(20S)-ginsenoside Rg3 multiple interactions ISO RGD:1347299 6480464 ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein] CTD PMID:24793912 (R)-lipoic acid multiple interactions ISO RGD:736957 6480464 Thioctic Acid inhibits the reaction [Bleomycin results in increased phosphorylation of SMAD2 protein] CTD PMID:35187969 (S)-nicotine decreases expression EXP 6480464 Nicotine results in decreased expression of SMAD2 mRNA, Nicotine results in decreased expression of SMAD2 protein CTD PMID:29660438 , PMID:31299270 1,2-dimethylhydrazine decreases expression EXP 6480464 1, 2-Dimethylhydrazine results in decreased expression of SMAD2 mRNA CTD PMID:32387197 1,2-dimethylhydrazine decreases expression ISO RGD:736957 6480464 1, 2-Dimethylhydrazine results in decreased expression of SMAD2 mRNA CTD PMID:22206623 1-naphthyl isothiocyanate multiple interactions ISO RGD:736957 6480464 [ITGA5 protein co-treated with ITGB6 protein] promotes the reaction [1-Naphthylisothiocyanate results in increased phosphorylation of SMAD2 protein] more ... CTD PMID:21037076 1-naphthyl isothiocyanate increases phosphorylation ISO RGD:736957 6480464 1-Naphthylisothiocyanate results in increased phosphorylation of SMAD2 protein CTD PMID:21037076 15-deoxy-Delta(12,14)-prostaglandin J2 multiple interactions ISO RGD:1347299 6480464 15-deoxy-delta(12 more ... CTD PMID:19429239 17alpha-ethynylestradiol multiple interactions ISO RGD:736957 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SMAD2 mRNA CTD PMID:17942748 17beta-estradiol decreases phosphorylation ISO RGD:736957 6480464 Estradiol results in decreased phosphorylation of SMAD2 protein CTD PMID:17255206 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:736957 6480464 Tetrachlorodibenzodioxin results in increased expression of SMAD2 mRNA, Tetrachlorodibenzodioxin results in increased expression of SMAD2 protein CTD PMID:18467041 , PMID:24058054 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of SMAD2 mRNA CTD PMID:34747641 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:736957 6480464 Tetrachlorodibenzodioxin results in decreased expression of SMAD2 protein, Tetrachlorodibenzodioxin results in decreased expression of SMAD2 protein modified form CTD PMID:33812962 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1347299 6480464 AHR protein affects the reaction [Tetrachlorodibenzodioxin affects the phosphorylation of SMAD2 protein] CTD PMID:31887333 2,3,7,8-tetrachlorodibenzodioxine affects phosphorylation ISO RGD:1347299 6480464 Tetrachlorodibenzodioxin affects the phosphorylation of SMAD2 protein CTD PMID:31887333 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:736957 6480464 Tetrachlorodibenzodioxin affects the expression of SMAD2 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine increases activity ISO RGD:736957 6480464 Tetrachlorodibenzodioxin results in increased activity of SMAD2 protein CTD PMID:18467041 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:736957 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SMAD2 mRNA, [Tetrachlorodibenzodioxin results in increased expression of TGFB1 protein] which results in increased activity of SMAD2 protein CTD PMID:17942748 , PMID:18467041 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile multiple interactions ISO RGD:1347299 6480464 Verapamil inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein] CTD PMID:34217686 2-acetamidofluorene multiple interactions EXP 6480464 [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD2 protein, IFNA2 protein promotes the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD2 protein] CTD PMID:15368444 2-amino-2-deoxy-D-galactopyranose multiple interactions EXP 6480464 Genistein inhibits the reaction [Galactosamine results in increased phosphorylation of SMAD2 protein] CTD PMID:27876602 2-amino-2-deoxy-D-galactopyranose increases phosphorylation EXP 6480464 Galactosamine results in increased phosphorylation of SMAD2 protein CTD PMID:27876602 2-amino-2-deoxy-D-glucopyranose multiple interactions ISO RGD:1347299 6480464 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Glucosamine analog results in increased phosphorylation of SMAD2 protein] CTD PMID:20458730 2-amino-2-deoxy-D-glucopyranose increases phosphorylation ISO RGD:1347299 6480464 Glucosamine analog results in increased phosphorylation of SMAD2 protein CTD PMID:20458730 2-hydroxypropanoic acid increases expression ISO RGD:1347299 6480464 Lactic Acid results in increased expression of SMAD2 mRNA CTD PMID:30851411 2-methoxy-17beta-estradiol multiple interactions EXP 6480464 2-Methoxyestradiol inhibits the reaction [testosterone enanthate results in increased phosphorylation of SMAD2 protein] CTD PMID:30154949 2-methoxyethanol increases expression EXP 6480464 methyl cellosolve results in increased expression of SMAD2 mRNA CTD PMID:21061450 3,4-dihydroxybenzaldehyde multiple interactions ISO RGD:1347299 6480464 protocatechualdehyde inhibits the reaction [Glucose results in increased phosphorylation of and affects the localization of SMAD2 protein], protocatechualdehyde inhibits the reaction [S100B protein results in increased phosphorylation of and affects the localization of SMAD2 protein] CTD PMID:17597607 3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione multiple interactions ISO RGD:736957 6480464 bisindolylmaleimide I inhibits the reaction [Cyclosporine results in increased phosphorylation of and results in increased activity of SMAD2 protein] CTD PMID:22155090 3-phenylprop-2-enal increases expression ISO RGD:1347299 6480464 cinnamaldehyde results in increased expression of SMAD2 mRNA CTD PMID:19524605 3H-1,2-dithiole-3-thione decreases expression EXP 6480464 1, 2-dithiol-3-thione results in decreased expression of SMAD2 mRNA CTD PMID:19162173 4,4'-sulfonyldiphenol increases expression ISO RGD:1347299 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of SMAD2 protein CTD PMID:34186270 4-nitrophenol decreases expression ISO RGD:736957 6480464 4-nitrophenol results in decreased expression of SMAD2 mRNA CTD PMID:34673133 5-aza-2'-deoxycytidine increases expression ISO RGD:736957 6480464 Decitabine results in increased expression of SMAD2 mRNA CTD PMID:27915011 5-aza-2'-deoxycytidine multiple interactions EXP 6480464 Decitabine inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein] CTD PMID:24211420 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of SMAD2 mRNA CTD PMID:30047161 6-propyl-2-thiouracil multiple interactions EXP 6480464 Propylthiouracil inhibits the reaction [Aminopropionitrile results in increased phosphorylation of SMAD2 protein] CTD