Smad2 (SMAD family member 2) - Rat Genome Database

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Gene: Smad2 (SMAD family member 2) Rattus norvegicus
Symbol: Smad2
Name: SMAD family member 2
RGD ID: 3031
Description: Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; SMAD binding activity; and enzyme binding activity. Predicted to contribute to DNA binding activity and DNA-binding transcription factor activity. Involved in several processes, including cell surface receptor protein serine/threonine kinase signaling pathway; cellular response to glucose stimulus; and regulation of gene expression. Part of protein-containing complex. Used to study hepatocellular carcinoma. Biomarker of colon cancer and myocardial infarction. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome; Lynch syndrome; cervical cancer; and ovarian cancer. Orthologous to human SMAD2 (SMAD family member 2); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; altered transforming growth factor-beta Smad dependent signaling pathway; colorectal cancer pathway; INTERACTS WITH (S)-nicotine; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MAD (mothers against decapentaplegic Drosophila) homolog 2; MAD (mothers against decapentaplegic, Drosophila) homolog 2; MAD homolog 2; MAD homolog 2 (Drosophila); mad-related protein 2; Madh2; MGC156656; mothers against decapentaplegic homolog 2; mothers against DPP homolog 2; SMAD 2
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Mcs34
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81872,124,792 - 72,193,345 (+)NCBIGRCr8
mRatBN7.21869,849,884 - 69,918,926 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1869,850,377 - 69,912,323 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1871,959,978 - 72,021,908 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01872,629,252 - 72,691,176 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01870,485,797 - 70,547,727 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01872,550,107 - 72,612,078 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1872,550,219 - 72,612,078 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01871,672,879 - 71,735,128 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41873,180,520 - 73,241,707 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11873,253,792 - 73,314,980 (+)NCBI
Celera1868,381,756 - 68,443,610 (+)NCBICelera
Cytogenetic Map18q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(20S)-ginsenoside Rg3  (ISO)
(R)-lipoic acid  (ISO)
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
1-naphthyl isothiocyanate  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methoxy-17beta-estradiol  (EXP)
2-methoxyethanol  (EXP)
3,4-dihydroxybenzaldehyde  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-nitrophenol  (ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
aconitic acid  (ISO)
acteoside  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
amlodipine  (ISO)
ammonium chloride  (EXP)
Ammothamnine  (ISO)
andrographolide  (ISO)
anthocyanin  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
atrazine  (ISO)
bellidifolin  (EXP)
benazepril  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-aminopropionitrile  (EXP)
beta-D-glucosamine  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP)
camostat  (ISO)
carbofuran  (EXP)
carnosine  (EXP)
ceruletide  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
chromium atom  (EXP)
chrysin  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
crocin-1  (EXP)
curcumin  (EXP)
cyclosporin A  (ISO)
cytochalasin D  (ISO)
D-glucose  (EXP,ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenziodolium  (EXP)
diethylstilbestrol  (ISO)
dimethyl sulfoxide  (ISO)
diminazene diaceturate  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
enalapril  (EXP)
endosulfan  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
ethanol  (EXP)
etoposide  (ISO)
farrerol  (EXP)
folic acid  (ISO)
FR900359  (ISO)
galangin  (ISO)
genistein  (EXP)
gentamycin  (EXP)
glucose  (EXP,ISO)
heptachlor  (ISO)
hispidin  (ISO)
Honokiol  (EXP,ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (ISO)
irbesartan  (EXP)
Isoangustone A  (ISO)
isoprenaline  (EXP)
isorhamnetin  (ISO)
ivermectin  (ISO)
leptomycin B  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
LY-2157299  (ISO)
LY294002  (ISO)
