Il6st (interleukin 6 cytokine family signal transducer) - Rat Genome Database

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Gene: Il6st (interleukin 6 cytokine family signal transducer) Rattus norvegicus
Analyze
Symbol: Il6st
Name: interleukin 6 cytokine family signal transducer
RGD ID: 2903
Description: Predicted to enable several functions, including ciliary neurotrophic factor receptor activity; ciliary neurotrophic factor receptor binding activity; and scaffold protein binding activity. Predicted to contribute to cytokine receptor activity; growth factor binding activity; and interleukin-6 receptor binding activity. Involved in several processes, including interleukin-6-mediated signaling pathway; positive regulation of smooth muscle cell migration; and triglyceride mobilization. Located in neuronal cell body membrane. Biomarker of brain ischemia; hepatocellular carcinoma; status epilepticus; and visual epilepsy. Human ortholog(s) of this gene implicated in arteriosclerosis; hyper IgE recurrent infection syndrome 4; hyperandrogenism; and primary immunodeficiency disease. Orthologous to human IL6ST (interleukin 6 cytokine family signal transducer); PARTICIPATES IN interleukin-6 signaling pathway; interleukin-27 signaling pathway; cytokine mediated signaling pathway; INTERACTS WITH 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ac1055; Gp130; IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; interleukin 6 signal transducer; interleukin-6 receptor subunit beta; interleukin-6 signal transducer; membrane glycoprotein 130; oncostatin-M receptor subunit alpha
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2244,065,979 - 44,106,255 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl244,066,130 - 44,109,936 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx251,196,571 - 51,225,818 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0249,255,007 - 49,284,254 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0244,122,946 - 44,152,152 (+)NCBIRnor_WKY
Rnor_6.0244,279,199 - 44,319,427 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl244,289,393 - 44,314,944 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0263,320,957 - 63,361,404 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4243,806,301 - 43,842,365 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1243,736,911 - 43,762,480 (+)NCBI
Celera239,857,022 - 39,886,283 (+)NCBICelera
Cytogenetic Map2q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (EXP)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-formyltetrahydrofolic acid  (ISO)
acetic acid  (ISO)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aflatoxin M1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
asperentin  (ISO)
auranofin  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromochloroacetic acid  (ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP)
carbon nanotube  (EXP,ISO)
CGP 52608  (ISO)
ciglitazone  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
ethanol  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
geldanamycin  (ISO)
glucose  (ISO)
hexachlorobenzene  (EXP)
hydrogen peroxide  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
indometacin  (ISO)
kojic acid  (ISO)
leflunomide  (ISO)
lenalidomide  (ISO)
lipopolysaccharide  (ISO)
methapyrilene  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mycophenolic acid  (ISO)
mycotoxin  (ISO)
neoechinulin A  (ISO)
nickel atom  (ISO)
obeticholic acid  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
PhIP  (EXP)
pirinixic acid  (EXP)
progesterone  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sterigmatocystin  (ISO)
streptozocin  (ISO)
succimer  (ISO)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
thalidomide  (ISO)
thapsigargin  (EXP)
theophylline  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
torcetrapib  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
trimethyltin  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Differential effects of locally and systemically administered soluble glycoprotein 130 on pain and inflammation in experimental arthritis. Boettger MK, etal., Arthritis Res Ther. 2010;12(4):R140. Epub 2010 Jul 13.
2. Reduced expression of the cytokine transducer gp130 inhibits hormone secretion, cell growth, and tumor development of pituitary lactosomatotrophic GH3 cells. Castro CP, etal., Endocrinology 2003 Feb;144(2):693-700.
3. Upregulation of gp130 and differential activation of STAT and p42/44 MAPK in the rat hippocampus following kainic acid-induced seizures. Choi JS, etal., Brain Res Mol Brain Res. 2003 Nov 6;119(1):10-8.
