAATGAAATTCCCCGATGCTGCCCATGTTACTGACTGATGATACCACCAGCTGCCCCAGGCC
TCCAGCCCTCTGTCCTCAGCTGAGCTTCCCACCACTGTGCTCTCCACCAAGACCTGCTAGGATG
AGCTGTCCTTCTGCTCGGACTGTCACCGCCAGCCAGGTAAACATGCAGTCTGCAACTACAGTTA
CTCTGTAACGAGATGGGCGTCTGGACAAAGAGTCTGCTGTCCCAGAGCTGGGTTTACCTGGAGA
CGTCCCCAGACCAGTCATCCTGCCAGAGAGAAAATGGCCTGAAGTGGTCCAGCACAAGAACTCC
TCATGGACCAATCAAATATGACATCCTTTGCTGAGGAGAAAGCCATGAATACCTCCAGCAGAAA
TGCCTCCCTGGGGACTTCACACCCACCCATTCCCATAGTGCACTGGGTCATCATGAGCATCTCT
CCTCTCGGCTTTGTGGAGAACGGGATCCTCCTCTGGTTCCTTTGCTTCCGGATGAGGAGAAATC
CCTTCACGGTCTATATCACCCACTTGTCCATTGCTGACATCTCCCTCCTGTTCTGTATTTTTAT
TCTGTCCATCGACTATGCTTTAGACTATGAACTCTCTTCTGGCCATTACTACACAATCGTGACG
TTATCGGTGACTTTTCTATTTGGCTACAACACAGGCCTCTATCTGCTGACAGCCATCAGTGTGG
AGAGATGCCTTTCAGTCCTCTACCCCATCTGGTACAGATGTCACCGCCCCAAGCACCAGTCGGC
ATTCGTCTGTGCCCTCCTGTGGGCACTTTCATGCTTGGTGACCACCATGGAGTACGTCATGTGT
ATTGACAGCGGAGAAGAGAGTCACTCTCAGAGTGACTGTCGGGCGGTCATCATCTTCATAGCCA
TCCTCAGCTTCTTGGTCTTCACTCCGCTCATGTTAGTGTCCAGCACCATCTTGGTGGTGAAGAT
ACGGAAGAACACATGGGCCTCCCATTCTTCGAAGCTGTACATCGTCATCATGGTCACCATTATC
ATATTCCTCATCTTTGCCATGCCCATGCGGGTCCTCTACCTGTTGTATTACGAGTACTGGTCAA
CCTTTGGGAACCTGCATAACATCTCCTTGCTTTTCTCCACCATCAATAGCAGCGCCAACCCTTT
CATCTACTTTTTTGTGGGCAGCAGTAAGAAGAAGCGCTTCAGGGAGTCCTTAAAAGTGGTCCTG
ACCAGAGCTTTCAAAGACGAGATGCAACCTAGGCGTCAGGAGGGCAATGGCAACACTGTATCCA
TTGAGACTGTGGTCTGAGGACCGCAGGGGGAGTCTTAGACAGAAACAGCTGAATGTGGGTGGCT
TTCGATTTGTGCTTGGAATGCAATTTAAGTCCATTTAAATCTCCTAAATCTGATAAGAAGGAAG
CATTCTACATGCATGGGGGTCTAATCGATGATGAGCTTGTGTTGCTACTTAGTATCTTCTGGAA
ATGCTTCCATATGTGACGGGACTCTGTCTTTTCTATCATTATCAAAGACTCATTCTTCTCTTAG
CTGTCCAGTAGTGTTCAACAGTTAACTATAAAAACTGCCCTAGCAGGAACTATCTGAATTGTGA
CTCAGAGAACCTGGGGAGGCTGTGTGATGACTGCTGTGTGCTCCTAGGTGACCTCAGGCAAGTG
GCTTGGGAGAGCCTGATTTCCCCTCTTAGTGGAAATAGTGACAGTCTGTACTGCTTAGGTTAGT
GTCCAGTATGATGAGGTAGGCAAAGCACCCAGCTCACTGTCAAAGTTCAATAAATATCCGTCTC
TCCTTGTCCTTTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006227860 ⟹ XP_006227922