PMID:33462684 7,9-dihydro-1H-purine-2,6,8(3H)-trione increases phosphorylation ISO RGD:1347299 6480464 Uric Acid results in increased phosphorylation of SMAD2 protein CTD PMID:36850003 acteoside increases phosphorylation ISO RGD:1347299 6480464 acteoside results in increased phosphorylation of SMAD2 protein CTD PMID:17634406 aldehydo-D-glucosamine multiple interactions ISO RGD:1347299 6480464 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Glucosamine analog results in increased phosphorylation of SMAD2 protein] CTD PMID:20458730 aldehydo-D-glucosamine increases phosphorylation ISO RGD:1347299 6480464 Glucosamine analog results in increased phosphorylation of SMAD2 protein CTD PMID:20458730 aldehydo-D-glucose increases phosphorylation ISO RGD:1347299 6480464 Glucose results in increased phosphorylation of SMAD2 protein CTD PMID:21367880 aldehydo-D-glucose multiple interactions EXP 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in increased phosphorylation of SMAD2 protein] more ... CTD PMID:31838053 aldehydo-D-glucose increases phosphorylation EXP 6480464 Glucose results in increased phosphorylation of SMAD2 protein CTD PMID:31838053 aldehydo-D-glucose multiple interactions ISO RGD:1347299 6480464 Glucose results in increased phosphorylation of and affects the localization of SMAD2 protein more ... CTD PMID:17597607 , PMID:21367880 all-trans-retinoic acid increases phosphorylation ISO RGD:1347299 6480464 Tretinoin results in increased phosphorylation of SMAD2 protein CTD PMID:17098229 all-trans-retinoic acid multiple interactions ISO RGD:736957 6480464 Tretinoin promotes the reaction [SMAD2 protein binds to MEG3 mRNA] CTD PMID:33493612 all-trans-retinoic acid decreases phosphorylation ISO RGD:1347299 6480464 Tretinoin results in decreased phosphorylation of SMAD2 protein CTD PMID:24374174 all-trans-retinoic acid decreases expression ISO RGD:736957 6480464 Tretinoin results in decreased expression of SMAD2 mRNA CTD PMID:18703560 all-trans-retinoic acid decreases expression ISO RGD:1347299 6480464 Tretinoin results in decreased expression of SMAD2 mRNA CTD PMID:15498508 all-trans-retinoic acid multiple interactions ISO RGD:1347299 6480464 Tamoxifen promotes the reaction [Tretinoin results in increased phosphorylation of SMAD2 protein], Tretinoin inhibits the reaction [TGFB1 results in increased phosphorylation of and results in increased localization of SMAD2 protein] CTD PMID:17098229 , PMID:21274875 all-trans-retinoic acid decreases phosphorylation ISO RGD:736957 6480464 Tretinoin results in decreased phosphorylation of SMAD2 protein CTD PMID:16410076 , PMID:33493612 amitrole decreases expression EXP 6480464 Amitrole results in decreased expression of SMAD2 mRNA CTD PMID:30047161 amlodipine multiple interactions ISO RGD:1347299 6480464 Amlodipine inhibits the reaction [[Doxorubicin co-treated with TGFB1 protein] results in increased phosphorylation of SMAD2 protein] CTD PMID:21337027 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of SMAD2 mRNA CTD PMID:16483693 Ammothamnine decreases expression ISO RGD:736957 6480464 oxymatrine results in decreased expression of SMAD2 protein CTD PMID:35785413 andrographolide multiple interactions ISO RGD:736957 6480464 andrographolide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein] CTD PMID:31706003 anthocyanin multiple interactions EXP 6480464 Anthocyanins inhibits the reaction [Paraquat results in increased phosphorylation of SMAD2 protein] CTD PMID:30403199 antirheumatic drug increases expression ISO RGD:1347299 6480464 Antirheumatic Agents results in increased expression of SMAD2 mRNA CTD PMID:24449571 arsane increases expression EXP 6480464 Arsenic results in increased expression of SMAD2 protein modified form CTD PMID:24348802 arsane multiple interactions EXP 6480464 Grape Seed Extract inhibits the reaction [Arsenic results in increased expression of SMAD2 protein modified form] CTD PMID:24348802 arsenic atom increases expression EXP 6480464 Arsenic results in increased expression of SMAD2 protein modified form CTD PMID:24348802 arsenic atom multiple interactions EXP 6480464 Grape Seed Extract inhibits the reaction [Arsenic results in increased expression of SMAD2 protein modified form] CTD PMID:24348802 arsenite(3-) multiple interactions ISO RGD:736957 6480464 arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD2 protein] more ... CTD PMID:25145660 , PMID:26354774 arsenous acid decreases expression ISO RGD:1347299 6480464 Arsenic Trioxide results in decreased expression of SMAD2 mRNA CTD PMID:25258189 arsenous acid increases expression ISO RGD:1347299 6480464 Arsenic Trioxide results in increased expression of SMAD2 mRNA CTD PMID:32240679 arsenous acid multiple interactions ISO RGD:1347299 6480464 Arsenic Trioxide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein] more ... CTD PMID:24762191 more ... asbestos multiple interactions ISO RGD:1347299 6480464 [Asbestos more ... CTD PMID:25358858 atrazine multiple interactions ISO RGD:1347299 6480464 [Atrazine co-treated with Arsenates] results in increased expression of SMAD2 mRNA CTD PMID:18585445 benazepril affects expression EXP 6480464 benazepril affects the expression of SMAD2 mRNA, benazepril affects the expression of SMAD2 protein CTD PMID:16635409 benazepril multiple interactions EXP 6480464 [benazepril co-treated with irbesartan] affects the expression of SMAD2 mRNA, [benazepril co-treated with irbesartan] affects the expression of SMAD2 protein CTD PMID:16635409 benzo[a]pyrene increases methylation ISO RGD:1347299 6480464 Benzo(a)pyrene results in increased methylation of SMAD2 5' UTR, Benzo(a)pyrene results in increased methylation of SMAD2 promoter CTD PMID:27901495 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:1347299 6480464 7 more ... CTD PMID:19150397 benzo[a]pyrene diol epoxide I increases expression ISO RGD:1347299 6480464 7 more ... CTD PMID:28529061 beta-aminopropionitrile increases phosphorylation EXP 6480464 Aminopropionitrile results in increased phosphorylation of SMAD2 protein CTD PMID:33462684 beta-aminopropionitrile multiple interactions EXP 6480464 Propylthiouracil inhibits the reaction [Aminopropionitrile results in increased phosphorylation of SMAD2 protein] CTD PMID:33462684 beta-D-glucosamine multiple interactions ISO RGD:1347299 6480464 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Glucosamine analog results in increased phosphorylation of SMAD2 protein] CTD PMID:20458730 beta-D-glucosamine increases phosphorylation ISO RGD:1347299 6480464 Glucosamine analog results in increased phosphorylation of SMAD2 protein CTD PMID:20458730 