melphalan  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methyl beta-cyclodextrin  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
mitoxantrone  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N-acetyl-L-cysteine  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
niclosamide  (ISO)
nicotine  (EXP)
nitrofen  (ISO)
ochratoxin A  (ISO)
oridonin  (ISO)
osthole  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP)
paraquat  (EXP,ISO)
paricalcitol  (EXP)
patulin  (EXP)
phenobarbital  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phloroglucinol  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
Phyllanthin  (ISO)
platycodin D  (ISO)
procymidone  (EXP)
progesterone  (ISO)
propiconazole  (ISO)
propofol  (ISO)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
ramipril  (EXP)
resveratrol  (EXP,ISO)
rutin  (EXP)
salubrinal  (ISO)
SB 203580  (EXP)
SB 431542  (EXP,ISO)
serpentine asbestos  (ISO)
sevoflurane  (ISO)
silver(1+) nitrate  (ISO)
simvastatin  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium nitrite  (EXP)
Soman  (EXP)
sorafenib  (ISO)
streptozocin  (EXP,ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
testosterone enanthate  (EXP)
tetrachloromethane  (EXP,ISO)
tetramethylpyrazine  (ISO)
theobromine  (IEP)
theophylline  (ISO)
thioacetamide  (EXP)
Thrombin  (ISO)
tolfenamic acid  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
verapamil  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activin receptor signaling pathway  (IBA,ISO)
adrenal gland development  (IDA)
anatomical structure morphogenesis  (IBA)
anterior/posterior pattern specification  (ISO,ISS)
aortic valve morphogenesis  (ISO)
cell differentiation  (IBA)
cell fate commitment  (ISO,ISS)
cell population proliferation  (ISO)
cellular response to glucose stimulus  (IEP)
cellular response to transforming growth factor beta stimulus  (IEP)
determination of left/right asymmetry in lateral mesoderm  (ISO)
developmental growth  (ISO)
embryonic cranial skeleton morphogenesis  (ISO)
embryonic foregut morphogenesis  (ISO)
embryonic pattern specification  (ISO)
endocardial cushion morphogenesis  (ISO)
endoderm development  (ISO)
endoderm formation  (ISO)
gastrulation  (ISO)
heart development  (ISO)
in utero embryonic development  (ISO)
insulin secretion  (ISO)
intracellular signal transduction  (ISO,ISS)
lung development  (ISO)
mesoderm formation  (ISO,ISS)
negative regulation of cell population proliferation  (IMP)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of gene expression  (ISO)
nodal signaling pathway  (ISO)
odontoblast differentiation  (ISO,ISS)
organ growth  (ISO)
pancreas development  (ISO)
paraxial mesoderm morphogenesis  (ISO,ISS)
pattern specification process  (ISO)
pericardium development  (ISO)
positive regulation of BMP signaling pathway  (ISO)
positive regulation of DNA-templated transcription  (ISO,ISS)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of transcription by RNA polymerase II  (IBA,IMP,ISO,ISS)
post-embryonic development  (ISO)
pulmonary valve morphogenesis  (ISO)
regulation of DNA-templated transcription  (IEA)
regulation of transforming growth factor beta receptor signaling pathway  (ISO)
response to cholesterol  (ISO)
response to glucose  (ISO)
response to transforming growth factor beta  (ISO)
secondary palate development  (ISO)
signal transduction involved in regulation of gene expression  (IMP)
SMAD protein signal transduction  (IBA,IMP,ISO)
transforming growth factor beta receptor signaling pathway  (IBA,IMP,ISO,ISS)
ureteric bud development  (ISO)
zygotic specification of dorsal/ventral axis  (ISO)

Cellular Component


References - curated
# Reference Title Reference Citation
1. Molecular mechanisms of TGF beta receptor-triggered signaling cascades rapidly induced by the calcineurin inhibitors cyclosporin A and FK506. Akool el-S, etal., J Immunol. 2008 Aug 15;181(4):2831-45.
2. Gene expression correlating with response to paclitaxel in ovarian carcinoma xenografts. Bani MR, etal., Mol Cancer Ther. 2004 Feb;3(2):111-21.
3. Cardioprotective role of growth/differentiation factor 1 in post-infarction left ventricular remodelling and dysfunction. Bao MW, etal., J Pathol. 2015 Jul;236(3):360-72. doi: 10.1002/path.4523. Epub 2015 Mar 30.
4. The development of a mouse model of ovarian endosalpingiosis. Bristol-Gould SK, etal., Endocrinology. 2005 Dec;146(12):5228-36. Epub 2005 Sep 1.
