Mal (mal, T-cell differentiation protein) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Mal (mal, T-cell differentiation protein) Rattus norvegicus
Analyze
Symbol: Mal
Name: mal, T-cell differentiation protein
RGD ID: 3037
Description: A structural constituent of myelin sheath. Involved in myelination. Located in Schmidt-Lanterman incisure. Human ortholog(s) of this gene implicated in metachromatic leukodystrophy. Orthologous to human MAL (mal, T cell differentiation protein); INTERACTS WITH (20S)-20-hydroxypregn-4-en-3-one; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 17 kDa myelin vesicular protein; MAL protein gene; MALGENE; MVP17; myelin and lymphocyte protein; myelin and lymphocyte protein, T-cell differentiation protein; NS 3; T-lymphocyte maturation-associated protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83135,317,664 - 135,341,423 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3135,317,664 - 135,341,423 (-)EnsemblGRCr8
mRatBN7.23114,864,378 - 114,888,136 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3114,864,378 - 114,888,136 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3118,753,666 - 118,777,409 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03127,349,206 - 127,372,951 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03125,009,582 - 125,033,317 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03120,209,647 - 120,233,655 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3120,209,647 - 120,233,655 (-)Ensemblrn6Rnor6.0
Rnor_5.03127,099,278 - 127,123,286 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43115,166,671 - 115,190,432 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3113,699,325 - 113,723,029 (-)NCBICelera
RGSC_v3.13115,072,243 - 115,096,005 (-)NCBI
RH 3.4 Map3998.6RGD
Cytogenetic Map3q36NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(20S)-20-hydroxypregn-4-en-3-one  (EXP)
1,1-dichloroethene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-acetamidofluorene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
butanal  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chloroprene  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clozapine  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (EXP)
dichlorine  (EXP)
doxorubicin  (ISO)
Echimidine  (EXP)
endosulfan  (EXP)
ethanol  (EXP,ISO)
ethylparaben  (ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
furan  (EXP)
genistein  (EXP,ISO)
glycidol  (EXP)
graphite  (EXP)
Heliotrine  (EXP)
ibuprofen  (ISO)
irinotecan  (ISO)
ketamine  (EXP)
L-methionine  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
nitrofen  (EXP)
olanzapine  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraquat  (EXP)
pentanal  (ISO)
perfluorobutyric acid  (EXP)
perfluorooctanoic acid  (EXP)
phencyclidine  (ISO)
phenobarbital  (ISO)
progesterone  (ISO)
propanal  (ISO)
rofecoxib  (ISO)
senecionine  (EXP)
Senkirkine  (EXP)
serpentine asbestos  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sulindac sulfide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetracycline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
Tributyltin oxide  (EXP)
trichloroethene  (EXP)
Tungsten carbide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rafts in adult peripheral nerve myelin contain major structural myelin proteins and myelin and lymphocyte protein (MAL) and CD59 as specific markers. Erne B, etal., J Neurochem 2002 Aug;82(3):550-62.
2. rMAL is a glycosphingolipid-associated protein of myelin and apical membranes of epithelial cells in kidney and stomach. Frank M, etal., J Neurosci 1998 Jul 1;18(13):4901-13.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Cloning and characterization of MVP17: a developmentally regulated myelin protein in oligodendrocytes. Kim T, etal., J Neurosci Res 1995 Oct 15;42(3):413-22.
6. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Specific downregulation and mistargeting of the lipid raft-associated protein MAL in a glycolipid storage disorder. Saravanan K, etal., Neurobiol Dis 2004 Jul;16(2):396-406.
13. The raft-associated protein MAL is required for maintenance of proper axon--glia interactions in the central nervous system. Schaeren-Wiemers N, etal., J Cell Biol 2004 Aug 30;166(5):731-42.
14. Characterization of a rat gene, rMAL, encoding a protein with four hydrophobic domains in central and peripheral myelin. Schaeren-Wiemers N, etal., J Neurosci 1995 Aug;15(8):5753-64.
15. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:8132541   PMID:11032882   PMID:12477932   PMID:12776198   PMID:15489334   PMID:17151798   PMID:20861303   PMID:21732912   PMID:22323295   PMID:23196718   PMID:23264465   PMID:24878628  
PMID:25993478  


