Il4 (interleukin 4) - Rat Genome Database

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Gene: Il4 (interleukin 4) Rattus norvegicus
Symbol: Il4
Name: interleukin 4
RGD ID: 2898
Description: Predicted to enable cytokine activity. Involved in several processes, including positive regulation of biosynthetic process; positive regulation of leukocyte migration; and regulation of defense response. Located in extracellular space. Used to study anti-basement membrane glomerulonephritis; autoimmune thyroiditis; and pelvic inflammatory disease. Biomarker of several diseases, including cerebrovascular disease (multiple); interstitial lung disease (multiple); irritant dermatitis; rhinitis (multiple); and trypanosomiasis. Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); hepatitis B; hepatitis C; and pancreatic cancer (multiple). Orthologous to human IL4 (interleukin 4); PARTICIPATES IN Fc epsilon receptor mediated signaling pathway; interleukin-12 signaling pathway; interleukin-4 signaling pathway; INTERACTS WITH (R)-lipoic acid; 1,2-dichloroethane; 2,4,6-trinitrobenzenesulfonic acid.
Type: protein-coding
Previously known as: B-cell growth factor 1; B-cell IGG differentiation factor; B-cell stimulatory factor 1; BSF-1; IL-4; Il4e12; interleukin-4; lymphocyte stimulatory factor 1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Eau7
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81038,272,003 - 38,277,549 (-)NCBIGRCr8
mRatBN7.21037,771,203 - 37,776,750 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1037,771,203 - 37,776,750 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1042,463,191 - 42,468,731 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01041,953,256 - 41,958,796 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01037,456,988 - 37,462,524 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01038,963,979 - 38,969,531 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1038,963,979 - 38,969,531 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01038,745,706 - 38,751,258 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41039,074,582 - 39,080,134 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11039,083,152 - 39,088,705 (-)NCBI
Celera1037,115,496 - 37,120,965 (-)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
Acute Experimental Pancreatitis  (IEP)
Acute Hepatitis  (IDA)
Acute Lung Injury  (IEP)
acute myocardial infarction  (IEP)
adult T-cell leukemia/lymphoma  (ISO)
allergic contact dermatitis  (ISO)
allergic disease  (ISO)
allergic rhinitis  (IEP,ISO)
alopecia universalis  (ISO)
Alzheimer's disease  (ISO)
Anaphylaxis  (ISO)
anogenital venereal wart  (ISO)
anti-basement membrane glomerulonephritis  (IDA,IMP)
aspirin-induced respiratory disease  (ISO)
asthma  (IEP,ISO)
atopic dermatitis  (ISO)
autistic disorder  (ISO)
autoimmune disease  (ISO)
autoimmune hepatitis  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
autoimmune thyroiditis  (IMP)
Behcet's disease  (ISO)
biliary tract benign neoplasm  (ISO)
Bovine Tuberculosis  (ISO)
Brain Injuries  (IEP)
bronchiolitis obliterans  (IEP)
cardiomyopathy  (ISO)
carotid stenosis  (IEP)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (IEP)
Chromosome Breakage  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
cognitive disorder  (IEP)
colitis  (ISO)
common cold  (ISO)
contact dermatitis  (ISO)
cutaneous leishmaniasis  (ISO)
cystic echinococcosis  (ISO)
cystitis  (IEP)
dermatitis  (ISO)
dermatomyositis  (ISO)
drug allergy  (ISO)
Drug Eruptions  (ISO)
Edema  (ISO)
Experimental Arthritis  (IEP,IMP,ISO)
Experimental Autoimmune Encephalomyelitis  (IEP,ISO)
Experimental Autoimmune Uveoretinitis  (IEP)
Experimental Diabetes Mellitus  (IEP)
Experimental Liver Cirrhosis  (ISO)
