Kpnb1 (karyopherin subunit beta 1) - Rat Genome Database

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Gene: Kpnb1 (karyopherin subunit beta 1) Rattus norvegicus
Analyze
Symbol: Kpnb1
Name: karyopherin subunit beta 1
RGD ID: 2909
Description: Enables kinesin binding activity. Predicted to be involved in import into nucleus; microtubule cytoskeleton organization; and mitotic sister chromatid segregation. Predicted to act upstream of or within ribosomal protein import into nucleus. Part of nuclear pore. Orthologous to human KPNB1 (karyopherin subunit beta 1); PARTICIPATES IN RNA transport pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Impnb; Importin beta; importin subunit beta-1; karyopherin (importin) beta 1; karyopherin subunit beta-1; karyopherin,beta 1; nuclear factor P97; pore targeting complex 97 kDa subunit; PTAC97
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81082,642,082 - 82,670,856 (-)NCBIGRCr8
mRatBN7.21082,145,662 - 82,174,437 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1082,145,420 - 82,174,605 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1087,094,110 - 87,122,899 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01086,592,172 - 86,620,969 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01081,984,776 - 82,013,559 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01085,096,517 - 85,124,641 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1085,093,841 - 85,124,644 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01084,886,484 - 84,914,805 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41085,882,382 - 85,910,805 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11085,896,751 - 85,925,175 (-)NCBI
Celera1080,906,145 - 80,931,812 (-)NCBICelera
Cytogenetic Map10q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,1-dichloroethene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
beauvericin  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
buspirone  (EXP)
butanal  (ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cocaine  (EXP)
Dibutyl phosphate  (ISO)
dimethylarsinic acid  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
enniatin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fenthion  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
gallic acid  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
ionomycin  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
L-methionine  (ISO)
lead(0)  (ISO)
levofloxacin  (EXP)
menadione  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
ozone  (ISO)
paracetamol  (ISO)
pentachlorophenol  (ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
propiconazole  (ISO)
prostaglandin F2alpha  (EXP)
raloxifene  (ISO)
resveratrol  (ISO)
rimonabant  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium acetate trihydrate  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
triadimefon  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
trovafloxacin  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vitamin E  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. RanGTP targets p97 to RanBP2, a filamentous protein localized at the cytoplasmic periphery of the nuclear pore complex. Delphin C, etal., Mol Biol Cell. 1997 Dec;8(12):2379-90.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteins. Hu T, etal., J Cell Biol 1996 Aug;134(3):589-601.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins. Moroianu J, etal., Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6532-6.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. Identification of a protein complex that is required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. Radu A, etal., Proc Natl Acad Sci U S A 1995 Feb 28;92(5):1769-73.
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Major binding sites for the nuclear import receptor are the internal nucleoporin Nup153 and the adjacent nuclear filament protein Tpr. Shah S, etal., J Cell Biol. 1998 Apr 6;141(1):31-49.
14. The molecular motor KIFC1 associates with a complex containing nucleoporin NUP62 that is regulated during development and by the small GTPase RAN. Yang WX, etal., Biol Reprod. 2006 Apr;74(4):684-90. Epub 2005 Dec 21.