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of SMAD2 mRNA CTD PMID:25181051 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of SMAD2 mRNA CTD PMID:34097993 bisphenol A increases expression ISO RGD:1347299 6480464 bisphenol A analog results in increased expression of SMAD2 mRNA, bisphenol A results in increased expression of SMAD2 protein CTD PMID:32387340 , PMID:34186270 bisphenol A increases methylation ISO RGD:1347299 6480464 bisphenol A results in increased methylation of SMAD2 promoter CTD PMID:27271280 bisphenol A affects methylation ISO RGD:736957 6480464 bisphenol A affects the methylation of SMAD2 promoter CTD PMID:27334623 bleomycin A2 multiple interactions ISO RGD:736957 6480464 camostat inhibits the reaction [Bleomycin results in increased phosphorylation of SMAD2 protein] more ... CTD PMID:26599507 more ... bleomycin A2 increases phosphorylation ISO RGD:736957 6480464 Bleomycin results in increased phosphorylation of SMAD2 protein CTD PMID:26599507 more ... butanal decreases expression ISO RGD:1347299 6480464 butyraldehyde results in decreased expression of SMAD2 mRNA CTD PMID:26079696 cadmium dichloride multiple interactions ISO RGD:1347299 6480464 [Cadmium Chloride co-treated with sodium arsenite] results in increased expression of SMAD2 mRNA, Acetylcysteine inhibits the reaction [[Cadmium Chloride co-treated with sodium arsenite] results in increased expression of SMAD2 mRNA] CTD PMID:29408318 caffeine decreases expression EXP 6480464 Caffeine results in decreased expression of SMAD2 mRNA, Caffeine results in decreased expression of SMAD2 protein CTD PMID:32663519 camostat multiple interactions ISO RGD:736957 6480464 camostat inhibits the reaction [Bleomycin results in increased phosphorylation of SMAD2 protein] CTD PMID:26599507 carbofuran increases expression EXP 6480464 Carbofuran results in increased expression of SMAD2 mRNA CTD PMID:28982980 carbofuran multiple interactions EXP 6480464 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Carbofuran results in increased phosphorylation of SMAD2 protein] CTD PMID:28982980 carbofuran increases phosphorylation EXP 6480464 Carbofuran results in increased phosphorylation of SMAD2 protein CTD PMID:28982980 carnosine multiple interactions EXP 6480464 Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of SMAD2 protein] CTD PMID:28266762 CGP 52608 multiple interactions ISO RGD:1347299 6480464 CGP 52608 promotes the reaction [RORA protein binds to SMAD2 gene] CTD PMID:28238834 chlorpyrifos increases phosphorylation ISO RGD:1347299 6480464 Chlorpyrifos results in increased phosphorylation of SMAD2 protein CTD PMID:32156659 chromium atom increases expression EXP 6480464 Chromium results in increased expression of SMAD2 mRNA CTD PMID:17692352 chrysin multiple interactions ISO RGD:736957 6480464 chrysin inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD2 mRNA] CTD PMID:26297989 cisplatin decreases expression ISO RGD:736957 6480464 Cisplatin results in decreased expression of SMAD2 protein CTD PMID:23628706 cisplatin multiple interactions EXP 6480464 Cisplatin inhibits the reaction [crocin results in decreased expression of SMAD2 protein], crocin inhibits the reaction [Cisplatin results in increased expression of SMAD2 protein] CTD PMID:32259551 cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of SMAD2 protein CTD PMID:32259551 cisplatin decreases expression EXP 6480464 Cisplatin results in decreased expression of SMAD2 protein CTD PMID:23628706 cobalt dichloride decreases expression ISO RGD:1347299 6480464 cobaltous chloride results in decreased expression of SMAD2 mRNA CTD PMID:19320972 , PMID:19376846 copper atom multiple interactions ISO RGD:1347299 6480464 [Chelating Agents binds to Copper] which results in increased expression of SMAD2 mRNA CTD PMID:30911355 copper(0) multiple interactions ISO RGD:1347299 6480464 [Chelating Agents binds to Copper] which results in increased expression of SMAD2 mRNA CTD PMID:30911355 copper(II) sulfate increases phosphorylation ISO RGD:736957 6480464 Copper Sulfate results in increased phosphorylation of SMAD2 protein CTD PMID:33744278 copper(II) sulfate increases expression ISO RGD:736957 6480464 Copper Sulfate results in increased expression of SMAD2 mRNA CTD PMID:33744278 corticosterone decreases expression EXP 6480464 Corticosterone results in decreased expression of SMAD2 mRNA, Corticosterone results in decreased expression of SMAD2 protein CTD PMID:29660438 , PMID:32663519 coumestrol multiple interactions ISO RGD:1347299 6480464 [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of SMAD2 mRNA CTD PMID:19167446 crocidolite asbestos affects expression ISO RGD:1347299 6480464 Asbestos, Crocidolite affects the expression of SMAD2 mRNA CTD PMID:17331233 crocidolite asbestos increases phosphorylation ISO RGD:1347299 6480464 Asbestos, Crocidolite results in increased phosphorylation of SMAD2 protein CTD PMID:17975199 crocin-1 decreases expression EXP 6480464 crocin results in decreased expression of SMAD2 protein CTD PMID:32259551 crocin-1 multiple interactions EXP 6480464 Cisplatin inhibits the reaction [crocin results in decreased expression of SMAD2 protein], crocin inhibits the reaction [Cisplatin results in increased expression of SMAD2 protein] CTD PMID:32259551 curcumin multiple interactions EXP 6480464 Curcumin inhibits the reaction [AGT protein results in increased phosphorylation of SMAD2 protein] CTD PMID:26648693 cyclosporin A multiple interactions ISO RGD:736957 6480464 bisindolylmaleimide I inhibits the reaction [Cyclosporine results in increased phosphorylation of and results in increased activity of SMAD2 protein] more ... CTD PMID:22155090 cytochalasin D affects localization ISO RGD:1347299 6480464 Cytochalasin D affects the localization of SMAD2 protein CTD PMID:25756282 D-glucose multiple interactions ISO RGD:1347299 6480464 Glucose results in increased phosphorylation of and affects the localization of SMAD2 protein more ... CTD PMID:17597607 , PMID:21367880 D-glucose increases phosphorylation EXP 6480464 Glucose results in increased phosphorylation of SMAD2 protein CTD PMID:31838053 D-glucose multiple interactions EXP 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in increased phosphorylation of SMAD2 protein] more ... CTD PMID:31838053 D-glucose increases phosphorylation ISO RGD:1347299 6480464 Glucose results in increased phosphorylation of SMAD2 protein CTD PMID:21367880 dexamethasone decreases expression ISO RGD:736957 6480464 Dexamethasone results in decreased expression of SMAD2 mRNA CTD PMID:29329878 diarsenic trioxide multiple