4. Upregulation of gp130 and STAT3 activation in the rat hippocampus following transient forebrain ischemia. Choi JS, etal., Glia 2003 Feb;41(3):237-46.
5. Role of interleukin-6 in chronic muscle hyperalgesic priming. Dina OA, etal., Neuroscience. 2008 Mar 18;152(2):521-5. Epub 2008 Jan 12.
6. Association of polymorphisms in the interleukin 6 receptor complex with obesity and hyperandrogenism. Escobar-Morreale HF, etal., Obes Res. 2003 Aug;11(8):987-96.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Involvement of the gp130 cytokine transducer in MtT/S pituitary somatotroph tumour development in an autocrine-paracrine model. Graciarena M, etal., Eur J Endocrinol. 2004 Nov;151(5):595-604.
10. Discriminant power of combined cerebrospinal fluid tau protein and of the soluble interleukin-6 receptor complex in the diagnosis of Alzheimer's disease. Hampel H, etal., Brain Res. 1999 Mar 27;823(1-2):104-12.
11. Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress. Hirota H, etal., Cell 1999 Apr 16;97(2):189-98.
12. Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling. Jones SA, etal., J Clin Invest. 2011 Sep 1;121(9):3375-83. doi: 10.1172/JCI57158. Epub 2011 Sep 1.
13. Ischemic preconditioning-induced expression of gp130 and STAT3 in astrocytes of the rat hippocampus. Kim SY, etal., Brain Res Mol Brain Res. 2004 Oct 22;129(1-2):96-103.
14. Evidence that IL-6-type cytokine signaling in cardiomyocytes is inhibited by oxidative stress: parthenolide targets JAK1 activation by generating ROS. Kurdi M and Booz GW, J Cell Physiol. 2007 Aug;212(2):424-31.
15. [Determination of serum soluble interleukin-6 receptor and soluble gp130 levels in patient with pregnancy induced hypertension and its significance] Li Y, etal., Zhonghua Fu Chan Ke Za Zhi. 2001 Jan;36(1):18-9.
16. Effects of protein malnutrition on IL-6-mediated signaling in the liver and the systemic acute-phase response in rats. Ling PR, etal., Am J Physiol Regul Integr Comp Physiol. 2004 Oct;287(4):R801-8.
17. Signal transducer of inflammation gp130 modulates atherosclerosis in mice and man. Luchtefeld M, etal., J Exp Med. 2007 Aug 6;204(8):1935-44. Epub 2007 Jul 30.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. IL-6/IL-6 receptor system and its role in physiological and pathological conditions. Mihara M, etal., Clin Sci (Lond). 2012 Feb;122(4):143-59. doi: 10.1042/CS20110340.
20. Interleukin-6 inhibits cell proliferation in a rat model of hepatocellular carcinoma. Moran DM, etal., Liver Int. 2005 Apr;25(2):445-57.
21. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
22. LIF and CNTF, which share the gp130 transduction system, stimulate hepatic lipid metabolism in rats. Nonogaki K, etal., Am J Physiol. 1996 Sep;271(3 Pt 1):E521-8.
23. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
24. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
25. GOA pipeline RGD automated data pipeline
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Comprehensive gene review and curation RGD comprehensive gene curation
28. Spatiotemporal distribution of gp130 cytokines and their receptors after status epilepticus: comparison with neuronal degeneration and microglial activation. Rosell DR, etal., Neuroscience. 2003;122(2):329-48.
29. Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice. Tebbutt NC, etal., Nat Med 2002 Oct;8(10):1089-97.
30. Preconditioning-induced protection of photoreceptors requires activation of the signal-transducing receptor gp130 in photoreceptors. Ueki Y, etal., Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21389-94. doi: 10.1073/pnas.0906156106. Epub 2009 Nov 30.
31. An essential role for gp130 in neointima formation following arterial injury. Wang D, etal., Circ Res. 2007 Mar 30;100(6):807-16. Epub 2007 Feb 22.
