Il6 (interleukin 6) - Rat Genome Database

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Gene: Il6 (interleukin 6) Rattus norvegicus
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Symbol: Il6
Name: interleukin 6
RGD ID: 2901
Description: Enables cytokine activity and interleukin-6 receptor binding activity. Involved in several processes, including cellular response to cytokine stimulus; positive regulation of cell communication; and positive regulation of metabolic process. Located in extracellular space. Used to study several diseases, including acute necrotizing pancreatitis; disseminated intravascular coagulation; hypertension (multiple); impotence; and steatotic liver disease. Biomarker of several diseases, including acute necrotizing pancreatitis; artery disease (multiple); auditory system disease (multiple); iron deficiency anemia; and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); glucose metabolism disease (multiple); and periodontal disease (multiple). Orthologous to human IL6 (interleukin 6); PARTICIPATES IN interleukin-6 signaling pathway; pro-inflammatory cytokine mediated pathway; interleukin-23 signaling pathway; INTERACTS WITH (+)-pilocarpine; (+)-sesamin; (+)-taxifolin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Ifnb2; IL-6; ILg6; Interleukin 6 (interferon beta 2); Interleukin 6 (interferon, beta 2); interleukin-6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Il6em1Yona  
Genetic Models: SD-Il6em1Yona-/-
Is Marker For: Strains:   SHR.BN-(Il6-Npy)   BN.SHR-(Il6-Cd36)/Cub  
QTLs:   Bp33   Scl23   Bp79   Plsm1   Stl2   Bp330  
Candidate Gene For: Plsm1
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr845,889,999 - 5,894,575 (-)NCBIGRCr8
mRatBN7.245,214,602 - 5,219,178 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl45,213,394 - 5,219,178 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx410,211,864 - 10,216,458 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.046,026,101 - 6,030,695 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.044,372,235 - 4,376,829 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.043,043,231 - 3,047,807 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl43,043,231 - 3,047,807 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.043,095,536 - 3,100,112 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44456,799 - 461,376 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14456,798 - 461,376 (-)NCBI
Celera45,093,593 - 5,098,169 (+)NCBICelera
Cytogenetic Map4q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model