interactions ISO RGD:1347299 6480464 Arsenic Trioxide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein] more ... CTD PMID:24762191 more ... diarsenic trioxide increases expression ISO RGD:1347299 6480464 Arsenic Trioxide results in increased expression of SMAD2 mRNA CTD PMID:32240679 diarsenic trioxide decreases expression ISO RGD:1347299 6480464 Arsenic Trioxide results in decreased expression of SMAD2 mRNA CTD PMID:25258189 dibenziodolium multiple interactions EXP 6480464 diphenyleneiodonium inhibits the reaction [Glucose results in increased phosphorylation of SMAD2 protein] CTD PMID:31838053 diethylstilbestrol decreases phosphorylation ISO RGD:736957 6480464 Diethylstilbestrol results in decreased phosphorylation of SMAD2 protein CTD PMID:17255206 dimethyl sulfoxide multiple interactions ISO RGD:1347299 6480464 [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of SMAD2 protein modified form CTD PMID:35366062 diminazene diaceturate decreases phosphorylation ISO RGD:1347299 6480464 diminazene aceturate results in decreased phosphorylation of SMAD2 protein CTD PMID:29977014 dioxygen multiple interactions ISO RGD:736957 6480464 rosiglitazone inhibits the reaction [Oxygen deficiency results in increased phosphorylation of SMAD2 protein] CTD PMID:21531777 dioxygen increases phosphorylation ISO RGD:1347299 6480464 Oxygen deficiency results in increased phosphorylation of SMAD2 protein CTD PMID:23725749 dioxygen increases phosphorylation ISO RGD:736957 6480464 Oxygen deficiency results in increased phosphorylation of SMAD2 protein CTD PMID:21531777 disodium selenite multiple interactions ISO RGD:736957 6480464 [Folic Acid co-treated with INS protein co-treated with TF protein co-treated with Sodium Selenite] results in increased expression of SMAD2 mRNA CTD PMID:32324263 dorsomorphin multiple interactions ISO RGD:1347299 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 doxorubicin decreases expression ISO RGD:1347299 6480464 Doxorubicin results in decreased expression of SMAD2 protein CTD PMID:18606404 doxorubicin increases expression EXP 6480464 Doxorubicin results in increased expression of SMAD2 mRNA CTD PMID:21337027 doxorubicin multiple interactions ISO RGD:1347299 6480464 [Doxorubicin co-treated with TGFB1 protein] results in increased expression of SMAD2 mRNA more ... CTD PMID:21337027 enalapril multiple interactions EXP 6480464 Enalapril promotes the reaction [paricalcitol results in decreased phosphorylation of SMAD2 protein] CTD PMID:17513326 endosulfan multiple interactions ISO RGD:1347299 6480464 Endosulfan results in decreased expression of and results in decreased phosphorylation of SMAD2 protein more ... CTD PMID:32413665 , PMID:36513242 endosulfan decreases expression ISO RGD:1347299 6480464 Endosulfan results in decreased expression of SMAD2 mRNA CTD PMID:30090376 Enterolactone multiple interactions ISO RGD:1347299 6480464 [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of SMAD2 mRNA CTD PMID:19167446 entinostat decreases expression ISO RGD:1347299 6480464 entinostat results in decreased expression of SMAD2 mRNA CTD PMID:26272509 entinostat multiple interactions ISO RGD:1347299 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMAD2 mRNA CTD PMID:27188386 ethanol decreases expression EXP 6480464 Ethanol results in decreased expression of SMAD2 mRNA CTD PMID:17920746 ethanol multiple interactions EXP 6480464 [Carbon Tetrachloride co-treated with Ethanol] results in increased phosphorylation of SMAD2 protein, methyl ferulate inhibits the reaction [[Carbon Tetrachloride co-treated with Ethanol] results in increased phosphorylation of SMAD2 protein] CTD PMID:30543783 etoposide multiple interactions ISO RGD:1347299 6480464 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Etoposide results in increased phosphorylation of SMAD2 protein] CTD PMID:22363485 etoposide increases phosphorylation ISO RGD:1347299 6480464 Etoposide results in increased phosphorylation of SMAD2 protein CTD PMID:22363485 farrerol multiple interactions EXP 6480464 farrerol inhibits the reaction [Glucose results in increased phosphorylation of SMAD2 protein] CTD PMID:31838053 folic acid multiple interactions ISO RGD:736957 6480464 [Folic Acid co-treated with INS protein co-treated with TF protein co-treated with Sodium Selenite] results in increased expression of SMAD2 mRNA CTD PMID:32324263 galangin increases phosphorylation ISO RGD:1347299 6480464 galangin results in increased phosphorylation of SMAD2 protein CTD PMID:25268046 galangin increases expression ISO RGD:1347299 6480464 galangin results in increased expression of SMAD2 mRNA CTD PMID:25268046 galangin multiple interactions ISO RGD:1347299 6480464 LY2109761 inhibits the reaction [galangin results in increased phosphorylation of SMAD2 protein] CTD PMID:25268046 genistein multiple interactions EXP 6480464 Genistein inhibits the reaction [Galactosamine results in increased phosphorylation of SMAD2 protein] CTD PMID:27876602 gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of SMAD2 mRNA CTD PMID:22061828 gentamycin decreases expression EXP 6480464 Gentamicins results in decreased expression of SMAD2 mRNA CTD PMID:33387578 glucose multiple interactions ISO RGD:1347299 6480464 Glucose results in increased phosphorylation of and affects the localization of SMAD2 protein more ... CTD PMID:17597607 , PMID:21367880 glucose increases phosphorylation EXP 6480464 Glucose results in increased phosphorylation of SMAD2 protein CTD PMID:31838053 glucose multiple interactions EXP 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in increased phosphorylation of SMAD2 protein] more ... CTD PMID:31838053 glucose increases phosphorylation ISO RGD:1347299 6480464 Glucose results in increased phosphorylation of SMAD2 protein CTD PMID:21367880 heptachlor increases expression ISO RGD:1347299 6480464 Heptachlor results in increased expression of SMAD2 mRNA, Heptachlor results in increased expression of SMAD2 protein modified form CTD PMID:30719927 hispidin multiple interactions ISO RGD:736957 6480464 hispidin inhibits the reaction [Cyclosporine results in increased phosphorylation of and results in increased activity of SMAD2 protein] CTD PMID:22155090 Honokiol multiple interactions ISO RGD:736957 6480464 honokiol inhibits the reaction [Bleomycin results in increased phosphorylation of SMAD2 protein] CTD PMID:32032644 Honokiol multiple interactions EXP 6480464 honokiol inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein] CTD PMID:21265825 Honokiol multiple interactions ISO RGD:1347299 6480464 honokiol inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein] CTD