Genomics

Comparative Map Data
Mal
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83135,317,664 - 135,341,423 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3135,317,664 - 135,341,423 (-)EnsemblGRCr8
mRatBN7.23114,864,378 - 114,888,136 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3114,864,378 - 114,888,136 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3118,753,666 - 118,777,409 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03127,349,206 - 127,372,951 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03125,009,582 - 125,033,317 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03120,209,647 - 120,233,655 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3120,209,647 - 120,233,655 (-)Ensemblrn6Rnor6.0
Rnor_5.03127,099,278 - 127,123,286 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43115,166,671 - 115,190,432 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3113,699,325 - 113,723,029 (-)NCBICelera
RGSC_v3.13115,072,243 - 115,096,005 (-)NCBI
RH 3.4 Map3998.6RGD
Cytogenetic Map3q36NCBI
MAL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38295,025,708 - 95,053,992 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl295,025,677 - 95,053,992 (+)Ensemblhg38GRCh38
GRCh37295,691,453 - 95,719,737 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36295,055,206 - 95,083,462 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34295,113,352 - 95,141,609NCBI
Celera290,041,551 - 90,070,642 (+)NCBICelera
Cytogenetic Map2q11.1ENTREZGENE
HuRef289,720,233 - 89,748,565 (+)NCBIHuRef
CHM1_1295,695,693 - 95,724,010 (+)NCBICHM1_1
T2T-CHM13v2.0295,532,209 - 95,560,493 (+)NCBIT2T-CHM13v2.0
Mal
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392127,475,146 - 127,498,615 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2127,475,146 - 127,498,615 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm382127,633,226 - 127,656,695 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2127,633,226 - 127,656,695 (-)Ensemblmm10GRCm38
MGSCv372127,458,962 - 127,482,431 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362127,324,671 - 127,347,724 (-)NCBIMGSCv36mm8
Celera2128,878,634 - 128,902,174 (-)NCBICelera
Cytogenetic Map2F1NCBI
cM Map262.06NCBI
Mal
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554703,372,577 - 3,398,836 (+)Ensembl
ChiLan1.0NW_0049554703,372,577 - 3,396,868 (+)NCBIChiLan1.0ChiLan1.0
MAL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21233,243,632 - 33,271,455 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A33,246,391 - 33,274,217 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A104,355,020 - 104,382,849 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A95,930,298 - 95,956,573 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A95,930,315 - 95,956,573 (+)EnsemblpanPan2panpan1.1
MAL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11734,977,298 - 35,000,690 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1734,977,298 - 35,001,349 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1734,746,124 - 34,769,084 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01735,748,374 - 35,771,352 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1735,748,374 - 35,772,227 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11734,876,424 - 34,899,422 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01734,945,386 - 34,968,323 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01735,154,731 - 35,177,728 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mal
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440507383,398 - 89,966 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493718563,274 - 68,187 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493718562,807 - 68,205 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl346,181,555 - 46,242,047 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1346,223,610 - 46,242,306 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2348,182,689 - 48,200,460 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11466,521 - 92,476 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1466,610 - 93,588 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041167,449,824 - 167,476,696 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mal
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247491,853,838 - 1,879,590 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247491,854,177 - 1,877,054 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Mal
140 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:588
Count of miRNA genes:259
Interacting mature miRNAs:319
Transcripts:ENSRNOT00000020870
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3102200529115665732Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)396127817115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)384091273129091273Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)373376539118376539Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3112287552135181505Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat

Markers in Region
RH134160  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23114,865,728 - 114,865,909 (+)MAPPERmRatBN7.2
Rnor_6.03120,210,998 - 120,211,178NCBIRnor6.0
Rnor_5.03127,121,755 - 127,121,935UniSTSRnor5.0
RGSC_v3.43115,168,022 - 115,168,202UniSTSRGSC3.4
Celera3113,700,676 - 113,700,856UniSTS
RH 3.4 Map3996.4UniSTS
Cytogenetic Map3q36UniSTS
RH142312  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23114,865,900 - 114,866,085 (+)MAPPERmRatBN7.2
Rnor_6.03120,211,170 - 120,211,354NCBIRnor6.0
Rnor_5.03127,121,579 - 127,121,763UniSTSRnor5.0
RGSC_v3.43115,168,194 - 115,168,378UniSTSRGSC3.4
Celera3113,700,848 - 113,701,032UniSTS
RH 3.4 Map3998.6UniSTS
Cytogenetic Map3q36UniSTS
RH134822  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr83135,317,694 - 135,317,904 (+)Marker Load Pipeline
mRatBN7.23114,864,408 - 114,864,618 (+)MAPPERmRatBN7.2
Rnor_6.03120,209,678 - 120,209,887NCBIRnor6.0
Rnor_5.03127,123,046 - 127,123,255UniSTSRnor5.0
RGSC_v3.43115,166,702 - 115,166,911UniSTSRGSC3.4
Celera3113,699,356 - 113,699,565UniSTS
RH 3.4 Map3987.1UniSTS
Cytogenetic Map3q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 146 91 90 59 92 59 6 356 192 11 125 81 92 31 12 12

