Jag2 (jagged canonical Notch ligand 2) - Rat Genome Database

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Gene: Jag2 (jagged canonical Notch ligand 2) Rattus norvegicus
Analyze
Symbol: Jag2
Name: jagged canonical Notch ligand 2
RGD ID: 2938
Description: Predicted to enable Notch binding activity and growth factor activity. Involved in several processes, including male gonad development; response to hypoxia; and spermatogenesis. Located in perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy. Orthologous to human JAG2 (jagged canonical Notch ligand 2); PARTICIPATES IN altered Notch signaling pathway; Notch signaling pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: jagged 2; protein jagged-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86137,804,133 - 137,826,738 (-)NCBIGRCr8
mRatBN7.26131,983,059 - 132,005,665 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6131,983,056 - 132,005,818 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6132,152,615 - 132,174,787 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06132,442,522 - 132,464,547 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06131,817,423 - 131,839,474 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06137,711,144 - 137,733,331 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6137,711,155 - 137,733,026 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06146,707,326 - 146,729,504 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46137,909,633 - 137,931,120 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16137,916,169 - 137,936,985 (-)NCBI
Celera6129,521,212 - 129,543,266 (-)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-methyladenine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
butan-1-ol  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
calciol  (EXP)
calcitriol  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
disulfiram  (ISO)
doxorubicin  (ISO)
enzalutamide  (ISO)
ethanol  (ISO)
fipronil  (EXP)
FR900359  (ISO)
gentamycin  (EXP)
isobutanol  (ISO)
ketamine  (EXP)
methoxychlor  (EXP)
mono(2-ethylhexyl) phthalate  (EXP)
monocrotaline  (ISO)
Muraglitazar  (EXP)
nickel atom  (ISO)
ozone  (ISO)
paracetamol  (ISO)
phenethyl isothiocyanate  (ISO)
piroxicam  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sulindac sulfide  (ISO)
T-2 toxin  (ISO)
tebuconazole  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP)
Theaflavin 3,3'-digallate  (ISO)
thioacetamide  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function
calcium ion binding  (IEA)
growth factor activity  (IEA,ISO,ISS)
Notch binding  (IBA,IEA,ISO,NAS)
protein binding  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development. Felli MP, etal., Int Immunol. 1999 Jul;11(7):1017-25.
2. Cell and molecular biology of Notch. Fiuza UM and Arias AM, J Endocrinol. 2007 Sep;194(3):459-74.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Human ligands of the Notch receptor. Gray GE, etal., Am J Pathol 1999 Mar;154(3):785-94.
6. Requirement of Notch 1 and its ligand jagged 2 expressions for spermatogenesis in rat and human testes. Hayashi T, etal., J Androl. 2001 Nov-Dec;22(6):999-1011.
7. Expression of the p63 and Notch signaling systems in rat testes during postnatal development: comparison with their expression levels in the epididymis and vas deferens. Hayashi T, etal., J Androl. 2004 Sep-Oct;25(5):692-8.
8. Patterns of Jagged1, Jagged2, Delta-like 1 and Delta-like 3 expression during late embryonic and postnatal brain development suggest multiple functional roles in progenitors and differentiated cells. Irvin DK, etal., J Neurosci Res 2004 Feb 1;75(3):330-43.
9. Notch signalling pathway mediates hair cell development in mammalian cochlea. Lanford PJ, etal., Nat Genet. 1999 Mar;21(3):289-92.
10. Members of the Jagged/Notch gene families are expressed in injured arteries and regulate cell phenotype via alterations in cell matrix and cell-cell interaction. Lindner V, etal., Am J Pathol. 2001 Sep;159(3):875-83. doi: 10.1016/S0002-9440(10)61763-4.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
15. GOA pipeline RGD automated data pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Jagged2: a serrate-like gene expressed during rat embryogenesis. Shawber C, etal., Dev Biol 1996 Nov 25;180(1):370-6.
18. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
19. Chronic hypoxia and rat lung development: analysis by morphometry and directed microarray. Truog WE, etal., Pediatr Res. 2008 Jul;64(1):56-62.
20. Mouse Jagged2 is differentially expressed in hematopoietic progenitors and endothelial cells and promotes the survival and proliferation of hematopoietic progenitors by direct cell-to-cell contact. Tsai S, etal., Blood. 2000 Aug 1;96(3):950-7.