PMID:32032644 hyaluronic acid multiple interactions ISO RGD:1347299 6480464 [4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased activity of [SMAD2 protein co-treated with SMAD3 protein]] inhibits the reaction [FSHB protein results in increased chemical synthesis of Hyaluronic Acid] CTD PMID:21520325 hydrogen peroxide increases phosphorylation ISO RGD:1347299 6480464 Hydrogen Peroxide results in increased phosphorylation of SMAD2 protein CTD PMID:15147944 hydrogen peroxide decreases expression ISO RGD:1347299 6480464 Hydrogen Peroxide results in decreased expression of SMAD2 mRNA CTD PMID:34581912 hydrogen peroxide multiple interactions ISO RGD:1347299 6480464 [Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SMAD2 protein CTD PMID:18951874 irbesartan multiple interactions EXP 6480464 [benazepril co-treated with irbesartan] affects the expression of SMAD2 mRNA, [benazepril co-treated with irbesartan] affects the expression of SMAD2 protein CTD PMID:16635409 irbesartan affects expression EXP 6480464 irbesartan affects the expression of SMAD2 mRNA, irbesartan affects the expression of SMAD2 protein CTD PMID:16635409 Isoangustone A multiple interactions ISO RGD:1347299 6480464 isoangustone A inhibits the reaction [Glucose results in increased phosphorylation of SMAD2 protein] CTD PMID:21367880 isoprenaline increases expression EXP 6480464 Isoproterenol results in increased expression of SMAD2 mRNA CTD PMID:35014750 isorhamnetin multiple interactions ISO RGD:1347299 6480464 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein] CTD PMID:27151496 ivermectin decreases expression ISO RGD:1347299 6480464 Ivermectin results in decreased expression of SMAD2 protein CTD PMID:32959892 leptomycin B multiple interactions ISO RGD:736957 6480464 leptomycin B inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD2 protein]] more ... CTD PMID:26354774 lipoic acid multiple interactions ISO RGD:736957 6480464 Thioctic Acid inhibits the reaction [Bleomycin results in increased phosphorylation of SMAD2 protein] CTD PMID:35187969 lipopolysaccharide increases expression ISO RGD:736957 6480464 Lipopolysaccharides results in increased expression of SMAD2 mRNA CTD PMID:10975854 lipopolysaccharide increases expression ISO RGD:1347299 6480464 Lipopolysaccharides results in increased expression of SMAD2 mRNA CTD PMID:35953652 lipopolysaccharide multiple interactions ISO RGD:1347299 6480464 Lipopolysaccharides inhibits the reaction [Propofol results in decreased expression of SMAD2 mRNA], Lipopolysaccharides inhibits the reaction [Sevoflurane results in decreased expression of SMAD2 mRNA] CTD PMID:35953652 lipopolysaccharide multiple interactions EXP 6480464 Lipopolysaccharides promotes the reaction [Thioacetamide results in increased expression of SMAD2 mRNA] CTD PMID:17621560 LY-2157299 multiple interactions ISO RGD:736957 6480464 [ABCB4 protein affects the susceptibility to LY-2157299] which affects the phosphorylation of SMAD2 protein CTD PMID:29808285 LY294002 multiple interactions ISO RGD:1347299 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cyanoginosin LR results in increased phosphorylation of SMAD2 protein] CTD PMID:27856280 melphalan multiple interactions ISO RGD:1347299 6480464 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Melphalan results in increased phosphorylation of SMAD2 protein] CTD PMID:22363485 melphalan increases phosphorylation ISO RGD:1347299 6480464 Melphalan results in increased phosphorylation of SMAD2 protein CTD PMID:22363485 mercury atom increases expression ISO RGD:1347299 6480464 Mercury results in increased expression of SMAD2 mRNA CTD PMID:19937285 mercury(0) increases expression ISO RGD:1347299 6480464 Mercury results in increased expression of SMAD2 mRNA CTD PMID:19937285 methimazole decreases expression EXP 6480464 Methimazole results in decreased expression of SMAD2 mRNA CTD PMID:30047161 methoxychlor decreases expression EXP 6480464 Methoxychlor results in decreased expression of SMAD2 mRNA CTD PMID:23303685 methoxychlor increases methylation EXP 6480464 Methoxychlor results in increased methylation of SMAD2 gene CTD PMID:23303685 methyl beta-cyclodextrin multiple interactions ISO RGD:1347299 6480464 methyl-beta-cyclodextrin inhibits the reaction [pentabromophenol inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]] CTD PMID:28230093 methyl methanesulfonate decreases expression ISO RGD:1347299 6480464 Methyl Methanesulfonate results in decreased expression of SMAD2 mRNA CTD PMID:23649840 methylmercury chloride decreases expression ISO RGD:1347299 6480464 methylmercuric chloride results in decreased expression of SMAD2 mRNA CTD PMID:28001369 microcystin-LR multiple interactions ISO RGD:1347299 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cyanoginosin LR results in increased phosphorylation of SMAD2 protein] more ... CTD PMID:27856280 mitoxantrone affects response to substance ISO RGD:1347299 6480464 SMAD2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 N-acetyl-L-cysteine decreases phosphorylation ISO RGD:1347299 6480464 Acetylcysteine results in decreased phosphorylation of SMAD2 protein CTD PMID:32947957 N-acetyl-L-cysteine multiple interactions ISO RGD:1347299 6480464 Acetylcysteine inhibits the reaction [[Cadmium Chloride co-treated with sodium arsenite] results in increased expression of SMAD2 mRNA] more ... CTD PMID:29408318 , PMID:30317545 N-ethyl-N-nitrosourea increases mutagenesis ISO RGD:736957 6480464 Ethylnitrosourea results in increased mutagenesis of SMAD2 gene CTD PMID:16724327 N-methyl-N'-nitro-N-nitrosoguanidine decreases expression ISO RGD:1347299 6480464 Methylnitronitrosoguanidine results in decreased expression of SMAD2 mRNA CTD PMID:12634122 N-nitrosodiethylamine multiple interactions EXP 6480464 [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD2 protein, IFNA2 protein promotes the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD2 protein] CTD PMID:15368444 N-nitrosodiethylamine decreases phosphorylation EXP 6480464 Diethylnitrosamine results in decreased phosphorylation of SMAD2 protein CTD PMID:18971187 N-nitrosodimethylamine increases phosphorylation EXP 6480464 Dimethylnitrosamine results in increased phosphorylation of SMAD2 protein CTD PMID:14568256 N-nitrosodimethylamine multiple interactions EXP 6480464 Leu-Ser-Lys-Leu peptide inhibits the reaction [Dimethylnitrosamine results in increased phosphorylation of SMAD2 protein] CTD PMID:14568256 niclosamide multiple interactions ISO RGD:1347299 6480464 Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein] CTD