familial adenomatous polyposis 1  (ISO)
Fibrosis  (ISO)
Gaucher's disease  (ISO)
genetic disease  (ISO)
Granuloma  (IDA)
Graves' disease  (ISO)
Hand Osteoarthritis  (ISO)
Hemorrhagic Shock  (IEP)
hepatitis B  (ISO)
hepatitis C  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
herpes zoster  (ISO)
high grade glioma  (ISO)
Human Influenza  (ISO)
hypothyroidism  (IEP)
Immediate Hypersensitivity  (ISO)
irritant dermatitis  (IEP)
Kawasaki disease  (ISO)
Knee Osteoarthritis  (IDA,ISO)
leishmaniasis  (ISO)
Lung Reperfusion Injury  (IDA)
malignant mesothelioma  (ISO)
Meningococcal Infections  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
middle cerebral artery infarction  (IEP)
multiple sclerosis  (ISO)
Nematode Infections  (IEP)
nephritis  (IEP)
nephrotic syndrome  (IEP)
Neurodevelopmental Disorders  (ISO)
Otitis Media with Effusion  (IEP)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
pelvic inflammatory disease  (IDA)
Perennial Allergic Rhinitis  (ISO)
pleural disease  (ISO)
pneumoconiosis  (ISO)
pneumonia  (ISO)
polymyositis  (ISO)
Premature Birth  (ISO)
primary biliary cholangitis  (IEP)
primary cutaneous T-cell non-Hodgkin lymphoma  (ISO)
psoriasis  (ISO)
pulmonary fibrosis  (IEP,ISO)
pulmonary hypertension  (ISO)
pulmonary tuberculosis  (ISO)
respiratory allergy  (ISO)
Respiratory Sounds  (ISO)
Respiratory Tract Infections  (ISO)
rhinitis  (IEP,ISO)
Rhinosinusitis  (ISO)
Seasonal Allergic Rhinitis  (ISO)
Sepsis  (ISO)
Sjogren's syndrome  (ISS)
Spinal Cord Injuries  (IMP)
Staphylococcal Infections  (ISO)
Stroke  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
temporal arteritis  (ISO)
toxocariasis  (ISO)
trypanosomiasis  (IEP)
type 1 diabetes mellitus  (ISS)
vitiligo  (ISO)
Weight Loss  (ISO)
Xerostomia  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-trans-(S)-allethrin  (ISO)
(-)-matairesinol  (ISO)
(20S)-ginsenoside Rh1  (ISO)
(4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid  (ISO)
(R)-lipoic acid  (EXP)
1,2-dibutyrin  (ISO)
1,2-dichloroethane  (EXP)
1,3,5-trinitrobenzene  (ISO)
1,4-phenylenediamine  (ISO)
1-chloro-2,4,6-trinitrobenzene  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
13,14-dihydro-15-ketoprostaglandin D2  (ISO)
15-acetyldeoxynivalenol  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9-hexadecafluorononanoic acid  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,4-D  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
2-tert-butylhydroquinone  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-acetyldeoxynivalenol  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4'-hydroxydiclofenac  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-ethylphenol  (ISO)
4-nonylphenol  (ISO)
4-tolyl isocyanate  (ISO)
5-azacytidine  (ISO)
6-anilino-5,8-quinolinedione  (ISO)
6alpha-methylprednisolone  (ISO)
8-Br-cAMP  (ISO)
8-bromo-3',5'-cyclic GMP  (ISO)
9-cis-retinoic acid  (ISO)
abacavir  (ISO)
acetaldehyde  (ISO)
acetone  (ISO)
acetylsalicylic acid  (ISO)
acrylic acid  (EXP)
albuterol  (ISO)
alclometasone dipropionate  (ISO)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
allicin  (EXP)
alpha-galactosylceramide  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
alpha-linolenic acid  (ISO)
aluminium atom  (ISO)
aluminium hydroxide  (ISO)
aluminium(0)  (ISO)
amiodarone  (EXP,ISO)
ammonium chloride  (EXP)
amorolfine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antigen  (ISO)
apigenin  (ISO)
arachidonic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
asperentin  (ISO)
atrazine  (EXP)
azathioprine  (ISO)
bazedoxifene  (ISO)
beclomethasone  (ISO)
benzalkonium chloride  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzofurans  (ISO)
berberine  (ISO)
beta-D-glucosamine  (ISO)
beta-endorphin  (ISO)
betamethasone valerate  (ISO)
