Itga5 (integrin subunit alpha 5) - Rat Genome Database

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Gene: Itga5 (integrin subunit alpha 5) Rattus norvegicus
Analyze
Symbol: Itga5
Name: integrin subunit alpha 5
RGD ID: 2925
Description: Enables epidermal growth factor receptor binding activity and integrin binding activity. Involved in several processes, including female pregnancy; integrin-mediated signaling pathway; and positive regulation of cell-substrate adhesion. Part of integrin complex. Is active in glutamatergic synapse and postsynaptic membrane. Orthologous to human ITGA5 (integrin subunit alpha 5); PARTICIPATES IN integrin mediated signaling pathway; altered integrin mediated signaling pathway; myocardial infarction pathway; INTERACTS WITH (+)-pilocarpine; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: integrin alpha 5; integrin alpha 5 (fibronectin receptor alpha); integrin alpha 5 (mapped); integrin alpha-5; integrin, alpha 5; integrin, alpha 5 (fibronectin receptor, alpha polypeptide); Integrin, alpha 5 (fibronectin receptor, alpha); Itga5_mapped; Itga5_retired
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87136,358,097 - 136,381,305 (-)NCBIGRCr8
mRatBN7.27134,478,963 - 134,502,837 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7134,478,968 - 134,502,837 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7136,234,784 - 136,258,229 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07138,464,152 - 138,487,593 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07138,450,391 - 138,473,685 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07144,970,444 - 144,993,652 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7144,970,444 - 144,993,652 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07142,749,459 - 142,773,323 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47142,254,256 - 142,277,464 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7130,903,975 - 130,927,190 (-)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-bromohexadecanoic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-bromo-2'-deoxyuridine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
acetone  (ISO)
acetylsalicylic acid  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
aluminium oxide  (ISO)
amitrole  (EXP)
amphetamine  (EXP)
Arg-Gly-Asp  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benomyl  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A5  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
capsaicin  (EXP)
carbendazim  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
cordycepin  (ISO)
cortisol  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
DDE  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (ISO)
diazepam  (ISO)
dibutyl phthalate  (EXP,ISO)
dioxygen  (EXP)
disodium selenite  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
ethanol  (ISO)
fenamidone  (ISO)
fenthion  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furosemide  (EXP)
genistein  (ISO)
glucose  (ISO)
glycidyl methacrylate  (ISO)
glyphosate  (ISO)
heptachlor  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
inulin  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
leuprolide  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
LY294002  (ISO)
magnesium atom  (ISO)
methapyrilene  (ISO)
methidathion  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
nitrofen  (EXP)
ozone  (ISO)
pentane-2,3-dione  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phytoestrogen  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
quercetin  (EXP,ISO)
quinoline  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
tetracycline  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
trichloroethene  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP,ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Integrin signaling in inflammatory and neuropathic pain in the rat. Dina OA, etal., Eur J Neurosci. 2004 Feb;19(3):634-42.
2. Primary afferent second messenger cascades interact with specific integrin subunits in producing inflammatory hyperalgesia. Dina OA, etal., Pain. 2005 May;115(1-2):191-203.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Regional Regulation of Purkinje Cell Dendritic Spines by Integrins and Eph/Ephrins. Heintz TG, etal., PLoS One. 2016 Aug 12;11(8):e0158558. doi: 10.1371/journal.pone.0158558. eCollection 2016.
5. Integrin alpha(5) interacts with EGFR, is necessary for FcvarepsilonRI signaling and is necessary for allergic inflammation in relation with angiogenesis. Kim Y, etal., Mol Immunol. 2011 Apr;48(8):1035-45. Epub 2011 Feb 23.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Initial signaling of the fibronectin receptor (alpha5beta1 integrin) in hepatic stellate cells is independent of tyrosine phosphorylation. Milliano MT and Luxon BA, J Hepatol 2003 Jul;39(1):32-7.
8. Differential expression of alpha 1, alpha 3 and alpha 5 integrin subunits in acute and chronic stages of myocardial infarction in rats. Nawata J, etal., Cardiovasc Res 1999 Aug 1;43(2):371-81.
