Amacr (alpha-methylacyl-CoA racemase) - Rat Genome Database

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Gene: Amacr (alpha-methylacyl-CoA racemase) Rattus norvegicus
Analyze
Symbol: Amacr
Name: alpha-methylacyl-CoA racemase
RGD ID: 3048
Description: Enables alpha-methylacyl-CoA racemase activity. Involved in bile acid biosynthetic process. Located in mitochondrion and peroxisome. Human ortholog(s) of this gene implicated in alpha-methylacyl-CoA racemase deficiency; congenital bile acid synthesis defect 4; and urinary bladder cancer. Orthologous to human AMACR (alpha-methylacyl-CoA racemase); PARTICIPATES IN bile acid biosynthetic pathway; cerebrotendinous xanthomatosis pathway; congenital bile acid synthesis defect pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2-arylpropionyl-CoA epimerase; 2-methylacyl-CoA racemase; Da1-8; Marc1; methylacyl-CoA racemase alpha
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8261,673,291 - 61,685,381 (+)NCBIGRCr8
mRatBN7.2259,946,158 - 59,958,255 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl259,946,153 - 59,958,255 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx267,055,385 - 67,067,396 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0265,176,896 - 65,188,909 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0260,178,272 - 60,190,287 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0260,949,276 - 60,961,342 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl260,949,256 - 60,961,326 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0283,723,119 - 83,735,166 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4260,332,292 - 60,344,326 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1260,260,524 - 60,272,557 (+)NCBI
Celera258,726,090 - 58,738,137 (-)NCBICelera
Cytogenetic Map2q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methylphenanthrene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
acetamide  (EXP)
aconitine  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphotericin B  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bicalutamide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A5  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
diquat  (ISO)
dorsomorphin  (ISO)
epoxiconazole  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gentamycin  (EXP)
glafenine  (EXP)
hydrazine  (EXP)
ibuprofen  (ISO)
indometacin  (EXP)
isotretinoin  (ISO)
mercury dichloride  (EXP,ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
nickel dichloride  (EXP)
ozone  (EXP)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenformin  (EXP)
phenobarbital  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
pterostilbene  (ISO)
quercetin  (ISO)
sarin  (ISO)
SB 431542  (ISO)
silibinin  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thalidomide  (ISO)
thioacetamide  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
Triptolide  (EXP)
trovafloxacin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, etal., Genome Res 1996 Sep;6(9):791-806.
2. The role of alpha-methylacyl-CoA racemase in bile acid synthesis. Cuebas DA, etal., Biochem J 2002 May 1;363(Pt 3):801-7.
3. Subcellular localization and physiological role of alpha-methylacyl-CoA racemase. Ferdinandusse S, etal., J Lipid Res. 2000 Nov;41(11):1890-6.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Expression of alpha-methylacyl-CoA racemase correlates with histopathologic grading in noninvasive bladder cancer. Gunia S, etal., Virchows Arch. 2008 Aug;453(2):165-70. Epub 2008 Jul 22.
7. Aberrant expression and potency as a cancer immunotherapy target of alpha-methylacyl-coenzyme A racemase in prostate cancer. Honma I, etal., J Transl Med. 2009 Dec 9;7:103.
8. Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease. Kikuchi M, etal., J Biol Chem. 2004 Jan 2;279(1):421-8. Epub 2003 Oct 15.
9. Alpha-methylacyl-CoA racemase (AMACR/P504S) protein expression in urothelial carcinoma of the upper urinary tract correlates with tumour progression. Langner C, etal., Virchows Arch. 2006 Mar;448(3):325-30. Epub 2005 Nov 29.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Purification and properties of an alpha-methylacyl-CoA racemase from rat liver. Schmitz W, etal., Eur J Biochem. 1994 Jun 1;222(2):313-23.
19. Purification and characterization of an alpha-methylacyl-CoA racemase from human liver. Schmitz W, etal., Eur J Biochem. 1995 Aug 1;231(3):815-22.
20. Prognostic significance of alpha-methylacyl-coA racemase among men with high grade prostatic intraepithelial neoplasia in prostate biopsies. Stewart J, etal., J Urol. 2008 May;179(5):1751-5; discussion 1755. Epub 2008 Mar 17.
21. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
22. Expression of alpha-methylacyl-CoA racemase in papillary renal cell carcinoma. Tretiakova MS, etal., Am J Surg Pathol. 2004 Jan;28(1):69-76.
23. Alpha-methylacyl-CoA racemase protein expression is associated with the degree of differentiation in breast cancer using quantitative image analysis. Witkiewicz AK, etal., Cancer Epidemiol Biomarkers Prev. 2005 Jun;14(6):1418-23.
