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Gene: Lipa (lipase A, lysosomal acid type) Rattus norvegicus
Symbol: Lipa
Name: lipase A, lysosomal acid type
RGD ID: 3008
Description: Exhibits sterol esterase activity. Involved in fatty acid metabolic process and sterol metabolic process. Localizes to lysosome. Human ortholog(s) of this gene implicated in Wolman disease; cholesterol ester storage disease; and lysosomal and lipase deficiency. Orthologous to human LIPA (lipase A, lysosomal acid type); PARTICIPATES IN alendronate pharmacodynamics pathway; bile acid biosynthetic pathway; cerebrotendinous xanthomatosis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; 3H-1,2-dithiole-3-thione.
Type: protein-coding
Also known as: acid cholesteryl ester hydrolase; Chole; Chole2; CHOLEST; cholesterol esterase (pancreatic); Cholesterol esterase (pancreatic) see D3Wox12 D3Wox13 D3Wox26 and D3Mgh25; cholesteryl esterase; LAL; Lip1; lipase A; lipase A, lysosomal acid; lipase A, lysosomal acid, cholesterol esterase; lysosomal acid lipase 1; lysosomal acid lipase A; lysosomal acid lipase/cholesteryl ester hydrolase; pancreatic cholesterol esterase; RATCHOLEST; sterol esterase
Homo sapiens (human) : LIPA (lipase A, lysosomal acid type)  HGNC  Alliance
Mus musculus (house mouse) : Lipa (lysosomal acid lipase A)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lipa (lipase A, lysosomal acid type)
Pan paniscus (bonobo/pygmy chimpanzee) : LIPA (lipase A, lysosomal acid type)
Canis lupus familiaris (dog) : LIPA (lipase A, lysosomal acid type)
Sus scrofa (pig) : LIPA (lipase A, lysosomal acid type)
Chlorocebus sabaeus (African green monkey) : LIPA (lipase A, lysosomal acid type)
Heterocephalus glaber (naked mole-rat) : Lipa (lipase A, lysosomal acid type)
more info ...
Is Marker For: Strains:   ALD/Hyo  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01252,816,536 - 252,959,348 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1252,816,527 - 252,849,904 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01260,038,180 - 260,091,819 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41238,466,493 - 238,500,195 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11238,630,381 - 238,664,124 (-)NCBI
Celera1229,136,934 - 229,170,119 (-)NCBICelera
Cytogenetic Map1q53NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Lipa
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3008
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.