Sequence


Ensembl Acc Id: ENSRNOT00000020870   ⟹   ENSRNOP00000020870
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3135,317,664 - 135,341,423 (-)Ensembl
mRatBN7.2 Ensembl3114,864,378 - 114,888,136 (-)Ensembl
Rnor_6.0 Ensembl3120,209,647 - 120,233,655 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114128   ⟹   ENSRNOP00000081217
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3135,317,664 - 135,341,346 (-)Ensembl
mRatBN7.2 Ensembl3114,864,378 - 114,888,059 (-)Ensembl
RefSeq Acc Id: NM_012798   ⟹   NP_036930
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83135,317,664 - 135,341,423 (-)NCBI
mRatBN7.23114,864,378 - 114,888,136 (-)NCBI
Rnor_6.03120,209,647 - 120,233,655 (-)NCBI
Rnor_5.03127,099,278 - 127,123,286 (+)NCBI
RGSC_v3.43115,166,671 - 115,190,432 (-)RGD
Celera3113,699,325 - 113,723,029 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036930 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC52366 (Get FASTA)   NCBI Sequence Viewer  
  AAH85755 (Get FASTA)   NCBI Sequence Viewer  
  CAA57903 (Get FASTA)   NCBI Sequence Viewer  
  EDL80124 (Get FASTA)   NCBI Sequence Viewer  
  EDL80125 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000020870
  ENSRNOP00000020870.1
GenBank Protein Q64349 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036930   ⟸   NM_012798
- UniProtKB: Q64349 (UniProtKB/Swiss-Prot),   A6HQ23 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000020870   ⟸   ENSRNOT00000020870
Ensembl Acc Id: ENSRNOP00000081217   ⟸   ENSRNOT00000114128
Protein Domains
MARVEL

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64349-F1-model_v2 AlphaFold Q64349 1-153 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692408
Promoter ID:EPDNEW_R2932
Type:multiple initiation site
Name:Mal_1
Description:mal, T-cell differentiation protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03120,233,655 - 120,233,715EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3037 AgrOrtholog
BioCyc Gene G2FUF-47972 BioCyc
Ensembl Genes ENSRNOG00000015445 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000020870 ENTREZGENE
  ENSRNOT00000020870.3 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7108924 IMAGE-MGC_LOAD
InterPro MAL UniProtKB/Swiss-Prot
  Marvel UniProtKB/Swiss-Prot
  MARVEL-CKLF_proteins UniProtKB/Swiss-Prot
KEGG Report rno:25263 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93584 IMAGE-MGC_LOAD
NCBI Gene 25263 ENTREZGENE
PANTHER MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN UniProtKB/Swiss-Prot
  MYELIN AND LYMPHOCYTE PROTEIN UniProtKB/Swiss-Prot
Pfam MARVEL UniProtKB/Swiss-Prot
PhenoGen Mal PhenoGen
PRINTS MALPROTEIN UniProtKB/Swiss-Prot
PROSITE MARVEL UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015445 RatGTEx
TIGR TC205636
UniProt A0A8I5ZSH2_RAT UniProtKB/TrEMBL
  A6HQ23 ENTREZGENE, UniProtKB/TrEMBL
  A6HQ24_RAT UniProtKB/TrEMBL
  MAL_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-24 Mal  mal, T-cell differentiation protein  Mal  myelin and lymphocyte protein, T-cell differentiation protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Mal  myelin and lymphocyte protein, T-cell differentiation protein    myelin and lymphocyte protein  Name updated 1299863 APPROVED
2002-11-06 Mal  myelin and lymphocyte protein    MAL protein gene  Name updated 625702 APPROVED
2002-06-10 Mal  MAL protein gene      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expression is highest during myelination 729172
gene_expression exclusively expressed in white and gray matter oligodendrocytes in the CNS and in myelinating Schwann cells in peripheral nerves 729172