bexarotene  (EXP,ISO)
bifenthrin  (ISO)
biochanin A  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
boric acid  (EXP,ISO)
boron atom  (EXP)
Brevetoxin B  (ISO)
bucladesine  (ISO)
budesonide  (ISO)
buprenorphine  (ISO)
butane-2,3-dione  (ISO)
butenafine  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
Calcimycin  (EXP,ISO)
calciol  (EXP)
calcipotriol  (ISO)
calcitriol  (EXP,ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP,ISO)
capsazepine  (ISO)
carbachol  (ISO)
carbamazepine  (EXP)
carbon monoxide  (EXP,ISO)
carbon nanotube  (ISO)
carveol  (ISO)
caryophyllene oxide  (ISO)
ceric oxide  (ISO)
cerium trichloride  (ISO)
cetirizine  (ISO)
chlorambucil  (ISO)
chloroform  (ISO)
chloroquine  (ISO)
chlorphenamine  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
chromium atom  (EXP)
chromium(6+)  (ISO)
chrysin  (ISO)
cilostazol  (ISO)
ciprofloxacin  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (EXP,ISO)
cladribine  (ISO)
clarithromycin  (ISO)
clopidogrel  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
corn oil  (EXP,ISO)
cortisol  (ISO)
crocidolite asbestos  (ISO)
cupressuflavone  (ISO)
curcumin  (EXP,ISO)
cycloastragenol  (EXP)
cyclopentanes  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyfluthrin  (ISO)
cyhalothrin  (EXP)
D-penicillamine  (EXP)
daidzein  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (EXP)
deoxynivalenol  (ISO)
desferrioxamine B  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP,ISO)
Di-n-octyl phthalate  (ISO)
Diallyl sulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenzothiazol-2-yl disulfide  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
dicloxacillin  (ISO)
dicyclohexylmethane-4,4'-diisocyanate  (ISO)
Didecyldimethylammonium  (ISO)
diethyl maleate  (ISO)
diethyl phthalate  (ISO)
diethylamine  (ISO)
diflorasone  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
diisopropyl fluorophosphate  (ISO)
Dimaprit  (ISO)
Dimethyl phthalate  (EXP)
dioscin  (ISO)
dioxygen  (EXP,ISO)
diphenylmethane-4,4'-diisocyanate  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diuron  (ISO)
donepezil hydrochloride  (ISO)
doxorubicin  (EXP,ISO)
dydrogesterone  (ISO)
edaravone  (EXP)
elemental boron  (EXP)
elemental selenium  (EXP,ISO)
emamectin benzoate  (ISO)
emodin  (ISO)
epinastine  (EXP,ISO)
equol  (ISO)
Erionite  (ISO)
estriol  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
famotidine  (ISO)
fentanyl  (ISO)
ferric oxide  (ISO)
fingolimod hydrochloride  (ISO)
fisetin  (ISO)
flavonoids  (ISO)
fluoranthene  (ISO)
fluorescein 5-isothiocyanate  (ISO)
flutamide  (ISO)
fluticasone  (ISO)
folic acid  (ISO)
fomepizole  (EXP)
formaldehyde  (EXP,ISO)
formononetin  (ISO)
formoterol fumarate  (EXP,ISO)
fragrance  (ISO)
fulvestrant  (ISO)
furfuryl alcohol  (ISO)
gadodiamide hydrate  (ISO)
gadolinium trichloride  (ISO)
Ganoderic acid C2  (ISO)
Gastrodin  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
ginsenoside C-K  (ISO)
glutathione  (ISO)
Glutathione ethyl ester  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
gossypin  (EXP)
graphite  (ISO)
harmaline  (ISO)
helenalin  (ISO)
heroin  (ISO)
hesperidin  (ISO)
hexachlorobenzene  (EXP)
hexamethylene diisocyanate  (ISO)
histamine  (ISO)
Honokiol  (ISO)
hydrogen peroxide  (EXP)
hydroquinone  (ISO)
hydroxysafflor yellow A  (ISO)
hydroxyzine  (ISO)
ibuprofen  (ISO)
IC-87114  (ISO)
idelalisib  (ISO)
imiquimod  (ISO)
immunological adjuvant  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indometacin  (EXP,ISO)
ionomycin  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (ISO)
isophorone diisocyanate  (ISO)
isoprenaline  (EXP,ISO)
isosilybin A  (ISO)
isotretinoin  (EXP)
itraconazole  (ISO)
kaempferol  (ISO)
ketoconazole  (ISO)
ketorolac  (ISO)
