Mapk4 (mitogen-activated protein kinase 4) - Rat Genome Database

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Gene: Mapk4 (mitogen-activated protein kinase 4) Rattus norvegicus
Analyze
Symbol: Mapk4
Name: mitogen-activated protein kinase 4
RGD ID: 3047
Description: Predicted to enable protein dimerization activity; protein kinase binding activity; and protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to be active in cytoplasm and nucleus. Orthologous to human MAPK4 (mitogen-activated protein kinase 4); INTERACTS WITH 1-naphthyl isothiocyanate; 3,4-methylenedioxymethamphetamine; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ERK-4; extracellular signal-regulated kinase 4; MAP kinase 4; MAP kinase isoform p63; MAPK 4; mitogen activated protein kinase 4; MNK2; p63-MAPK
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81869,788,058 - 69,937,524 (-)NCBIGRCr8
mRatBN7.21867,512,805 - 67,661,271 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1867,512,807 - 67,661,842 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1869,620,897 - 69,669,673 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01870,295,745 - 70,344,543 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01868,160,877 - 68,209,680 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01869,894,692 - 70,043,634 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1869,894,684 - 69,944,632 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01869,038,436 - 69,087,394 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41870,707,645 - 70,755,517 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11870,784,791 - 70,828,233 (-)NCBI
Celera1865,696,152 - 65,744,928 (-)NCBICelera
Cytogenetic Map18q12.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA,ISO,ISS)
nucleus  (IBA,IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Isolation of a cDNA encoding the rat MAP-kinase homolog of human p63mapk. Garcia JI, etal., Mamm Genome 1996 Nov;7(11):810-4.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12777378   PMID:16973613  


Genomics

Comparative Map Data
Mapk4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81869,788,058 - 69,937,524 (-)NCBIGRCr8
mRatBN7.21867,512,805 - 67,661,271 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1867,512,807 - 67,661,842 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1869,620,897 - 69,669,673 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01870,295,745 - 70,344,543 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01868,160,877 - 68,209,680 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01869,894,692 - 70,043,634 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1869,894,684 - 69,944,632 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01869,038,436 - 69,087,394 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41870,707,645 - 70,755,517 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11870,784,791 - 70,828,233 (-)NCBI
Celera1865,696,152 - 65,744,928 (-)NCBICelera
Cytogenetic Map18q12.2NCBI
MAPK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381850,559,612 - 50,731,826 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1850,560,087 - 50,731,826 (+)EnsemblGRCh38hg38GRCh38
GRCh371848,086,457 - 48,258,196 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361846,340,482 - 46,512,194 (+)NCBINCBI36Build 36hg18NCBI36
Build 341846,443,835 - 46,512,189NCBI
Celera1844,943,273 - 45,114,970 (+)NCBICelera
Cytogenetic Map18q21.1-q21.2NCBI
HuRef1844,941,139 - 45,112,864 (+)NCBIHuRef
CHM1_11848,082,055 - 48,253,737 (+)NCBICHM1_1
T2T-CHM13v2.01850,761,375 - 50,933,569 (+)NCBIT2T-CHM13v2.0
Mapk4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391874,061,557 - 74,198,643 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1874,061,557 - 74,198,430 (-)EnsemblGRCm39 Ensembl
GRCm381873,928,486 - 74,065,434 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1873,928,486 - 74,065,359 (-)EnsemblGRCm38mm10GRCm38
MGSCv371874,088,140 - 74,224,603 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361874,053,858 - 74,190,298 (-)NCBIMGSCv36mm8
Celera1875,153,306 - 75,290,462 (-)NCBICelera
Cytogenetic Map18E2NCBI
cM Map1850.31NCBI
Mapk4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540235,616,701 - 35,672,035 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540235,521,398 - 35,671,977 (+)NCBIChiLan1.0ChiLan1.0
MAPK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21768,084,494 - 68,256,160 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11853,777,098 - 53,948,764 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01843,937,446 - 44,108,709 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11847,284,492 - 47,455,477 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1847,383,072 - 47,455,477 (+)Ensemblpanpan1.1panPan2
MAPK4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1780,654,500 - 80,801,212 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl780,744,313 - 80,821,267 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha780,065,812 - 80,213,476 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0780,742,157 - 80,890,788 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl780,833,686 - 80,911,359 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1780,455,019 - 80,602,388 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0780,485,405 - 80,633,823 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0780,773,177 - 80,921,788 (+)NCBIUU_Cfam_GSD_1.0
Mapk4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494437,297,344 - 37,442,930 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649712,536,015 - 12,588,524 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649712,536,375 - 12,591,477 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1100,107,935 - 100,291,585 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11100,107,429 - 100,291,594 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21110,082,138 - 110,155,094 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAPK4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11830,235,915 - 30,406,684 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1830,235,794 - 30,406,664 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660504,367,333 - 4,543,211 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mapk4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477814,106,920 - 14,267,870 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477814,106,931 - 14,267,794 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mapk4
1704 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:222
Count of miRNA genes:140
Interacting mature miRNAs:156
Transcripts:ENSRNOT00000020851, ENSRNOT00000047271
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)185253976376104388Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)185253976376104388Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)184852004483828827Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)185253976376104388Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)185253976376104388Rat
61384Bp48Blood pressure QTL 4819.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186062231177209844Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185253976376104388Rat
1298072Cia26Collagen induced arthritis QTL 263.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)185470976983828827Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)185253976376104388Rat
6903353Bp353Blood pressure QTL 3532.8arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)185979647883828827Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185146473383218561Rat
6903356Bp354Blood pressure QTL 3544.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185979647883828827Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183587072380870723Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184334502283828827Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184664067583828827Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)185253976369140759Rat
2300157Bmd66Bone mineral density QTL 6613.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
738005Anxrr11Anxiety related response QTL 113.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)183003981375039813Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183139332077209694Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184664067583828827Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184664067583828827Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)185971241776477814Rat
2293704Bss35Bone structure and strength QTL 354.590.0002femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)182896485373964853Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)182979296574792965Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182557098570570985Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)182979296574792965Rat
1331770Bp234Blood pressure QTL 2343.807arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185979647871893566Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)184852004483828827Rat
2300177Bmd65Bone mineral density QTL 6519.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
1598826Anxrr20Anxiety related response QTL 203.04body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)184143297183828827Rat
2301969Bp324Blood pressure QTL 3244.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185971241776477814Rat
631675Iddm15Insulin dependent diabetes mellitus QTL 15urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)186062231177209844Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183135940883218561Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)185253976376104388Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183135940870263868Rat
724542Kidm2Kidney mass QTL 22.6kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)185917211583828827Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183819245583192455Rat
1359020Ppulsi2Prepulse inhibition QTL 22.71prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)185229287573997283Rat
2312600Bp341Blood pressure QTL 3410.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185933040970263868Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)182979296574792965Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182979296574792965Rat

