Jund (JunD proto-oncogene, AP-1 transcription factor subunit) - Rat Genome Database

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Gene: Jund (JunD proto-oncogene, AP-1 transcription factor subunit) Rattus norvegicus
Symbol: Jund
Name: JunD proto-oncogene, AP-1 transcription factor subunit
RGD ID: 2945
Description: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; nuclear receptor binding activity; and transcription coactivator activity. Involved in several processes, including cellular response to hypoxia; positive regulation of macrophage activation; and response to lipopolysaccharide. Part of protein-DNA complex. Is active in nucleus. Biomarker of crescentic glomerulonephritis and renal carcinoma. Orthologous to human JUND (JunD proto-oncogene, AP-1 transcription factor subunit); PARTICIPATES IN platelet-derived growth factor signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH (S)-amphetamine; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: jun D proto-oncogene; JunD-FL isoform; MGC72300; transcription factor AP-1 subunit JunD; transcription factor jun-D; transcription factor JunD
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Jundem1Tja  
Genetic Models: WKY-Jundem1Tja
Candidate Gene For: Glom16
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21618,734,121 - 18,735,799 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,734,122 - 18,735,799 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1618,775,785 - 18,777,473 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01619,908,865 - 19,910,549 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,828,735 - 18,830,423 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01620,485,028 - 20,486,707 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,485,029 - 20,486,707 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01620,342,096 - 20,343,775 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41619,239,694 - 19,241,529 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11619,239,692 - 19,241,527 (-)NCBI
Celera1618,926,295 - 18,927,907 (-)NCBICelera
Cytogenetic Map16p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-Pimaric acid  (ISO)
(-)-anisomycin  (ISO)
(S)-amphetamine  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-tert-butylhydroquinone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxynon-2-enal  (EXP,ISO)
5'-S-methyl-5'-thioadenosine  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetylsalicylic acid  (ISO)
aflatoxin B1  (EXP)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP,ISO)
ampicillin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atazanavir sulfate  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bortezomib  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
capsaicin  (EXP)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
clozapine  (EXP)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
curcumin  (ISO)
cyclosporin A  (EXP,ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
depsipeptide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP,ISO)
dichloroacetic acid  (ISO)
diclofenac  (EXP,ISO)
dieldrin  (EXP,ISO)
diuron  (ISO)
dobutamine  (EXP)
emodin  (ISO)
etoxazole  (ISO)
fenthion  (ISO)
fenvalerate  (EXP)
fluconazole  (EXP)
flufenoxuron  (ISO)
flutamide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fucoidan  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
isoflavones  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
luteolin  (ISO)
mechlorethamine  (ISO)
metformin  (ISO)
methapyrilene  (ISO)
methidathion  (ISO)
methoxychlor  (ISO)
methylmercury chloride  (EXP)
metoprolol  (EXP)
microcystin-LR  (ISO)
motexafin gadolinium  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
nefazodone  (EXP,ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
Nodularin  (ISO)
obeticholic acid  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentobarbital  (EXP)
phencyclidine  (EXP)
phenobarbital  (ISO)
phenylephrine  (ISO)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phorone  (EXP)
pirinixic acid  (ISO)
piroxicam  (ISO)
pomalidomide  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
prothioconazole  (EXP)
putrescine  (EXP)
quercetin  (ISO)
quinomethionate  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
retinyl acetate  (ISO)
rotenone  (ISO)
sertraline  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sulindac  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
topotecan  (EXP)
triadimefon  (EXP)
trichloroethene  (EXP,ISO)
triticonazole  (EXP)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vanillin  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Jund is a determinant of macrophage activation and is associated with glomerulonephritis susceptibility. Behmoaras J, etal., Nat Genet. 2008 May;40(5):553-9.
2. Impaired transforming growth factor-β (TGF-β) transcriptional activity and cell proliferation control of a menin in-frame deletion mutant associated with multiple endocrine neoplasia type 1 (MEN1). Canaff L, etal., J Biol Chem. 2012 Mar 9;287(11):8584-97. doi: 10.1074/jbc.M112.341958. Epub 2012 Jan 24.
