TAS2R14 (taste 2 receptor member 14) - Rat Genome Database

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Gene: TAS2R14 (taste 2 receptor member 14) Homo sapiens
Analyze
Symbol: TAS2R14
Name: taste 2 receptor member 14
RGD ID: 30305929
HGNC Page HGNC:14920
Description: Enables bitter taste receptor activity. Involved in detection of chemical stimulus involved in sensory perception of bitter taste. Predicted to be located in plasma membrane. Predicted to be active in membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: T2R14; taste receptor type 2 member 14; taste receptor, family B, member 1; taste receptor, type 2, member 14; TRB1
RGD Orthologs
Mouse
Rat
Green Monkey
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381210,937,410 - 10,939,263 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1210,937,408 - 11,171,573 (-)EnsemblGRCh38hg38GRCh38
GRCh371211,090,009 - 11,091,862 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map12p13.2NCBI
HuRef1210,819,236 - 10,820,189 (-)NCBIHuRef
CHM1_11211,060,160 - 11,061,113 (-)NCBICHM1_1
T2T-CHM13v2.01210,810,447 - 10,812,300 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IBA,IC,IEA)
plasma membrane  (IEA,TAS)

Molecular Function

References
Additional References at PubMed
PMID:10761934   PMID:10761935   PMID:10766242   PMID:10774719   PMID:11696554   PMID:12139982   PMID:12477932   PMID:12581520   PMID:15489334   PMID:15496549   PMID:15744053   PMID:16335952  
PMID:16720576   PMID:20022913   PMID:20534144   PMID:20930049   PMID:21873635   PMID:21942422   PMID:26825540   PMID:27342779   PMID:28145731   PMID:28373278   PMID:28986522   PMID:29040583  
PMID:30358435   PMID:31430434   PMID:31541354   PMID:31894529   PMID:32272108   PMID:32818866   PMID:33253444   PMID:33465377   PMID:33559200   PMID:33961781   PMID:34684394   PMID:34747964  
PMID:36662576   PMID:38776963  


