Il18 (interleukin 18) - Rat Genome Database

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Gene: Il18 (interleukin 18) Rattus norvegicus
Symbol: Il18
Name: interleukin 18
RGD ID: 2889
Description: Predicted to enable cytokine activity and interleukin-18 receptor binding activity. Involved in several processes, including cellular response to hormone stimulus; positive regulation of cell population proliferation; and positive regulation of cytokine production. Located in apical plasma membrane and extracellular space. Used to study brain edema; heart disease; status epilepticus; steatotic liver disease; and vasculitis. Biomarker of several diseases, including artery disease (multiple); cardiac arrest; ischemia (multiple); lung disease (multiple); and perinatal necrotizing enterocolitis. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; allergic rhinitis; autoimmune disease (multiple); biliary atresia; and hepatitis B. Orthologous to human IL18 (interleukin 18); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-23 signaling pathway; interleukin-27 signaling pathway; INTERACTS WITH (+)-taxifolin; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: IFN-gamma-inducing factor; IL-1 gamma; IL-18; interferon gamma-inducing factor; interferon-gamma-inducing factor; interleukin-1 gamma; interleukin-18
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8859,802,072 - 59,829,275 (+)NCBIGRCr8
mRatBN7.2850,904,630 - 50,932,887 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl850,906,960 - 50,932,887 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx856,411,470 - 56,438,574 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0854,690,368 - 54,717,472 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0852,554,644 - 52,581,752 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0855,009,666 - 55,016,286 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl854,993,859 - 55,016,299 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0853,606,988 - 53,613,608 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4853,936,584 - 53,943,228 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1853,955,637 - 53,962,282 (+)NCBI
Celera850,474,845 - 50,479,055 (+)NCBICelera
Cytogenetic Map8q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Lung Injury  (IEP)
alcoholic hepatitis  (ISO)
allergic contact dermatitis  (ISO)
allergic disease  (ISO)
allergic rhinitis  (ISO)
alopecia areata  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
asthma  (ISO)
atherosclerosis  (IEP,ISO)
atopic dermatitis  (ISO)
autoimmune hepatitis  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
bacterial pneumonia  (ISO)
Behcet's disease  (ISO)
BH4-deficient hyperphenylalaninemia A  (ISO)
biliary atresia  (ISO)
brain edema  (IDA)
Brain Injuries  (IMP,ISO)
brain ischemia  (IEP,ISO)
breast cancer  (ISO)
Bronchial Hyperreactivity  (ISO)
Burns  (ISO)
calcinosis  (ISO)
Carcinoma, Lewis Lung  (ISO)
cardiac arrest  (IEP)
Cardiomegaly  (ISO)
Carotid Artery Injuries  (IEP,IMP)
cataract  (IEP)
cerebral infarction  (IEP)
Chemical and Drug Induced Liver Injury  (ISO)
Chromosome 11, Partial Trisomy 11q  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
chronic obstructive pulmonary disease  (ISO)
contact dermatitis  (ISO)
Coronary Disease  (ISO)
cystic fibrosis  (ISO)
cystitis  (IEP)
dermatitis  (ISO)
dermatomyositis  (ISO)
diabetic retinopathy  (ISO)
disease of cellular proliferation  (ISO)
Drug Eruptions  (ISO)
Eczema  (ISO)
Edema  (IMP)
Embryo Loss  (IEP)
Experimental Arthritis  (IEP,IMP)
Experimental Autoimmune Encephalomyelitis  (IEP,IMP)
Experimental Liver Cirrhosis  (ISO)
Experimental Melanoma  (ISO)
Experimental Radiation Injuries  (ISO)
eye disease  (ISO)
familial mediterranean fever  (ISO)
genetic disease  (ISO)
glomerulonephritis  (ISO)
Graves ophthalmopathy  (ISO)
Graves' disease  (ISO)
heart disease  (IMP)
heart valve disease  (ISO)
hemophagocytic lymphohistiocytosis  (ISO)
Hemorrhagic Shock  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
herpes simplex  (ISO)
high grade glioma  (ISO)
HIV-Associated Lipodystrophy Syndrome  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (ISO)