5. Transforming growth factor-beta pathway in human renal cell carcinoma and surrounding normal-appearing renal parenchyma. Cardillo MR, etal., Anal Quant Cytol Histol. 2001 Apr;23(2):109-17.
6. Cited2 modulates TGF-beta-mediated upregulation of MMP9. Chou YT, etal., Oncogene. 2006 Sep 7;25(40):5547-60. Epub 2006 Apr 17.
7. Ovarian follicle populations of the rat express TGF-beta signalling pathways. Drummond AE, etal., Mol Cell Endocrinol. 2003 Apr 28;202(1-2):53-7.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Pharmacological application of caffeine inhibits TGF-beta-stimulated connective tissue growth factor expression in hepatocytes via PPARgamma and SMAD2/3-dependent pathways. Gressner OA, etal., J Hepatol. 2008 Nov;49(5):758-67. Epub 2008 Apr 30.
10. Interaction between angiotensin II and Smad proteins in fibroblasts in failing heart and in vitro. Hao J, etal., Am J Physiol Heart Circ Physiol. 2000 Dec;279(6):H3020-30.
11. [Changes in TGF-beta1/Smads signaling pathway in rats with chemical hepatocarcinogenesis]. Hua YP, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2008 Oct;28(10):1848-52.
12. Poly(ADP-ribose) polymerase 1 is indispensable for transforming growth factor-beta Induced Smad3 activation in vascular smooth muscle cell. Huang D, etal., PLoS One. 2011;6(10):e27123. doi: 10.1371/journal.pone.0027123. Epub 2011 Oct 31.
13. Effect of wound type on Smad 2 and 4 translocation. Hutcheon AE, etal., Invest Ophthalmol Vis Sci. 2005 Jul;46(7):2362-8.
14. Overexpression of Smad2 and colocalization with TGF-beta1 in human pancreatic cancer. Kleeff J, etal., Dig Dis Sci. 1999 Sep;44(9):1793-802.
15. Lefty1 Ameliorates Post-infarction Fibrosis by Suppressing p-Smad2 and p-ERK1/2 Signaling Pathways. Li CY, etal., J Cardiovasc Transl Res. 2021 Aug;14(4):636-646. doi: 10.1007/s12265-020-10089-2. Epub 2021 Jan 6.
16. Expression of Smad2 and Smad4, transforming growth factor-beta signal transducers in rat endometrium during the estrous cycle, pre-, and peri-implantation. Lin HY, etal., Anim Reprod Sci 2004 Feb;80(3-4):303-16.
17. cAMP inhibits transforming growth factor-beta-stimulated collagen synthesis via inhibition of extracellular signal-regulated kinase 1/2 and Smad signaling in cardiac fibroblasts. Liu X, etal., Mol Pharmacol. 2006 Dec;70(6):1992-2003. Epub 2006 Sep 7.
18. Expression and location of Smad2, 4 mRNAs during and after liver fibrogenesis of rats. Liu Y, etal., World J Gastroenterol. 2006 Mar 14;12(10):1577-82.
19. Loss of expression, and mutations of Smad 2 and Smad 4 in human cervical cancer. Maliekal TT, etal., Oncogene. 2003 Jul 31;22(31):4889-97.
20. TGFbeta in Cancer. Massagué J, Cell. 2008 Jul 25;134(2):215-30. doi: 10.1016/j.cell.2008.07.001.
21. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
22. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
23. Altered expression of Smad family members in injured motor neurons of rat. Okuyama N, etal., Brain Res. 2007 Feb 9;1132(1):36-41. Epub 2006 Dec 12.
24. Expression and localization of the transforming growth factor-beta type I receptor and Smads in preneoplastic lesions during chemical hepatocarcinogenesis in rats. Park do Y, etal., J Korean Med Sci 2003 Aug;18(4):510-9.
25. Expression and intracellular localization of Smad proteins in human endometrial cancer. Piestrzeniewicz-Ulanska D, etal., Oncol Rep. 2003 Sep-Oct;10(5):1539-44.
26. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
27. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
28. GOA pipeline RGD automated data pipeline
29. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
30. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
31. Mutation analysis of SMAD2, SMAD3, and SMAD4 genes in hereditary non-polyposis colorectal. Roth S, etal., J Med Genet. 2000 Apr;37(4):298-300.
32. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Shi Y and Massague J, Cell. 2003 Jun 13;113(6):685-700.
33. Oncopreventive effects of theanine and theobromine on dimethylhydrazine-induced colon cancer model. Shojaei-Zarghani S, etal., Biomed Pharmacother. 2021 Feb;134:111140. doi: 10.1016/j.biopha.2020.111140. Epub 2020 Dec 24.
34. Novel roles of Akt and mTOR in suppressing TGF-beta/ALK5-mediated Smad3 activation. Song K, etal., EMBO J. 2006 Jan 11;25(1):58-69. Epub 2005 Dec 15.
35. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
36. Smad2 and Smad3 play different roles in rat hepatic stellate cell function and alpha-smooth muscle actin organization. Uemura M, etal., Mol Biol Cell. 2005 Sep;16(9):4214-24. Epub 2005 Jun 29.
37. MicroRNA-323-3p inhibits cell invasion and metastasis in pancreatic ductal adenocarcinoma via direct suppression of SMAD2 and SMAD3. Wang C, etal., Oncotarget. 2016 Mar 22;7(12):14912-24. doi: 10.18632/oncotarget.7482.
38. MicroRNA-31/184 is involved in transforming growth factor-β-induced apoptosis in A549 human alveolar adenocarcinoma cells. Wang CJ, etal., Life Sci. 2020 Feb 1;242:117205. doi: 10.1016/j.lfs.2019.117205. Epub 2019 Dec 23.
39. Analysis of specific gene mutations in the transforming growth factor-beta signal transduction pathway in human ovarian cancer. Wang D, etal., Cancer Res. 2000 Aug 15;60(16):4507-12.
40. Activin signal transduction in the fetal rat adrenal gland and in human H295R cells. Wang EY, etal., J Endocrinol 2003 Jul;178(1):137-48.
41. Alterations of Smad signaling in human breast carcinoma are associated with poor outcome: a tissue microarray study. Xie W, etal., Cancer Res. 2002 Jan 15;62(2):497-505.
42. Stage-specific expression of Smad2 and Smad3 during folliculogenesis. Xu J, etal., Biol Reprod 2002 Jun;66(6):1571-8.
43. TGF-beta signaling alterations and susceptibility to colorectal cancer. Xu Y and Pasche B, Hum Mol Genet. 2007 Apr 15;16 Spec No 1:R14-20.
44. Altered gene expression profile in mouse bladder cancers induced by hydroxybutyl(butyl)nitrosamine. Yao R, etal., Neoplasia. 2004 Sep-Oct;6(5):569-77.
45. Lefty-1 inhibits renal epithelial-mesenchymal transition by antagonizing the TGF-β/Smad signaling pathway. Zhang L, etal., J Mol Histol. 2020 Feb;51(1):77-87. doi: 10.1007/s10735-020-09859-8. Epub 2020 Feb 17.
46. Involvement of Smad proteins in the differentiation of pancreatic AR42J cells induced by activin A. Zhang YQ, etal., Diabetologia 1999 Jun;42(6):719-27.
47. Regulation of Smad3 expression in bleomycin-induced pulmonary fibrosis: a negative feedback loop of TGF-beta signaling. Zhao Y and Geverd DA, Biochem Biophys Res Commun 2002 Jun 7;294(2):319-23.