Additional References at PubMed
PMID:9315665   PMID:9531541   PMID:10958687   PMID:15721140   PMID:15886206   PMID:16607638   PMID:19503073   PMID:23232913   PMID:24098462   PMID:24907271   PMID:38277398  


Genomics

Comparative Map Data
Jag2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86137,804,133 - 137,826,738 (-)NCBIGRCr8
mRatBN7.26131,983,059 - 132,005,665 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6131,983,056 - 132,005,818 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6132,152,615 - 132,174,787 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06132,442,522 - 132,464,547 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06131,817,423 - 131,839,474 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06137,711,144 - 137,733,331 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6137,711,155 - 137,733,026 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06146,707,326 - 146,729,504 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46137,909,633 - 137,931,120 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16137,916,169 - 137,936,985 (-)NCBI
Celera6129,521,212 - 129,543,266 (-)NCBICelera
Cytogenetic Map6q32NCBI
JAG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814105,140,995 - 105,168,776 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14105,140,982 - 105,168,824 (-)EnsemblGRCh38hg38GRCh38
GRCh3714105,607,332 - 105,635,113 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3614104,679,121 - 104,706,206 (-)NCBINCBI36Build 36hg18NCBI36
Build 3414104,679,120 - 104,706,206NCBI
Celera1485,661,503 - 85,688,392 (-)NCBICelera
Cytogenetic Map14q32.33NCBI
HuRef1485,798,697 - 85,815,481 (-)NCBIHuRef
CHM1_114105,545,299 - 105,572,922 (-)NCBICHM1_1
T2T-CHM13v2.01499,382,854 - 99,410,701 (-)NCBIT2T-CHM13v2.0
Jag2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912112,871,439 - 112,893,437 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12112,871,439 - 112,893,396 (-)EnsemblGRCm39 Ensembl
GRCm3812112,907,803 - 112,929,812 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12112,907,819 - 112,929,776 (-)EnsemblGRCm38mm10GRCm38
MGSCv3712114,146,801 - 114,167,706 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612113,356,398 - 113,377,303 (-)NCBIMGSCv36mm8
Celera12114,118,903 - 114,139,458 (-)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1261.37NCBI
Jag2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555383,421,685 - 3,433,842 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555383,421,685 - 3,433,829 (-)NCBIChiLan1.0ChiLan1.0
JAG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v215106,321,986 - 106,348,518 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan114105,538,488 - 105,565,020 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01485,785,586 - 85,812,056 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.114105,569,837 - 105,604,408 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl14105,569,837 - 105,585,878 (-)Ensemblpanpan1.1panPan2
JAG2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1872,535,539 - 72,553,531 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl872,535,107 - 72,550,322 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha872,047,599 - 72,068,957 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0872,823,360 - 72,848,984 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl872,822,931 - 72,856,860 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1872,503,851 - 72,525,225 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0872,554,984 - 72,576,363 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0872,944,852 - 72,966,232 (-)NCBIUU_Cfam_GSD_1.0
Jag2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086401,534,532 - 1,551,659 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936621366,616 - 380,618 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936621363,489 - 380,616 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JAG2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.27131,225,201 - 131,245,220 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JAG2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12483,050,412 - 83,081,982 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2483,051,368 - 83,076,820 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605370,482,903 - 70,500,481 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Jag2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624734308,375 - 327,604 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624734308,371 - 327,496 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Jag2
53 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:135
Count of miRNA genes:112
Interacting mature miRNAs:122
Transcripts:ENSRNOT00000019213
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6106752656132339866Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)6122549046137801795Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)6122549046140994061Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6112636280140994061Rat
2312560Pur20Proteinuria QTL 202.10.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)6125628133137801795Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6122549046140286318Rat

Markers in Region
AI101320  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26131,988,972 - 131,989,365 (+)MAPPERmRatBN7.2
Rnor_6.06137,717,061 - 137,717,453NCBIRnor6.0
Rnor_5.06146,713,243 - 146,713,635UniSTSRnor5.0
