Aadat (aminoadipate aminotransferase) - Rat Genome Database

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Gene: Aadat (aminoadipate aminotransferase) Rattus norvegicus
Analyze
Symbol: Aadat
Name: aminoadipate aminotransferase
RGD ID: 2948
Description: Enables 2-aminoadipate transaminase activity; kynurenine-glyoxylate transaminase activity; and kynurenine-oxoglutarate transaminase activity. Predicted to be involved in 2-oxoglutarate metabolic process; glutamate metabolic process; and kynurenine metabolic process. Predicted to be located in mitochondrion. Orthologous to human AADAT (aminoadipate aminotransferase); PARTICIPATES IN tryptophan metabolic pathway; 2-aminoadipic 2-oxoadipic aciduria pathway; glutaric aciduria type I pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 2-aminoadipate aminotransferase; 2-aminoadipate transaminase; alpha-aminoadipate aminotransferase; glycine transaminase AADAT; KAT/AadAT; Kat2; kynurenine aminotransferase 2; kynurenine aminotransferase II; kynurenine--glyoxylate transaminase AADAT; kynurenine--oxoglutarate aminotransferase II; kynurenine--oxoglutarate transaminase 2; kynurenine--oxoglutarate transaminase II; kynurenine/alpha-aminoadipate aminotransferase, mitochondrial; methionine--glyoxylate transaminase AADAT
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81634,520,236 - 34,566,388 (-)NCBIGRCr8
mRatBN7.21629,509,392 - 29,544,332 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1629,509,394 - 29,544,332 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1633,104,268 - 33,139,214 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01636,538,015 - 36,572,956 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01632,738,925 - 32,773,893 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01632,832,001 - 32,868,680 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1632,832,061 - 32,868,702 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01632,665,727 - 32,705,543 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41632,845,006 - 32,885,600 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11632,845,082 - 32,885,675 (-)NCBI
Celera1629,503,305 - 29,538,406 (-)NCBICelera
Cytogenetic Map16p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,1-dichloroethene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-diaminotoluene  (ISO)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
aldrin  (ISO)
amiodarone  (EXP)
amitriptyline  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
chlorpyrifos  (ISO)
clofibrate  (ISO)
clomipramine  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dicrotophos  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enzalutamide  (ISO)
ethanol  (ISO)
flutamide  (EXP)
furan  (EXP)
gabapentin  (EXP)
gentamycin  (EXP)
imipramine  (EXP)
ketoconazole  (EXP)
lead diacetate  (EXP)
methapyrilene  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
nefazodone  (EXP)
nitrofen  (EXP)
paracetamol  (EXP,ISO)
phenobarbital  (ISO)
PhIP  (EXP)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
quercetin  (ISO)
rotenone  (ISO)
sodium arsenite  (EXP)
sotorasib  (ISO)
sulfasalazine  (ISO)
sunitinib  (ISO)
tauroursodeoxycholic acid  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thioacetamide  (EXP)
thyroxine  (EXP)
tiagabine  (EXP)
toluene  (EXP)
trametinib  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
uranium atom  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vigabatrin  (EXP)
vinclozolin  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Cloning and functional expression of a soluble form of kynurenine/alpha-aminoadipate aminotransferase from rat kidney. Buchli R, etal., J Biol Chem 1995 Dec 8;270(49):29330-5.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Structure, expression, and function of kynurenine aminotransferases in human and rodent brains. Han Q, etal., Cell Mol Life Sci. 2010 Feb;67(3):353-68. doi: 10.1007/s00018-009-0166-4. Epub 2009 Oct 15.
4. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Enzymatic studies on tryptophan metabolism disorder in rats chronically exposed to carbon disulfide. Okayama A, etal., Toxicol Appl Pharmacol. 1988 Jul;94(3):356-61.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
14. Kynurenine metabolism in vitamin-B-6-deficient rat liver after tryptophan injection. Takeuchi F and Shibata Y, Biochem J. 1984 Jun 15;220(3):693-9.
15. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:14651853   PMID:15489334   PMID:15880762   PMID:16258845   PMID:17024659   PMID:18056995   PMID:18056996   PMID:18614015   PMID:18620547  