L-ascorbic acid  (ISO)
lactacystin  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
lead(II) chloride  (ISO)
leflunomide  (ISO)
leukotriene B4  (ISO)
levamisole  (EXP,ISO)
lidocaine  (ISO)
linoleic acid  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (EXP)
lipoxin A4  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
loperamide  (ISO)
losartan  (EXP)
Luliconazole  (ISO)
luteolin  (EXP,ISO)
LY294002  (EXP,ISO)
malathion  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melatonin  (ISO)
mercury atom  (ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (ISO)
mesalamine  (EXP)
methadone  (ISO)
methanol  (EXP)
methimazole  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methyl isocyanate  (ISO)
methyl salicylate  (ISO)
miconazole  (ISO)
microcystin-LR  (EXP)
mifepristone  (ISO)
mitogen  (ISO)
MK 571  (ISO)
Monobutylphthalate  (ISO)
monodansylcadaverine  (ISO)
montelukast  (ISO)
morphine  (ISO)
Morroniside  (ISO)
moxifloxacin  (ISO)
mycophenolic acid  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-beta-D-glucosamine  (ISO)
N-acetyl-D-glucosamine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naphthalene  (ISO)
naproxen  (EXP)
naringin  (ISO)
neocuproine  (ISO)
nicardipine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nitrendipine  (ISO)
nitric oxide  (ISO)
nitrites  (ISO)
nitrogen dioxide  (ISO)
nitroprusside  (ISO)
Nivalenol  (ISO)
nonanoic acid  (ISO)
Nonylphenol  (ISO)
NS-398  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
Olopatadine hydrochloride  (EXP,ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
patulin  (ISO)
PCB138  (ISO)
pentachlorophenol  (ISO)
pentamidine  (ISO)
Pentoxifylline  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosgene  (EXP)
phthalaldehyde  (ISO)
phthalic anhydride  (ISO)
pioglitazone  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (EXP,ISO)
poly(I:C)  (ISO)
polyphosphates  (ISO)
prednisolone  (EXP,ISO)
prednisone  (ISO)
progesterone  (ISO)
prostaglandin D2  (ISO)
prostaglandin E2  (ISO)
prostaglandin F2alpha  (ISO)
pyrene  (ISO)
Pyridostigmine bromide  (EXP)
pyruvic acid  (EXP)
quercetin  (EXP,ISO)
raloxifene  (EXP,ISO)
ranitidine  (EXP)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
retinyl acetate  (ISO)
ribavirin  (ISO)
ricinoleic acid  (ISO)
Ro 41-5253  (ISO)
rolipram  (ISO)
rotenone  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
salicylic acid  (ISO)
Sanggenon C  (EXP)
SB 203580  (EXP,ISO)
SB 290157  (ISO)
selenium atom  (EXP,ISO)
selenomethionine  (ISO)
serotonin  (ISO)
serpentine asbestos  (ISO)
sildenafil citrate  (ISO)
silicon dioxide  (ISO)
Silidianin  (ISO)
silver(1+) nitrate  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium aurothiomalate  (ISO)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (EXP)
sodium hexachloroplatinate  (ISO)
Sodium salicylate  (ISO)
sodium stibogluconate  (ISO)
solasodine  (EXP)
spathulenol  (ISO)
SR 144528  (ISO)
staurosporine  (EXP)
streptozocin  (EXP)
styrene  (ISO)
Sucralfate  (EXP)
sulfasalazine  (EXP)
sulforaphane  (ISO)
sulfur dioxide  (ISO)
sumatriptan  (EXP)
sunitinib  (ISO)
Sunset Yellow FCF  (ISO)
synephrine  (ISO)
syringin  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (EXP,ISO)
tamibarotene  (EXP)
tamoxifen  (ISO)
terbinafine  (ISO)
Terfenadine  (ISO)
tetrachloroethene  (EXP)
tetrachloromethane  (EXP,ISO)
tetracyclines  (ISO)
thalidomide  (EXP)
thapsigargin  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
thromboxane B2  (ISO)
thymoquinone  (EXP)
titanium dioxide  (ISO)
TMC-120A  (ISO)
tofacitinib  (ISO)
tolnaftate  (ISO)
toluene  (ISO)
toluene 2,4-diisocyanate  (EXP,ISO)
trans-caffeic acid  (ISO)
trans-piceid  (EXP)
tremolite asbestos  (ISO)
tributylstannane  (EXP)
Tributyltin oxide  (EXP)
tributyrin  (ISO)