9. Connective tissue growth factor with a novel fibronectin binding site promotes cell adhesion and migration during rat oval cell activation. Pi L, etal., Hepatology. 2008 Mar;47(3):996-1004.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12. Endothelial-to-mesenchymal transition in pulmonary hypertension. Ranchoux B, etal., Circulation. 2015 Mar 17;131(11):1006-18. doi: 10.1161/CIRCULATIONAHA.114.008750. Epub 2015 Jan 15.
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Uterine stretch regulates temporal and spatial expression of fibronectin protein and its alpha 5 integrin receptor in myometrium of unilaterally pregnant rats. Shynlova O, etal., Biol Reprod. 2007 Nov;77(5):880-8. doi: 10.1095/biolreprod.107.062356. Epub 2007 Aug 22.
16. The integrins. Takada Y, etal., Genome Biol. 2007;8(5):215.
Additional References at PubMed
PMID:8306881   PMID:8557754   PMID:8601592   PMID:9553049   PMID:10022831   PMID:11869556   PMID:12189152   PMID:12493556   PMID:12807887   PMID:12867986   PMID:12904471   PMID:14644171  
PMID:14970227   PMID:15006356   PMID:15635129   PMID:15722407   PMID:16100245   PMID:16554304   PMID:17123509   PMID:17158881   PMID:17213186   PMID:17483236   PMID:18330891   PMID:18638458  
PMID:19027743   PMID:19141530   PMID:19460962   PMID:19581412   PMID:19703720   PMID:19933311   PMID:20049771   PMID:20563599   PMID:21178109   PMID:21423176   PMID:21559527   PMID:21747167  
PMID:22865233   PMID:23023225   PMID:23154389   PMID:23325413   PMID:23658023   PMID:24959065   PMID:26010756   PMID:26093969   PMID:26494230   PMID:26997644   PMID:27535240   PMID:27842221  
PMID:28176845   PMID:28739685   PMID:29162887   PMID:29324307   PMID:31090958   PMID:31331973   PMID:32351169   PMID:33049071   PMID:35352799  


Genomics

Comparative Map Data
Itga5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87136,358,097 - 136,381,305 (-)NCBIGRCr8
mRatBN7.27134,478,963 - 134,502,837 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7134,478,968 - 134,502,837 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7136,234,784 - 136,258,229 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07138,464,152 - 138,487,593 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07138,450,391 - 138,473,685 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07144,970,444 - 144,993,652 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7144,970,444 - 144,993,652 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07142,749,459 - 142,773,323 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47142,254,256 - 142,277,464 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7130,903,975 - 130,927,190 (-)NCBICelera
Cytogenetic Map7q36NCBI
ITGA5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381254,395,261 - 54,419,266 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1254,395,261 - 54,419,266 (-)EnsemblGRCh38hg38GRCh38
GRCh371254,789,045 - 54,813,050 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361253,075,312 - 53,099,317 (-)NCBINCBI36Build 36hg18NCBI36
Build 341253,075,313 - 53,099,317NCBI
Celera1254,440,888 - 54,464,894 (-)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1251,828,142 - 51,852,148 (-)NCBIHuRef
CHM1_11254,755,737 - 54,779,741 (-)NCBICHM1_1
T2T-CHM13v2.01254,361,846 - 54,385,852 (-)NCBIT2T-CHM13v2.0
Itga5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915103,252,713 - 103,275,218 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15103,252,713 - 103,275,190 (-)EnsemblGRCm39 Ensembl
GRCm3815103,344,286 - 103,366,791 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15103,344,286 - 103,366,763 (-)EnsemblGRCm38mm10GRCm38
MGSCv3715103,174,717 - 103,197,179 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615103,172,320 - 103,194,797 (-)NCBIMGSCv36mm8
Celera15105,510,278 - 105,532,530 (-)NCBICelera
Cytogenetic Map15F3NCBI
cM Map1558.9NCBI
Itga5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554581,632,282 - 1,658,295 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554581,635,554 - 1,657,609 (-)NCBIChiLan1.0ChiLan1.0