Genomics

Comparative Map Data
Aadat
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81634,520,236 - 34,566,388 (-)NCBIGRCr8
mRatBN7.21629,509,392 - 29,544,332 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1629,509,394 - 29,544,332 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1633,104,268 - 33,139,214 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01636,538,015 - 36,572,956 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01632,738,925 - 32,773,893 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01632,832,001 - 32,868,680 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1632,832,061 - 32,868,702 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01632,665,727 - 32,705,543 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41632,845,006 - 32,885,600 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11632,845,082 - 32,885,675 (-)NCBI
Celera1629,503,305 - 29,538,406 (-)NCBICelera
Cytogenetic Map16p12NCBI
AADAT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384170,060,222 - 170,094,292 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4170,060,222 - 170,091,699 (-)EnsemblGRCh38hg38GRCh38
GRCh374170,981,373 - 171,011,538 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364171,217,948 - 171,247,947 (-)NCBINCBI36Build 36hg18NCBI36
Celera4168,313,662 - 168,343,661 (-)NCBICelera
Cytogenetic Map4q33NCBI
HuRef4166,736,223 - 166,766,217 (-)NCBIHuRef
CHM1_14170,957,912 - 170,987,911 (-)NCBICHM1_1
T2T-CHM13v2.04173,420,406 - 173,454,472 (-)NCBIT2T-CHM13v2.0
Aadat
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39860,958,877 - 60,998,711 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl860,958,966 - 60,998,711 (+)EnsemblGRCm39 Ensembl
GRCm38860,505,843 - 60,545,677 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl860,505,932 - 60,545,677 (+)EnsemblGRCm38mm10GRCm38
MGSCv37862,984,921 - 63,024,474 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36863,398,266 - 63,437,819 (+)NCBIMGSCv36mm8
Celera863,093,543 - 63,132,626 (+)NCBICelera
Cytogenetic Map8B3.1NCBI
cM Map830.85NCBI
AADAT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23167,840,395 - 167,870,662 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14168,196,263 - 168,228,815 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04162,283,569 - 162,313,720 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14174,353,766 - 174,383,471 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4174,353,766 - 174,383,471 (-)Ensemblpanpan1.1panPan2
AADAT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12520,920,118 - 20,944,251 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2520,920,139 - 20,945,387 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2521,552,316 - 21,578,183 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02521,095,996 - 21,122,120 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2521,095,909 - 21,122,348 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12520,979,787 - 21,005,336 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02520,916,219 - 20,941,386 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02521,013,862 - 21,039,554 (-)NCBIUU_Cfam_GSD_1.0
Aadat
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494321,612,298 - 21,637,776 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365162,029,715 - 2,052,041 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365162,030,032 - 2,052,025 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AADAT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1419,768,776 - 19,792,256 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11419,768,816 - 19,792,254 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21421,067,885 - 21,091,280 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AADAT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17116,268,241 - 116,299,509 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7116,268,253 - 116,298,336 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603796,208,477 - 96,238,271 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aadat
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247691,581,727 - 1,610,793 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247691,586,036 - 1,611,092 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Aadat
234 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:340
Count of miRNA genes:187
Interacting mature miRNAs:211
Transcripts:ENSRNOT00000015974
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat

Markers in Region
AI746383  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21629,534,433 - 29,534,573 (+)MAPPERmRatBN7.2
Rnor_6.01632,858,777 - 32,858,916NCBIRnor6.0
Rnor_5.01632,692,503 - 32,692,642UniSTSRnor5.0
RGSC_v3.41632,875,697 - 32,875,836UniSTSRGSC3.4
Celera1629,528,506 - 29,528,645UniSTS
Cytogenetic Map16p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 9
Medium 43 39 39 3 26 6
Low 13 11 2 7 2 4 4 39 34 7 4
Below cutoff 3 28 3 10 4 5 32 1 3 4