Additional References at PubMed
PMID:8752209   PMID:8980228   PMID:9111321   PMID:9256479   PMID:9311995   PMID:9389648   PMID:9436979   PMID:9529255   PMID:9702197   PMID:9702198   PMID:9732876   PMID:10670756  
PMID:11160896   PMID:11418863   PMID:11557747   PMID:11937490   PMID:12411310   PMID:12477932   PMID:12842913   PMID:14507671   PMID:14555988   PMID:14656760   PMID:14691138   PMID:14749725  
PMID:14982932   PMID:15084457   PMID:15126250   PMID:15150278   PMID:15183723   PMID:15231848   PMID:15253713   PMID:15282343   PMID:15326485   PMID:15489334   PMID:15657445   PMID:16751101  
PMID:16806156   PMID:16931807   PMID:17038494   PMID:17159989   PMID:17239842   PMID:17392319   PMID:17438144   PMID:17545585   PMID:17568773   PMID:17849440   PMID:17878231   PMID:18057996  
PMID:18095586   PMID:18212064   PMID:18287512   PMID:18287961   PMID:18548003   PMID:18611337   PMID:18679024   PMID:18832382   PMID:18990706   PMID:19122240   PMID:19197123   PMID:19366699  
PMID:19555739   PMID:19941153   PMID:20226149   PMID:20375011   PMID:20676968   PMID:20818498   PMID:20874717   PMID:20979836   PMID:21144460   PMID:21300867   PMID:21429339   PMID:21468608  
PMID:21599657   PMID:21724602   PMID:21804025   PMID:21822279   PMID:21828274   PMID:22338217   PMID:22362485   PMID:23064763   PMID:23152446   PMID:23291610   PMID:23390484   PMID:23403244  
PMID:23516280   PMID:24273150   PMID:24290497   PMID:24329763   PMID:24500776   PMID:24530353   PMID:24886336   PMID:24914373   PMID:24964035   PMID:25040634   PMID:25178280   PMID:25245272  
PMID:25416030   PMID:25538336   PMID:25893292   PMID:26165845   PMID:26341460   PMID:26802603   PMID:26954391   PMID:27282665   PMID:27530924   PMID:27618520   PMID:28000380   PMID:28266762  
PMID:28552397   PMID:28582407   PMID:29104873   PMID:29128362   PMID:29175126   PMID:29402324   PMID:29511803   PMID:30549198   PMID:30894415   PMID:31486510   PMID:31582430   PMID:31758917  
PMID:31917288   PMID:31960436   PMID:33448318   PMID:33760134   PMID:33769459   PMID:34246804   PMID:36631456   PMID:36857632   PMID:37676431  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81872,124,792 - 72,193,345 (+)NCBIGRCr8
mRatBN7.21869,849,884 - 69,918,926 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1869,850,377 - 69,912,323 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1871,959,978 - 72,021,908 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01872,629,252 - 72,691,176 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01870,485,797 - 70,547,727 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01872,550,107 - 72,612,078 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1872,550,219 - 72,612,078 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01871,672,879 - 71,735,128 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41873,180,520 - 73,241,707 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11873,253,792 - 73,314,980 (+)NCBI
Celera1868,381,756 - 68,443,610 (+)NCBICelera
Cytogenetic Map18q12.3NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381847,808,957 - 47,930,872 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1847,808,957 - 47,931,146 (-)EnsemblGRCh38hg38GRCh38
GRCh371845,335,328 - 45,457,243 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361843,613,464 - 43,711,510 (-)NCBINCBI36Build 36hg18NCBI36
Build 341843,618,434 - 43,710,924NCBI
Celera1842,208,816 - 42,306,655 (-)NCBICelera
Cytogenetic Map18q21.1NCBI
HuRef1842,208,822 - 42,306,925 (-)NCBIHuRef
CHM1_11845,354,416 - 45,452,506 (-)NCBICHM1_1
T2T-CHM13v2.01847,999,960 - 48,121,861 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391876,369,898 - 76,444,819 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1876,374,651 - 76,444,034 (+)EnsemblGRCm39 Ensembl
GRCm381876,241,090 - 76,311,748 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1876,241,580 - 76,310,963 (+)EnsemblGRCm38mm10GRCm38
MGSCv371876,401,579 - 76,465,385 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361876,367,290 - 76,431,096 (+)NCBIMGSCv36mm8
Celera1877,499,761 - 77,546,271 (+)NCBICelera
Cytogenetic Map18E3NCBI
