Il7 (interleukin 7) - Rat Genome Database

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Gene: Il7 (interleukin 7) Rattus norvegicus
Symbol: Il7
Name: interleukin 7
RGD ID: 2904
Description: Predicted to enable cytokine activity and growth factor activity. Involved in cellular response to hypoxia and response to X-ray. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Used to study high grade glioma. Biomarker of periodontal disease. Human ortholog(s) of this gene implicated in epidermodysplasia verruciformis. Orthologous to human IL7 (interleukin 7); PARTICIPATES IN cytokine mediated signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride.
Type: protein-coding
Previously known as: IL-7; interleukin-7
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8296,142,523 - 96,186,282 (+)NCBIGRCr8
mRatBN7.2294,235,219 - 94,280,075 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl294,234,766 - 94,280,075 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2100,777,208 - 100,821,004 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0298,898,266 - 98,942,070 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0293,955,118 - 93,998,914 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0296,427,884 - 96,474,979 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl296,439,286 - 96,474,977 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02116,171,246 - 116,216,348 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4296,356,083 - 96,399,796 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1296,301,044 - 96,344,792 (+)NCBI
Celera289,787,744 - 89,831,293 (+)NCBICelera
RH 3.4 Map2592.4RGD
Cytogenetic Map2q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-nitrotoluene  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
5'-S-methyl-5'-thioadenosine  (ISO)
5-fluorouracil  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
anthracen-2-amine  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP)
bleomycin A2  (ISO)
cadmium dichloride  (EXP)
cadmium sulfate  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP)
CGP 52608  (ISO)
choline  (ISO)
cisplatin  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crotonaldehyde  (ISO)
cyclosporin A  (EXP,ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dioxygen  (ISO)
doxorubicin  (EXP)
emamectin benzoate  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
ferulic acid  (ISO)
fragrance  (ISO)
furan  (EXP)
gentamycin  (EXP)
imiquimod  (ISO)
indometacin  (ISO)
isoprenaline  (EXP,ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melatonin  (ISO)
melphalan  (ISO)
methapyrilene  (ISO)
methyl carbamate  (ISO)
methyl methanesulfonate  (ISO)
microcystin-LR  (ISO)
N-ethyl-N-nitrosourea  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nicotine  (ISO)
nonanoic acid  (ISO)
oxaliplatin  (EXP)
oxymetholone  (ISO)
paracetamol  (EXP)
paraquat  (EXP,ISO)
PCB138  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
quercetin  (ISO)
riddelliine  (EXP)
ritonavir  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sodium arsenite  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
vinorelbine  (ISO)
zinc acetate  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Semiquantitative detection of cytokine messages in X-irradiated and regenerating rat thymus. Adachi Y, etal., Radiat Res. 2005 Apr;163(4):400-7.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Biomarkers of basic activities of daily living in Alzheimer's disease. Hall JR, etal., J Alzheimers Dis. 2012;31(2):429-37. doi: 10.3233/JAD-2012-111481.
4. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Huang C, etal., Lancet. 2020 Feb 15;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5. Epub 2020 Jan 24.
5. A Special Ingredient (VtR) Containing Oligostilbenes Isolated from Vitis thunbergii Prevents Bone Loss in Ovariectomized Mice: In Vitro and In Vivo Study. Huang YL, etal., Evid Based Complement Alternat Med. 2013;2013:409421. doi: 10.1155/2013/409421. Epub 2013 Apr 11.
6. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
7. Adaptive immune response in osteoclastic bone resorption induced by orally administered Aggregatibacter actinomycetemcomitans in a rat model of periodontal disease. Li Y, etal., Mol Oral Microbiol. 2010 Aug;25(4):275-92.
8. Down-regulation of interleukin 7 mRNA by hypoxia is calcium dependent. Lu A, etal., Neurol Res. 2009 Jun;31(5):545-9. doi: 10.1179/174313209X380928. Epub 2008 Dec 3.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. [The expressions of IL-7 and IL-7R and the relationship between them with lymph node metastasis and prognosis in non-small cell lung cancer]. MING J, etal., Zhongguo Fei Ai Za Zhi. 2010 Dec;13(12):1101-6. doi: 10.3779/j.issn.1009-3419.2010.12.04.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Structural basis for binding multiple ligands by the common cytokine receptor gamma-chain. Olosz F and Malek TR, J Biol Chem 2002 Apr 5;277(14):12047-52.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. GOA pipeline RGD automated data pipeline
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Comprehensive gene review and curation RGD comprehensive gene curation
17. Increased bone resorption and osteopenia are a part of the lymphoproliferative phenotype of mice with systemic over-expression of interleukin-7 gene driven by MHC class II promoter. Salopek D, etal., Immunol Lett. 2008 Dec 22;121(2):134-9. doi: 10.1016/j.imlet.2008.10.002. Epub 2008 Nov 4.