3. Obesity-induced activation of JunD promotes myocardial lipid accumulation and metabolic cardiomyopathy. Costantino S, etal., Eur Heart J. 2019 Mar 21;40(12):997-1008. doi: 10.1093/eurheartj/ehy903.
4. A farnesoid x receptor-small heterodimer partner regulatory cascade modulates tissue metalloproteinase inhibitor-1 and matrix metalloprotease expression in hepatic stellate cells and promotes resolution of liver fibrosis. Fiorucci S, etal., J Pharmacol Exp Ther. 2005 Aug;314(2):584-95. Epub 2005 Apr 28.
5. Is light-regulated AP-1 binding in the rat suprachiasmatic nucleus gated by the circadian clock? Francois-Bellan AM, etal., Brain Res Mol Brain Res. 2000 Dec 28;85(1-2):161-70.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Circadian binding activity of AP-1, a regulator of the arylalkylamine N-acetyltransferase gene in the rat pineal gland, depends on circadian Fra-2, c-Jun, and Jun-D expression and is regulated by the clock's zeitgebers. Guillaumond F, etal., J Neurochem. 2000 Oct;75(4):1398-407.
9. Protein kinase p-JNK is correlated with the activation of AP-1 and its associated Jun family proteins in hepatocellular carcinoma. Guo L, etal., Life Sci. 2005 Aug 26;77(15):1869-78. doi: 10.1016/j.lfs.2005.03.019.
10. Selective participation of c-Jun with Fra-2/c-Fos promotes aggressive tumor phenotypes and poor prognosis in tongue cancer. Gupta S, etal., Sci Rep. 2015 Nov 19;5:16811. doi: 10.1038/srep16811.
11. Oral methylthioadenosine administration attenuates fibrosis and chronic liver disease progression in Mdr2-/- mice. Latasa MU, etal., PLoS One. 2010 Dec 29;5(12):e15690. doi: 10.1371/journal.pone.0015690.
12. Impaired activation of AP-1 and altered expression of constituent proteins in rat adrenal during ageing. Medicherla R, etal., Mech Ageing Dev. 2001 Aug;122(11):1169-86.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Fos- and Jun-related transcription factors are involved in the signal transduction pathway of mechanical loading in condylar chondrocytes. Papachristou D, etal., Eur J Orthod. 2006 Feb;28(1):20-6. Epub 2005 Dec 22.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
18. Cell selective induction and transcriptional activation of immediate early genes by hypoxia. Prabhakar NR, etal., Brain Res. 1995 Oct 30;697(1-2):266-70. doi: 10.1016/0006-8993(95)00994-2.
19. GOA pipeline RGD automated data pipeline
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Regulation of AP1 (Jun/Fos) factor expression and activation in ovarian granulosa cells. Relation of JunD and Fra2 to terminal differentiation. Sharma SC and Richards JS, J Biol Chem. 2000 Oct 27;275(43):33718-28.
22. Translational regulation of the JunD messenger RNA. Short JD and Pfarr CM, J Biol Chem 2002 Sep 6;277(36):32697-705.
23. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
24. CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins. Ubeda M, etal., Mol Cell Biol. 1999 Nov;19(11):7589-99.
25. Overexpression of members of the AP-1 transcriptional factor family from an early stage of renal carcinogenesis and inhibition of cell growth by AP-1 gene antisense oligonucleotides in the Tsc2 gene mutant (Eker) rat model. Urakami S, etal., Biochem Biophys Res Commun. 1997 Dec 8;241(1):24-30.
26. Basic fibroblast growth factor stimulates collagenase-3 promoter activity in osteoblasts through an activator protein-1-binding site. Varghese S, etal., Endocrinology. 2000 Jun;141(6):2185-91.
27. Sequential increase in Egr-1 and AP-1 DNA binding activity in the dentate gyrus following the induction of long-term potentiation. Williams JM, etal., Brain Res Mol Brain Res. 2000 May 5;77(2):258-66.
28. The differential molecular mechanisms underlying proenkephalin mRNA expression induced by forskolin and phorbol-12-myristic-13-acetate in primary cultured astrocytes. Won JS and Suh HW, Brain Res Mol Brain Res. 2000 Dec 8;84(1-2):41-51.