cM Map1851.42NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495540233,136,778 - 33,216,844 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540233,131,760 - 33,217,144 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v21765,367,623 - 65,457,402 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11851,053,093 - 51,150,005 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01841,213,001 - 41,309,902 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11844,572,213 - 44,669,008 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1844,580,905 - 44,668,530 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1743,696,883 - 43,778,063 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl743,700,445 - 43,769,983 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha743,181,631 - 43,262,778 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0743,649,238 - 43,731,066 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl743,649,269 - 43,723,505 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1743,350,952 - 43,432,066 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0743,405,083 - 43,486,241 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0743,688,637 - 43,769,813 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494439,484,164 - 39,562,655 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649714,723,199 - 14,801,697 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649714,723,199 - 14,812,160 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl197,415,716 - 97,511,357 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1197,415,360 - 97,511,388 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21106,898,131 - 106,991,500 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11833,017,138 - 33,105,320 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1833,017,492 - 33,104,606 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660507,285,525 - 7,381,371 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462477811,384,769 - 11,501,078 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477811,380,656 - 11,460,566 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Smad2
420 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:352
Count of miRNA genes:210
Interacting mature miRNAs:238
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)185253976376104388Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)185253976376104388Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)184852004483828827Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)185253976376104388Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)185253976376104388Rat
61384Bp48Blood pressure QTL 4819.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186062231177209844Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185253976376104388Rat
1298072Cia26Collagen induced arthritis QTL 263.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)185470976983828827Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)185253976376104388Rat
6903353Bp353Blood pressure QTL 3532.8arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)185979647883828827Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185146473383218561Rat
6903356Bp354Blood pressure QTL 3544.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185979647883828827Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183587072380870723Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184334502283828827Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184664067583828827Rat
738005Anxrr11Anxiety related response QTL 113.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)183003981375039813Rat
2300157Bmd66Bone mineral density QTL 6613.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183139332077209694Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184664067583828827Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184664067583828827Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)185971241776477814Rat
2293704Bss35Bone structure and strength QTL 354.590.0002femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)182896485373964853Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)182979296574792965Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182557098570570985Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
1331770Bp234Blood pressure QTL 2343.807arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185979647871893566Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)182979296574792965Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)184852004483828827Rat
631675Iddm15Insulin dependent diabetes mellitus QTL 15urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)186062231177209844Rat
1598826Anxrr20Anxiety related response QTL 203.04body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)184143297183828827Rat
2300177Bmd65Bone mineral density QTL 6519.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
2301969Bp324Blood pressure QTL 3244.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185971241776477814Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183135940883218561Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)185253976376104388Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183135940870263868Rat