32. Interleukin-6 protects cerebellar granule neurons from NMDA-induced neurotoxicity. Wang XC, etal., Sheng Li Xue Bao. 2007 Apr 25;59(2):150-156.
33. Molecular cloning and characterization of the rat liver IL-6 signal transducing molecule, gp130. Wang Y, etal., Genomics 1992 Nov;14(3):666-72.
34. Characteristic localization of gp130 (the signal-transducing receptor component used in common for IL-6/IL-11/CNTF/LIF/OSM) in the rat brain. Watanabe D, etal., Eur J Neurosci. 1996 Aug;8(8):1630-40.
Additional References at PubMed
PMID:2261637   PMID:7957045   PMID:8353278   PMID:8385113   PMID:8999038   PMID:10205167   PMID:10486560   PMID:10989258   PMID:11275690   PMID:12108784   PMID:12147685   PMID:12372336  
PMID:12629177   PMID:12643274   PMID:12707266   PMID:12829785   PMID:14600146   PMID:14764690   PMID:15051883   PMID:15327998   PMID:16272873   PMID:18593565   PMID:19479985   PMID:19946888  
PMID:20226789   PMID:20879018   PMID:22875468   PMID:22993404   PMID:23064267   PMID:23376485   PMID:23533145   PMID:24501689   PMID:25340554   PMID:26222740   PMID:26589480   PMID:29629897  
PMID:32024466  


Genomics

Comparative Map Data
Il6st
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2244,065,979 - 44,106,255 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl244,066,130 - 44,109,936 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx251,196,571 - 51,225,818 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0249,255,007 - 49,284,254 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0244,122,946 - 44,152,152 (+)NCBIRnor_WKY
Rnor_6.0244,279,199 - 44,319,427 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl244,289,393 - 44,314,944 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0263,320,957 - 63,361,404 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4243,806,301 - 43,842,365 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1243,736,911 - 43,762,480 (+)NCBI
Celera239,857,022 - 39,886,283 (+)NCBICelera
Cytogenetic Map2q14NCBI
IL6ST
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38555,935,095 - 55,994,963 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl555,935,095 - 55,995,022 (-)EnsemblGRCh38hg38GRCh38
GRCh37555,230,923 - 55,290,791 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36555,272,451 - 55,326,520 (-)NCBINCBI36Build 36hg18NCBI36
Build 34555,272,451 - 55,326,520NCBI
Celera552,184,738 - 52,244,652 (-)NCBICelera
Cytogenetic Map5q11.2NCBI
HuRef552,204,630 - 52,264,547 (-)NCBIHuRef
CHM1_1555,234,877 - 55,294,748 (-)NCBICHM1_1
T2T-CHM13v2.0556,763,505 - 56,823,387 (-)NCBIT2T-CHM13v2.0
Il6st
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913112,600,604 - 112,643,394 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13112,600,604 - 112,646,620 (+)EnsemblGRCm39 Ensembl
GRCm3813112,464,070 - 112,506,860 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13112,464,070 - 112,510,086 (+)EnsemblGRCm38mm10GRCm38
MGSCv3713113,254,278 - 113,297,068 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613113,584,987 - 113,627,719 (+)NCBIMGSCv36mm8
Celera13116,768,393 - 116,811,051 (+)NCBICelera
Cytogenetic Map13D2.2NCBI
cM Map1363.73NCBI
Il6st
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544611,790,444 - 11,835,001 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544611,790,636 - 11,837,734 (+)NCBIChiLan1.0ChiLan1.0
IL6ST
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1559,650,833 - 59,708,817 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl559,669,606 - 59,708,817 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0558,023,704 - 58,081,895 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
IL6ST
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1243,214,050 - 43,273,014 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl243,214,050 - 43,248,124 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha240,260,413 - 40,306,615 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0243,679,923 - 43,738,936 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl243,679,928 - 43,738,942 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1240,758,131 - 40,804,315 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0241,560,510 - 41,606,926 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0242,380,727 - 42,426,940 (-)NCBIUU_Cfam_GSD_1.0
Il6st
