Itgb1 (integrin subunit beta 1) - Rat Genome Database

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Gene: Itgb1 (integrin subunit beta 1) Rattus norvegicus
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Symbol: Itgb1
Name: integrin subunit beta 1
RGD ID: 2927
Description: Enables several functions, including cytoskeletal protein binding activity; enzyme binding activity; and fibronectin binding activity. Involved in several processes, including bicellular tight junction assembly; regulation of cell projection organization; and regulation of neuron differentiation. Located in several cellular components, including acrosomal vesicle; focal adhesion; and hemidesmosome. Part of integrin alpha3-beta1 complex and integrin alpha9-beta1 complex. Is active in glutamatergic synapse; glycinergic synapse; and postsynaptic membrane. Used to study hydrocephalus and myocardial infarction. Biomarker of glomerulonephritis. Orthologous to human ITGB1 (integrin subunit beta 1); PARTICIPATES IN integrin mediated signaling pathway; altered integrin mediated signaling pathway; altered Reelin signaling pathway; INTERACTS WITH (+)-pilocarpine; (R)-adrenaline; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: beta OL; beta oligodendroglia; collagen alpha-1(I) chain-like; fibronectin receptor subunit beta; Integrin beta 1; integrin beta 1 (fibronectin receptor beta); integrin beta-1; integrin VLA-4 subunit beta; integrin, beta 1; LOC102556297; VLA-4 subunit beta
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81973,602,277 - 73,650,271 (+)NCBIGRCr8
GRCr8 Ensembl1973,602,126 - 73,650,269 (+)EnsemblGRCr8 Ensembl
mRatBN7.21956,705,123 - 56,753,199 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1956,705,171 - 56,753,195 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1963,495,092 - 63,543,090 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01964,355,011 - 64,403,009 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01966,437,682 - 66,485,679 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01961,677,512 - 61,725,537 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1961,677,542 - 61,725,535 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01972,324,582 - 72,372,325 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41958,600,095 - 58,647,531 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1956,037,604 - 56,085,651 (+)NCBICelera
RGSC_v3.11958,605,791 - 58,652,463 (-)NCBI
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP,ISO)
(20S)-ginsenoside Rh1  (ISO)
(24S)-24-hydroxycholesterol  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(R)-adrenaline  (EXP)
(S)-nicotine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2'-Methylenebis(4-methyl-6-tert-butylphenol)  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-D  (ISO)
2,4-dinitrotoluene  (EXP)
2,5-hexanedione  (EXP)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-deoxy-D-glucose  (ISO)
2-methoxyethanol  (EXP)
2-nitrotoluene  (EXP)
26-hydroxycholesterol  (ISO)
3',5'-cyclic AMP  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
7alpha-hydroxycholesterol  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
alternariol  (ISO)
Altertoxin II  (ISO)
aluminium oxide  (ISO)
ammonium chloride  (EXP,ISO)
antirheumatic drug  (ISO)
Arg-Gly-Asp  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
artesunate  (ISO)
atorvastatin calcium  (EXP,ISO)
atrazine  (ISO)
aucubin  (ISO)
Azoxymethane  (ISO)
beauvericin  (ISO)
benomyl  (ISO)
benzo[a]pyrene  (ISO)
beta-carotene  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
blebbistatin  (ISO)
bromochloroacetic acid  (EXP)
bucladesine  (ISO)
C.I. Natural Red 20  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calciol  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbendazim  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
carvone  (ISO)
CEDRELONE  (ISO)
CGP 52608  (ISO)
chloroacetaldehyde  (ISO)
chloropicrin  (ISO)
chrysene  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clotrimazole  (EXP)
cocaine  (ISO)
colforsin daropate hydrochloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
crocidolite asbestos  (EXP,ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
DDT  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
diclofenac  (ISO)
dicrotophos  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (EXP,ISO)
disulfiram  (ISO)
diuron  (EXP)
dobutamine  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enniatin  (ISO)
erlotinib hydrochloride  (EXP)
ethanol  (ISO)
ethyl trans-caffeate  (ISO)
etodolac  (ISO)
eugenol  (ISO)
fenamidone  (ISO)
fenhexamid  (ISO)
fenofibrate  (EXP)
folic acid  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
furan  (EXP)
furfural  (ISO)
gefitinib  (ISO)
genistein  (ISO)
geranylgeraniol  (EXP,ISO)
ginsenoside C-K  (ISO)
glucose  (EXP,ISO)
glycidyl methacrylate  (ISO)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
ifosfamide  (ISO)
indirubin  (ISO)
indometacin  (EXP)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
latrunculin A  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
lovastatin  (ISO)
magnesium atom  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
medroxyprogesterone acetate  (ISO)
mercury atom  (EXP)
mercury(0)  (EXP)
metformin  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylseleninic acid  (ISO)
mevalonic acid  (EXP,ISO)
microcystin-LR  (ISO)
ML-7  (ISO)
monocrotaline  (ISO)
morusin  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nicotine  (ISO)
nitrates  (ISO)