724542Kidm2Kidney mass QTL 22.6kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)185917211583828827Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183819245583192455Rat
1359020Ppulsi2Prepulse inhibition QTL 22.71prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)185229287573997283Rat
2312600Bp341Blood pressure QTL 3410.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185933040970263868Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)182979296574792965Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182979296574792965Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21869,876,866 - 69,877,088 (+)MAPPERmRatBN7.2
Rnor_6.01872,576,791 - 72,577,012NCBIRnor6.0
Rnor_5.01871,699,554 - 71,699,775UniSTSRnor5.0
RGSC_v3.41873,206,755 - 73,206,977RGDRGSC3.4
RGSC_v3.41873,206,756 - 73,206,977UniSTSRGSC3.4
RGSC_v3.11873,280,029 - 73,280,250RGD
Celera1868,408,328 - 68,408,547UniSTS
RH 3.4 Map18735.2RGD
RH 3.4 Map18735.2UniSTS
RH 2.0 Map18195.4RGD
SHRSP x BN Map1844.4299RGD
Cytogenetic Map18q12.3UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21869,911,949 - 69,912,169 (+)MAPPERmRatBN7.2
Rnor_6.01872,611,835 - 72,612,054NCBIRnor6.0
Rnor_5.01871,734,740 - 71,734,959UniSTSRnor5.0
RGSC_v3.41873,241,884 - 73,242,103UniSTSRGSC3.4
Celera1868,443,367 - 68,443,586UniSTS
RH 3.4 Map18730.7UniSTS
Cytogenetic Map18q12.3UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21869,911,181 - 69,911,594 (+)MAPPERmRatBN7.2
Rnor_6.01872,611,067 - 72,611,479NCBIRnor6.0
Rnor_5.01871,733,972 - 71,734,384UniSTSRnor5.0
RGSC_v3.41873,241,116 - 73,241,528UniSTSRGSC3.4
Celera1868,442,599 - 68,443,011UniSTS
Cytogenetic Map18q12.3UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21869,911,339 - 69,911,533 (+)MAPPERmRatBN7.2
Rnor_6.01872,611,225 - 72,611,418NCBIRnor6.0
Rnor_5.01871,734,130 - 71,734,323UniSTSRnor5.0
RGSC_v3.41873,241,274 - 73,241,467UniSTSRGSC3.4
Celera1868,442,757 - 68,442,950UniSTS
RH 3.4 Map18723.3UniSTS
Cytogenetic Map18q12.3UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21869,911,154 - 69,911,762 (+)MAPPERmRatBN7.2
Rnor_6.01872,611,040 - 72,611,647NCBIRnor6.0
Rnor_5.01871,733,945 - 71,734,552UniSTSRnor5.0
RGSC_v3.41873,241,089 - 73,241,696UniSTSRGSC3.4
Celera1868,442,572 - 68,443,179UniSTS
Cytogenetic Map18q12.3UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 31 46 30 19 30 2 2 74 35 38 11 2
Low 12 11 11 11 6 9 3 6
Below cutoff


RefSeq Acc Id: ENSRNOT00000046847   ⟹   ENSRNOP00000048329
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1869,850,398 - 69,912,323 (+)Ensembl
Rnor_6.0 Ensembl1872,550,219 - 72,612,078 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000089468   ⟹   ENSRNOP00000071524
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1869,850,390 - 69,911,740 (+)Ensembl
Rnor_6.0 Ensembl1872,571,327 - 72,611,291 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000092173   ⟹   ENSRNOP00000075341
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1869,850,536 - 69,912,193 (+)Ensembl
Rnor_6.0 Ensembl1872,550,454 - 72,612,078 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000109129   ⟹   ENSRNOP00000097880
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1869,850,377 - 69,908,841 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000110593   ⟹   ENSRNOP00000080684
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1869,870,327 - 69,912,193 (+)Ensembl
RefSeq Acc Id: NM_001277450   ⟹   NP_001264379
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr81872,125,344 - 72,187,240 (+)NCBI
mRatBN7.21869,850,301 - 69,912,193 (+)NCBI
Rnor_6.01872,550,219 - 72,612,078 (+)NCBI
Rnor_5.01871,672,879 - 71,735,128 (+)NCBI
Celera1868,381,756 - 68,443,610 (+)NCBI
RefSeq Acc Id: NM_019191   ⟹   NP_062064
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr81872,125,579 - 72,187,240 (+)NCBI
mRatBN7.21869,850,536 - 69,912,193 (+)NCBI
Rnor_6.01872,550,454 - 72,612,078 (+)NCBI
Rnor_5.01871,672,879 - 71,735,128 (+)NCBI
RGSC_v3.41873,180,520 - 73,241,707 (+)RGD
Celera1868,381,991 - 68,443,610 (+)NCBI
RefSeq Acc Id: XM_006254945   ⟹   XP_006255007
Rat AssemblyChrPosition (strand)Source
GRCr81872,124,926 - 72,193,345 (+)NCBI
mRatBN7.21869,849,884 - 69,918,926 (+)NCBI
Rnor_6.01872,550,107 - 72,612,078 (+)NCBI
Rnor_5.01871,672,879 - 71,735,128 (+)NCBI
RefSeq Acc Id: XM_006254946   ⟹   XP_006255008
Rat AssemblyChrPosition (strand)Source
GRCr81872,146,597 - 72,193,345 (+)NCBI
mRatBN7.21869,871,537 - 69,918,926 (+)NCBI
Rnor_6.01872,571,530 - 72,612,078 (+)NCBI
Rnor_5.01871,672,879 - 71,735,128 (+)NCBI
RefSeq Acc Id: XM_063277279   ⟹   XP_063133349
Rat AssemblyChrPosition (strand)Source
GRCr81872,124,792 - 72,193,345 (+)NCBI