tricaproin  (ISO)
trichloroethene  (EXP,ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
Triptolide  (ISO)
uranium atom  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vanadium atom  (EXP,ISO)
vanadium(0)  (EXP,ISO)
verrucarin A  (ISO)
vitamin D  (EXP)
vitamin E  (EXP,ISO)
WIN 55212-2  (EXP)
wortmannin  (EXP)
zearalenone  (ISO)
zidovudine  (ISO)
zileuton  (ISO)
zinc atom  (ISO)
zinc oxide  (EXP)
zinc(0)  (ISO)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activated T cell proliferation  (ISO)
B cell activation  (ISO)
B cell costimulation  (ISO)
B cell proliferation  (ISO)
cellular response to mercury ion  (IEP)
cholesterol metabolic process  (ISO)
defense response to protozoan  (ISO)
dendritic cell differentiation  (ISO)
extrinsic apoptotic signaling pathway  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
female pregnancy  (IEP)
innate immune response in mucosa  (ISO)
interleukin-4-mediated signaling pathway  (IBA,ISO)
isotype switching to IgE isotypes  (ISO)
isotype switching to IgG isotypes  (ISO)
macrophage activation  (ISO)
MHC class II biosynthetic process  (ISO)
microglial cell activation  (IDA)
myeloid dendritic cell differentiation  (ISO)
negative regulation of acute inflammatory response  (IDA)
negative regulation of cellular response to transforming growth factor beta stimulus  (ISO)
negative regulation of chronic inflammatory response  (IDA)
negative regulation of complement-dependent cytotoxicity  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of endothelial cell apoptotic process  (ISO)
negative regulation of epithelial cell migration  (ISO)
negative regulation of extrinsic apoptotic signaling pathway  (ISO)
negative regulation of inflammatory response  (IBA,ISO)
negative regulation of macrophage activation  (IMP)
negative regulation of nitric oxide biosynthetic process  (IDA)
negative regulation of osteoclast differentiation  (ISO)
negative regulation of T cell activation  (ISO)
negative regulation of T-helper 17 cell differentiation  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
negative regulation of white fat cell proliferation  (ISO)
neuroinflammatory response  (IDA)
positive regulation of activated T cell proliferation  (ISO)
positive regulation of amyloid-beta clearance  (IDA,ISO)
positive regulation of ATP biosynthetic process  (ISO)
positive regulation of B cell activation  (ISO)
positive regulation of B cell proliferation  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (IDA,ISO)
positive regulation of cellular respiration  (ISO)
positive regulation of chemokine production  (ISO)
positive regulation of cold-induced thermogenesis  (ISO,ISS)
positive regulation of defense response to virus by host  (IDA)
positive regulation of DNA-templated transcription  (IBA,IDA,ISO)
positive regulation of eosinophil chemotaxis  (IDA)
positive regulation of establishment of endothelial barrier  (ISO)
positive regulation of gene expression  (IDA,ISO)
positive regulation of immunoglobulin production  (ISO)
positive regulation of interleukin-10 production  (IDA,ISO)
positive regulation of interleukin-13 production  (ISO)
positive regulation of isotype switching to IgE isotypes  (ISO)
positive regulation of isotype switching to IgG isotypes  (ISO)
positive regulation of macroautophagy  (ISO,ISS)
positive regulation of mast cell degranulation  (ISO)
positive regulation of MHC class II biosynthetic process  (ISO)
positive regulation of mononuclear cell migration  (IDA)
positive regulation of myoblast fusion  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of reactive oxygen species biosynthetic process  (IDA)
positive regulation of receptor signaling pathway via JAK-STAT  (ISO)
positive regulation of receptor-mediated endocytosis  (IDA,ISO)