Markers in Region
RH130297  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21867,512,921 - 67,513,120 (+)MAPPERmRatBN7.2
Rnor_6.01869,894,807 - 69,895,005NCBIRnor6.0
Rnor_5.01869,038,551 - 69,038,749UniSTSRnor5.0
RGSC_v3.41870,706,460 - 70,706,658UniSTSRGSC3.4
Celera1865,696,267 - 65,696,465UniSTS
RH 3.4 Map18686.8UniSTS
Cytogenetic Map18q12.2UniSTS
BF387492  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21867,555,397 - 67,555,559 (+)MAPPERmRatBN7.2
Rnor_6.01869,937,459 - 69,937,620NCBIRnor6.0
Rnor_5.01869,081,203 - 69,081,364UniSTSRnor5.0
RGSC_v3.41870,748,930 - 70,749,091UniSTSRGSC3.4
Celera1865,738,737 - 65,738,898UniSTS
RH 3.4 Map18675.6UniSTS
Cytogenetic Map18q12.2UniSTS
BF405832  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21867,555,512 - 67,555,689 (+)MAPPERmRatBN7.2
Rnor_6.01869,937,574 - 69,937,750NCBIRnor6.0
Rnor_5.01869,081,318 - 69,081,494UniSTSRnor5.0
RGSC_v3.41870,749,045 - 70,749,221UniSTSRGSC3.4
Celera1865,738,852 - 65,739,028UniSTS
RH 3.4 Map18683.8UniSTS
Cytogenetic Map18q12.2UniSTS
BF387441  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21867,515,043 - 67,515,226 (+)MAPPERmRatBN7.2
Rnor_6.01869,896,929 - 69,897,111NCBIRnor6.0
Rnor_5.01869,040,673 - 69,040,855UniSTSRnor5.0
RGSC_v3.41870,708,582 - 70,708,764UniSTSRGSC3.4
Celera1865,698,389 - 65,698,571UniSTS
RH 3.4 Map18681.0UniSTS
Cytogenetic Map18q12.2UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 68 11
Low 2 4 12 4 8 4 2 2 6 24 30 2
Below cutoff 1 35 24 16 11 16 6 9 11 9 6