notoginsenoside R1  (ISO)
Octicizer  (ISO)
Ophiopogonin D  (ISO)
ozone  (EXP)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
pentane-2,3-dione  (EXP)
perfluorohexanesulfonic acid  (ISO)
phenobarbital  (EXP)
phenytoin  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
potassium iodide  (EXP)
pravastatin  (EXP,ISO)
prednisone  (ISO)
progesterone  (EXP)
prostaglandin E2  (EXP)
quercetin  (EXP,ISO)
quercitrin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rimonabant  (ISO)
rotenone  (EXP,ISO)
ruxolitinib  (ISO)
SB 431542  (ISO)
Shikonin  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
Soman  (EXP)
spiromesifen  (ISO)
streptozocin  (EXP,ISO)
sulfadimethoxine  (EXP)
superoxide  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
Y-27632  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
autophagy  (ISO)
axon extension  (ISO)
basement membrane organization  (ISO)
bicellular tight junction assembly  (IMP)
calcium-independent cell-matrix adhesion  (ISO)
cardiac cell fate specification  (ISO)
cardiac muscle cell differentiation  (ISO)
cardiac muscle cell myoblast differentiation  (ISO)
CD40 signaling pathway  (ISO)
cell adhesion  (IEA,ISO)
cell adhesion mediated by integrin  (IBA,IGI,ISO,ISS)
cell migration  (IBA)
cell migration involved in sprouting angiogenesis  (ISO)
cell population proliferation  (ISO)
cell projection organization  (IMP)
cell-cell adhesion  (IBA)
cell-cell adhesion mediated by integrin  (ISO)
cell-matrix adhesion  (IBA,IEA,ISO)
cell-substrate adhesion  (ISO)
cellular response to ionizing radiation  (IEP)
cellular response to low-density lipoprotein particle stimulus  (ISO,ISS)
cellular response to mechanical stimulus  (IEA,IEP)
cellular response to vitamin D  (IEP)
central nervous system neuron differentiation  (ISO)
dendrite morphogenesis  (ISO)
endocytosis  (IEA)
establishment of mitotic spindle orientation  (ISO)
establishment of Sertoli cell barrier  (IEP)
formation of radial glial scaffolds  (ISO)
G1/S transition of mitotic cell cycle  (ISO)
germ cell migration  (ISO)
heterotypic cell-cell adhesion  (ISO)
in utero embryonic development  (ISO)
integrin-mediated signaling pathway  (IBA,IEA,ISO)
lamellipodium assembly  (IMP)
leukocyte cell-cell adhesion  (ISO)
leukocyte tethering or rolling  (ISO)
maintenance of postsynaptic specialization structure  (EXP,IDA,IEA)
maternal process involved in female pregnancy  (IEP)
mesodermal cell differentiation  (ISO)
modulation of chemical synaptic transmission  (ISO)
muscle organ development  (IEA)
myoblast differentiation  (ISS)
myoblast fate specification  (ISO)
myoblast fusion  (ISS)
negative regulation of anoikis  (ISO)
negative regulation of apoptotic process  (IDA)
negative regulation of autophagy  (ISO)
negative regulation of cell population proliferation  (IMP)
negative regulation of cell projection organization  (IMP)
negative regulation of neuron differentiation  (IEA,IMP,ISO)
negative regulation of Rho protein signal transduction  (ISO)
negative regulation of vasoconstriction  (ISO,ISS)
neuroblast proliferation  (ISO)
neuron projection development  (ISO)
obsolete regulation of inward rectifier potassium channel activity  (ISO)
phagocytosis  (IMP)
positive regulation of angiogenesis  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of cell adhesion  (IEA)
positive regulation of cell migration  (IMP)
positive regulation of cell-substrate adhesion  (IMP)
positive regulation of developmental process  (IEA)
positive regulation of endocytosis  (IMP)
positive regulation of fibroblast growth factor receptor signaling pathway  (ISO)
positive regulation of fibroblast migration  (ISO)
positive regulation of glutamate uptake involved in transmission of nerve impulse  (ISO)
positive regulation of GTPase activity  (ISO)
positive regulation of neuroblast proliferation  (ISO)
positive regulation of neuron differentiation  (IMP)
positive regulation of neuron projection development  (IMP)
positive regulation of peptidyl-tyrosine phosphorylation  (IMP)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of protein localization to plasma membrane  (ISO,ISS)
positive regulation of vascular endothelial growth factor signaling pathway  (ISO)
positive regulation of wound healing  (ISO)
protein transport within lipid bilayer  (IMP)
reactive gliosis  (ISO)
receptor internalization  (ISO,ISS)
regulation of cell cycle  (ISO)
regulation of cell population proliferation  (IEA)
regulation of collagen catabolic process  (ISO,ISS)
regulation of G protein-coupled receptor signaling pathway  (IMP)
regulation of postsynaptic neurotransmitter receptor diffusion trapping  (EXP,IDA,IEA)
regulation of spontaneous synaptic transmission  (ISO)
regulation of synapse pruning  (ISO)
regulation of transport  (IEA)
response to activity  (IEA,IEP)
response to gonadotropin  (IEP)
response to muscle activity  (ISO)
response to nutrient levels  (IEP)
response to radiation  (IEA)
response to transforming growth factor beta  (IEP)
response to xenobiotic stimulus  (IEP)
sarcomere organization  (ISO)
stress fiber assembly  (ISO)
synaptic membrane adhesion to extracellular matrix  (IC)
tissue development  (IEA)
tissue homeostasis  (IMP)
transforming growth factor beta receptor signaling pathway  (ISO)
visual learning  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Integrin dynamics produce a delayed stage of long-term potentiation and memory consolidation. Babayan AH, etal., J Neurosci. 2012 Sep 12;32(37):12854-61. doi: 10.1523/JNEUROSCI.2024-12.2012.