positive regulation of T cell differentiation  (ISO)
positive regulation of T cell proliferation  (ISO)
positive regulation of T-helper 2 cell cytokine production  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
regulation of immune response  (IBA,ISO)
regulation of protein export from nucleus  (ISO)
regulation of proton transport  (IDA)
response to cytokine  (IEP)
response to ethanol  (IEP)
response to nutrient  (IEP)
response to organic cyclic compound  (IEP)
response to xenobiotic stimulus  (IEP)
retina development in camera-type eye  (IEP)
T cell activation  (ISO)
T cell proliferation  (ISO)
T-helper 1 cell lineage commitment  (ISO)
T-helper 2 cell differentiation  (ISO)
transcription by RNA polymerase II  (ISO)

Cellular Component

Molecular Function


References - curated
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100. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
101. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
102. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
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107. GOA pipeline RGD automated data pipeline
108. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
109. Comprehensive gene review and curation RGD comprehensive gene curation
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Additional References at PubMed
PMID:1588041   PMID:1903705   PMID:1983334   PMID:7749983   PMID:7927664   PMID:8022486   PMID:8200916   PMID:8566034   PMID:9013979   PMID:9110977   PMID:9798653   PMID:9841920  
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PMID:12574355   PMID:12757709   PMID:12882831   PMID:12941478   PMID:14607964   PMID:14988498   PMID:15087456   PMID:15187136   PMID:15238617   PMID:15251393   PMID:15826818   PMID:15944273  
PMID:16002150   PMID:16034134   PMID:16116184   PMID:16129705   PMID:16169702   PMID:16229173   PMID:16275384   PMID:16493007   PMID:16503976   PMID:16522370   PMID:16606666   PMID:16769892  
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PMID:18762567   PMID:18792410   PMID:18827184   PMID:18997793   PMID:19139201   PMID:19235892   PMID:19346497   PMID:19420081   PMID:19666510   PMID:20120734   PMID:20399120   PMID:20500673  
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PMID:23904363   PMID:24139939   PMID:24280217   PMID:24319732   PMID:24347527   PMID:24801739   PMID:25256599   PMID:26003274   PMID:26416964   PMID:26927369   PMID:26951461   PMID:28092075  
PMID:28414034   PMID:29061364   PMID:29469038   PMID:30017262   PMID:30634164   PMID:30890073   PMID:31341902   PMID:31432141   PMID:32258110   PMID:32704142   PMID:35240467   PMID:36723732  
PMID:37982769   PMID:38315435  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81038,272,003 - 38,277,549 (-)NCBIGRCr8
mRatBN7.21037,771,203 - 37,776,750 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1037,771,203 - 37,776,750 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1042,463,191 - 42,468,731 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01041,953,256 - 41,958,796 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01037,456,988 - 37,462,524 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01038,963,979 - 38,969,531 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1038,963,979 - 38,969,531 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01038,745,706 - 38,751,258 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41039,074,582 - 39,080,134 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11039,083,152 - 39,088,705 (-)NCBI
Celera1037,115,496 - 37,120,965 (-)NCBICelera
Cytogenetic Map10q22NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh385132,673,989 - 132,682,678 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5132,673,986 - 132,682,678 (+)Ensembl