Additional References at PubMed
PMID:7615630   PMID:9687515   PMID:11809816   PMID:11984006   PMID:15689618   PMID:15748847   PMID:15964792   PMID:16574786   PMID:16854843   PMID:17728463   PMID:18816794   PMID:19056867  
PMID:19581287   PMID:19796622   PMID:19946888   PMID:20458337   PMID:20699224   PMID:20709160   PMID:21291862   PMID:22681889   PMID:22701565   PMID:22841314   PMID:23533145   PMID:23783028  
PMID:24625528   PMID:25931508   PMID:26316108   PMID:27430620   PMID:32357304  


Genomics

Comparative Map Data
Kpnb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81082,642,082 - 82,670,856 (-)NCBIGRCr8
mRatBN7.21082,145,662 - 82,174,437 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1082,145,420 - 82,174,605 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1087,094,110 - 87,122,899 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01086,592,172 - 86,620,969 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01081,984,776 - 82,013,559 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01085,096,517 - 85,124,641 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1085,093,841 - 85,124,644 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01084,886,484 - 84,914,805 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41085,882,382 - 85,910,805 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11085,896,751 - 85,925,175 (-)NCBI
Celera1080,906,145 - 80,931,812 (-)NCBICelera
Cytogenetic Map10q31NCBI
KPNB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381747,649,919 - 47,685,505 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1747,649,476 - 47,685,505 (+)EnsemblGRCh38hg38GRCh38
GRCh371745,727,285 - 45,762,871 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361743,082,274 - 43,116,003 (+)NCBINCBI36Build 36hg18NCBI36
Build 341743,082,273 - 43,116,003NCBI
Celera1742,179,952 - 42,213,682 (+)NCBICelera
Cytogenetic Map17q21.32NCBI
HuRef1741,096,264 - 41,130,080 (+)NCBIHuRef
CHM1_11745,792,168 - 45,825,949 (+)NCBICHM1_1
T2T-CHM13v2.01748,511,703 - 48,547,295 (+)NCBIT2T-CHM13v2.0
Kpnb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391197,050,536 - 97,078,718 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1197,050,540 - 97,078,707 (-)EnsemblGRCm39 Ensembl
GRCm381197,159,710 - 97,187,892 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1197,159,714 - 97,187,881 (-)EnsemblGRCm38mm10GRCm38
MGSCv371197,021,024 - 97,049,206 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361196,975,800 - 97,003,982 (-)NCBIMGSCv36mm8
Celera11106,812,630 - 106,840,820 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1160.95NCBI
Kpnb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545113,365,476 - 13,398,491 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545113,365,881 - 13,398,491 (-)NCBIChiLan1.0ChiLan1.0
KPNB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21917,417,441 - 17,453,002 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11719,382,919 - 19,418,880 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0179,852,424 - 9,887,111 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11710,035,738 - 10,068,401 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1710,035,732 - 10,068,913 (-)Ensemblpanpan1.1panPan2
KPNB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1924,004,191 - 24,031,370 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl924,003,968 - 24,028,531 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha923,470,348 - 23,497,535 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0924,796,218 - 24,823,411 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl924,795,998 - 24,821,055 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1923,566,722 - 23,593,892 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0923,827,962 - 23,855,184 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0923,954,771 - 23,981,965 (+)NCBIUU_Cfam_GSD_1.0
Kpnb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560223,439,655 - 23,471,619 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649013,603,498 - 13,635,682 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649013,603,520 - 13,635,567 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KPNB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1223,916,164 - 23,944,588 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11223,915,783 - 23,945,407 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21223,785,821 - 23,813,399 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KPNB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11668,047,473 - 68,083,290 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1668,047,491 - 68,084,778 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607739,091,438 - 39,128,535 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kpnb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247954,371,749 - 4,403,217 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247954,372,014 - 4,403,061 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kpnb1
71 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:126
Count of miRNA genes:103
Interacting mature miRNAs:109
Transcripts:ENSRNOT00000012376
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
61402Niddm3Non-insulin dependent diabetes mellitus QTL 34.58blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)106134541382564856Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