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	50,446,962 - 50,459,537 (+)	NCBI
mRatBN7.2	1	47,899,794 - 47,911,500 (+)	NCBI
Rnor_6.0	1	48,093,445 - 48,108,021 (+)	NCBI
Rnor_5.0	1	51,644,462 - 51,675,365 (-)	NCBI

Sequence:

show sequence

AGAGACATCCTTCGGTGTTTGAAATCACTGTGACCCTTTTAACTGGGATGGGATGGACCATGCT
TCCTGATGTCTTGTCAATCAATCTAACCATTCCTCCTGCTTCAGACTGCCTAGCCCTGTAGTCA
CGGCACCCGTGATTCCAAGGAACCCAGAAAGGCCTCCGTTCATTTCGTGTATGTTTGATCTGGC
ATTTTCATTTTGGACCCAATGGTGCGTTGCCTGTCGGCTATAGCCATCTTTACTGGTCACAGGC
AGTCTGTCGGAGGGGAGTGGCCCCGGAGGCATTCTCAGGGCCCTTAGCACAAATGCCATCTTTG
CTTAGGACTGCCACCCATCCTGGGTCTCTTGGTGTCCTCATTGCTCAGGAAAAGTTCTTCTATT
GGGTGGGATAAAACCTCCGTTCAGACAGAGGATGTCAGGGAGCTCTAGGGGCTGGGCCACGTTC
AGGCTGTGGCCTCCTTGCTACATCTATCTTCCTAAACCAATCGTTTTCTCTCTTCATATCCAGT
CTTCCACCTTGTAGAAGGGCTGGTTCTCACTAGACTTGGTCATGCGGGCCTGTCTAAGTGGAAG
GCCAAGCACACGAGGGAGGTGGGACAGTTCTCCTTCAGACTCGATGTCTAAGAAGTGTGCTCTG
AAAATGAAAATCCTTGGCTGGGACAGATCCAGCCAATCCCTGTATGAGTTAGGAAAAAAGATTG
CCCCAGGCTGGTGGGATCAAATGGGCCTGGGAGAGTTTCATTCTCAGAGTTTTATCTTTGGCTT
TTATCTGGTCACTGAGATCTGAAGACTCTATTGCAGGGCTAGAAGGGCAGAGGGTGGGAATGTC
CTGCCCCAAGAGCTTGTCAATCAGAAGGATGGGGGACTGGTTCTGCTCTGAGAGCCTGTCTGTC
AGAACTACGAGATACAGAACCGCTTAGCCAAATTTTCTCTAGTCAAGTTTGGAAGATCAGATTT
CTAGCATCCCTGAAGTCAATTCCGTTCCAAACGGTGTAACAGGACAGTGTACACTGGGCTGTCT
GTCAGCATGTTCTGTGTGTCTGACCTGTCTTCCTTCTGTCTCTCTAGTTACCAGTTCTTCCGGC
TTTCTGGATTCTCAAAGTCAGAAGGGGAACCCTGGGCTTTGGTGAAGCACTCGAGGCTCTCTTC
CTGTGATCGACAATCAACATCTAGGACTGGGTAGAGTTGGTTCCAGGTGAGGACACATTTGGGG
ATTGGACTGAAGCGCACCTGCTTCCCTAGGTCAGCGAGAGTCGTGCCCCCTTACCCCTGGCCCC
TGCCCAGGGACTAAGGGGCTTAAGATAGAAGGGGAGGGGATTCCAACGCACAGGGCGGGGTCGA
CTTCTGGGTTCTACCGCTCGGACTCCACCACTCACTAGTCGCCTACTATGGGTCTACCACCTGG
CTTCCTGTGTTACTATGTGTGAGAGTCAAGCCCCTTGGCACGCCCGTCAAGGATTGTCTCTTAG
GTTGAGCGGGTTTGGAAGCCCCATTCGGTACCTGGGCAGCGCCATTCACACCATGGGTCAGGGT
TCTGGGCTGAATGTAAAGGAGGAAACTGGCCGAGCAACGGCGTTCCTTGCTCTCTGCCTCCTGA
CTGCTGGTAGAATGTGACCAGAAGCCCCATGCTCCTGTTGGTCTAACTTCCTCACCATGACGGA
TTGGACCCTTGAACTGTGAGCCAAAAACCCTTCCTTACGTTACTTTCGTATTATCTTTTCTCCT