RGSC_v3.46137,914,765 - 137,915,157UniSTSRGSC3.4
Celera6129,527,129 - 129,527,521UniSTS
RH 3.4 Map6783.1UniSTS
Cytogenetic Map6q32UniSTS
UniSTS:465459  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26131,984,610 - 131,984,888 (+)MAPPERmRatBN7.2
Rnor_6.06137,712,699 - 137,712,976NCBIRnor6.0
Rnor_5.06146,708,881 - 146,709,158UniSTSRnor5.0
RGSC_v3.46137,910,403 - 137,910,680UniSTSRGSC3.4
Celera6129,522,767 - 129,523,044UniSTS
Cytogenetic Map6q32UniSTS
D17S1789  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2987,972,545 - 87,973,112 (+)MAPPERmRatBN7.2
mRatBN7.26131,984,729 - 131,985,679 (+)MAPPERmRatBN7.2
Rnor_6.06137,712,818 - 137,713,767NCBIRnor6.0
Rnor_6.0994,396,513 - 94,397,079NCBIRnor6.0
Rnor_5.0994,119,127 - 94,119,693UniSTSRnor5.0
Rnor_5.06146,709,000 - 146,709,949UniSTSRnor5.0
RGSC_v3.46137,910,522 - 137,911,471UniSTSRGSC3.4
RGSC_v3.4986,112,181 - 86,112,747UniSTSRGSC3.4
Celera985,384,401 - 85,384,967UniSTS
Celera6129,522,886 - 129,523,835UniSTS
Cytogenetic Map9q35UniSTS
Cytogenetic Map6q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000019213   ⟹   ENSRNOP00000019213
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6131,983,056 - 132,005,818 (-)Ensembl
Rnor_6.0 Ensembl6137,711,155 - 137,733,026 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100725   ⟹   ENSRNOP00000083204
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6131,983,056 - 132,005,818 (-)Ensembl
RefSeq Acc Id: NM_001375303   ⟹   NP_001362232
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86137,804,133 - 137,826,336 (-)NCBI
mRatBN7.26131,983,059 - 132,005,263 (-)NCBI
RefSeq Acc Id: NM_001414899   ⟹   NP_001401828
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86137,804,133 - 137,826,738 (-)NCBI
mRatBN7.26131,983,059 - 132,005,665 (-)NCBI
RefSeq Acc Id: XM_039111823   ⟹   XP_038967751
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86137,804,149 - 137,826,533 (-)NCBI
mRatBN7.26131,983,059 - 132,005,359 (-)NCBI
RefSeq Acc Id: XM_039111824   ⟹   XP_038967752
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86137,810,415 - 137,826,481 (-)NCBI
mRatBN7.26131,989,337 - 132,005,359 (-)NCBI
RefSeq Acc Id: XM_063261573   ⟹   XP_063117643
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86137,804,149 - 137,826,533 (-)NCBI
Ensembl Acc Id: ENSRNOP00000019213   ⟸   ENSRNOT00000019213
RefSeq Acc Id: NP_001362232   ⟸   NM_001375303
- Peptide Label: isoform 2
- UniProtKB: A6KBW9 (UniProtKB/TrEMBL),   A6KBX0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967751   ⟸   XM_039111823
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZUZ8 (UniProtKB/TrEMBL),   A6KBX0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967752   ⟸   XM_039111824
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000083204   ⟸   ENSRNOT00000100725
RefSeq Acc Id: NP_001401828   ⟸   NM_001414899
- Peptide Label: isoform 1 precursor
- UniProtKB: A6KBX0 (UniProtKB/TrEMBL),   E9PU23 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117643   ⟸   XM_063261573
- Peptide Label: isoform X1
- UniProtKB: A6KBX0 (UniProtKB/TrEMBL)
Protein Domains
DSL   EGF-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97607-F1-model_v2 AlphaFold P97607 1-1202 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2938 AgrOrtholog
BioCyc Gene G2FUF-35770 BioCyc
Ensembl Genes ENSRNOG00000013927 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019213.7 UniProtKB/TrEMBL
  ENSRNOT00000100725.1 UniProtKB/TrEMBL
Gene3D-CATH 2.10.25.140 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.3510 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DSL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Jagged/Serrate UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOTCH1_EGF-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOTCH_homolog UniProtKB/TrEMBL
  Notch_ligand_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Notch_signaling UniProtKB/TrEMBL
  VWF_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 29147 ENTREZGENE
PANTHER CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2 UniProtKB/Swiss-Prot
  EGF-LIKE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  EGF-LIKE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1-RELATED UniProtKB/Swiss-Prot
  NOTCH LIGAND FAMILY MEMBER UniProtKB/TrEMBL
  PROTEIN JAGGED-2 UniProtKB/TrEMBL
Pfam DL-JAG_EGF-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DSL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  hEGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MNNL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Jag2 PhenoGen
PRINTS EGFBLOOD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  JAGGEDFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DSL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013927 RatGTEx
SMART DSL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWC_out UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FnI-like domain UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC205341
UniProt A0A8I5ZUZ8 ENTREZGENE, UniProtKB/TrEMBL
  A6KBW9 ENTREZGENE, UniProtKB/TrEMBL
  A6KBX0 ENTREZGENE, UniProtKB/TrEMBL
  E9PU23 ENTREZGENE, UniProtKB/TrEMBL
  JAG2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-10 Jag2  jagged canonical Notch ligand 2  Jag2  jagged 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Jag2  jagged 2       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the apical ectodermal ridge and thymus 69864
gene_process may be involved in Notch directed T-cell fate 69864