Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Kcnj3 | Rat | (S)-duloxetine hydrochloride | multiple interactions | ISO | Kcnj3 (Mus musculus) | 6480464 | Duloxetine Hydrochloride results in decreased activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA] and Duloxetine Hydrochloride results in decreased activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA] | CTD | PMID:22164246 | Kcnj3 | Rat | 1,2-dimethylhydrazine | decreases expression | ISO | Kcnj3 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of KCNJ3 mRNA | CTD | PMID:22206623 | Kcnj3 | Rat | 17alpha-ethynylestradiol | decreases expression | ISO | KCNJ3 (Homo sapiens) | 6480464 | Ethinyl Estradiol results in decreased expression of KCNJ3 mRNA | CTD | PMID:18936297 | Kcnj3 | Rat | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of KCNJ3 mRNA | CTD | PMID:29097150 | Kcnj3 | Rat | 17beta-estradiol | decreases expression | ISO | KCNJ3 (Homo sapiens) | 6480464 | Estradiol results in decreased expression of KCNJ3 mRNA | CTD | PMID:31614463 | Kcnj3 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of KCNJ3 mRNA | CTD | PMID:32109520 | Kcnj3 | Rat | 4,4'-sulfonyldiphenol | increases expression | ISO | Kcnj3 (Mus musculus) | 6480464 | bisphenol S results in increased expression of KCNJ3 mRNA | CTD | PMID:30951980 | Kcnj3 | Rat | 4,4'-sulfonyldiphenol | affects methylation | ISO | Kcnj3 (Mus musculus) | 6480464 | bisphenol S affects the methylation of KCNJ3 gene | CTD | PMID:31683443 | Kcnj3 | Rat | 5-aza-2'-deoxycytidine | decreases methylation | ISO | Kcnj3 (Mus musculus) | 6480464 | Decitabine results in decreased methylation of KCNJ3 gene | CTD | PMID:27923600 | Kcnj3 | Rat | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of KCNJ3 mRNA | CTD | PMID:24780913 and PMID:30047161 | Kcnj3 | Rat | acrylamide | increases expression | EXP | | 6480464 | Acrylamide results in increased expression of KCNJ3 mRNA | CTD | PMID:28959563 | Kcnj3 | Rat | aflatoxin B1 | decreases methylation | ISO | KCNJ3 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of KCNJ3 gene and Aflatoxin B1 results in decreased methylation of KCNJ3 intron | CTD | PMID:27153756 and PMID:30157460 | Kcnj3 | Rat | aflatoxin B1 | increases expression | EXP | | 6480464 | Aflatoxin B1 results in increased expression of KCNJ3 mRNA | CTD | PMID:25378103 | Kcnj3 | Rat | all-trans-retinoic acid | increases expression | ISO | KCNJ3 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of KCNJ3 mRNA | CTD | PMID:30416051 | Kcnj3 | Rat | amitrole | decreases expression | EXP | | 6480464 | Amitrole results in decreased expression of KCNJ3 mRNA | CTD | PMID:30047161 | Kcnj3 | Rat | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of KCNJ3 mRNA | CTD | PMID:16483693 | Kcnj3 | Rat | amoxapine | multiple interactions | ISO | Kcnj3 (Mus musculus) | 6480464 | Amoxapine results in decreased activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA] and Amoxapine results in decreased activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA] | CTD | PMID:22164246 | Kcnj3 | Rat | aripiprazole | increases expression | EXP | | 6480464 | Aripiprazole results in increased expression of KCNJ3 mRNA | CTD | PMID:17868501 | Kcnj3 | Rat | aristolochic acid A | decreases expression | ISO | KCNJ3 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of KCNJ3 mRNA | CTD | PMID:33212167 | Kcnj3 | Rat | arsenous acid | decreases expression | ISO | KCNJ3 (Homo sapiens) | 6480464 | Arsenic Trioxide results in decreased expression of KCNJ3 mRNA | CTD | PMID:26705709 | Kcnj3 | Rat | atropine | multiple interactions | ISO | KCNJ3 (Homo sapiens) | 6480464 | Atropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] | CTD | PMID:18171729 | Kcnj3 | Rat | belinostat | multiple interactions | ISO | KCNJ3 (Homo sapiens) | 6480464 | [NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KCNJ3 mRNA | CTD | PMID:27188386 | Kcnj3 | Rat | benzo[a]pyrene | increases expression | ISO | KCNJ3 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of KCNJ3 mRNA | CTD | PMID:22316170 | Kcnj3 | Rat | benzo[a]pyrene | decreases expression | ISO | KCNJ3 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of KCNJ3 mRNA | CTD | PMID:32234424 | Kcnj3 | Rat | benzo[a]pyrene | affects methylation | ISO | KCNJ3 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of KCNJ3 promoter | CTD | PMID:27901495 | Kcnj3 | Rat | benzo[a]pyrene | decreases expression | ISO | Kcnj3 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of KCNJ3 mRNA | CTD | PMID:20127859 and PMID:22228805 | Kcnj3 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of KCNJ3 mRNA | CTD | PMID:25181051 | Kcnj3 | Rat | bisphenol A | decreases expression | ISO | Kcnj3 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of KCNJ3 mRNA | CTD | PMID:32156529 | Kcnj3 | Rat | bisphenol A | increases expression | ISO | Kcnj3 (Mus musculus) | 6480464 | bisphenol A results in increased expression of KCNJ3 mRNA | CTD | PMID:30951980 | Kcnj3 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of KCNJ3 mRNA | CTD | PMID:30816183 | Kcnj3 | Rat | bisphenol F | increases expression | ISO | Kcnj3 (Mus musculus) | 6480464 | bisphenol F results in increased expression of KCNJ3 mRNA | CTD | PMID:30951980 | Kcnj3 | Rat | cadmium dichloride | increases expression | EXP | | 6480464 | Cadmium Chloride results in increased expression of KCNJ3 mRNA | CTD | PMID:33453195 | Kcnj3 | Rat | carbachol | multiple interactions | ISO | KCNJ3 (Homo sapiens) | 6480464 | [Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium more ... | CTD | PMID:18171729 | Kcnj3 | Rat | Cuprizon | decreases expression | EXP | | 6480464 | Cuprizone results in decreased expression of KCNJ3 mRNA | CTD | PMID:26577399 | Kcnj3 | Rat | diarsenic trioxide | decreases expression | ISO | KCNJ3 (Homo sapiens) | 6480464 | Arsenic Trioxide results in decreased expression of KCNJ3 mRNA | CTD | PMID:26705709 | Kcnj3 | Rat | dioxygen | increases expression | ISO | KCNJ3 (Homo sapiens) | 6480464 | Oxygen deficiency results in increased expression of KCNJ3 mRNA | CTD | PMID:24236059 | Kcnj3 | Rat | dorsomorphin | multiple interactions | ISO | KCNJ3 (Homo sapiens) | 6480464 | [NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Kcnj3 | Rat | doxorubicin | decreases expression | ISO | KCNJ3 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of KCNJ3 mRNA | CTD | PMID:29803840 | Kcnj3 | Rat | endosulfan | increases expression | EXP | | 6480464 | Endosulfan results in increased expression of KCNJ3 mRNA | CTD | PMID:29391264 | Kcnj3 | Rat | entinostat | multiple interactions | ISO | KCNJ3 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KCNJ3 mRNA | CTD | PMID:27188386 | Kcnj3 | Rat | ethanol | multiple interactions | ISO | Kcnj3 (Mus musculus) | 6480464 | Ethanol results in increased activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA] and Sertraline inhibits the reaction [Ethanol results in increased activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA]] | CTD | PMID:22164246 | Kcnj3 | Rat | ethanol | multiple interactions | EXP | | 6480464 | Ethanol promotes the reaction [[KCNJ3 protein binds to KCNJ6 protein] which results in increased transport of Potassium] and Ethosuximide inhibits the reaction [Ethanol promotes the reaction [[KCNJ3 protein binds to KCNJ6 protein] which results in increased transport of Potassium]] | CTD | PMID:18977371 | Kcnj3 | Rat | ethosuximide | multiple interactions | EXP | | 6480464 | Ethosuximide inhibits the reaction [[KCNJ5 protein binds to KCNJ3 protein] which results in increased transport of Potassium] and Ethosuximide inhibits the reaction [Ethanol promotes the reaction [[KCNJ3 protein binds to KCNJ6 protein] which results in increased transport of Potassium]] | CTD | PMID:18977371 | Kcnj3 | Rat | ethosuximide | multiple interactions | ISO | Kcnj3 (Mus musculus) | 6480464 | Ethosuximide inhibits the