2. Alpha1beta1-integrin is an essential signal for neurite outgrowth induced by thrombospondin type 1 repeats of SCO-spondin. Bamdad M, etal., Cell Tissue Res. 2004 Jan;315(1):15-25. Epub 2003 Oct 16.
3. Integrins regulate opioid receptor signaling in trigeminal ganglion neurons. Berg KA, etal., Neuroscience. 2007 Feb 9;144(3):889-97. Epub 2006 Dec 8.
4. Connection between integrins and cell activation in rat adrenal glomerulosa cells: a role for Arg-Gly-Asp peptide in the activation of the p42/p44(mapk) pathway and intracellular calcium. Campbell S, etal., Endocrinology. 2003 Apr;144(4):1486-95.
5. Integrin beta1 is involved in the signaling of glial cell line-derived neurotrophic factor. Cao JP, etal., J Comp Neurol. 2008 Jul 10;509(2):203-10.
6. Dystrophin Dp71f associates with the beta1-integrin adhesion complex to modulate PC12 cell adhesion. Cerna J, etal., J Mol Biol. 2006 Oct 6;362(5):954-65. Epub 2006 Aug 1.
7. A crosstalk between β1 and β3 integrins controls glycine receptor and gephyrin trafficking at synapses. Charrier C, etal., Nat Neurosci. 2010 Nov;13(11):1388-95. doi: 10.1038/nn.2645. Epub 2010 Oct 10.
8. Dp71f modulates GSK3-beta recruitment to the beta1-integrin adhesion complex. Cortes JC, etal., Neurochem Res. 2009 Mar;34(3):438-44. Epub 2008 Aug 2.
9. Integrin signaling in inflammatory and neuropathic pain in the rat. Dina OA, etal., Eur J Neurosci. 2004 Feb;19(3):634-42.
10. Primary afferent second messenger cascades interact with specific integrin subunits in producing inflammatory hyperalgesia. Dina OA, etal., Pain. 2005 May;115(1-2):191-203.
11. Transforming growth factor-beta prevents osteoblast apoptosis induced by skeletal unloading via PI3K/Akt, Bcl-2, and phospho-Bad signaling. Dufour C, etal., Am J Physiol Endocrinol Metab. 2008 Apr;294(4):E794-801.
12. Reelin glycoprotein: structure, biology and roles in health and disease. Fatemi SH Mol Psychiatry. 2005 Mar;10(3):251-7.
13. Purification and characterization of integrin alpha 9 beta 1. Forsberg E, etal., Exp Cell Res. 1994 Jul;213(1):183-90.
14. Crucial role of fibroblast integrins alpha2 and beta1 in maintaining the structural and mechanical properties of the skin. Fujimura T, etal., J Dermatol Sci. 2007 Jan;45(1):45-53. Epub 2006 Nov 21.
15. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
16. Localization of integrin beta 1, alpha 1, alpha 5 and alpha 9 subunits in the rat testis. Giebel J, etal., Int J Androl. 1997 Feb;20(1):3-9.
17. Alpha8 integrin in glomerular mesangial cells and in experimental glomerulonephritis. Hartner A, etal., Kidney Int 1999 Oct;56(4):1468-80.
18. Binding of laminin-1 to monosialoganglioside GM1 in lipid rafts is crucial for neurite outgrowth. Ichikawa N, etal., J Cell Sci. 2009 Jan 15;122(Pt 2):289-99.
19. Erythropoietin promotes Schwann cell migration and assembly of the provisional extracellular matrix by recruiting beta1 integrin to the cell surface. Inoue G, etal., Glia. 2010 Mar;58(4):399-409.
20. The Effect of Maternal Undernutrition On Vascular Expression of Micro and Messenger RNA in Newborn and Aging Offspring. Khorram O, etal., Am J Physiol Regul Integr Comp Physiol. 2010 Mar 3.
21. Laminin alpha 5 mediates ectopic adhesion of hepatocellular carcinoma through integrins and/or Lutheran/basal cell adhesion molecule. Kikkawa Y, etal., Exp Cell Res. 2008 Aug 15;314(14):2579-90. Epub 2008 Jun 7.
22. Endothelin-1 is a potent stimulator of alpha1beta1 integrin-mediated collagen matrix remodeling by rat mesangial cells. Kitamura A, etal., Biochem Biophys Res Commun 2002 Dec 13;299(4):555-61.
23. UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis. Koizumi S, etal., Nature. 2007 Apr 26;446(7139):1091-5. doi: 10.1038/nature05704. Epub 2007 Apr 4.