29. Sequence analysis of the rat jun-D gene. Yamada T, etal., Gene 1995 Feb 14;153(2):285-6.
Additional References at PubMed
PMID:1903194   PMID:2504580   PMID:8889548   PMID:10508860   PMID:12220541   PMID:15189336   PMID:15489334   PMID:15563473   PMID:17253961   PMID:17681951   PMID:19303854   PMID:20181929  
PMID:22827527   PMID:23382074   PMID:25788572  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21618,734,121 - 18,735,799 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,734,122 - 18,735,799 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1618,775,785 - 18,777,473 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01619,908,865 - 19,910,549 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,828,735 - 18,830,423 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01620,485,028 - 20,486,707 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,485,029 - 20,486,707 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01620,342,096 - 20,343,775 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41619,239,694 - 19,241,529 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11619,239,692 - 19,241,527 (-)NCBI
Celera1618,926,295 - 18,927,907 (-)NCBICelera
Cytogenetic Map16p14NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381918,279,694 - 18,281,622 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1918,279,694 - 18,281,622 (-)EnsemblGRCh38hg38GRCh38
GRCh371918,390,504 - 18,392,432 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361918,251,570 - 18,253,432 (-)NCBINCBI36Build 36hg18NCBI36
Build 341918,251,569 - 18,253,468NCBI
Celera1918,292,287 - 18,294,173 (-)NCBICelera
Cytogenetic Map19p13.11NCBI
HuRef1917,954,230 - 17,965,959 (-)NCBIHuRef
CHM1_11918,390,809 - 18,392,678 (-)NCBICHM1_1
T2T-CHM13v2.01918,413,794 - 18,415,722 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39871,150,389 - 71,153,265 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl871,151,599 - 71,153,265 (+)EnsemblGRCm39 Ensembl
GRCm38870,697,739 - 70,700,616 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,698,949 - 70,700,616 (+)EnsemblGRCm38mm10GRCm38
MGSCv37873,221,638 - 73,224,515 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36873,627,938 - 73,629,605 (+)NCBIMGSCv36mm8
Celera873,254,240 - 73,257,113 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.15NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0NW_0049555243,176,849 - 3,177,936 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan11922,145,537 - 22,147,409 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01917,755,331 - 17,757,164 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11918,728,466 - 18,729,502 (-)NCBIpanpan1.1PanPan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12044,737,021 - 44,738,932 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2044,736,832 - 44,763,020 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2044,651,244 - 44,653,089 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02045,222,928 - 45,224,778 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2045,222,673 - 45,224,061 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12044,460,059 - 44,461,903 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02044,870,705 - 44,872,544 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02045,145,944 - 45,147,789 (+)NCBIUU_Cfam_GSD_1.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1259,530,991 - 59,532,846 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1616,754,553 - 16,756,458 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl616,755,247 - 16,756,290 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660742,598,780 - 2,600,647 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046249081,573,174 - 1,574,113 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249081,572,628 - 1,574,205 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Jund
1 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:51
Count of miRNA genes:46
Interacting mature miRNAs:49
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
631517Scl9Serum cholesterol level QTL 93.3blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)161572643321034895Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21618,736,631 - 18,736,930 (+)MAPPERmRatBN7.2
Rnor_6.01620,487,540 - 20,487,834NCBIRnor6.0
Rnor_5.01620,344,608 - 20,344,902UniSTSRnor5.0
RGSC_v3.41619,242,205 - 19,242,500RGDRGSC3.4
RGSC_v3.41619,242,206 - 19,242,500UniSTSRGSC3.4
RGSC_v3.11619,242,204 - 19,242,498RGD
Celera1618,928,740 - 18,929,006UniSTS
RH 3.4 Map16202.5UniSTS