PMID:36870549 nicotine decreases expression EXP 6480464 Nicotine results in decreased expression of SMAD2 mRNA, Nicotine results in decreased expression of SMAD2 protein CTD PMID:29660438 , PMID:31299270 nitrofen decreases expression ISO RGD:736957 6480464 nitrofen results in decreased expression of SMAD2 mRNA CTD PMID:12149686 ochratoxin A increases expression ISO RGD:736957 6480464 ochratoxin A results in increased expression of SMAD2 mRNA CTD PMID:32617660 , PMID:35543154 ochratoxin A increases response to substance ISO RGD:1347299 6480464 SMAD2 results in increased susceptibility to ochratoxin A CTD PMID:35543154 ochratoxin A multiple interactions ISO RGD:736957 6480464 ochratoxin A results in increased expression of and results in increased phosphorylation of SMAD2 protein CTD PMID:35543154 ochratoxin A multiple interactions ISO RGD:1347299 6480464 4-(4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamide inhibits the reaction [ochratoxin A results in increased expression of SMAD2 mRNA] more ... CTD PMID:32617660 , PMID:35543154 ochratoxin A increases expression ISO RGD:1347299 6480464 ochratoxin A results in increased expression of SMAD2 mRNA CTD PMID:32617660 , PMID:35543154 oridonin multiple interactions ISO RGD:1347299 6480464 oridonin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein] CTD PMID:30243739 osthole multiple interactions ISO RGD:1347299 6480464 [platycodin D co-treated with osthol] inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein] more ... CTD PMID:23603464 panobinostat multiple interactions ISO RGD:1347299 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMAD2 mRNA CTD PMID:27188386 panobinostat decreases expression ISO RGD:1347299 6480464 panobinostat results in decreased expression of SMAD2 mRNA CTD PMID:26272509 paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of SMAD2 mRNA CTD PMID:16701773 paraquat increases expression ISO RGD:1347299 6480464 Paraquat results in increased expression of SMAD2 protein modified form CTD PMID:27682480 paraquat increases phosphorylation ISO RGD:1347299 6480464 Paraquat results in increased phosphorylation of SMAD2 protein CTD PMID:30265375 paraquat increases expression ISO RGD:736957 6480464 Paraquat results in increased expression of SMAD2 mRNA CTD PMID:32462952 paraquat multiple interactions ISO RGD:736957 6480464 tetramethylpyrazine inhibits the reaction [Paraquat results in increased phosphorylation of SMAD2 protein] more ... CTD PMID:30744607 , PMID:32462952 paraquat increases phosphorylation ISO RGD:736957 6480464 Paraquat results in increased phosphorylation of SMAD2 protein CTD PMID:30744607 , PMID:32462952 paraquat multiple interactions ISO RGD:1347299 6480464 sodium bisulfide inhibits the reaction [Paraquat results in increased phosphorylation of SMAD2 protein], TGFB1 protein promotes the reaction [Paraquat results in increased expression of SMAD2 protein modified form] CTD PMID:27682480 , PMID:30265375 paraquat multiple interactions EXP 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Paraquat results in increased phosphorylation of SMAD2 protein] more ... CTD PMID:25873302 , PMID:30403199 paraquat increases phosphorylation EXP 6480464 Paraquat results in increased phosphorylation of SMAD2 protein CTD PMID:25873302 , PMID:30403199 paricalcitol decreases phosphorylation EXP 6480464 paricalcitol results in decreased phosphorylation of SMAD2 protein CTD PMID:17513326 paricalcitol multiple interactions EXP 6480464 Enalapril promotes the reaction [paricalcitol results in decreased phosphorylation of SMAD2 protein] CTD PMID:17513326 patulin increases phosphorylation EXP 6480464 Patulin results in increased phosphorylation of SMAD2 protein CTD PMID:34896196 phenobarbital affects expression ISO RGD:1347299 6480464 Phenobarbital affects the expression of SMAD2 mRNA CTD PMID:19159669 phenylephrine multiple interactions EXP 6480464 Phenylephrine results in increased phosphorylation of and results in increased localization of and results in increased activity of SMAD2 protein CTD PMID:19443575 phenylmercury acetate decreases expression ISO RGD:1347299 6480464 Phenylmercuric Acetate results in decreased expression of SMAD2 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:1347299 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMAD2 mRNA CTD PMID:27188386 phloroglucinol multiple interactions ISO RGD:1347299 6480464 Phloroglucinol analog inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein] CTD PMID:26054450 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:736957 6480464 Tetradecanoylphorbol Acetate results in increased expression of and affects the localization of SMAD2 protein more ... CTD PMID:20172950 phorbol 13-acetate 12-myristate increases expression ISO RGD:736957 6480464 Tetradecanoylphorbol Acetate results in increased expression of SMAD2 protein CTD PMID:20172950 platycodin D multiple interactions ISO RGD:1347299 6480464 [platycodin D co-treated with osthol] inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein] more ... CTD PMID:23603464 procymidone decreases expression EXP 6480464 procymidone results in decreased expression of SMAD2 mRNA CTD PMID:15686871 progesterone affects expression ISO RGD:736957 6480464 Progesterone affects the expression of SMAD2 mRNA CTD PMID:17251523 progesterone multiple interactions ISO RGD:1347299 6480464 [4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased activity of [SMAD2 protein co-treated with SMAD3 protein]] promotes the reaction [FSHB protein results in increased chemical synthesis of Progesterone] CTD PMID:21520325 propofol multiple interactions ISO RGD:1347299 6480464 Lipopolysaccharides inhibits the reaction [Propofol results in decreased expression of SMAD2 mRNA] CTD PMID:35953652 propofol decreases expression ISO RGD:1347299 6480464 Propofol results in decreased expression of SMAD2 mRNA CTD PMID:35953652 quercetin multiple interactions ISO RGD:1347299 6480464 Quercetin inhibits the reaction [SMAD2 protein modified form binds to SMAD3 protein modified form binds to SMAD4 protein], SHH protein inhibits the reaction [Quercetin results in decreased phosphorylation of SMAD2 protein] CTD PMID:15580028 , PMID:33070227 quercetin multiple interactions EXP 6480464 Quercetin inhibits the reaction [Sodium Nitrite results in increased expression of SMAD2 protein] CTD PMID:28000380 quercetin multiple interactions ISO RGD:736957 6480464 Quercetin promotes the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein] CTD PMID:21216973 quercetin decreases phosphorylation ISO RGD:1347299 6480464 Quercetin results in decreased phosphorylation