Sequence


RefSeq Acc Id: ENSRNOT00000015974   ⟹   ENSRNOP00000015974
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1629,509,394 - 29,544,332 (-)Ensembl
Rnor_6.0 Ensembl1632,832,061 - 32,868,680 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000082392   ⟹   ENSRNOP00000073124
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1632,832,611 - 32,868,702 (-)Ensembl
RefSeq Acc Id: NM_017193   ⟹   NP_058889
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81634,520,236 - 34,555,180 (-)NCBI
mRatBN7.21629,509,392 - 29,544,332 (-)NCBI
Rnor_6.01632,832,059 - 32,868,680 (-)NCBI
Rnor_5.01632,665,727 - 32,705,543 (-)NCBI
RGSC_v3.41632,845,006 - 32,885,600 (-)RGD
Celera1629,503,305 - 29,538,406 (-)RGD
Sequence:
RefSeq Acc Id: XM_063275270   ⟹   XP_063131340
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81634,520,236 - 34,554,913 (-)NCBI
RefSeq Acc Id: XM_063275271   ⟹   XP_063131341
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81634,520,236 - 34,566,388 (-)NCBI
RefSeq Acc Id: NP_058889   ⟸   NM_017193
- UniProtKB: Q64602 (UniProtKB/Swiss-Prot),   A6KIT5 (UniProtKB/TrEMBL),   A0A8L2Q812 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073124   ⟸   ENSRNOT00000082392
RefSeq Acc Id: ENSRNOP00000015974   ⟸   ENSRNOT00000015974
RefSeq Acc Id: XP_063131341   ⟸   XM_063275271
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063131340   ⟸   XM_063275270
- Peptide Label: isoform X1
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64602-F1-model_v2 AlphaFold Q64602 1-425 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700074
Promoter ID:EPDNEW_R10597
Type:initiation region
Name:Aadat_1
Description:aminoadipate aminotransferase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01632,868,695 - 32,868,755EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2948 AgrOrtholog
BioCyc Gene G2FUF-11569 BioCyc
BioCyc Pathway LYSINE-DEG1-PWY [L-lysine degradation XI (mammalian)] BioCyc
BioCyc Pathway Image LYSINE-DEG1-PWY BioCyc
Ensembl Genes ENSRNOG00000011861 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00055012248 UniProtKB/Swiss-Prot
  ENSRNOG00060006840 UniProtKB/Swiss-Prot
  ENSRNOG00065004394 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015974 ENTREZGENE
  ENSRNOT00000015974.6 UniProtKB/TrEMBL
  ENSRNOT00055020837 UniProtKB/Swiss-Prot
  ENSRNOT00060011207 UniProtKB/Swiss-Prot
  ENSRNOT00065006411 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.640.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7109210 IMAGE-MGC_LOAD
InterPro Aminotransferase_I/II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_major UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29416 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93526 IMAGE-MGC_LOAD
NCBI Gene 29416 ENTREZGENE
PANTHER AMINOTRANSFERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KYNURENINE/ALPHA-AMINOADIPATE AMINOTRANSFERASE, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Aminotran_1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Aadat PhenoGen
RatGTEx ENSRNOG00000011861 RatGTEx
  ENSRNOG00055012248 RatGTEx
  ENSRNOG00060006840 RatGTEx
  ENSRNOG00065004394 RatGTEx
Superfamily-SCOP SSF53383 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC230508
UniProt A0A8L2Q812 ENTREZGENE, UniProtKB/TrEMBL
  A6KIT5 ENTREZGENE, UniProtKB/TrEMBL
  A6KIT6_RAT UniProtKB/TrEMBL
  AADAT_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Aadat  aminoadipate aminotransferase  Kat2  kynurenine aminotransferase 2  Symbol and Name updated 1299863 APPROVED
2002-06-10 Kat2  kynurenine aminotransferase 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function converts L-kynurenine into kynurenic acid 69866
gene_protein soluble protein of 425 amino acid 69866