CCCTTGCTCCCTTGAGTACCTCAAAGCTTTTTTCCCTCTTTCTGTCATTTGACAGGAGGAACAG
GTGTGTTTAGGGAACTCTGGAAGGTATGACTTATCTCTCAGGAGTGCAGTCTAGAACTTCTCTG
GAAGGAAAGTTGGGGGCCACAGACTTCTCTTCCCCGGGCTTGGTTGGCCCTGTTCCTGCTCTTT
CAGTACCTCCTTCCCCCTCAAATCTTCCCACCTCTGAAGAGAATGATTCCTCGCAACGACAAAC
CAGCACAGAAATAGCCGTCCTATTTGTGGCTTAAATGCAGGCAGCTTTATTTTTACAGTAAGAT
GCTGTATTTTCTCTAAGCAGAAATCATTATCTACCACAAATGAAACTCCGGCCCCATCTGTGAT
AGTTCCTGTTTTGTTGGCGGTGCCAATTAGTCACAAAACAATTGGCATCTTCCCCCACCCACTC
ATTCTGTGGGAGGAGAGCCATCCCTTACAGCAGCCCCCTTCCCTGGAGACGGACTGACCCCTTA
GCCTCCTGGGAGCTCTGCTCTGCATTCACCTGGTGACTGGTATCAACTTCCAAACCGGGTGACT
TGTCCTCTGTCAGGGTGGCCAGGCATCTCAGTTGTGAATAGAGACGAGGGTGGGGGGGATTAGG
GGGAGCAAATTGGTGCGCTCCTCTGTTCTGTTGACTTAAACAATGACGTTGGAGTCTTCTCTCT
AGTTGGTCACTCTGTTCAGGATTCCACTACCTGCCTGGGAGGACAACTGTTCATCAAATCTGAA
CTGTCTCAGCTCTAAGTGTGGATAGAAGAGCAGAGAAGATCCCTCTGTTCCGTCTTTCCTTCCT
CCTCCCCCCTCCCCCATGCCATGCCCGGGAACCTCTTGGCCAGCCCCTTTCTTGGCTCTCATTG
GATCCTACTGGCTCCTCTCGTGAATCCCTCCCCACGGTGTGTCCTTCCTCTCTACCTTGCAGTG
TGTCCTTAGTGGGGTTTCCTTTCTCTCTCTGACTTTGCTCCTGAAACTTACGCTTCTCCAGGAG
GCTGGCCTTCCCTTCTTTTAGGACATGGAAATCAGGTAACGGGGAAGAGTTTTTGACATCTGGC
CAGAGCTCACTGATTCTGTTGACTTACCCTTTGCCTGCGCCTGCTGCTGGGACCAGCCGTGCTC
TGAAGGTCTTTGGGGGTATATGGTCCCCACCCCCTCATTCCCAGCCCCTGGAGAACTGAGCCCC
TGGCTTCCTGCAGTGCAATTGCGCTCCTGCCCTTCAGACTTGCTTTGGAAAGAGTTTGAGTGGA
CACCTGCTTTCTAATAGGTTAGAATCGCCTTCCCTCCCCTTTGATCTGACTGGATCCGGAGTCA
TTGCTGCTTCACCATTGTAACTGGAGGAAGCCCCCTGAAAAGAAGAGGCGTGGACAGAAGTAGA
GCCAGGGTAGCTCTTCACTGTGGGCGTGGCTACCTGTGGTCCTCCACTGTGGGCGTGGTTACTT
GAGATCCAGGTGTTCTAGAATTCTCTTGCTTGGTTTTATCTTGGGTTCTTGGAGAAAAGTGGGC
AGAGGCCAGGGAGAAAGATGTTTAATGCTGTGTTTCTGAGTTCCTGTGTGAGAACCTCTACCTA
ACAATTCCTGGGAAGGAATTTGCCTGTGCATTGCCACAGAACAGACAAACCCCCTCTATCACAG
ACCCCTCTACCTTGACTTCCCTTCCTCTCTATTACCTCAGCCCAATTTTCTGCACGATGTTGTT
CATGATATACTCCAAGGACTTGTAAGAAGGAATTTATACTGAATTATACTGAATTACCCATGTG
CCTCCCACTGTGCTGATTTAGACATACACGTCCCTTTAAGGTAATGTTAAGAATCCATTTTACA
GTGAAGAACACTGAGTCTTCAAGAGTGCAATGCGGGTCACGTGATTACTTCACTTCTCAGCTCT
GCTAGAAATAGGAATGGTCCTATGTATTCTGCCCTCTAAGACATCATGTTTTGGGAGCACTGCT
CTCCTTAGACCAGGCTAGCCCCTGTCTTGGGTGATGAGCCACTTCGTGCTGTACACAGCCCATT