RH 3.4 Map16202.5RGD
RH 2.0 Map16183.7RGD
Cytogenetic Map16p14UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21618,735,975 - 18,736,194 (+)MAPPERmRatBN7.2
Rnor_6.01620,486,884 - 20,487,102NCBIRnor6.0
Rnor_5.01620,343,952 - 20,344,170UniSTSRnor5.0
RGSC_v3.41619,241,550 - 19,241,768UniSTSRGSC3.4
Celera1618,928,084 - 18,928,302UniSTS
RH 3.4 Map16181.4UniSTS
Cytogenetic Map16p14UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21618,734,138 - 18,734,324 (+)MAPPERmRatBN7.2
Rnor_6.01620,485,046 - 20,485,231NCBIRnor6.0
Rnor_5.01620,342,114 - 20,342,299UniSTSRnor5.0
RGSC_v3.41619,239,712 - 19,239,897UniSTSRGSC3.4
Celera1618,926,313 - 18,926,498UniSTS
Cytogenetic Map16p14UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21618,734,382 - 18,735,350 (+)MAPPERmRatBN7.2
Rnor_6.01620,485,290 - 20,486,258NCBIRnor6.0
Rnor_5.01620,342,358 - 20,343,326UniSTSRnor5.0
RGSC_v3.41619,239,956 - 19,240,924UniSTSRGSC3.4
Celera1618,926,557 - 18,927,524UniSTS
Cytogenetic Map16p14UniSTS

Genetic Models
This gene Jund is modified in the following models/strains:


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Below cutoff


RefSeq Acc Id: ENSRNOT00000026470   ⟹   ENSRNOP00000026470
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1618,734,122 - 18,735,799 (-)Ensembl
Rnor_6.0 Ensembl1620,485,029 - 20,486,707 (-)Ensembl
RefSeq Acc Id: NM_001286966   ⟹   NP_001273895
RefSeq Status: REVIEWED
Rat AssemblyChrPosition (strand)Source
mRatBN7.21618,734,121 - 18,735,799 (-)NCBI
Rnor_6.01620,485,028 - 20,486,707 (-)NCBI
Rnor_5.01620,342,096 - 20,343,775 (-)NCBI
Celera1618,926,295 - 18,927,907 (-)NCBI
RefSeq Acc Id: NM_138875   ⟹   NP_620230
RefSeq Status: REVIEWED
Rat AssemblyChrPosition (strand)Source
mRatBN7.21618,734,121 - 18,735,799 (-)NCBI
Rnor_6.01620,485,028 - 20,486,707 (-)NCBI
Rnor_5.01620,342,096 - 20,343,775 (-)NCBI
RGSC_v3.41619,239,694 - 19,241,529 (-)RGD
Celera1618,926,295 - 18,927,907 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001273895 (Get FASTA)   NCBI Sequence Viewer  
  NP_620230 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH62053 (Get FASTA)   NCBI Sequence Viewer  
  BAA05369 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000026470
GenBank Protein P52909 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_620230   ⟸   NM_138875
- Peptide Label: isoform JunD-FL
- UniProtKB: P52909 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001273895   ⟸   NM_001286966
- Peptide Label: isoform deltaJunD
- UniProtKB: A0A8L2QFM6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000026470   ⟸   ENSRNOT00000026470
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P52909-F1-model_v2 AlphaFold P52909 1-341 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13700019
Promoter ID:EPDNEW_R10542
Type:single initiation site
Description:JunD proto-oncogene, AP-1 transcription factor subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01620,486,720 - 20,486,780EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2945 AgrOrtholog
BioCyc Gene G2FUF-11798 BioCyc
Ensembl Genes ENSRNOG00000019568 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026470 ENTREZGENE
  ENSRNOT00000026470.7 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro bZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  bZIP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  JNK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leuzip_Jun UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TF_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24518 UniProtKB/Swiss-Prot
  PTHR11462:SF7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam bZIP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Jun UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Jund PhenoGen
  BZIP_BASIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019568 RatGTEx
SMART BRLZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47454 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57959 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-11 Jund  JunD proto-oncogene, AP-1 transcription factor subunit  Jund  jun D proto-oncogene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-11-06 Jund  jun D proto-oncogene  Jund  Jun D proto-oncogene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Jund  Jun D proto-oncogene      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_product member of the Jun family of nuclear transcription proteins 633074
gene_protein exists in two isoforms of 39-kDa and 34-kDa 633074
gene_transcript three non-AUG codons help in cap-dependent translation 633074