RefSeq Acc Id: XM_063277280   ⟹   XP_063133350
Rat AssemblyChrPosition (strand)Source
GRCr81872,125,626 - 72,193,345 (+)NCBI
RefSeq Acc Id: NP_062064   ⟸   NM_019191
- UniProtKB: A0JPM1 (UniProtKB/Swiss-Prot),   O70436 (UniProtKB/Swiss-Prot),   A6KMS7 (UniProtKB/TrEMBL),   A0A8L2QQK5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001264379   ⟸   NM_001277450
- UniProtKB: A0JPM1 (UniProtKB/Swiss-Prot),   O70436 (UniProtKB/Swiss-Prot),   A6KMS7 (UniProtKB/TrEMBL),   A0A8L2QQK5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255007   ⟸   XM_006254945
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K0P2 (UniProtKB/TrEMBL),   A6KMS9 (UniProtKB/TrEMBL),   A0A8I6ASQ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255008   ⟸   XM_006254946
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZQC4 (UniProtKB/TrEMBL),   A0A8I5ZS20 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075341   ⟸   ENSRNOT00000092173
RefSeq Acc Id: ENSRNOP00000071524   ⟸   ENSRNOT00000089468
RefSeq Acc Id: ENSRNOP00000048329   ⟸   ENSRNOT00000046847
RefSeq Acc Id: ENSRNOP00000080684   ⟸   ENSRNOT00000110593
RefSeq Acc Id: ENSRNOP00000097880   ⟸   ENSRNOT00000109129
RefSeq Acc Id: XP_063133349   ⟸   XM_063277279
- Peptide Label: isoform X1
- UniProtKB: O70436 (UniProtKB/Swiss-Prot),   A0JPM1 (UniProtKB/Swiss-Prot),   A0A8L2QQK5 (UniProtKB/TrEMBL),   A6KMS7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133350   ⟸   XM_063277280
- Peptide Label: isoform X2
- UniProtKB: A0A8I6ASQ0 (UniProtKB/TrEMBL),   A0A0G2K0P2 (UniProtKB/TrEMBL),   A6KMS9 (UniProtKB/TrEMBL)
Protein Domains
MH1   MH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O70436-F1-model_v2 AlphaFold O70436 1-467 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13700873
Promoter ID:EPDNEW_R11396
Type:initiation region
Description:SMAD family member 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01872,550,297 - 72,550,357EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3031 AgrOrtholog
BioCyc Gene G2FUF-6961 BioCyc
Ensembl Genes ENSRNOG00000008620 UniProtKB/TrEMBL
  ENSRNOG00000018140 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055013852 UniProtKB/Swiss-Prot
  ENSRNOG00060010583 UniProtKB/Swiss-Prot
  ENSRNOG00065022764 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000046847.5 UniProtKB/TrEMBL
  ENSRNOT00000089468.2 UniProtKB/TrEMBL
  ENSRNOT00000092173.2 UniProtKB/Swiss-Prot
  ENSRNOT00000099327.1 UniProtKB/TrEMBL
  ENSRNOT00000109129.1 UniProtKB/TrEMBL
  ENSRNOT00000110593.1 UniProtKB/TrEMBL
  ENSRNOT00055023871 UniProtKB/Swiss-Prot
  ENSRNOT00060017914 UniProtKB/Swiss-Prot
  ENSRNOT00065039114 UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.520.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Dwarfin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAD_homology1_Dwarfin-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAD_homology_MH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD_dom_Dwarfin-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD_FHA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD_MH1_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29357 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR13703 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Smad2 PhenoGen
PROSITE MH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008620 RatGTEx
  ENSRNOG00000018140 RatGTEx
  ENSRNOG00055013852 RatGTEx
  ENSRNOG00060010583 RatGTEx
  ENSRNOG00065022764 RatGTEx
SMART DWA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DWB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49879 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56366 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC217521
  O70436 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A0JPM1 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-23 Smad2  SMAD family member 2  Smad2  MAD homolog 2 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Smad2  MAD homolog 2 (Drosophila)      Symbol updated 1299863 APPROVED
2002-06-10 Madh2  MAD homolog 2 (Drosophila)      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease may be involved in pulmonary fibrosis 625421
gene_drugs bleomycin at a dose of 9U/kg body weight causes no significant change in the expression of the protein 625421
gene_process an essential downstream intracellular target of the TGF-beta receptor signaling pathway 625421
gene_process involved in folliculogenesis 727374
gene_process activation induces apoptosis in pancreatic AR42J cells induced by activin A 69876
gene_product member of the family of Smad proteins 625421
gene_regulation phosphorylated by activated TGF-beta type 1 receptor 625421