Additional References at PubMed
PMID:8615858   PMID:9106621   PMID:9307041   PMID:10655068   PMID:10770938   PMID:11060344   PMID:12477932   PMID:14651853   PMID:18614015   PMID:20102405   PMID:20178365  


Genomics

Comparative Map Data
Amacr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8261,673,291 - 61,685,381 (+)NCBIGRCr8
mRatBN7.2259,946,158 - 59,958,255 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl259,946,153 - 59,958,255 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx267,055,385 - 67,067,396 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0265,176,896 - 65,188,909 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0260,178,272 - 60,190,287 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0260,949,276 - 60,961,342 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl260,949,256 - 60,961,326 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0283,723,119 - 83,735,166 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4260,332,292 - 60,344,326 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1260,260,524 - 60,272,557 (+)NCBI
Celera258,726,090 - 58,738,137 (-)NCBICelera
Cytogenetic Map2q16NCBI
AMACR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38533,986,165 - 34,008,050 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl533,986,165 - 34,008,104 (-)EnsemblGRCh38hg38GRCh38
GRCh37533,986,270 - 34,008,155 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36534,023,652 - 34,043,963 (-)NCBINCBI36Build 36hg18NCBI36
Build 34534,023,658 - 34,043,963NCBI
Celera533,875,521 - 33,896,657 (-)NCBICelera
Cytogenetic Map5p13.2NCBI
HuRef533,965,051 - 33,986,185 (-)NCBIHuRef
CHM1_1533,988,659 - 34,009,789 (-)NCBICHM1_1
T2T-CHM13v2.0534,108,084 - 34,129,983 (-)NCBIT2T-CHM13v2.0
Amacr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391510,981,875 - 10,995,693 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1510,981,842 - 10,996,712 (+)EnsemblGRCm39 Ensembl
GRCm381510,981,756 - 10,996,624 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1510,981,756 - 10,996,626 (+)EnsemblGRCm38mm10GRCm38
MGSCv371510,911,511 - 10,926,379 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361510,926,481 - 10,941,349 (+)NCBIMGSCv36mm8
Celera1510,773,835 - 10,788,820 (+)NCBICelera
Cytogenetic Map15A1NCBI
cM Map155.39NCBI
Amacr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542619,570,070 - 19,580,818 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542619,570,179 - 19,580,920 (-)NCBIChiLan1.0ChiLan1.0
AMACR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2476,300,803 - 76,321,985 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1574,455,666 - 74,477,720 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0576,336,631 - 76,358,724 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1581,722,973 - 81,742,806 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl581,687,891 - 81,742,003 (+)Ensemblpanpan1.1panPan2
AMACR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1473,815,438 - 73,836,016 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl473,815,291 - 73,867,437 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha473,431,203 - 73,451,716 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0474,321,712 - 74,342,286 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl474,321,704 - 74,376,263 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1474,068,256 - 74,088,061 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0474,191,815 - 74,212,352 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0474,725,962 - 74,746,514 (+)NCBIUU_Cfam_GSD_1.0
Amacr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213224,282,991 - 224,299,409 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365187,072,403 - 7,088,929 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365187,072,436 - 7,088,927 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AMACR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1619,956,366 - 20,023,289 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11620,005,741 - 20,023,339 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21620,765,256 - 20,782,844 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AMACR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1433,221,777 - 33,244,829 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl433,225,754 - 33,244,836 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607123,518,099 - 23,540,732 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Amacr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475920,495,980 - 20,510,582 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475920,495,697 - 20,506,343 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Amacr
72 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:84
Count of miRNA genes:36
Interacting mature miRNAs:42
Transcripts:ENSRNOT00000025323, ENSRNOT00000040701
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578777Stresp15Stress response QTL 1520.05blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)259846005104846005Rat
6480225Gdil1Gastrointestinal dilation QTL 1enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)25666087974786777Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
631500Bp99Blood pressure QTL 992.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)259324719102755241Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23502311780023117Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
10755434Coatc7Coat color QTL 70.04794coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23064806575648065Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243162366111362592Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)243162366111362592Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