CCCACTGTGGATCAGGGTACAGATTTTCACTTGTGTGTCAGCGGATGATGCCATTTGAAACTCG
GCTTCTGCTGATAAGCGTGGGACCATCTGCCTAGCGCAGCTCAAATATTTCAGCACTGGGAGAG
CAGCTCTGACTTCTGAGACTCGCCTGCAGTCATCCTGGGAGATGCTGGGACCGGGGACCTGGCG
GGCTAGCCGGGTATGGATGCCACAGGATTCAAAGGAGCCATCCCCTTGCTGTCACCTCTGACCC
TTCCTGAGCAAAGGACACCAGTGAGTCCACGCTCCAGCGTGTGGAGTTGTTCAGATGCTCTTGA
CAAGCGCAGAGATGCTTCCATGAGAAACAGGAAGGGAATGAAATTCCCCGATGCTGCCCATGTT
ACTGACTGATGATACCACCAGCTGCCCCAGGCCTCCAGCCCTCTGTCCTCAGCTGAGCTTCCCA
CCACTGTGCTCTCCACCAAGACCTGCTAGGATGAGCTGTCCTTCTGCTCGGACTGTCACCGCCA
GCCAGGTAAACATGCAGTCTGCAACTACAGTTACTCTGTAACGAGATGGGCGTCTGGACAAAGA
GTCTGCTGTCCCAGAGCTGGGTTTACCTGGAGACGTCCCCAGACCAGTCATCCTGCCAGAGAGA
AAATGGCCTGAAGTGGTCCAGCACAAGAACTCCTCATGGACCAATCAAATATGACATCCTTTGC
TGAGGAGAAAGCCATGAATACCTCCAGCAGAAATGCCTCCCTGGGGACTTCACACCCACCCATT
CCCATAGTGCACTGGGTCATCATGAGCATCTCTCCTCTCGGCTTTGTGGAGAACGGGATCCTCC
TCTGGTTCCTTTGCTTCCGGATGAGGAGAAATCCCTTCACGGTCTATATCACCCACTTGTCCAT
TGCTGACATCTCCCTCCTGTTCTGTATTTTTATTCTGTCCATCGACTATGCTTTAGACTATGAA
CTCTCTTCTGGCCATTACTACACAATCGTGACGTTATCGGTGACTTTTCTATTTGGCTACAACA
CAGGCCTCTATCTGCTGACAGCCATCAGTGTGGAGAGATGCCTTTCAGTCCTCTACCCCATCTG
GTACAGATGTCACCGCCCCAAGCACCAGTCGGCATTCGTCTGTGCCCTCCTGTGGGCACTTTCA
TGCTTGGTGACCACCATGGAGTACGTCATGTGTATTGACAGCGGAGAAGAGAGTCACTCTCAGA
GTGACTGTCGGGCGGTCATCATCTTCATAGCCATCCTCAGCTTCTTGGTCTTCACTCCGCTCAT
GTTAGTGTCCAGCACCATCTTGGTGGTGAAGATACGGAAGAACACATGGGCCTCCCATTCTTCG
AAGCTGTACATCGTCATCATGGTCACCATTATCATATTCCTCATCTTTGCCATGCCCATGCGGG
TCCTCTACCTGTTGTATTACGAGTACTGGTCAACCTTTGGGAACCTGCATAACATCTCCTTGCT
TTTCTCCACCATCAATAGCAGCGCCAACCCTTTCATCTACTTTTTTGTGGGCAGCAGTAAGAAG
AAGCGCTTCAGGGAGTCCTTAAAAGTGGTCCTGACCAGAGCTTTCAAAGACGAGATGCAACCTA
GGCGTCAGGAGGGCAATGGCAACACTGTATCCATTGAGACTGTGGTCTGAGGACCGCAGGGGGA
GTCTTAGACAGAAACAGCTGAATGTGGGTGGCTTTCGATTTGTGCTTGGAATGCAATTTAAGTC
CATTTAAATCTCCTAAATCTGATAAGAAGGAAGCATTCTACATGCATGGGGGTCTAATCGATGA
TGAGCTTGTGTTGCTACTTAGTATCTTCTGGAAATGCTTCCATATGTGACGGGACTCTGTCTTT
TCTATCATTATCAAAGACTCATTCTTCTCTTAGCTGTCCAGTAGTGTTCAACAGTTAACTATAA
AAACTGCCCTAGCAGGAACTATCTGAATTGTGACTCAGAGAA