24. Expression of beta 1-integrins on activated mesangial cells in human glomerulonephritis. Kuhara T, etal., J Am Soc Nephrol. 1997 Nov;8(11):1679-87. doi: 10.1681/ASN.V8111679.
25. Bcl-2 and ß1-integrin predict survival in a tissue microarray of small cell lung cancer. Lawson MH, etal., Br J Cancer. 2010 Nov 23;103(11):1710-5. doi: 10.1038/sj.bjc.6605950. Epub 2010 Nov 9.
26. Integrin ß1 Increases Stem Cell Survival and Cardiac Function after Myocardial Infarction. Li L, etal., Front Pharmacol. 2017 Mar 17;8:135. doi: 10.3389/fphar.2017.00135. eCollection 2017.
27. Cyclic force upregulates mechano-growth factor and elevates cell proliferation in 3D cultured skeletal myoblasts. Li Y, etal., Arch Biochem Biophys. 2009 Oct 15;490(2):171-6. Epub 2009 Aug 29.
28. High expression of miR-493-5p positively correlates with clinical prognosis of non small cell lung cancer by targeting oncogene ITGB1. Liang Z, etal., Oncotarget. 2017 Jul 18;8(29):47389-47399. doi: 10.18632/oncotarget.17650.
29. Beta 1 integrin-mediated effects of tenascin-R domains EGFL and FN6-8 on neural stem/progenitor cell proliferation and differentiation in vitro. Liao H, etal., J Biol Chem. 2008 Oct 10;283(41):27927-36. Epub 2008 Jul 24.
30. Laminin-332-beta1 integrin interactions negatively regulate invadopodia. Liu S, etal., J Cell Physiol. 2010 Apr;223(1):134-42.
31. Distribution of basal membrane complex components in elongating lens fibers. Lu JY, etal., Mol Vis. 2008 Jun 30;14:1187-203.
32. Cloning and sequence of the cDNA encoding the rat oligodendrocyte integrin beta 1 subunit. Malek-Hedayat S and Rome LH, Gene 1995 Jun 9;158(2):287-90.
33. Role of MT1-MMP in the osteogenic differentiation. Manduca P, etal., Bone. 2009 Feb;44(2):251-65. Epub 2008 Nov 5.
34. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
35. Matrix metalloproteinase-9 controls NMDA receptor surface diffusion through integrin beta1 signaling. Michaluk P, etal., J Neurosci. 2009 May 6;29(18):6007-12.
36. Initial signaling of the fibronectin receptor (alpha5beta1 integrin) in hepatic stellate cells is independent of tyrosine phosphorylation. Milliano MT and Luxon BA, J Hepatol 2003 Jul;39(1):32-7.
37. Effect of irradiation on gene expression of rat liver adhesion molecules: in vivo and in vitro studies. Moriconi F, etal., Strahlenther Onkol. 2009 Jul;185(7):460-8. Epub 2009 Aug 28.
38. Rat seminiferous epithelium contains a unique junction (Ectoplasmic specialization) with signaling properties both of cell/cell and cell/matrix junctions. Mulholland DJ, etal., Biol Reprod. 2001 Jan;64(1):396-407.
39. alpha4beta1- and alpha6beta1-integrins are functional receptors for midkine, a heparin-binding growth factor. Muramatsu H, etal., J Cell Sci. 2004 Oct 15;117(Pt 22):5405-15. doi: 10.1242/jcs.01423. Epub 2004 Oct 5.
40. Intraventricular injection of antibodies to beta1-integrins generates pressure gradients in the brain favoring hydrocephalus development in rats. Nagra G, etal., Am J Physiol Regul Integr Comp Physiol. 2009 Nov;297(5):R1312-21. Epub 2009 Sep 2.
41. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
42. Podocyte foot process effacement in very early phase of passive Heymann nephritis is not a prerequisite for proteinuria. Nosaka H, etal., J Nephrol. 2009 Jul-Aug;22(4):484-90.
43. Merlin, the neurofibromatosis type 2 gene product, and beta1 integrin associate in isolated and differentiating Schwann cells. Obremski VJ, etal., J Neurobiol. 1998 Dec;37(4):487-501.
44. P2Y12 receptor-mediated integrin-beta1 activation regulates microglial process extension induced by ATP. Ohsawa K, etal., Glia. 2010 May;58(7):790-801.
45. Increased expression of integrin beta1 is a poor prognostic factor in small-cell lung cancer. Oshita F, etal., Anticancer Res. 2002 Mar-Apr;22(2B):1065-70.
46. Maternal Thyroid Hormone before the Onset of Fetal Thyroid Function Regulates Reelin and Downstream Signaling Cascade Affecting Neocortical Neuronal Migration. Pathak A, etal., Cereb Cortex. 2010 Apr 5.
47. Connective tissue growth factor with a novel fibronectin binding site promotes cell adhesion and migration during rat oval cell activation. Pi L, etal., Hepatology. 2008 Mar;47(3):996-1004.
48. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
49. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
50. GOA pipeline RGD automated data pipeline
51. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
52. Beta1 integrins participate in the hypertrophic response of rat ventricular myocytes. Ross RS, etal., Circ Res 1998 Jun 15;82(11):1160-72.