2298481Eau9Experimental allergic uveoretinitis QTL 90.0169uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)106592723382565079Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
12880053Cm104Cardiac mass QTL 1040.009heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)107345299283463334Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)107437208484007272Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)107563188787055282Rat
2325836Bp346Blood pressure QTL 3460.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608584007272Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
724516Uae17Urinary albumin excretion QTL 173.6urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)107821062285220348Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)107889965587307728Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)107981378985160854Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108051528791230079Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat

Markers in Region
RH142486  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21082,175,810 - 82,175,921 (+)MAPPERmRatBN7.2
Rnor_6.01085,126,015 - 85,126,125NCBIRnor6.0
Rnor_5.01084,915,982 - 84,916,092UniSTSRnor5.0
RGSC_v3.41085,912,179 - 85,912,289UniSTSRGSC3.4
Celera1080,935,319 - 80,935,429UniSTS
RH 3.4 Map10732.4UniSTS
Cytogenetic Map10q32.1UniSTS
RH143721  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21082,161,905 - 82,162,095 (+)MAPPERmRatBN7.2
Rnor_6.01085,112,112 - 85,112,301NCBIRnor6.0
Rnor_5.01084,902,079 - 84,902,268UniSTSRnor5.0
RGSC_v3.41085,898,274 - 85,898,463UniSTSRGSC3.4
Celera1080,921,740 - 80,921,929UniSTS
RH 3.4 Map10783.1UniSTS
Cytogenetic Map10q32.1UniSTS
STS-H47054  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21082,147,552 - 82,148,946 (+)MAPPERmRatBN7.2
Rnor_6.01085,097,763 - 85,099,156NCBIRnor6.0
Rnor_5.01084,887,730 - 84,889,123UniSTSRnor5.0
RGSC_v3.41085,883,924 - 85,885,318UniSTSRGSC3.4
Celera1080,907,397 - 80,908,791UniSTS
Cytogenetic Map10q32.1UniSTS
UniSTS:225255  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21082,146,330 - 82,146,508 (+)MAPPERmRatBN7.2
Rnor_6.01085,096,541 - 85,096,718NCBIRnor6.0
Rnor_5.01084,886,508 - 84,886,685UniSTSRnor5.0
RGSC_v3.41085,882,406 - 85,882,583UniSTSRGSC3.4
Celera1080,906,169 - 80,906,346UniSTS
Cytogenetic Map10q32.1UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000012376   ⟹   ENSRNOP00000012376
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1082,145,420 - 82,174,605 (-)Ensembl
Rnor_6.0 Ensembl1085,093,841 - 85,124,644 (-)Ensembl
RefSeq Acc Id: NM_017063   ⟹   NP_058759
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81082,642,082 - 82,670,856 (-)NCBI
mRatBN7.21082,145,662 - 82,174,437 (-)NCBI
Rnor_6.01085,096,517 - 85,124,641 (-)NCBI
Rnor_5.01084,886,484 - 84,914,805 (-)NCBI
RGSC_v3.41085,882,382 - 85,910,805 (-)RGD
Celera1080,906,145 - 80,931,812 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_058759 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC42047 (Get FASTA)   NCBI Sequence Viewer  
  EDM05851 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000012376
  ENSRNOP00000012376.3
GenBank Protein P52296 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058759   ⟸   NM_017063
- UniProtKB: P52296 (UniProtKB/Swiss-Prot),   F2Z3Q8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000012376   ⟸   ENSRNOT00000012376
Protein Domains
Importin N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P52296-F1-model_v2 AlphaFold P52296 1-875 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2909 AgrOrtholog
BioCyc Gene G2FUF-23428 BioCyc
Ensembl Genes ENSRNOG00000009275 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012376 ENTREZGENE
  ENSRNOT00000012376.5 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Armadillo UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEAT_type_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Importin-beta_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Importin_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24917 UniProtKB/Swiss-Prot
NCBI Gene 24917 ENTREZGENE
PANTHER IMPORTIN SUBUNIT BETA-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10527 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HEAT_EZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IBN_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kpnb1 PhenoGen
PROSITE HEAT_REPEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IMPORTIN_B_NT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009275 RatGTEx
SMART ARM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IBN_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6HIJ6_RAT UniProtKB/TrEMBL
  F2Z3Q8 ENTREZGENE, UniProtKB/TrEMBL
  IMB1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kpnb1  karyopherin subunit beta 1  Kpnb1  karyopherin (importin) beta 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Kpnb1  karyopherin (importin) beta 1    karyopherin,beta 1  Name updated 1299863 APPROVED
2002-11-06 Kpnb1  karyopherin,beta 1  Impnb  Importin beta  Symbol and Name updated 625702 APPROVED
2002-06-10 Impnb  Importin beta      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction binds to nucleoporin Nup98 729014
gene_protein 97-kDa 729014