of SMAD2 protein CTD PMID:33070227 quercetin decreases expression ISO RGD:1347299 6480464 Quercetin results in decreased expression of SMAD2 protein, Quercetin results in decreased expression of SMAD2 protein modified form CTD PMID:15580028 rac-lactic acid increases expression ISO RGD:1347299 6480464 Lactic Acid results in increased expression of SMAD2 mRNA CTD PMID:30851411 raloxifene decreases phosphorylation ISO RGD:1347299 6480464 Raloxifene Hydrochloride results in decreased phosphorylation of SMAD2 protein CTD PMID:32947957 ramipril multiple interactions EXP 6480464 [Streptozocin co-treated with Resveratrol co-treated with Ramipril] results in decreased phosphorylation of SMAD2 protein CTD PMID:31062909 resveratrol multiple interactions EXP 6480464 [Streptozocin co-treated with Resveratrol co-treated with Ramipril] results in decreased phosphorylation of SMAD2 protein, Resveratrol inhibits the reaction [Streptozocin results in increased phosphorylation of SMAD2 protein] CTD PMID:21300041 , PMID:31062909 resveratrol multiple interactions ISO RGD:736957 6480464 resveratrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of SMAD2 protein] CTD PMID:25234611 resveratrol decreases expression ISO RGD:1347299 6480464 resveratrol results in decreased expression of SMAD2 mRNA, resveratrol results in decreased expression of SMAD2 protein CTD PMID:18089832 , PMID:25721869 resveratrol decreases phosphorylation ISO RGD:736957 6480464 resveratrol results in decreased phosphorylation of SMAD2 protein CTD PMID:21679764 rutin multiple interactions EXP 6480464 Rutin inhibits the reaction [Cholesterol, Dietary results in increased expression of SMAD2 mRNA] CTD PMID:27239252 salubrinal multiple interactions ISO RGD:736957 6480464 salubrinal inhibits the reaction [Cyclosporine results in increased phosphorylation of and results in increased activity of SMAD2 protein] CTD PMID:22155090 SB 203580 multiple interactions EXP 6480464 [SB 203580 co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] inhibits the reaction [Paraquat results in increased phosphorylation of SMAD2 protein], SB 203580 inhibits the reaction [Paraquat results in increased phosphorylation of SMAD2 protein] CTD PMID:25873302 SB 431542 decreases phosphorylation EXP 6480464 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased phosphorylation of SMAD2 protein CTD PMID:28982980 SB 431542 affects phosphorylation ISO RGD:1347299 6480464 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide affects the phosphorylation of SMAD2 protein CTD PMID:22363485 SB 431542 decreases phosphorylation ISO RGD:736957 6480464 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased phosphorylation of SMAD2 protein CTD PMID:20852150 SB 431542 multiple interactions ISO RGD:736957 6480464 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of and results in increased localization of SMAD2 protein] CTD PMID:20852150 SB 431542 multiple interactions ISO RGD:1347299 6480464 4-(5-benzo(1 more ... CTD PMID:20074812 more ... SB 431542 multiple interactions EXP 6480464 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Carbofuran results in increased phosphorylation of SMAD2 protein] CTD PMID:28982980 serpentine asbestos affects localization ISO RGD:1347299 6480464 Asbestos, Serpentine affects the localization of SMAD2 protein modified form CTD PMID:26685284 serpentine asbestos increases phosphorylation ISO RGD:1347299 6480464 Asbestos, Serpentine results in increased phosphorylation of SMAD2 protein CTD PMID:30609805 serpentine asbestos multiple interactions ISO RGD:1347299 6480464 [Asbestos more ... CTD PMID:25358858 sevoflurane multiple interactions ISO RGD:1347299 6480464 Lipopolysaccharides inhibits the reaction [Sevoflurane results in decreased expression of SMAD2 mRNA] CTD PMID:35953652 sevoflurane increases expression ISO RGD:1347299 6480464 Sevoflurane results in increased expression of SMAD2 mRNA CTD PMID:35953652 silver(1+) nitrate decreases expression ISO RGD:1347299 6480464 Silver Nitrate analog results in decreased expression of SMAD2 mRNA CTD PMID:22831968 silver(1+) nitrate increases expression ISO RGD:1347299 6480464 Silver Nitrate results in increased expression of SMAD2 mRNA CTD PMID:22831968 simvastatin decreases phosphorylation EXP 6480464 Simvastatin results in decreased phosphorylation of SMAD2 protein CTD PMID:19659652 simvastatin increases phosphorylation ISO RGD:736957 6480464 Simvastatin results in increased phosphorylation of SMAD2 protein CTD PMID:33034787 simvastatin multiple interactions ISO RGD:736957 6480464 FST protein inhibits the reaction [Simvastatin results in increased phosphorylation of SMAD2 protein] CTD PMID:33034787 simvastatin increases expression ISO RGD:736957 6480464 Simvastatin results in increased expression of SMAD2 mRNA CTD PMID:18310456 sodium arsenite increases phosphorylation EXP 6480464 sodium arsenite results in increased phosphorylation of SMAD2 protein CTD PMID:21605584 sodium arsenite increases expression EXP 6480464 sodium arsenite results in increased expression of SMAD2 protein modified form CTD PMID:34673086 sodium arsenite decreases expression ISO RGD:1347299 6480464 sodium arsenite results in decreased expression of SMAD2 mRNA CTD PMID:29301061 sodium arsenite multiple interactions ISO RGD:1347299 6480464 [Cadmium Chloride co-treated with sodium arsenite] results in increased expression of SMAD2 mRNA, Acetylcysteine inhibits the reaction [[Cadmium Chloride co-treated with sodium arsenite] results in increased expression of SMAD2 mRNA] CTD PMID:29408318 sodium arsenite multiple interactions EXP 6480464 Grape Seed Extract inhibits the reaction [sodium arsenite results in increased phosphorylation of SMAD2 protein] CTD PMID:21605584 sodium arsenite decreases phosphorylation ISO RGD:736957 6480464 sodium arsenite results in decreased phosphorylation of SMAD2 protein CTD PMID:23732083 sodium arsenite multiple interactions ISO RGD:736957 6480464 sodium arsenite affects the expression of and affects the phosphorylation of SMAD2 protein, sodium arsenite inhibits the reaction [TGFB2 protein results in increased phosphorylation of and affects the localization of SMAD2 protein] CTD PMID:23732083 , PMID:28206643 sodium nitrite increases expression EXP 6480464 Sodium Nitrite results in increased expression of SMAD2 protein CTD PMID:28000380 , PMID:28266762 sodium nitrite multiple interactions EXP 6480464 Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of SMAD2 protein], Quercetin inhibits the reaction [Sodium Nitrite results in increased expression of SMAD2 protein] CTD PMID:28000380 , PMID:28266762 