53. Effect of ovarian stimulation with human menopausal gonadotropin and recombinant follicle stimulating hormone on the expression of integrins alpha3, beta1 in the rat endometrium during the implantation period. Sendag F, etal., Eur J Obstet Gynecol Reprod Biol. 2010 May;150(1):57-60. Epub 2010 Mar 1.
54. Caveolin-1-dependent beta1 integrin endocytosis is a critical regulator of fibronectin turnover. Shi F and Sottile J, J Cell Sci. 2008 Jul 15;121(Pt 14):2360-71. Epub 2008 Jun 24.
55. Filamin A is a regulator of blood-testis barrier assembly during postnatal development in the rat testis. Su W, etal., Endocrinology. 2012 Oct;153(10):5023-35. Epub 2012 Aug 7.
56. Temporal response and localization of integrins beta1 and beta3 in the heart after myocardial infarction: regulation by cytokines. Sun M, etal., Circulation 2003 Feb 25;107(7):1046-52.
57. The integrins. Takada Y, etal., Genome Biol. 2007;8(5):215.
58. Expression of collagen binding integrins during cardiac development and hypertrophy. Terracio L, etal., Circ Res. 1991 Mar;68(3):734-44.
59. Calcium-sensing receptor modulates cell adhesion and migration via integrins. Tharmalingam S, etal., J Biol Chem. 2011 Nov 25;286(47):40922-33. doi: 10.1074/jbc.M111.265454. Epub 2011 Oct 3.
60. A neuronal cell line (PC12) expresses two beta 1-class integrins-alpha 1 beta 1 and alpha 3 beta 1-that recognize different neurite outgrowth-promoting domains in laminin. Tomaselli KJ, etal., Neuron. 1990 Nov;5(5):651-62.
61. Increased migratory properties of aortal smooth muscle cells exposed to calcitriol in culture. Tukaj C, etal., J Steroid Biochem Mol Biol. 2010 Mar 18.
62. Fibronectin and focal adhesion kinase small interfering RNA modulate rat retinal Muller cells adhesion and migration. Wang XL, etal., Cell Mol Neurobiol. 2009 Jun;29(4):549-56. Epub 2009 Jan 27.
63. Spatiotemporal expression of alpha(1), alpha(3) and beta(1) integrin subunits is altered in rat myometrium during pregnancy and labour. Williams SJ, etal., Reprod Fertil Dev. 2010;22(4):718-32.
64. An autocrine axis in the testis that coordinates spermiation and blood-testis barrier restructuring during spermatogenesis. Yan HH, etal., Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):8950-5. Epub 2008 Jun 25.
65. Osteopontin is a mediator of the lateral migration of neuroblasts from the subventricular zone after focal cerebral ischemia. Yan YP, etal., Neurochem Int. 2009 Dec;55(8):826-32. Epub 2009 Aug 15.
66. Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery Zhong Q, etal., Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2010 Feb;24(2):133-7.
Additional References at PubMed
PMID:1715889   PMID:1833411   PMID:1839357   PMID:7544313   PMID:8306881   PMID:8601592   PMID:9004034   PMID:9415431   PMID:9553049   PMID:10079228   PMID:10455171   PMID:11732910  
PMID:11792823   PMID:11869556   PMID:12189152   PMID:12417594   PMID:12477932   PMID:12509413   PMID:12591243   PMID:12642506   PMID:12651615   PMID:12670870   PMID:12697723   PMID:12807887  
PMID:12869515   PMID:12879062   PMID:12904471   PMID:12957148   PMID:14522949   PMID:14550305   PMID:14559243   PMID:14660602   PMID:14715956   PMID:14970227   PMID:15006356   PMID:15056720  
PMID:15174102   PMID:15189273   PMID:15366013   PMID:15618357   PMID:15705967   PMID:15811857   PMID:16148033   PMID:16424942   PMID:16459165   PMID:16467530   PMID:16554304   PMID:16557522  
PMID:16608848   PMID:16750664   PMID:16783488   PMID:16803572   PMID:16935002   PMID:17065460   PMID:17099249   PMID:17123509   PMID:17158881   PMID:17583725   PMID:17593555   PMID:17598176  
PMID:17665129   PMID:17704059   PMID:18037995   PMID:18156211   PMID:18188865   PMID:18245559   PMID:18308860   PMID:18333785   PMID:18573216   PMID:18611855   PMID:18778724   PMID:18922173  
PMID:19056867   PMID:19215949   PMID:19234460   PMID:19364818   PMID:19487454   PMID:19581412   PMID:19651211   PMID:19703720   PMID:19933311   PMID:19946888   PMID:20019333   PMID:20049771  
PMID:20103531   PMID:20183869   PMID:20213330   PMID:20237282   PMID:20563599   PMID:20810886   PMID:21136191   PMID:21149578   PMID:21178109   PMID:21185282   PMID:21310825   PMID:21423176  
PMID:21508095   PMID:21593411   PMID:21620958   PMID:21696820   PMID:21738954   PMID:21747167   PMID:21932337   PMID:22198504   PMID:22357865   PMID:22413019   PMID:22659335   PMID:22664869  
PMID:22692550   PMID:22812390   PMID:22865233   PMID:22890232   PMID:23023225   PMID:23058350   PMID:23118988   PMID:23125415   PMID:23154389   PMID:23238717   PMID:23297403   PMID:23325413  
PMID:23376485   PMID:23382103   PMID:23382219   PMID:23395392   PMID:23468528   PMID:23533145   PMID:23620790   PMID:23658023   PMID:23659290   PMID:23715271   PMID:23755149   PMID:23981064  