hide sequence

RefSeq Acc Id:

XM_039101408 ⟹ XP_038957336

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	50,446,962 - 50,459,537 (+)	NCBI
mRatBN7.2	1	47,899,795 - 47,911,500 (+)	NCBI

RefSeq Acc Id:

XM_039101409 ⟹ XP_038957337

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	50,428,064 - 50,459,537 (+)	NCBI
mRatBN7.2	1	47,879,956 - 47,911,500 (+)	NCBI

RefSeq Acc Id:

XM_039101416 ⟹ XP_038957344

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	50,446,962 - 50,459,537 (+)	NCBI
mRatBN7.2	1	47,899,795 - 47,911,500 (+)	NCBI

RefSeq Acc Id:

XM_063281307 ⟹ XP_063137377

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	50,445,359 - 50,459,537 (+)	NCBI

RefSeq Acc Id:

XM_063281312 ⟹ XP_063137382

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	50,452,991 - 50,459,537 (+)	NCBI

RefSeq Acc Id:

XM_063281318 ⟹ XP_063137388

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	50,446,962 - 50,459,537 (+)	NCBI

RefSeq Acc Id:

XM_063281319 ⟹ XP_063137389

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	50,428,080 - 50,459,537 (+)	NCBI

RefSeq Acc Id:

XM_063281329 ⟹ XP_063137399

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	50,428,064 - 50,459,537 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_036889	(Get FASTA)	NCBI Sequence Viewer
	XP_006227922	(Get FASTA)	NCBI Sequence Viewer
	XP_038957336	(Get FASTA)	NCBI Sequence Viewer
	XP_038957337	(Get FASTA)	NCBI Sequence Viewer
	XP_038957344	(Get FASTA)	NCBI Sequence Viewer
	XP_063137377	(Get FASTA)	NCBI Sequence Viewer
	XP_063137382	(Get FASTA)	NCBI Sequence Viewer
	XP_063137388	(Get FASTA)	NCBI Sequence Viewer
	XP_063137389	(Get FASTA)	NCBI Sequence Viewer
	XP_063137399	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA41573	(Get FASTA)	NCBI Sequence Viewer
	AAH78884	(Get FASTA)	NCBI Sequence Viewer
	CDG86234	(Get FASTA)	NCBI Sequence Viewer
	EDL83047	(Get FASTA)	NCBI Sequence Viewer
	EDL83048	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000020100
	ENSRNOP00000020100.4
	ENSRNOP00000097396
	ENSRNOP00000097396.1
	ENSRNOP00000100641
	ENSRNOP00000103225
	ENSRNOP00000104659
GenBank Protein	P12526	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_036889 ⟸ NM_012757

- UniProtKB:

P12526 (UniProtKB/Swiss-Prot), W8W3M4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDQSNMTSFAEEKAMNTSSRNASLGTSHPPIPIVHWVIMSISPLGFVENGILLWFLCFRMRRNP
FTVYITHLSIADISLLFCIFILSIDYALDYELSSGHYYTIVTLSVTFLFGYNTGLYLLTAISVE
RCLSVLYPIWYRCHRPKHQSAFVCALLWALSCLVTTMEYVMCIDSGEESHSQSDCRAVIIFIAI
LSFLVFTPLMLVSSTILVVKIRKNTWASHSSKLYIVIMVTIIIFLIFAMPMRVLYLLYYEYWST
FGNLHNISLLFSTINSSANPFIYFFVGSSKKKRFRESLKVVLTRAFKDEMQPRRQEGNGNTVSI
ETVV