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213202,931,083 - 202,977,366 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648011,884,582 - 11,909,635 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493648011,867,573 - 11,913,563 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL6ST
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1635,101,306 - 35,192,220 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11635,101,304 - 35,151,832 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21637,476,140 - 37,522,638 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IL6ST
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1452,174,893 - 52,232,475 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl452,174,312 - 52,214,584 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660491,050,897 - 1,108,503 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il6st
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247593,276,741 - 3,312,601 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247593,258,324 - 3,315,265 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Il6st
131 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:569
Count of miRNA genes:281
Interacting mature miRNAs:371
Transcripts:ENSRNOT00000018877
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)21185206249003364Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22691781781754745Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
1643006Pain1Pain QTL 13.630.005mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)22699957148268661Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22715716072157160Rat
1300160Hrtrt3Heart rate QTL 33.62heart pumping trait (VT:2000009)absolute change in heart rate (CMO:0000534)22997159351729300Rat
10755434Coatc7Coat color QTL 70.04794coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23064806575648065Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23502311780023117Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23513484188029593Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)240067944102785628Rat
12879863Bp402Blood pressure QTL 4020.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24112578956532139Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)24280460760653831Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243162366111362592Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)243162366111362592Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
631208Bw1Body weight QTL15.09mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)24317101783575226Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat

Markers in Region
AI171807  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2244,103,374 - 44,103,597 (+)MAPPERmRatBN7.2
Rnor_6.0244,316,547 - 44,316,769NCBIRnor6.0
Rnor_5.0263,358,524 - 63,358,746UniSTSRnor5.0
RGSC_v3.4243,835,804 - 43,836,026UniSTSRGSC3.4
Celera239,883,403 - 39,883,625UniSTS
RH 3.4 Map2278.9UniSTS
Cytogenetic Map2q14-q16UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 42 57 41 19 41 8 11 74 35 38 11 8
Low 1 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000018877   ⟹   ENSRNOP00000018877
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl244,079,652 - 44,109,936 (+)Ensembl
Rnor_6.0 Ensembl244,289,393 - 44,314,944 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000105192   ⟹   ENSRNOP00000077391
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl244,066,141 - 44,103,846 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000106583   ⟹   ENSRNOP00000083772
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl244,066,141 - 44,103,846 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000109781   ⟹   ENSRNOP00000090692
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl244,076,423 - 44,106,255 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000111915   ⟹   ENSRNOP00000097802
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl244,074,604 - 44,109,936 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000113764   ⟹   ENSRNOP00000086828
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl244,066,164 - 44,102,036 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000114610   ⟹   ENSRNOP00000081709
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl244,066,130 - 44,091,441 (+)Ensembl
RefSeq Acc Id: NM_001008725   ⟹   NP_001008725
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2244,076,984 - 44,106,255 (+)NCBI
Rnor_6.0244,290,075 - 44,319,427 (+)NCBI