ITGA5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21039,753,055 - 39,777,261 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11239,749,994 - 39,774,030 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01234,326,182 - 34,350,050 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11235,052,994 - 35,076,860 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1235,052,994 - 35,075,835 (+)Ensemblpanpan1.1panPan2
ITGA5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.127904,892 - 924,757 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl27904,102 - 924,084 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2745,330,567 - 45,350,366 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.027902,131 - 921,978 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl27902,131 - 921,969 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.127893,448 - 913,731 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.027902,991 - 922,682 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02745,734,450 - 45,754,318 (-)NCBIUU_Cfam_GSD_1.0
Itga5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494561,552,202 - 61,576,027 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651211,588,645 - 11,612,669 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493651211,588,818 - 11,612,580 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITGA5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl519,586,746 - 19,610,362 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1519,587,361 - 19,610,580 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2520,441,721 - 20,465,338 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ITGA5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11150,507,673 - 50,535,358 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1150,510,714 - 50,535,328 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037195,501,908 - 195,526,109 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itga5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249042,417,269 - 2,440,087 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249042,418,140 - 2,439,945 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Itga5
113 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:345
Count of miRNA genes:197
Interacting mature miRNAs:220
Transcripts:ENSRNOT00000055277
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000087748   ⟹   ENSRNOP00000071805
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7134,479,628 - 134,502,837 (-)Ensembl
Rnor_6.0 Ensembl7144,970,444 - 144,993,652 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109863   ⟹   ENSRNOP00000088245
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7134,479,663 - 134,502,636 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115763   ⟹   ENSRNOP00000077413
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7134,478,968 - 134,502,609 (-)Ensembl
RefSeq Acc Id: NM_001108118   ⟹   NP_001101588
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87136,358,097 - 136,381,305 (-)NCBI
mRatBN7.27134,479,628 - 134,502,837 (-)NCBI
Rnor_6.07144,970,444 - 144,993,652 (-)NCBI
Rnor_5.07142,749,459 - 142,773,323 (-)NCBI
RGSC_v3.47142,254,256 - 142,277,464 (-)RGD
Celera7130,903,975 - 130,927,190 (-)RGD
Sequence:
RefSeq Acc Id: XM_039079352   ⟹   XP_038935280
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87136,358,099 - 136,381,273 (-)NCBI
mRatBN7.27134,478,963 - 134,502,800 (-)NCBI
RefSeq Acc Id: XM_063263684   ⟹   XP_063119754
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87136,359,191 - 136,381,276 (-)NCBI
RefSeq Acc Id: XM_063263685   ⟹   XP_063119755
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87136,359,190 - 136,381,278 (-)NCBI
RefSeq Acc Id: NP_001101588   ⟸   NM_001108118
- UniProtKB: A0A8I5YCC9 (UniProtKB/TrEMBL),   A6KD08 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071805   ⟸   ENSRNOT00000087748
RefSeq Acc Id: XP_038935280   ⟸   XM_039079352
- Peptide Label: isoform X3