reaction [[KCNJ3 protein binds to KCNJ6 protein] which results in increased transport of Potassium] | CTD | PMID:18977371 | Kcnj3 | Rat | fluoxetine | multiple interactions | ISO | Kcnj3 (Mus musculus) | 6480464 | Fluoxetine inhibits the reaction [[KCNJ3 protein co-treated with KCNJ5 protein] results in increased transport of Potassium] and Fluoxetine inhibits the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium] | CTD | PMID:12684268 | Kcnj3 | Rat | folic acid | increases expression | ISO | Kcnj3 (Mus musculus) | 6480464 | Folic Acid results in increased expression of KCNJ3 mRNA | CTD | PMID:25006883 | Kcnj3 | Rat | genistein | decreases expression | ISO | Kcnj3 (Mus musculus) | 6480464 | Genistein results in decreased expression of KCNJ3 mRNA | CTD | PMID:32186404 | Kcnj3 | Rat | glycidol | decreases expression | EXP | | 6480464 | glycidol results in decreased expression of KCNJ3 mRNA | CTD | PMID:24915197 | Kcnj3 | Rat | maneb | multiple interactions | ISO | Kcnj3 (Mus musculus) | 6480464 | [Maneb co-treated with Paraquat] results in increased expression of KCNJ3 mRNA | CTD | PMID:36117858 | Kcnj3 | Rat | manganese atom | increases expression | ISO | KCNJ3 (Homo sapiens) | 6480464 | Manganese results in increased expression of KCNJ3 mRNA | CTD | PMID:17175027 | Kcnj3 | Rat | manganese(0) | increases expression | ISO | KCNJ3 (Homo sapiens) | 6480464 | Manganese results in increased expression of KCNJ3 mRNA | CTD | PMID:17175027 | Kcnj3 | Rat | manganese(II) chloride | increases expression | ISO | KCNJ3 (Homo sapiens) | 6480464 | manganese chloride results in increased expression of KCNJ3 mRNA | CTD | PMID:17175027 | Kcnj3 | Rat | methamphetamine | decreases expression | ISO | Kcnj3 (Mus musculus) | 6480464 | Methamphetamine results in decreased expression of KCNJ3 mRNA | CTD | PMID:21886566 | Kcnj3 | Rat | methimazole | decreases expression | EXP | | 6480464 | Methimazole results in decreased expression of KCNJ3 mRNA | CTD | PMID:30047161 | Kcnj3 | Rat | methoxychlor | affects methylation | EXP | | 6480464 | Methoxychlor affects the methylation of KCNJ3 gene | CTD | PMID:35440735 | Kcnj3 | Rat | mianserin | multiple interactions | ISO | Kcnj3 (Mus musculus) | 6480464 | Mianserin affects the activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA] and Mianserin affects the activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA] | CTD | PMID:22164246 | Kcnj3 | Rat | mirtazapine | multiple interactions | ISO | Kcnj3 (Mus musculus) | 6480464 | mirtazapine affects the activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA] and mirtazapine affects the activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA] | CTD | PMID:22164246 | Kcnj3 | Rat | N-acetyl-1,4-benzoquinone imine | affects response to substance | ISO | KCNJ3 (Homo sapiens) | 6480464 | KCNJ3 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine | CTD | PMID:21177773 | Kcnj3 | Rat | nefazodone | multiple interactions | ISO | Kcnj3 (Mus musculus) | 6480464 | nefazodone affects the activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA] and nefazodone affects the activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA] | CTD | PMID:22164246 | Kcnj3 | Rat | nitrofen | increases expression | EXP | | 6480464 | nitrofen results in increased expression of KCNJ3 mRNA | CTD | PMID:33484710 | Kcnj3 | Rat | O-methyleugenol | decreases expression | ISO | KCNJ3 (Homo sapiens) | 6480464 | methyleugenol results in decreased expression of KCNJ3 mRNA | CTD | PMID:32234424 | Kcnj3 | Rat | p-chloromercuribenzoic acid | multiple interactions | ISO | KCNJ3 (Homo sapiens) | 6480464 | [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KCNJ3 mRNA | CTD | PMID:27188386 | Kcnj3 | Rat | panobinostat | multiple interactions | ISO | KCNJ3 (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KCNJ3 mRNA | CTD | PMID:27188386 | Kcnj3 | Rat | paraquat | decreases expression | EXP | | 6480464 | Paraquat results in