Genomics

Comparative Map Data
TAS2R14
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381210,937,410 - 10,939,263 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1210,937,408 - 11,171,573 (-)EnsemblGRCh38hg38GRCh38
GRCh371211,090,009 - 11,091,862 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map12p13.2NCBI
HuRef1210,819,236 - 10,820,189 (-)NCBIHuRef
CHM1_11211,060,160 - 11,061,113 (-)NCBICHM1_1
T2T-CHM13v2.01210,810,447 - 10,812,300 (-)NCBIT2T-CHM13v2.0
Tas2r140
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396133,031,818 - 133,032,756 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6133,031,780 - 133,032,779 (-)EnsemblGRCm39 Ensembl
GRCm386133,054,855 - 133,055,793 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6133,054,817 - 133,055,816 (-)EnsemblGRCm38mm10GRCm38
MGSCv376133,004,873 - 133,005,811 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366133,020,548 - 133,021,486 (-)NCBIMGSCv36mm8
Celera6132,839,014 - 132,839,953 (+)NCBICelera
Cytogenetic Map6G1NCBI
cM Map664.03NCBI
Tas2r116
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84167,998,392 - 167,999,366 (-)NCBIGRCr8
mRatBN7.24166,266,984 - 166,267,958 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4166,266,984 - 166,267,958 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4172,560,445 - 172,561,419 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04168,343,476 - 168,344,450 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04166,977,511 - 166,978,485 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04167,144,122 - 167,145,096 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4167,144,122 - 167,145,096 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04229,672,818 - 229,673,792 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44170,211,237 - 170,212,211 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4154,863,644 - 154,864,618 (-)NCBICelera
Cytogenetic Map4q42NCBI
TAS2R14
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11110,802,306 - 10,811,946 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1110,803,151 - 10,804,107 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660892,886,915 - 2,889,875 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in TAS2R14
29 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_023922.2(TAS2R14):c.609C>T (p.Phe203=) single nucleotide variant not provided [RCV000973960] Chr12:10938599 [GRCh38]
Chr12:11091198 [GRCh37]
Chr12:12p13.2		 benign
GRCh37/hg19 12p13.33-q24.33(chr12:1-133851895)x3 copy number gain See cases [RCV000258805] Chr12:1..133851895 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic|likely pathogenic
GRCh37/hg19 12p13.33-11.21(chr12:191619-31733044)x3 copy number gain not provided [RCV000750245] Chr12:191619..31733044 [GRCh37]
Chr12:12p13.33-11.21		 pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:173786-34835837)x2,3 copy number gain not provided [RCV000683478] Chr12:173786..34835837 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33		 pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:54427-34608071)x4 copy number gain See cases [RCV000139787] Chr12:54427..34608071 [GRCh38]
Chr12:282465..34761006 [GRCh37]
Chr12:33854..34652273 [NCBI36]
Chr12:12p13.33-11.1		 pathogenic
GRCh37/hg19 12p13.33-q11(chr12:274676-37869301)x4 copy number gain not provided [RCV001006470] Chr12:274676..37869301 [GRCh37]
Chr12:12p13.33-q11		 pathogenic
GRCh38/hg38 12p13.33-12.2(chr12:1258274-20657577)x3 copy number gain See cases [RCV000141905] Chr12:1258274..20657577 [GRCh38]
Chr12:1367440..20810511 [GRCh37]
Chr12:1237701..20701778 [NCBI36]
Chr12:12p13.33-12.2		 pathogenic
GRCh38/hg38 12p13.33-12.3(chr12:2871741-14987348)x3 copy number gain See cases [RCV000137694] Chr12:2871741..14987348 [GRCh38]
Chr12:2980907..15140282 [GRCh37]
Chr12:2851168..15031549 [NCBI36]
Chr12:12p13.33-12.3		 pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:173786-34835837)x3 copy number gain See cases [RCV000447551] Chr12:173786..34835837 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
GRCh37/hg19 12p13.2(chr12:11047687-11751920)x4 copy number gain See cases [RCV000510534] Chr12:11047687..11751920 [GRCh37]
Chr12:12p13.2		 uncertain significance
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)x3 copy number gain See cases [RCV000510482] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:621220-133779118)x3 copy number gain not provided [RCV000750253] Chr12:621220..133779118 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:212976-33926913)x4 copy number gain See cases [RCV000053666] Chr12:212976..33926913 [GRCh38]
Chr12:322142..34079848 [GRCh37]
Chr12:192403..33971115 [NCBI36]
Chr12:12p13.33-11.1		 pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:121271-34603261)x3 copy number gain See cases [RCV000139052] Chr12:121271..34603261 [GRCh38]
Chr12:282465..34756196 [GRCh37]
Chr12:100698..34647463 [NCBI36]
Chr12:12p13.33-11.1		 pathogenic
GRCh37/hg19 12p13.2(chr12:10959031-11214383)x3 copy number gain not provided [RCV000737773] Chr12:10959031..11214383 [GRCh37]
Chr12:12p13.2		 benign
GRCh37/hg19 12p13.33-q11(chr12:173786-37869301)x3 copy number gain See cases [RCV000449191] Chr12:173786..37869301 [GRCh37]
Chr12:12p13.33-q11		 pathogenic
GRCh38/hg38 12p13.33-11.22(chr12:121055-28415184)x1 copy number loss See cases [RCV000052776] Chr12:121055..28415184 [GRCh38]