18. Regression of intracerebral rat glioma isografts by therapeutic subcutaneous immunization with interferon-gamma, interleukin-7, or B7-1-transfected tumor cells. Visse E, etal., Cancer Gene Ther 1999 Jan-Feb;6(1):37-44.
19. Increased expression of non-interleukin-2 T cell growth factors and their implications during liver allograft rejection in rats. Wang WL, etal., J Gastroenterol Hepatol. 2007 Jul;22(7):1141-7. Epub 2007 May 27.
Additional References at PubMed
PMID:7671324   PMID:8950980   PMID:9252127   PMID:10429671   PMID:11418668   PMID:12431371   PMID:12490655   PMID:12970760   PMID:16797412   PMID:19249122   PMID:21178173   PMID:25666089  
PMID:27023180   PMID:29581031  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8296,142,523 - 96,186,282 (+)NCBIGRCr8
mRatBN7.2294,235,219 - 94,280,075 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl294,234,766 - 94,280,075 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2100,777,208 - 100,821,004 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0298,898,266 - 98,942,070 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0293,955,118 - 93,998,914 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0296,427,884 - 96,474,979 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl296,439,286 - 96,474,977 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02116,171,246 - 116,216,348 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4296,356,083 - 96,399,796 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1296,301,044 - 96,344,792 (+)NCBI
Celera289,787,744 - 89,831,293 (+)NCBICelera
RH 3.4 Map2592.4RGD
Cytogenetic Map2q23NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38878,675,044 - 78,805,463 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl878,675,743 - 78,805,523 (-)EnsemblGRCh38hg38GRCh38
GRCh37879,645,007 - 79,717,698 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36879,807,560 - 79,880,313 (-)NCBINCBI36Build 36hg18NCBI36
Build 34879,807,560 - 79,880,313NCBI
Celera875,648,737 - 75,721,711 (-)NCBICelera
Cytogenetic Map8q21.13NCBI
HuRef875,134,557 - 75,207,310 (-)NCBIHuRef
CHM1_1879,696,615 - 79,769,400 (-)NCBICHM1_1
T2T-CHM13v2.0879,106,579 - 79,236,843 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3937,637,088 - 7,678,820 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl37,635,054 - 7,678,820 (-)EnsemblGRCm39 Ensembl
GRCm3837,572,028 - 7,613,760 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl37,569,994 - 7,613,760 (-)EnsemblGRCm38mm10GRCm38
MGSCv3737,572,077 - 7,613,427 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3637,555,150 - 7,596,500 (-)NCBIMGSCv36mm8
Celera37,588,657 - 7,629,776 (-)NCBICelera
Cytogenetic Map3A1NCBI
cM Map32.02NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0NW_0049554442,365,077 - 2,400,953 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v2794,468,097 - 94,546,977 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1870,095,550 - 70,175,284 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0875,254,166 - 75,337,373 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1876,894,158 - 76,967,685 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl876,895,095 - 76,966,918 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12926,384,493 - 26,422,586 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2926,384,493 - 26,422,737 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2926,651,877 - 26,696,032 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02926,502,024 - 26,546,251 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2926,501,104 - 26,546,713 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12926,548,175 - 26,592,337 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02926,592,034 - 26,636,185 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02926,943,719 - 26,987,896 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440530352,717,829 - 52,769,445 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936702111,211 - 162,322 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936702110,625 - 162,957 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl457,684,796 - 57,744,709 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1457,677,895 - 57,744,713 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2462,888,668 - 62,949,085 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1874,230,493 - 74,292,985 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl874,231,809 - 74,292,384 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603966,940,681 - 67,051,084 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462474412,567,661 - 12,604,074 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474412,562,536 - 12,604,037 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Il7
230 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:467
Count of miRNA genes:222
Interacting mature miRNAs:281
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578777Stresp15Stress response QTL 1520.05blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)259846005104846005Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)281018907126018907Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)282345893130923501Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243162366111362592Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)243162366111362592Rat
1598862Glom9Glomerulus QTL 93.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)292337601137337601Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