PMID:24036928   PMID:24044949   PMID:24122940   PMID:24220332   PMID:24472554   PMID:24535659   PMID:24681597   PMID:24742749   PMID:24823363   PMID:25063885   PMID:25098415   PMID:25220424  
PMID:25300309   PMID:25336636   PMID:25468996   PMID:25713411   PMID:25715677   PMID:25716834   PMID:25754303   PMID:25911094   PMID:25974241   PMID:26093969   PMID:26143257   PMID:26316108  
PMID:26335442   PMID:26467923   PMID:26520903   PMID:26763945   PMID:26997644   PMID:27169768   PMID:27879672   PMID:28176845   PMID:28760342   PMID:28765893   PMID:29023021   PMID:29162887  
PMID:29223350   PMID:29237506   PMID:29324307   PMID:29599211   PMID:30121936   PMID:30206251   PMID:30992345   PMID:31096970   PMID:31331973   PMID:31699892   PMID:33049071   PMID:33426760  
PMID:33640375   PMID:33847460   PMID:35352799   PMID:35655382   PMID:36336138   PMID:38063256  


Genomics

Comparative Map Data
Itgb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81973,602,277 - 73,650,271 (+)NCBIGRCr8
GRCr8 Ensembl1973,602,126 - 73,650,269 (+)EnsemblGRCr8 Ensembl
mRatBN7.21956,705,123 - 56,753,199 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1956,705,171 - 56,753,195 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1963,495,092 - 63,543,090 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01964,355,011 - 64,403,009 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01966,437,682 - 66,485,679 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01961,677,512 - 61,725,537 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1961,677,542 - 61,725,535 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01972,324,582 - 72,372,325 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41958,600,095 - 58,647,531 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1956,037,604 - 56,085,651 (+)NCBICelera
RGSC_v3.11958,605,791 - 58,652,463 (-)NCBI
Cytogenetic Map19q12NCBI
ITGB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381032,900,318 - 32,958,230 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1032,887,273 - 33,005,792 (-)EnsemblGRCh38hg38GRCh38
GRCh371033,189,246 - 33,247,158 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361033,229,326 - 33,287,204 (-)NCBINCBI36Build 36hg18NCBI36
Build 341033,236,244 - 33,264,492NCBI
Celera1032,954,580 - 33,012,639 (-)NCBICelera
Cytogenetic Map10p11.22NCBI
HuRef1032,908,756 - 32,966,834 (-)NCBIHuRef
CHM1_11033,190,855 - 33,248,907 (-)NCBICHM1_1
T2T-CHM13v2.01032,929,042 - 32,986,969 (-)NCBIT2T-CHM13v2.0
Itgb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398129,412,135 - 129,460,060 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8129,412,135 - 129,459,681 (+)EnsemblGRCm39 Ensembl
GRCm388128,685,654 - 128,733,579 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8128,685,654 - 128,733,200 (+)EnsemblGRCm38mm10GRCm38
MGSCv378131,209,554 - 131,257,479 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368131,571,871 - 131,619,287 (+)NCBIMGSCv36mm8
Celera8133,002,434 - 133,050,263 (+)NCBICelera
Cytogenetic Map8E2NCBI
cM Map876.09NCBI
Itgb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554624,454,809 - 4,484,842 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554624,454,809 - 4,483,227 (+)NCBIChiLan1.0ChiLan1.0
ITGB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2845,544,239 - 45,602,146 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11045,549,559 - 45,607,471 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01033,023,573 - 33,081,384 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11033,608,978 - 33,662,258 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1033,608,978 - 33,644,031 (-)Ensemblpanpan1.1panPan2
ITGB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.123,728,472 - 3,757,696 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl23,670,596 - 3,756,961 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha23,811,003 - 3,857,059 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.024,006,817 - 4,053,107 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl24,006,751 - 4,081,502 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.123,785,306 - 3,831,383 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.023,819,236 - 3,865,356 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.023,939,078 - 3,985,170 (+)NCBIUU_Cfam_GSD_1.0