Chr12:282465..28568117 [GRCh37]
Chr12:100482..28459384 [NCBI36]
Chr12:12p13.33-11.22		 pathogenic
GRCh37/hg19 12p13.33-13.2(chr12:173786-11677456)x3 copy number gain See cases [RCV000510853] Chr12:173786..11677456 [GRCh37]
Chr12:12p13.33-13.2		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:191619-133777645)x3 copy number gain not provided [RCV000750246] Chr12:191619..133777645 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:121255-34603274)x3 copy number gain See cases [RCV000136611] Chr12:121255..34603274 [GRCh38]
Chr12:282465..34756209 [GRCh37]
Chr12:100682..34647476 [NCBI36]
Chr12:12p13.33-11.1		 pathogenic
GRCh38/hg38 12p13.33-12.1(chr12:80412-25470329)x3 copy number gain See cases [RCV000053662] Chr12:80412..25470329 [GRCh38]
Chr12:282465..25623263 [GRCh37]
Chr12:59839..25514530 [NCBI36]
Chr12:12p13.33-12.1		 pathogenic
GRCh37/hg19 12p13.33-q11(chr12:173786-37869107)x3 copy number gain not provided [RCV000683480] Chr12:173786..37869107 [GRCh37]
Chr12:12p13.33-q11		 pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:77187-34380176)x3 copy number gain See cases [RCV000053660] Chr12:77187..34380176 [GRCh38]
Chr12:282465..34533111 [GRCh37]
Chr12:56614..34424378 [NCBI36]
Chr12:12p13.33-11.1		 pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:148034-34178799)x4 copy number gain See cases [RCV000240164] Chr12:148034..34178799 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:64620-34682902)x4 copy number gain See cases [RCV000142149] Chr12:64620..34682902 [GRCh38]
Chr12:173786..34835837 [GRCh37]
Chr12:44047..34727104 [NCBI36]
Chr12:12p13.33-11.1		 pathogenic
NM_023922.2(TAS2R14):c.197G>T (p.Trp66Leu) single nucleotide variant not specified [RCV004307718] Chr12:10939011 [GRCh38]
Chr12:11091610 [GRCh37]
Chr12:12p13.2		 uncertain significance
GRCh37/hg19 12p13.33-11.1(chr12:565369-34835837)x3 copy number gain See cases [RCV000511580] Chr12:565369..34835837 [GRCh37]
Chr12:12p13.33-11.1		 likely pathogenic
chr12:10074776-18800953 complex variant complex Breast ductal adenocarcinoma [RCV000207105] Chr12:10074776..18800953 [GRCh37]
Chr12:12p13.31-12.3		 uncertain significance
GRCh37/hg19 12p13.2-13.1(chr12:10717428-14032860)x1 copy number loss not provided [RCV000683470] Chr12:10717428..14032860 [GRCh37]
Chr12:12p13.2-13.1		 pathogenic
GRCh37/hg19 12p13.33-12.3(chr12:189216-15001420) copy number gain not provided [RCV000767817] Chr12:189216..15001420 [GRCh37]
Chr12:12p13.33-12.3		 pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:189578-34756150) copy number gain See cases [RCV000446017] Chr12:189578..34756150 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:173786-34835837) copy number gain not specified [RCV002052957] Chr12:173786..34835837 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
GRCh37/hg19 12p13.2-12.1(chr12:10853887-24103810)x1 copy number loss not provided [RCV002292878] Chr12:10853887..24103810 [GRCh37]
Chr12:12p13.2-12.1		 pathogenic
NM_023922.2(TAS2R14):c.880G>C (p.Val294Leu) single nucleotide variant not specified [RCV004228979] Chr12:10938328 [GRCh38]
Chr12:11090927 [GRCh37]
Chr12:12p13.2		 uncertain significance
NM_023922.2(TAS2R14):c.271G>A (p.Val91Met) single nucleotide variant not specified [RCV004234473] Chr12:10938937 [GRCh38]
Chr12:11091536 [GRCh37]
Chr12:12p13.2		 uncertain significance
NM_023922.2(TAS2R14):c.248G>A (p.Arg83Lys) single nucleotide variant not specified [RCV004140181] Chr12:10938960 [GRCh38]
Chr12:11091559 [GRCh37]
Chr12:12p13.2		 uncertain significance
NM_023922.2(TAS2R14):c.432T>A (p.Asn144Lys) single nucleotide variant not specified [RCV004123598] Chr12:10938776 [GRCh38]
Chr12:11091375 [GRCh37]
Chr12:12p13.2		 uncertain significance
NM_023922.2(TAS2R14):c.163C>G (p.Arg55Gly) single nucleotide variant not specified [RCV004271343] Chr12:10939045 [GRCh38]
Chr12:11091644 [GRCh37]
Chr12:12p13.2		 uncertain significance
NM_023922.2(TAS2R14):c.925G>A (p.Gly309Ser) single nucleotide variant not specified [RCV004866541] Chr12:10938283 [GRCh38]
Chr12:11090882 [GRCh37]
Chr12:12p13.2		 uncertain significance
NM_023922.2(TAS2R14):c.872C>T (p.Ser291Phe) single nucleotide variant not specified [RCV004866539] Chr12:10938336 [GRCh38]
Chr12:11090935 [GRCh37]
Chr12:12p13.2		 likely benign
NM_023922.2(TAS2R14):c.15A>G (p.Ile5Met) single nucleotide variant not provided [RCV000890020] Chr12:10939193 [GRCh38]
Chr12:11091792 [GRCh37]
Chr12:12p13.2		 benign
GRCh37/hg19 12p13.33-12.2(chr12:173786-20026080)x3 copy number gain See cases [RCV000446050] Chr12:173786..20026080 [GRCh37]
Chr12:12p13.33-12.2		 pathogenic
NM_023922.2(TAS2R14):c.87G>A (p.Leu29=) single nucleotide variant not provided [RCV000916527] Chr12:10939121 [GRCh38]
Chr12:11091720 [GRCh37]
Chr12:12p13.2		 likely benign
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902) copy number gain See cases [RCV000511643] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-12.1(chr12:173786-25286865)x3 copy number gain See cases [RCV000449287] Chr12:173786..25286865 [GRCh37]
Chr12:12p13.33-12.1		 pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:173786-34835837)x3 copy number gain not provided [RCV000683479] Chr12:173786..34835837 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:173786-34496628)x3 copy number gain not provided [RCV000847209] Chr12:173786..34496628 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
