Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Jak2 (Janus kinase 2) Rattus norvegicus
Symbol: Jak2
Name: Janus kinase 2
RGD ID: 2939
Description: Exhibits several functions, including insulin receptor substrate binding activity; protein C-terminus binding activity; and signaling receptor binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of macromolecule metabolic process; and regulation of apoptotic process. Localizes to several cellular components, including euchromatin; glutamatergic synapse; and nucleolus. Used to study several diseases, including hyperuricemia; liver disease (multiple); retinal detachment; thrombocytosis; and transient cerebral ischemia. Biomarker of heart disease; hepatocellular carcinoma; liver cancer; liver cirrhosis; and obesity. Human ortholog(s) of this gene implicated in several diseases, including familial erythrocytosis 1; hematologic cancer (multiple); inflammatory bowel disease (multiple); liver disease (multiple); and thrombocytosis. Orthologous to human JAK2 (Janus kinase 2); PARTICIPATES IN aldosterone signaling pathway; angiotensin II signaling pathway; angiotensin II signaling pathway via AT1 receptor; INTERACTS WITH (4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid; (R)-mevalonic acid; (S)-nicotine.
Type: protein-coding
Also known as: JAK-2; Janus kinase 2 (a protein tyrosine kinase); tyrosine-protein kinase JAK2
Homo sapiens (human) : JAK2 (Janus kinase 2)  HGNC  Alliance
Mus musculus (house mouse) : Jak2 (Janus kinase 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Jak2 (Janus kinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : JAK2 (Janus kinase 2)
Canis lupus familiaris (dog) : JAK2 (Janus kinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Jak2 (Janus kinase 2)
Sus scrofa (pig) : JAK2 (Janus kinase 2)
Chlorocebus sabaeus (African green monkey) : JAK2 (Janus kinase 2)
Heterocephalus glaber (naked mole-rat) : Jak2 (Janus kinase 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01247,398,667 - 247,457,521 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1247,398,598 - 247,458,509 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01254,646,160 - 254,706,478 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41232,915,995 - 232,974,763 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11233,080,017 - 233,138,786 (+)NCBI
Celera1224,147,256 - 224,206,104 (+)NCBICelera
Cytogenetic Map1q52NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Jak2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2939
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-09-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.