hide sequence

RefSeq Acc Id:	XP_006227922 ⟸ XM_006227860
- Peptide Label:	isoform X1
- UniProtKB:	P12526 (UniProtKB/Swiss-Prot), W8W3M4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MDQSNMTSFAEEKAMNTSSRNASLGTSHPPIPIVHWVIMSISPLGFVENGILLWFLCFRMRRNP FTVYITHLSIADISLLFCIFILSIDYALDYELSSGHYYTIVTLSVTFLFGYNTGLYLLTAISVE RCLSVLYPIWYRCHRPKHQSAFVCALLWALSCLVTTMEYVMCIDSGEESHSQSDCRAVIIFIAI LSFLVFTPLMLVSSTILVVKIRKNTWASHSSKLYIVIMVTIIIFLIFAMPMRVLYLLYYEYWST FGNLHNISLLFSTINSSANPFIYFFVGSSKKKRFRESLKVVLTRAFKDEMQPRRQEGNGNTVSI ETVV hide sequence

Ensembl Acc Id:

ENSRNOP00000020100 ⟸ ENSRNOT00000020100

RefSeq Acc Id:	XP_038957337 ⟸ XM_039101409
- Peptide Label:	isoform X1
- UniProtKB:	P12526 (UniProtKB/Swiss-Prot), W8W3M4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038957336 ⟸ XM_039101408
- Peptide Label:	isoform X1
- UniProtKB:	P12526 (UniProtKB/Swiss-Prot), W8W3M4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038957344 ⟸ XM_039101416
- Peptide Label:	isoform X1
- UniProtKB:	P12526 (UniProtKB/Swiss-Prot), W8W3M4 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000097396 ⟸ ENSRNOT00000104217

RefSeq Acc Id:	XP_063137399 ⟸ XM_063281329
- Peptide Label:	isoform X1
- UniProtKB:	P12526 (UniProtKB/Swiss-Prot), W8W3M4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063137389 ⟸ XM_063281319
- Peptide Label:	isoform X1
- UniProtKB:	P12526 (UniProtKB/Swiss-Prot), W8W3M4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063137377 ⟸ XM_063281307
- Peptide Label:	isoform X1
- UniProtKB:	P12526 (UniProtKB/Swiss-Prot), W8W3M4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063137388 ⟸ XM_063281318
- Peptide Label:	isoform X1
- UniProtKB:	P12526 (UniProtKB/Swiss-Prot), W8W3M4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063137382 ⟸ XM_063281312
- Peptide Label:	isoform X1
- UniProtKB:	P12526 (UniProtKB/Swiss-Prot), W8W3M4 (UniProtKB/TrEMBL)

Protein Domains

G-protein coupled receptors family 1 profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P12526-F1-model_v2	AlphaFold	P12526	1-324	view protein structure
MAS	I-TASSER model	P12526	1-325	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13689618

Promoter ID:

EPDNEW_R141

Type:

single initiation site

Name:

Mas1_1

Description:

MAS1 proto-oncogene, G protein-coupled receptor

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	48,076,990 - 48,077,050	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:3049	AgrOrtholog
BioCyc Gene	G2FUF-61577	BioCyc
Ensembl Genes	ENSRNOG00000014971	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000020100	ENTREZGENE
	ENSRNOT00000020100.6	UniProtKB/Swiss-Prot
	ENSRNOT00000104217	ENTREZGENE
	ENSRNOT00000104217.1	UniProtKB/Swiss-Prot
	ENSRNOT00000127520	ENTREZGENE
	ENSRNOT00000132244	ENTREZGENE
	ENSRNOT00000164553	ENTREZGENE
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7131760	IMAGE-MGC_LOAD
InterPro	GPCR_Rhodpsn	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_Rhodpsn_7TM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MRGPCRFAMILY	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Proto-oncogene_Mas	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:25153	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:93580	IMAGE-MGC_LOAD
NCBI Gene	25153	ENTREZGENE
PANTHER	MAS-RELATED G-PROTEIN COUPLED RECEPTOR MRG-RELATED	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR11334	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB	MAS1	RGD
PhenoGen	Mas1	PhenoGen
PRINTS	GPCRRHODOPSN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MASONCOGENE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F1_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000014971	RatGTEx
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR	TC235714
UniProt	MAS_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	W8W3M4	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2002-06-10	Mas1	MAS1 oncogene			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in hippocampus and cerebral cortex	728946

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)