GRCh37/hg19 12p13.2-13.1(chr12:10336209-13535349) copy number loss Multiple endocrine neoplasia type 4 [RCV000767604] Chr12:10336209..13535349 [GRCh37]
Chr12:12p13.2-13.1		 pathogenic
GRCh37/hg19 12p13.2(chr12:11043965-11260347)x4 copy number gain not provided [RCV000683403] Chr12:11043965..11260347 [GRCh37]
Chr12:12p13.2		 likely benign
NM_023922.2(TAS2R14):c.189C>T (p.Phe63=) single nucleotide variant not provided [RCV000892489] Chr12:10939019 [GRCh38]
Chr12:11091618 [GRCh37]
Chr12:12p13.2		 benign
GRCh37/hg19 12p13.33-11.22(chr12:173786-28219229)x3 copy number gain See cases [RCV000510961] Chr12:173786..28219229 [GRCh37]
Chr12:12p13.33-11.22		 pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:89061-34178799)x3 copy number gain See cases [RCV000240487] Chr12:89061..34178799 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
NM_023922.2(TAS2R14):c.389T>G (p.Val130Gly) single nucleotide variant not specified [RCV004673261] Chr12:10938819 [GRCh38]
Chr12:11091418 [GRCh37]
Chr12:12p13.2		 uncertain significance
NM_023922.2(TAS2R14):c.436G>A (p.Ala146Thr) single nucleotide variant not specified [RCV004681961] Chr12:10938772 [GRCh38]
Chr12:11091371 [GRCh37]
Chr12:12p13.2		 uncertain significance
NM_023922.2(TAS2R14):c.658G>A (p.Gly220Arg) single nucleotide variant not specified [RCV004673260] Chr12:10938550 [GRCh38]
Chr12:11091149 [GRCh37]
Chr12:12p13.2		 likely benign
GRCh37/hg19 12p13.33-12.1(chr12:173786-25286865) copy number gain not specified [RCV002052955] Chr12:173786..25286865 [GRCh37]
Chr12:12p13.33-12.1		 pathogenic
GRCh37/hg19 12p13.33-q11(chr12:173786-37869301) copy number gain not specified [RCV002052958] Chr12:173786..37869301 [GRCh37]
Chr12:12p13.33-q11		 pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:176047-34179852)x4 copy number gain Pallister-Killian syndrome [RCV003154827] Chr12:176047..34179852 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
NM_023922.2(TAS2R14):c.463A>T (p.Ser155Cys) single nucleotide variant not specified [RCV004148036] Chr12:10938745 [GRCh38]
Chr12:11091344 [GRCh37]
Chr12:12p13.2		 uncertain significance
NM_023922.2(TAS2R14):c.164G>A (p.Arg55Gln) single nucleotide variant not specified [RCV004181734] Chr12:10939044 [GRCh38]
Chr12:11091643 [GRCh37]
Chr12:12p13.2		 uncertain significance
NM_023922.2(TAS2R14):c.614T>C (p.Met205Thr) single nucleotide variant not specified [RCV004142339] Chr12:10938594 [GRCh38]
Chr12:11091193 [GRCh37]
Chr12:12p13.2		 uncertain significance
NM_023922.2(TAS2R14):c.356T>G (p.Phe119Cys) single nucleotide variant not specified [RCV004356384] Chr12:10938852 [GRCh38]
Chr12:11091451 [GRCh37]
Chr12:12p13.2		 uncertain significance
NM_023922.2(TAS2R14):c.454A>C (p.Ile152Leu) single nucleotide variant not specified [RCV004354394] Chr12:10938754 [GRCh38]
Chr12:11091353 [GRCh37]
Chr12:12p13.2		 uncertain significance
NM_023922.2(TAS2R14):c.790C>G (p.Leu264Val) single nucleotide variant not specified [RCV004349911] Chr12:10938418 [GRCh38]
Chr12:11091017 [GRCh37]
Chr12:12p13.2		 uncertain significance
Single allele duplication not provided [RCV003448692] Chr12:188053..34856694 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
GRCh37/hg19 12p13.2(chr12:10588512-11788901)x3 copy number gain not provided [RCV003484864] Chr12:10588512..11788901 [GRCh37]
Chr12:12p13.2		 uncertain significance
GRCh37/hg19 12p13.33-11.1(chr12:173786-34835641)x3 copy number gain not specified [RCV003986979] Chr12:173786..34835641 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
NM_023922.2(TAS2R14):c.833G>A (p.Cys278Tyr) single nucleotide variant not specified [RCV004469338] Chr12:10938375 [GRCh38]
Chr12:11090974 [GRCh37]
Chr12:12p13.2		 uncertain significance
NM_023922.2(TAS2R14):c.928C>T (p.His310Tyr) single nucleotide variant not specified [RCV004469339] Chr12:10938280 [GRCh38]
Chr12:11090879 [GRCh37]
Chr12:12p13.2		 uncertain significance
NM_023922.2(TAS2R14):c.625C>G (p.Arg209Gly) single nucleotide variant not specified [RCV004469335] Chr12:10938583 [GRCh38]
Chr12:11091182 [GRCh37]
Chr12:12p13.2		 uncertain significance
NM_023922.2(TAS2R14):c.697G>A (p.Val233Met) single nucleotide variant not specified [RCV004469337] Chr12:10938511 [GRCh38]
Chr12:11091110 [GRCh37]
Chr12:12p13.2		 uncertain significance
NM_023922.2(TAS2R14):c.260A>G (p.Asn87Ser) single nucleotide variant not specified [RCV004469333] Chr12:10938948 [GRCh38]
Chr12:11091547 [GRCh37]
Chr12:12p13.2		 uncertain significance
NM_023922.2(TAS2R14):c.641A>G (p.His214Arg) single nucleotide variant not specified [RCV004469336] Chr12:10938567 [GRCh38]
Chr12:11091166 [GRCh37]
Chr12:12p13.2		 uncertain significance
GRCh37/hg19 12p13.2-11.1(chr12:10155706-34051988)x3 copy number gain not provided [RCV004819309] Chr12:10155706..34051988 [GRCh37]
Chr12:12p13.2-11.1		 pathogenic
NM_023922.2(TAS2R14):c.818C>T (p.Pro273Leu) single nucleotide variant not specified [RCV004866540] Chr12:10938390 [GRCh38]
Chr12:11090989 [GRCh37]
Chr12:12p13.2		 uncertain significance
GRCh37/hg19 12p13.33-11.1(chr12:173787-34835837)x4 copy number gain not provided [RCV004819308] Chr12:173787..34835837 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
NM_023922.2(TAS2R14):c.175G>A (p.Val59Ile) single nucleotide variant not specified [RCV004866538] Chr12:10939033 [GRCh38]
Chr12:11091632 [GRCh37]
Chr12:12p13.2		 uncertain significance

Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENST00000381852
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1210,937,408 - 11,171,573 (-)Ensembl
Ensembl Acc Id: ENST00000537503   ⟹   ENSP00000441949
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1210,937,410 - 10,939,263 (-)Ensembl
RefSeq Acc Id: NM_023922   ⟹   NP_076411
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381210,937,410 - 10,939,263 (-)NCBI
T2T-CHM13v2.01210,810,447 - 10,812,300 (-)NCBI
Sequence:
RefSeq Acc Id: NP_076411   ⟸   NM_023922
- UniProtKB: Q645X3 (UniProtKB/Swiss-Prot),   Q9NYV8 (UniProtKB/Swiss-Prot),   Q50KP5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000441949   ⟸   ENST00000537503

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9NYV8-F1-model_v2 AlphaFold Q9NYV8 1-317 view protein structure


Additional Information

Database Acc Id Source(s)
COSMIC TAS2R14 COSMIC
Ensembl Genes ENSG00000212127 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSG00000261984 UniProtKB/Swiss-Prot
  ENSG00000276541 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000537503 ENTREZGENE
  ENST00000537503.2 UniProtKB/Swiss-Prot
  ENST00000575008.1 UniProtKB/Swiss-Prot
  ENST00000614274.2 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000212127 GTEx
  ENSG00000261984 GTEx
  ENSG00000276541 GTEx
HGNC ID HGNC:14920 ENTREZGENE
Human Proteome Map TAS2R14 Human Proteome Map
InterPro T2R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:50840 UniProtKB/Swiss-Prot
NCBI Gene TAS2R14 ENTREZGENE
OMIM 604790 OMIM
PANTHER TASTE RECEPTOR TYPE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TASTE RECEPTOR TYPE 2 MEMBER 14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TAS2R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA37930 PharmGKB
RNAcentral URS00008B9DFD RNACentral
  URS0002617F35 RNACentral
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Q50KP5 ENTREZGENE, UniProtKB/TrEMBL
  Q645X3 ENTREZGENE
  Q9NYV8 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q645X3 UniProtKB/Swiss-Prot