Sequence


RefSeq Acc Id: ENSRNOT00000047271   ⟹   ENSRNOP00000050164
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1867,512,807 - 67,661,842 (-)Ensembl
Rnor_6.0 Ensembl1869,894,684 - 69,944,632 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000098156   ⟹   ENSRNOP00000083194
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1867,515,337 - 67,661,842 (-)Ensembl
RefSeq Acc Id: NM_019319   ⟹   NP_062192
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81869,788,060 - 69,836,838 (-)NCBI
mRatBN7.21867,512,807 - 67,561,589 (-)NCBI
Rnor_6.01869,894,692 - 69,943,650 (-)NCBI
Rnor_5.01869,038,436 - 69,087,394 (-)NCBI
Celera1865,696,152 - 65,744,928 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008772166   ⟹   XP_008770388
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81869,788,058 - 69,935,902 (-)NCBI
mRatBN7.21867,512,805 - 67,660,651 (-)NCBI
Rnor_6.01869,894,692 - 70,043,484 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008772167   ⟹   XP_008770389
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81869,788,058 - 69,937,524 (-)NCBI
mRatBN7.21867,512,805 - 67,661,271 (-)NCBI
Rnor_6.01869,894,692 - 70,043,634 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601014   ⟹   XP_017456503
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81869,788,058 - 69,935,357 (-)NCBI
mRatBN7.21867,512,805 - 67,660,219 (-)NCBI
Rnor_6.01869,894,692 - 70,043,484 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039097051   ⟹   XP_038952979
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81869,788,058 - 69,935,895 (-)NCBI
mRatBN7.21867,512,805 - 67,660,624 (-)NCBI
RefSeq Acc Id: XM_063277522   ⟹   XP_063133592
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81869,788,058 - 69,935,843 (-)NCBI
RefSeq Acc Id: XM_063277523   ⟹   XP_063133593
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81869,788,058 - 69,935,320 (-)NCBI
RefSeq Acc Id: XM_063277524   ⟹   XP_063133594
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81869,790,458 - 69,935,320 (-)NCBI
RefSeq Acc Id: XM_063277525   ⟹   XP_063133595
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81869,789,878 - 69,937,524 (-)NCBI
RefSeq Acc Id: NP_062192   ⟸   NM_019319
- UniProtKB: G3V9J9 (UniProtKB/TrEMBL),   A6KRD4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008770389   ⟸   XM_008772167
- Peptide Label: isoform X1
- UniProtKB: G3V9J9 (UniProtKB/TrEMBL),   A6KRD4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008770388   ⟸   XM_008772166
- Peptide Label: isoform X1
- UniProtKB: G3V9J9 (UniProtKB/TrEMBL),   A6KRD4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456503   ⟸   XM_017601014
- Peptide Label: isoform X1
- UniProtKB: G3V9J9 (UniProtKB/TrEMBL),   A6KRD4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000050164   ⟸   ENSRNOT00000047271
RefSeq Acc Id: XP_038952979   ⟸   XM_039097051
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000083194   ⟸   ENSRNOT00000098156
RefSeq Acc Id: XP_063133592   ⟸   XM_063277522
- Peptide Label: isoform X1
- UniProtKB: A6KRD4 (UniProtKB/TrEMBL),   G3V9J9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133593   ⟸   XM_063277523
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063133595   ⟸   XM_063277525
- Peptide Label: isoform X3
- UniProtKB: Q63454 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063133594   ⟸   XM_063277524
- Peptide Label: isoform X3
- UniProtKB: Q63454 (UniProtKB/Swiss-Prot)
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63454-F1-model_v2 AlphaFold Q63454 1-274 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3047 AgrOrtholog
BioCyc Gene G2FUF-7047 BioCyc
Ensembl Genes ENSRNOG00000015401 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000047271.6 UniProtKB/TrEMBL
  ENSRNOT00000098156.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAPK_ERK3/4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:54268 UniProtKB/TrEMBL
NCBI Gene 54268 ENTREZGENE
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MITOGEN-ACTIVATED PROTEIN KINASE 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mapk4 PhenoGen
PIRSF Integrin-linked_kinase UniProtKB/TrEMBL
PRINTS ERK3ERK4MAPK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015401 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZYT0_RAT UniProtKB/TrEMBL
  A6KRD4 ENTREZGENE, UniProtKB/TrEMBL
  G3V9J9 ENTREZGENE, UniProtKB/TrEMBL
  MK04_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Mapk4  mitogen-activated protein kinase 4    mitogen activated protein kinase 4  Name updated 1299863 APPROVED
2002-06-10 Mapk4  mitogen activated protein kinase 4      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in choroid plexus, hippocampus and lung 69881
gene_homology has 94.5% identity to human p63(MAPK) 69881