5684996Bmd85Bone mineral density QTL 854.70.024tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)259324377103795077Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22715716072157160Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)240067944102785628Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
631208Bw1Body weight QTL15.09mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)24317101783575226Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)24280460760653831Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
5684990Bmd82Bone mineral density QTL 822.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)259324377103795077Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22691781781754745Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)259134147127460910Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354592Rf50Renal function QTL 503.5urine output (VT:0003620)timed urine volume (CMO:0000260)25382274774786777Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23513484188029593Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
1582246Cm60Cardiac mass QTL 605.8heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)25760561276539510Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)259324377141596857Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat

Markers in Region
RH127386  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2259,957,936 - 59,958,155 (+)MAPPERmRatBN7.2
Rnor_6.0260,961,024 - 60,961,242NCBIRnor6.0
Rnor_5.0283,723,219 - 83,723,437UniSTSRnor5.0
RGSC_v3.4260,344,008 - 60,344,226UniSTSRGSC3.4
Celera258,726,190 - 58,726,408UniSTS
Cytogenetic Map2q16UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 21 53 41 8 41 2 5 65 35 32 8 2
Low 1 22 4 11 6 6 9 9 3 6
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000025323   ⟹   ENSRNOP00000025323
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl259,946,153 - 59,958,255 (+)Ensembl
Rnor_6.0 Ensembl260,949,256 - 60,961,326 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000040701   ⟹   ENSRNOP00000040100
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl259,946,153 - 59,958,255 (+)Ensembl
Rnor_6.0 Ensembl260,949,283 - 60,960,987 (+)Ensembl
RefSeq Acc Id: NM_012816   ⟹   NP_036948
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8261,673,335 - 61,685,381 (+)NCBI
mRatBN7.2259,946,209 - 59,958,255 (+)NCBI
Rnor_6.0260,949,276 - 60,961,342 (+)NCBI
Rnor_5.0283,723,119 - 83,735,166 (-)NCBI
RGSC_v3.4260,332,292 - 60,344,326 (+)RGD
Celera258,726,090 - 58,738,137 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039101775   ⟹   XP_038957703
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8261,673,291 - 61,685,381 (+)NCBI
mRatBN7.2259,946,158 - 59,957,759 (+)NCBI
RefSeq Acc Id: NP_036948   ⟸   NM_012816
- UniProtKB: P70473 (UniProtKB/Swiss-Prot),   O09176 (UniProtKB/Swiss-Prot),   G3V8F9 (UniProtKB/TrEMBL),   A6KJS2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000025323   ⟸   ENSRNOT00000025323
RefSeq Acc Id: ENSRNOP00000040100   ⟸   ENSRNOT00000040701
RefSeq Acc Id: XP_038957703   ⟸   XM_039101775
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70473-F1-model_v2 AlphaFold P70473 1-382 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691188
Promoter ID:EPDNEW_R1713
Type:multiple initiation site
Name:Amacr_1
Description:alpha-methylacyl-CoA racemase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0260,949,273 - 60,949,333EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3048 AgrOrtholog
BioCyc Gene G2FUF-54068 BioCyc
BioCyc Pathway PWY-6061 [bile acid biosynthesis, neutral pathway] BioCyc
BioCyc Pathway Image PWY-6061 BioCyc
Ensembl Genes ENSRNOG00000018662 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00055025508 UniProtKB/Swiss-Prot
  ENSRNOG00060021618 UniProtKB/Swiss-Prot
  ENSRNOG00065020908 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025323 ENTREZGENE
  ENSRNOT00000025323.6 UniProtKB/TrEMBL
  ENSRNOT00000040701.5 UniProtKB/TrEMBL
  ENSRNOT00055044076 UniProtKB/Swiss-Prot
  ENSRNOT00060037521 UniProtKB/Swiss-Prot
  ENSRNOT00065035542 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.1540.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7110324 IMAGE-MGC_LOAD
  IMAGE:7130642 IMAGE-MGC_LOAD
  IMAGE:7325347 IMAGE-MGC_LOAD
InterPro CoA-Trfase_fam_III UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CoA-Trfase_III_dom3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CoA-Trfase_III_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25284 UniProtKB/TrEMBL
MGC_CLONE MGC:108744 IMAGE-MGC_LOAD
  MGC:156672 IMAGE-MGC_LOAD
  MGC:93581 IMAGE-MGC_LOAD
NCBI Gene 25284 ENTREZGENE
PANTHER ALPHA-METHYLACYL-COA RACEMASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUCCINYL-COA--D-CITRAMALATE COA-TRANSFERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CoA_transf_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Amacr PhenoGen
RatGTEx ENSRNOG00000018662 RatGTEx
  ENSRNOG00055025508 RatGTEx
  ENSRNOG00060021618 RatGTEx
  ENSRNOG00065020908 RatGTEx
Superfamily-SCOP SSF89796 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC229699
UniProt A6KJS2 ENTREZGENE, UniProtKB/TrEMBL
  AMACR_RAT UniProtKB/Swiss-Prot
  G3V8F9 ENTREZGENE, UniProtKB/TrEMBL
  O09176 ENTREZGENE
  P70473 ENTREZGENE
  Q5BK88_RAT UniProtKB/TrEMBL
  Q7TP08_RAT UniProtKB/TrEMBL
UniProt Secondary O09176 UniProtKB/Swiss-Prot
  Q68FY5 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2001-06-22 Amacr  alpha-methylacyl-CoA racemase      Symbol and Name updated to reflect Human and Mouse nomenclature 67952 APPROVED
2001-06-22 1-Mar  Methylacyl-CoA racemase alpha      Symbol and Name withdrawn 67952 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_process involved in racemization of 2-methyl-branched fatty acid coa esters and responsible for the conversion of pristanoyl-coa and c27-bile acyl-coas to their (s)-stereoisomers 724707
gene_process has a role in drug metabolism as well as probably in lipid metabolism 724707