Soman increases expression EXP 6480464 Soman results in increased expression of SMAD2 mRNA CTD PMID:19281266 sorafenib affects localization ISO RGD:736957 6480464 sorafenib affects the localization of SMAD2 protein CTD PMID:21360571 sorafenib multiple interactions ISO RGD:736957 6480464 sorafenib inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein] CTD PMID:21360571 streptozocin increases phosphorylation EXP 6480464 Streptozocin results in increased phosphorylation of SMAD2 protein CTD PMID:21300041 streptozocin multiple interactions EXP 6480464 [Streptozocin co-treated with Resveratrol co-treated with Ramipril] results in decreased phosphorylation of SMAD2 protein, Resveratrol inhibits the reaction [Streptozocin results in increased phosphorylation of SMAD2 protein] CTD PMID:21300041 , PMID:31062909 sulfadimethoxine decreases expression EXP 6480464 Sulfadimethoxine results in decreased expression of SMAD2 mRNA CTD PMID:30047161 sunitinib increases expression ISO RGD:1347299 6480464 Sunitinib results in increased expression of SMAD2 mRNA CTD PMID:31533062 tamibarotene decreases expression ISO RGD:1347299 6480464 tamibarotene results in decreased expression of SMAD2 mRNA CTD PMID:15498508 tamibarotene increases phosphorylation ISO RGD:1347299 6480464 tamibarotene results in increased phosphorylation of SMAD2 protein CTD PMID:17611697 tamoxifen multiple interactions ISO RGD:1347299 6480464 Tamoxifen promotes the reaction [Tretinoin results in increased phosphorylation of SMAD2 protein] CTD PMID:17098229 tamoxifen increases phosphorylation ISO RGD:1347299 6480464 Tamoxifen results in increased phosphorylation of SMAD2 protein CTD PMID:17098229 testosterone enanthate multiple interactions EXP 6480464 2-Methoxyestradiol inhibits the reaction [testosterone enanthate results in increased phosphorylation of SMAD2 protein] CTD PMID:30154949 testosterone enanthate increases phosphorylation EXP 6480464 testosterone enanthate results in increased phosphorylation of SMAD2 protein CTD PMID:30154949 tetrachloromethane increases phosphorylation EXP 6480464 Carbon Tetrachloride results in increased phosphorylation of SMAD2 protein CTD PMID:24211420 , PMID:25150141 tetrachloromethane multiple interactions EXP 6480464 [Carbon Tetrachloride co-treated with Ethanol] results in increased phosphorylation of SMAD2 protein, methyl ferulate inhibits the reaction [[Carbon Tetrachloride co-treated with Ethanol] results in increased phosphorylation of SMAD2 protein] CTD PMID:30543783 tetrachloromethane multiple interactions ISO RGD:736957 6480464 chrysin inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD2 mRNA], Silymarin inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD2 mRNA] CTD PMID:26297989 tetrachloromethane increases expression ISO RGD:736957 6480464 Carbon Tetrachloride results in increased expression of SMAD2 mRNA CTD PMID:26297989 tetrachloromethane decreases expression ISO RGD:736957 6480464 Carbon Tetrachloride results in decreased expression of SMAD2 protein modified form CTD PMID:25566828 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of SMAD2 mRNA CTD PMID:16570350 tetrachloromethane affects response to substance ISO RGD:736957 6480464 SMAD2 protein affects the susceptibility to Carbon Tetrachloride CTD PMID:16382155 tetramethylpyrazine multiple interactions ISO RGD:736957 6480464 tetramethylpyrazine inhibits the reaction [Paraquat results in increased phosphorylation of SMAD2 protein] CTD PMID:30744607 theobromine treatment IEP 127229954 [Theobromine co-treated with Theanine] inhibits the reaction [1 more ... RGD theophylline multiple interactions ISO RGD:1347299 6480464 [Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SMAD2 protein CTD PMID:18951874 thioacetamide multiple interactions EXP 6480464 Lipopolysaccharides promotes the reaction [Thioacetamide results in increased expression of SMAD2 mRNA] CTD PMID:17621560 thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of SMAD2 mRNA CTD PMID:17621560 , PMID:23411599 tolfenamic acid multiple interactions ISO RGD:1347299 6480464 tolfenamic acid inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein] CTD PMID:31381904 trichloroethene increases expression ISO RGD:736957 6480464 Trichloroethylene results in increased expression of SMAD2 mRNA CTD PMID:19448997 trichostatin A decreases expression ISO RGD:1347299 6480464 trichostatin A results in decreased expression of SMAD2 mRNA CTD PMID:24935251 , PMID:26272509 trichostatin A multiple interactions ISO RGD:1347299 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMAD2 mRNA CTD PMID:27188386 troglitazone multiple interactions ISO RGD:1347299 6480464 troglitazone inhibits the reaction [TGFB2 protein results in increased phosphorylation of and affects the localization of SMAD2 protein] CTD PMID:18253093 valproic acid decreases expression ISO RGD:736957 6480464 Valproic Acid results in decreased expression of SMAD2 mRNA CTD PMID:21427059 valproic acid decreases expression ISO RGD:1347299 6480464 Valproic Acid results in decreased expression of SMAD2 mRNA CTD PMID:24383497 more ... valproic acid multiple interactions ISO RGD:1347299 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMAD2 mRNA CTD PMID:27188386 valproic acid increases methylation ISO RGD:1347299 6480464 Valproic Acid results in increased methylation of SMAD2 gene CTD PMID:29154799 valproic acid affects expression ISO RGD:1347299 6480464 Valproic Acid affects the expression of SMAD2 mRNA CTD PMID:23179753 , PMID:25979313 vancomycin decreases expression ISO RGD:736957 6480464 Vancomycin results in decreased expression of SMAD2 mRNA CTD PMID:18930951 verapamil multiple interactions ISO RGD:1347299 6480464 Verapamil inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein] CTD PMID:34217686 vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of SMAD2 mRNA CTD PMID:15686871 vincristine decreases expression ISO RGD:1347299 6480464 Vincristine results in decreased expression of SMAD2 mRNA CTD PMID:23649840 vorinostat decreases expression ISO RGD:1347299 6480464 vorinostat results in decreased expression of SMAD2 mRNA CTD PMID:26272509 vorinostat multiple interactions ISO RGD:1347299 6480464 [NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMAD2 mRNA CTD PMID:27188386 zinc atom multiple interactions ISO RGD:736957 6480464 Zinc inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD2 protein]] more ... CTD PMID:22228435 , PMID:26354774 zinc(0) multiple interactions ISO RGD:736957 6480464 Zinc inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD2 protein]] more ... CTD PMID:22228435 , PMID:26354774