decreased expression of KCNJ3 mRNA | CTD | PMID:32680482 | Kcnj3 | Rat | paraquat | multiple interactions | ISO | Kcnj3 (Mus musculus) | 6480464 | [Maneb co-treated with Paraquat] results in increased expression of KCNJ3 mRNA | CTD | PMID:36117858 | Kcnj3 | Rat | paroxetine | multiple interactions | ISO | Kcnj3 (Mus musculus) | 6480464 | Paroxetine results in decreased activity of [KCNJ3 protein binds to KCNJ6 protein] | CTD | PMID:17072103 | Kcnj3 | Rat | phenylmercury acetate | multiple interactions | ISO | KCNJ3 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KCNJ3 mRNA | CTD | PMID:27188386 | Kcnj3 | Rat | potassium atom | multiple interactions | EXP | | 6480464 | [KCNJ5 protein binds to KCNJ3 protein] which results in increased transport of Potassium more ... | CTD | PMID:18977371 | Kcnj3 | Rat | potassium atom | multiple interactions | ISO | Kcnj3 (Mus musculus) | 6480464 | [KCNJ3 protein binds to KCNJ6 protein] which results in increased transport of Potassium more ... | CTD | PMID:12684268 and PMID:18977371 | Kcnj3 | Rat | propranolol | increases expression | ISO | KCNJ3 (Homo sapiens) | 6480464 | Propranolol results in increased expression of KCNJ3 mRNA | CTD | PMID:15603589 | Kcnj3 | Rat | rotenone | decreases expression | EXP | | 6480464 | Rotenone results in decreased expression of KCNJ3 mRNA | CTD | PMID:28374803 | Kcnj3 | Rat | SB 431542 | multiple interactions | ISO | KCNJ3 (Homo sapiens) | 6480464 | [NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Kcnj3 | Rat | scopolamine | multiple interactions | ISO | KCNJ3 (Homo sapiens) | 6480464 | Scopolamine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] | CTD | PMID:18171729 | Kcnj3 | Rat | sertraline | multiple interactions | ISO | Kcnj3 (Mus musculus) | 6480464 | Sertraline inhibits the reaction [Ethanol results in increased activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA]] more ... | CTD | PMID:22164246 | Kcnj3 | Rat | sodium arsenite | affects methylation | ISO | KCNJ3 (Homo sapiens) | 6480464 | sodium arsenite affects the methylation of KCNJ3 gene | CTD | PMID:28589171 | Kcnj3 | Rat | sodium arsenite | decreases expression | ISO | Kcnj3 (Mus musculus) | 6480464 | sodium arsenite results in decreased expression of KCNJ3 mRNA | CTD | PMID:37682722 | Kcnj3 | Rat | sunitinib | increases expression | ISO | KCNJ3 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of KCNJ3 mRNA | CTD | PMID:31533062 | Kcnj3 | Rat | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of KCNJ3 mRNA | CTD | PMID:16644059 | Kcnj3 | Rat | thallium | multiple interactions | ISO | KCNJ3 (Homo sapiens) | 6480464 | [Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium more ... | CTD | PMID:18171729 and PMID:22275899 | Kcnj3 | Rat | titanium dioxide | decreases expression | EXP | | 6480464 | titanium dioxide results in decreased expression of KCNJ3 mRNA | CTD | PMID:30012374 | Kcnj3 | Rat | triclosan | increases expression | ISO | KCNJ3 (Homo sapiens) | 6480464 | Triclosan results in increased expression of KCNJ3 mRNA | CTD | PMID:30510588 | Kcnj3 | Rat | tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate | multiple interactions | ISO | KCNJ3 (Homo sapiens) | 6480464 | Atropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] | CTD | PMID:18171729 | Kcnj3 | Rat | Tropicamide | multiple interactions | ISO | KCNJ3 (Homo sapiens) | 6480464 | Tropicamide inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] | CTD | PMID:18171729 | Kcnj3 | Rat | venlafaxine hydrochloride | multiple interactions | ISO | Kcnj3 (Mus musculus) | 6480464 | Venlafaxine Hydrochloride affects the activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA] and Venlafaxine Hydrochloride affects the activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA] | CTD | PMID:22164246 | Kcnj3 | Rat | vinclozolin | increases methylation | EXP | | 6480464 | vinclozolin results in increased methylation of KCNJ3 gene | CTD | PMID:31079544 | |