Rnor_5.0263,320,957 - 63,361,404 (+)NCBI
RGSC_v3.4243,806,301 - 43,842,365 (+)RGD
Celera239,857,022 - 39,886,283 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006231928   ⟹   XP_006231990
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2244,065,979 - 44,106,253 (+)NCBI
Rnor_6.0244,279,199 - 44,319,425 (+)NCBI
Rnor_5.0263,320,957 - 63,361,404 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008760736   ⟹   XP_008758958
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2244,069,544 - 44,103,854 (+)NCBI
Rnor_6.0244,281,697 - 44,317,935 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039101766   ⟹   XP_038957694
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2244,069,659 - 44,103,854 (+)NCBI
RefSeq Acc Id: XM_039101767   ⟹   XP_038957695
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2244,086,891 - 44,106,253 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001008725   ⟸   NM_001008725
- Peptide Label: precursor
- UniProtKB: H9BFG4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231990   ⟸   XM_006231928
- Peptide Label: isoform X1
- UniProtKB: A0A8I5Y7Q5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008758958   ⟸   XM_008760736
- Peptide Label: isoform X1
- UniProtKB: A0A8I5Y7Q5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000018877   ⟸   ENSRNOT00000018877
RefSeq Acc Id: XP_038957694   ⟸   XM_039101766
- Peptide Label: isoform X1
- UniProtKB: A0A8I5Y7Q5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957695   ⟸   XM_039101767
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000090692   ⟸   ENSRNOT00000109781
RefSeq Acc Id: ENSRNOP00000077391   ⟸   ENSRNOT00000105192
RefSeq Acc Id: ENSRNOP00000083772   ⟸   ENSRNOT00000106583
RefSeq Acc Id: ENSRNOP00000086828   ⟸   ENSRNOT00000113764
RefSeq Acc Id: ENSRNOP00000081709   ⟸   ENSRNOT00000114610
RefSeq Acc Id: ENSRNOP00000097802   ⟸   ENSRNOT00000111915
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P40190-F1-model_v2 AlphaFold P40190 1-918 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2903 AgrOrtholog
BioCyc Gene G2FUF-54396 BioCyc
Ensembl Genes ENSRNOG00000013963 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000018877.7 UniProtKB/TrEMBL
  ENSRNOP00000077391 ENTREZGENE
  ENSRNOP00000077391.1 UniProtKB/TrEMBL
  ENSRNOP00000081709.1 UniProtKB/TrEMBL
  ENSRNOP00000083772 ENTREZGENE
  ENSRNOP00000083772.1 UniProtKB/TrEMBL
  ENSRNOP00000086828.1 UniProtKB/TrEMBL
  ENSRNOP00000090692 ENTREZGENE
  ENSRNOP00000090692.1 UniProtKB/TrEMBL
  ENSRNOP00000097802.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018877.8 UniProtKB/TrEMBL
  ENSRNOT00000105192 ENTREZGENE
  ENSRNOT00000105192.1 UniProtKB/TrEMBL
  ENSRNOT00000106583 ENTREZGENE
  ENSRNOT00000106583.1 UniProtKB/TrEMBL
  ENSRNOT00000109781 ENTREZGENE
  ENSRNOT00000109781.1 UniProtKB/TrEMBL
  ENSRNOT00000111915.1 UniProtKB/TrEMBL
  ENSRNOT00000113764.1 UniProtKB/TrEMBL
  ENSRNOT00000114610.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hematopoietin_rcpt_Gp130_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IgC2-like_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL6_recept-bd UniProtKB/TrEMBL
KEGG Report rno:25205 UniProtKB/TrEMBL
NCBI Gene 25205 ENTREZGENE
Pfam fn3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL6Ra-bind UniProtKB/TrEMBL
  Lep_receptor_Ig UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Il6st PhenoGen
PROSITE FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEMATOPO_REC_L_F2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
  SSF49265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5Y7Q5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZSM2_RAT UniProtKB/TrEMBL
  A0A8I5ZXR5_RAT UniProtKB/TrEMBL
  A0A8I6A213_RAT UniProtKB/TrEMBL
  A0A8I6AAL6_RAT UniProtKB/TrEMBL
  F1LPK1_RAT UniProtKB/TrEMBL
  H9BFG4 ENTREZGENE, UniProtKB/TrEMBL
  IL6RB_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q7TQ89_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-02-18 Il6st  interleukin 6 cytokine family signal transducer  Il6st  interleukin 6 signal transducer  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Il6st  Interleukin 6 signal transducer      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in hepatocytes, astrocytes, fibroblasts, and endothelial cells 728912
gene_physical_interaction interacts with the Il6 receptor 728912
gene_regulation activated by interaction with the activated Il6 receptor 728912