Itgb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934411,966,401 - 11,996,275 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365741,465,897 - 1,495,762 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365741,465,981 - 1,495,717 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITGB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1056,078,396 - 56,173,326 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11056,078,393 - 56,130,608 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21061,450,695 - 61,502,941 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ITGB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1932,201,030 - 32,258,247 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl932,202,204 - 32,258,154 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605641,260,215 - 41,317,418 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itgb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248058,765,949 - 8,802,149 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248058,748,848 - 8,800,259 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:565
Count of miRNA genes:275
Interacting mature miRNAs:327
Transcripts:ENSRNOT00000014785
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194438513474246245Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)193253961574246245Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)196124916174246245Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)194622677874246245Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)193236531174246245Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)194172254674246245Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat

Markers in Region
Itgb1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21956,744,391 - 56,745,956 (+)MAPPERmRatBN7.2
Rnor_6.01961,716,730 - 61,718,294NCBIRnor6.0
Rnor_5.01972,363,518 - 72,365,082UniSTSRnor5.0
RGSC_v3.41958,607,339 - 58,608,903UniSTSRGSC3.4
Celera1956,076,843 - 56,078,407UniSTS
Cytogenetic Map19q12UniSTS
AU048052  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21956,741,837 - 56,741,996 (+)MAPPERmRatBN7.2
Rnor_6.01961,714,176 - 61,714,334NCBIRnor6.0
Rnor_5.01972,360,964 - 72,361,122UniSTSRnor5.0
RGSC_v3.41958,611,298 - 58,611,456UniSTSRGSC3.4
Celera1956,074,289 - 56,074,447UniSTS
Cytogenetic Map19q12UniSTS
RH138141  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21956,705,988 - 56,706,174 (+)MAPPERmRatBN7.2
Rnor_6.01961,678,326 - 61,678,511NCBIRnor6.0
Rnor_5.01972,325,396 - 72,325,581UniSTSRnor5.0
RGSC_v3.41958,646,562 - 58,646,747UniSTSRGSC3.4
Celera1956,038,388 - 56,038,573UniSTS
Cytogenetic Map19q12UniSTS
UniSTS:256618  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21956,744,391 - 56,745,956 (+)MAPPERmRatBN7.2
Rnor_6.01961,716,730 - 61,718,294NCBIRnor6.0
Rnor_5.01972,363,518 - 72,365,082UniSTSRnor5.0
RGSC_v3.41958,607,339 - 58,608,903UniSTSRGSC3.4
Celera1956,076,843 - 56,078,407UniSTS
Cytogenetic Map19q12UniSTS
Itgb1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21956,744,518 - 56,746,039 (+)MAPPERmRatBN7.2
Rnor_6.01961,716,857 - 61,718,377NCBIRnor6.0
Rnor_5.01972,363,645 - 72,365,165UniSTSRnor5.0
RGSC_v3.41958,607,256 - 58,608,776UniSTSRGSC3.4
Celera1956,076,970 - 56,078,490UniSTS
Cytogenetic Map19q12UniSTS
Itgb1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21956,752,981 - 56,753,153 (+)MAPPERmRatBN7.2
Rnor_6.01961,725,320 - 61,725,491NCBIRnor6.0
Rnor_5.01972,372,108 - 72,372,279UniSTSRnor5.0
RGSC_v3.41958,600,141 - 58,600,312UniSTSRGSC3.4
Celera1956,085,434 - 56,085,605UniSTS
Cytogenetic Map19q12UniSTS
Itgb1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21956,752,911 - 56,753,152 (+)MAPPERmRatBN7.2
Rnor_6.01961,725,250 - 61,725,490NCBIRnor6.0
Rnor_5.01972,372,038 - 72,372,278UniSTSRnor5.0
RGSC_v3.41958,600,142 - 58,600,382UniSTSRGSC3.4
Celera1956,085,364 - 56,085,604UniSTS
Cytogenetic Map19q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000014785   ⟹   ENSRNOP00000014785
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1973,621,826 - 73,650,259 (+)Ensembl
mRatBN7.2 Ensembl1956,724,752 - 56,752,639 (+)Ensembl
Rnor_6.0 Ensembl1961,677,542 - 61,725,535 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109602   ⟹   ENSRNOP00000093150
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1973,602,126 - 73,650,259 (+)Ensembl
mRatBN7.2 Ensembl1956,705,171 - 56,753,195 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000134870   ⟹   ENSRNOP00000108731
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1973,605,986 - 73,650,269 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000164127   ⟹   ENSRNOP00000105381
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1973,621,826 - 73,650,269 (+)Ensembl
RefSeq Acc Id: NM_017022   ⟹   NP_058718
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81973,602,277 - 73,650,271 (+)NCBI
mRatBN7.21956,705,205 - 56,753,199 (+)NCBI
Rnor_6.01961,677,542 - 61,725,537 (+)NCBI
Rnor_5.01972,324,582 - 72,372,325 (+)NCBI
RGSC_v3.41958,600,095 - 58,647,531 (-)RGD
Celera1956,037,604 - 56,085,651 (+)RGD
Sequence:
RefSeq Acc Id: XM_063277783   ⟹   XP_063133853
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81973,602,311 - 73,644,003 (+)NCBI
Protein Sequences
Protein RefSeqs NP_058718 (Get FASTA)   NCBI Sequence Viewer  
  XP_063133853 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA86669 (Get FASTA)   NCBI Sequence Viewer  
  AAI31846 (Get FASTA)   NCBI Sequence Viewer  
  EDL96787 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000014785
  ENSRNOP00000093150
GenBank Protein P49134 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058718   ⟸   NM_017022
- Peptide Label: precursor
- UniProtKB: A2RRT8 (UniProtKB/Swiss-Prot),   P49134 (UniProtKB/Swiss-Prot),   A6KJ65 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014785   ⟸   ENSRNOT00000014785
Ensembl Acc Id: ENSRNOP00000093150   ⟸   ENSRNOT00000109602
RefSeq Acc Id: XP_063133853   ⟸   XM_063277783
- Peptide Label: isoform X1
- UniProtKB: P49134 (UniProtKB/Swiss-Prot),   A2RRT8 (UniProtKB/Swiss-Prot),   A0A0G2JSK5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000108731   ⟸   ENSRNOT00000134870
Ensembl Acc Id: ENSRNOP00000105381   ⟸   ENSRNOT00000164127
Protein Domains
I-EGF   Integrin beta subunit cytoplasmic   Integrin beta subunit tail   Integrin beta subunit VWA   PSI   VWFA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P49134-F1-model_v2 AlphaFold P49134 1-799 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701260
Promoter ID:EPDNEW_R11783
Type:initiation region
Name:Itgb1_1
Description:integrin subunit beta 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01961,677,508 - 61,677,568EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2927 AgrOrtholog
BioCyc Gene G2FUF-5121 BioCyc
Ensembl Genes ENSRNOG00000010966 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000014785 ENTREZGENE
  ENSRNOT00000109602 ENTREZGENE
Gene3D-CATH 3.40.50.410 UniProtKB/Swiss-Prot
  4.10.1240.30 UniProtKB/Swiss-Prot
  Cytochrome c1, transmembrane anchor, C-terminal UniProtKB/Swiss-Prot
  Laminin UniProtKB/Swiss-Prot
  ligand-binding face of the semaphorins, domain 2 UniProtKB/Swiss-Prot
  ntegrin, alpha v. Chain A, domain 3 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:8366766 IMAGE-MGC_LOAD
InterPro EGF_extracell UniProtKB/Swiss-Prot
  I-EGF_1 UniProtKB/Swiss-Prot
  Integrin_beta_N UniProtKB/Swiss-Prot
  Integrin_bsu UniProtKB/Swiss-Prot
  Integrin_bsu_cyt_dom UniProtKB/Swiss-Prot
  Integrin_bsu_tail UniProtKB/Swiss-Prot
  Integrin_bsu_tail_dom_sf UniProtKB/Swiss-Prot
  Integrin_bsu_VWA UniProtKB/Swiss-Prot
  Integrin_dom_sf UniProtKB/Swiss-Prot
  PSI UniProtKB/Swiss-Prot
  vWFA_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:24511 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156664 IMAGE-MGC_LOAD
NCBI Gene 24511 ENTREZGENE
PANTHER PTHR10082 UniProtKB/Swiss-Prot
  PTHR10082:SF28 UniProtKB/Swiss-Prot
Pfam EGF_2 UniProtKB/Swiss-Prot
  EGF_integrin UniProtKB/Swiss-Prot
  I-EGF_1 UniProtKB/Swiss-Prot
  Integrin_b_cyt UniProtKB/Swiss-Prot
  Integrin_B_tail UniProtKB/Swiss-Prot
  Integrin_beta UniProtKB/Swiss-Prot
  PSI_integrin UniProtKB/Swiss-Prot
PhenoGen Itgb1 PhenoGen
PIRSF Integrin_B UniProtKB/Swiss-Prot
PRINTS INTEGRINB UniProtKB/Swiss-Prot
PROSITE EGF_1 UniProtKB/Swiss-Prot
  I_EGF_2 UniProtKB/Swiss-Prot
  INTEGRIN_BETA UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010966 RatGTEx
SMART INB UniProtKB/Swiss-Prot
  Integrin_b_cyt UniProtKB/Swiss-Prot
  Integrin_B_tail UniProtKB/Swiss-Prot
  PSI UniProtKB/Swiss-Prot
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot
  Plexin repeat UniProtKB/Swiss-Prot
  SSF53300 UniProtKB/Swiss-Prot
  SSF69179 UniProtKB/Swiss-Prot
  SSF69687 UniProtKB/Swiss-Prot
UniProt A0A0G2JSK5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GKJ1_RAT UniProtKB/TrEMBL
  A2RRT8 ENTREZGENE
  A6KJ65 ENTREZGENE, UniProtKB/TrEMBL
  ITB1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A2RRT8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Itgb1  integrin subunit beta 1  LOC102556297  collagen alpha-1(I) chain-like  Data merged from RGD:7738144 737654 PROVISIONAL
2015-12-23 Itgb1  integrin subunit beta 1  Itgb1  integrin, beta 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-12-18 LOC102556297  collagen alpha-1(I) chain-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2009-12-15 Itgb1  integrin, beta 1  Itgb1  integrin beta 1 (fibronectin receptor beta)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Itgb1  integrin beta 1 (fibronectin receptor beta)      Name updated 1299863 APPROVED
2002-06-10 Itgb1  Integrin, beta 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in fibroblasts and inflammatory cells 633129
gene_process may be involved in inflammation and fibrosis 633129