- UniProtKB: A0A8I5YCC9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000077413   ⟸   ENSRNOT00000115763
Ensembl Acc Id: ENSRNOP00000088245   ⟸   ENSRNOT00000109863
RefSeq Acc Id: XP_063119755   ⟸   XM_063263685
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063119754   ⟸   XM_063263684
- Peptide Label: isoform X1
Protein Domains
Integrin alpha first immunoglubulin-like   Integrin alpha second immunoglobulin-like   Integrin alpha third immunoglobulin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K1E2-F1-model_v2 AlphaFold A0A0G2K1E2 1-1099 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2925 AgrOrtholog
BioCyc Gene G2FUF-31876 BioCyc
Ensembl Genes ENSRNOG00000057451 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000087748.2 UniProtKB/TrEMBL
  ENSRNOT00000109863.1 UniProtKB/TrEMBL
  ENSRNOT00000115763.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.130 UniProtKB/TrEMBL
  Bicelle-embedded integrin alpha(iib) transmembrane segment UniProtKB/TrEMBL
  Integrin domains. Chain A, domain 2 UniProtKB/TrEMBL
  ntegrin, alpha v. Chain A, domain 3 UniProtKB/TrEMBL
  ntegrin, alpha v. Chain A, domain 4 UniProtKB/TrEMBL
InterPro FG-GAP UniProtKB/TrEMBL
  Int_alpha_beta-p UniProtKB/TrEMBL
  Integrin_alpha UniProtKB/TrEMBL
  Integrin_alpha-2 UniProtKB/TrEMBL
  Integrin_alpha_C_CS UniProtKB/TrEMBL
  Integrin_alpha_Ig-like_2 UniProtKB/TrEMBL
  Integrin_alpha_Ig-like_3 UniProtKB/TrEMBL
  Integrin_alpha_N UniProtKB/TrEMBL
  Integrin_dom UniProtKB/TrEMBL
KEGG Report rno:315346 UniProtKB/TrEMBL
NCBI Gene Itga5 ENTREZGENE
PANTHER INTEGRIN ALPHA UniProtKB/TrEMBL
  INTEGRIN ALPHA-5 UniProtKB/TrEMBL
Pfam FG-GAP UniProtKB/TrEMBL
  Integrin_A_Ig_2 UniProtKB/TrEMBL
  Integrin_A_Ig_3 UniProtKB/TrEMBL
  Integrin_alpha2 UniProtKB/TrEMBL
PhenoGen Itga5 PhenoGen
PRINTS INTEGRINA UniProtKB/TrEMBL
PROSITE FG_GAP UniProtKB/TrEMBL
  INTEGRIN_ALPHA UniProtKB/TrEMBL
RatGTEx ENSRNOG00000057451 RatGTEx
SMART Int_alpha UniProtKB/TrEMBL
Superfamily-SCOP SSF69179 UniProtKB/TrEMBL
  SSF69318 UniProtKB/TrEMBL
UniProt A0A0G2K1E2_RAT UniProtKB/TrEMBL
  A0A8I5YCC9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A7G7_RAT UniProtKB/TrEMBL
  A6KD08 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-23 Itga5  integrin subunit alpha 5  Itga5  integrin alpha 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-12-09 Itga5  integrin alpha 5  Itga5  integrin, alpha 5 (fibronectin receptor, alpha polypeptide)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-02-24 Itga5  integrin, alpha 5 (fibronectin receptor, alpha polypeptide)  Itga5  integrin, alpha 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-02-09 Itga5  integrin, alpha 5  Itga5  integrin, alpha 5 (fibronectin receptor, alpha polypeptide)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-01-14 Itga5  integrin, alpha 5 (fibronectin receptor, alpha polypeptide)  Itga5  integrin, alpha 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-12-15 Itga5  integrin, alpha 5  Itga5  integrin alpha 5 (fibronectin receptor alpha)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-19 Itga5  integrin alpha 5 (fibronectin receptor alpha)  Itga5  integrin alpha 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-04-11 Itga5  integrin alpha 5  Itga5_mapped  integrin alpha 5 (mapped)  Symbol updated 737654 APPROVED
2007-04-11 Itga5_mapped  integrin alpha 5 (mapped)  Itga5_retired  integrin alpha 5 (mapped)  Data merged from RGD:1589748 737654 APPROVED
2007-04-11 Itga5_retired    Itga5  integrin alpha 5 (mapped)  Symbol updated 737654 PENDING
2006-11-19 Itga5  integrin alpha 5 (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Itga5_mapped  integrin alpha 5 (mapped)      Symbol and Name updated 1556543 APPROVED
2002-06-10 Itga5  Integrin, alpha 5 (fibronectin receptor, alpha)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function acts as a receptor for fibronectin with beta 1 integrin subunit 1300196
gene_physical_interaction interacts with integrin beta 1 subunit 1300196
gene_process involved in activation of hepatic stellate cells 1300196