1598863Cm65Cardiac mass QTL 652.3heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)292337601137337601Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
61465Bp13Blood pressure QTL 133.3blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)276539322102785628Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)240067944102785628Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
2300165Bmd49Bone mineral density QTL 494.80.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)288862519133862519Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
5684990Bmd82Bone mineral density QTL 822.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)259324377103795077Rat
2300170Bmd45Bone mineral density QTL 4512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
7411551Bw131Body weight QTL 13129.60.001body mass (VT:0001259)body weight gain (CMO:0000420)267942638112942638Rat
1359034Bp274Blood pressure QTL 274arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)27478666494359546Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)278665616143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
2300185Bmd46Bone mineral density QTL 468.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
631500Bp99Blood pressure QTL 992.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)259324719102755241Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)280270434125270434Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
5684996Bmd85Bone mineral density QTL 854.70.024tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)259324377103795077Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
7207808Bmd89Bone mineral density QTL 894.1femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)288862519133862519Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)259134147127460910Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)264366971109366971Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)259324377141596857Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2294,276,311 - 94,276,401 (+)MAPPERmRatBN7.2
Rnor_6.0296,472,323 - 96,472,412NCBIRnor6.0
Rnor_5.02116,213,692 - 116,213,781UniSTSRnor5.0
RGSC_v3.4296,397,184 - 96,397,273UniSTSRGSC3.4
Celera289,828,637 - 89,828,726UniSTS
RH 3.4 Map2592.4UniSTS
Cytogenetic Map2q23UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2294,278,646 - 94,278,811 (+)MAPPERmRatBN7.2
Rnor_6.0296,474,658 - 96,474,822NCBIRnor6.0
Rnor_5.02116,216,027 - 116,216,191UniSTSRnor5.0
RGSC_v3.4296,399,519 - 96,399,683UniSTSRGSC3.4
Celera289,830,972 - 89,831,136UniSTS
Cytogenetic Map2q23UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2294,278,889 - 94,279,100 (+)MAPPERmRatBN7.2
Rnor_6.0296,474,901 - 96,475,111NCBIRnor6.0
Rnor_5.02116,216,270 - 116,216,480UniSTSRnor5.0
Celera289,831,215 - 89,831,425UniSTS
Cytogenetic Map2q23UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 8 15
Low 3 5 35 27 4 27 4 4 8 16 24 11 4
Below cutoff 26 14 14 14 4 6 11 15 13 4


RefSeq Acc Id: ENSRNOT00000016091   ⟹   ENSRNOP00000016091
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl294,243,644 - 94,280,075 (+)Ensembl
Rnor_6.0 Ensembl296,439,286 - 96,474,977 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000095233   ⟹   ENSRNOP00000097908
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl294,234,766 - 94,280,075 (+)Ensembl
RefSeq Acc Id: NM_013110   ⟹   NP_037242
Rat AssemblyChrPosition (strand)Source
GRCr8296,142,640 - 96,186,282 (+)NCBI
mRatBN7.2294,235,336 - 94,278,968 (+)NCBI
Rnor_6.0296,430,768 - 96,474,979 (+)NCBI
Rnor_5.02116,171,246 - 116,216,348 (+)NCBI
RGSC_v3.4296,356,083 - 96,399,796 (+)RGD
Celera289,787,744 - 89,831,293 (+)RGD
RefSeq Acc Id: XM_006232139   ⟹   XP_006232201
Rat AssemblyChrPosition (strand)Source
GRCr8296,142,523 - 96,183,980 (+)NCBI
mRatBN7.2294,235,219 - 94,276,666 (+)NCBI
Rnor_6.0296,427,884 - 96,473,108 (+)NCBI
Rnor_5.02116,171,246 - 116,216,348 (+)NCBI
RefSeq Acc Id: XM_063281372   ⟹   XP_063137442
Rat AssemblyChrPosition (strand)Source
GRCr8296,142,523 - 96,185,680 (+)NCBI
RefSeq Acc Id: NP_037242   ⟸   NM_013110
- Peptide Label: precursor
- UniProtKB: P56478 (UniProtKB/Swiss-Prot),   Q91Y32 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232201   ⟸   XM_006232139
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000016091   ⟸   ENSRNOT00000016091
RefSeq Acc Id: ENSRNOP00000097908   ⟸   ENSRNOT00000095233
RefSeq Acc Id: XP_063137442   ⟸   XM_063281372
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P56478-F1-model_v2 AlphaFold P56478 1-154 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2904 AgrOrtholog
BioCyc Gene G2FUF-53693 BioCyc
Ensembl Genes ENSRNOG00000011973 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016091.8 UniProtKB/TrEMBL
  ENSRNOT00000095233.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro IL-7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-7/IL-9_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL7_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25647 UniProtKB/TrEMBL
  INTERLEUKIN-7 UniProtKB/Swiss-Prot
Pfam IL7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Il7 PhenoGen
PIRSF IL-7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011973 RatGTEx
SMART IL7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6IH79_RAT UniProtKB/TrEMBL
  IL7_RAT UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Il7  Interleukin 7      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process increased expression decreases intracerebral brain tumor cell growth 727266