Hyperalgesia  (IMP)
Hyperoxia  (IDA)
Hyperphagia  (ISO)
IgA glomerulonephritis  (ISO)
Immediate Hypersensitivity  (ISO)
Insulin Resistance  (ISO)
intellectual disability  (ISO)
interstitial lung disease  (IEP,ISO)
intrahepatic cholestasis of pregnancy  (ISO)
invasive ductal carcinoma  (ISO)
ischemia  (IEP)
Kawasaki disease  (ISO)
Kidney Reperfusion Injury  (IMP)
Legionnaires' disease  (ISO)
leishmaniasis  (ISO)
liver cirrhosis  (ISO)
Liver Failure  (IEP)
Liver Injury  (IEP,ISO)
Liver Reperfusion Injury  (IEP,ISO)
lung disease  (ISO)
lung non-small cell carcinoma  (ISO)
lupus nephritis  (ISO)
Lymphatic Metastasis  (ISO)
Macrophage Activation Syndrome  (ISO)
metabolic dysfunction-associated steatotic liver disease  (IEP,ISO)
Metabolic Syndrome  (IEP,ISO)
Mouth Neoplasms  (ISO)
myocardial infarction  (IEP)
Myocardial Reperfusion Injury  (IDA,ISO)
myositis  (ISO)
Neoplasm Metastasis  (ISO)
neuroblastoma  (ISO)
Nontuberculous Mycobacterium Infections  (ISO)
obesity  (IEP,ISO)
Oral Lichen Planus  (ISO)
Pain  (IDA)
pancreatitis  (IEP)
paracoccidioidomycosis  (ISO)
Perennial Allergic Rhinitis  (ISO)
perinatal necrotizing enterocolitis  (IEP,ISO)
Peripheral Nerve Injuries  (IEP)
Pneumococcal Pneumonia  (ISO)
pneumonia  (IEP,ISO)
polymyositis  (ISO)
Polyomavirus Infections  (ISO)
primary cutaneous T-cell non-Hodgkin lymphoma  (ISO)
Prostatic Neoplasms  (ISO)
Pseudomonas Aeruginosa Keratitis  (ISO)
psoriasis  (ISO)
pulmonary edema  (ISO)
pulmonary emphysema  (IEP,ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
pulmonary sarcoidosis  (ISO)
pulmonary tuberculosis  (ISO)
Pyruvate Dehydrogenase E2 Deficiency  (ISO)
Reperfusion Injury  (ISO)
respiratory failure  (ISO)
respiratory syncytial virus infectious disease  (ISO)
Retinal Neovascularization  (ISO)
rheumatoid arthritis  (ISO)
rhinitis  (ISO)
sarcoidosis  (ISO)
Schistosomiasis Japonica  (ISO)
Seasonal Allergic Rhinitis  (ISO)
severe acute respiratory syndrome  (ISO)
Sjogren's syndrome  (ISO)
sleep apnea  (ISO)
Spinal Cord Injuries  (IDA,IEP)
Staphylococcal Skin Infections  (ISO)
status epilepticus  (IDA)
steatotic liver disease  (IDA)
Stroke  (IEP)
strongyloidiasis  (ISO)
temporal arteritis  (ISO)
Tibial Fractures  (IEP)
Transplant Rejection  (IMP)
type 1 diabetes mellitus  (ISO)
urinary tract infection  (IEP)
urticaria  (ISO)
uveitis  (IEP)
vasculitis  (IDA)
Venous Thrombosis  (IEP)
visceral leishmaniasis  (ISO)
Wallerian Degeneration  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-taxifolin  (EXP)
(1->4)-beta-D-glucan  (ISO)
(4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid  (ISO)
(E)-cinnamyl alcohol  (ISO)
(S)-nicotine  (ISO)
(S)-ropivacaine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
1,4-phenylenediamine  (ISO)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (ISO)
1-chloro-2,4,6-trinitrobenzene  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,4-D  (EXP,ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP,ISO)
2-bromo-2-(bromomethyl)pentanedinitrile  (ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-methyladenine  (EXP,ISO)
3-methylcholanthrene  (ISO)
3-Nitrobenzanthrone  (ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-methylhistamine  (ISO)
4-nitrobenzyl bromide  (ISO)
4-phenylbutyric acid  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (ISO)
8-chloro-2'-deoxyguanosine  (ISO)
acetamide  (EXP)
acetic acid  (EXP)
acetylsalicylic acid  (ISO)
aconitine  (EXP,ISO)
acrolein  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (EXP)
alendronic acid  (ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (EXP)
aluminium sulfate (anhydrous)  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
amphibole asbestos  (EXP,ISO)
ampicillin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
anthranilic acid  (ISO)
antirheumatic drug  (ISO)
apocynin  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asperentin  (ISO)
atorvastatin calcium  (ISO)
atrazine  (ISO)
aucubin  (ISO)
aurantio-obtusin  (ISO)
bellidifolin  (ISO)
Belnacasan  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzocaine  (ISO)
benzylpenicillin  (ISO)
Bergenin  (EXP)
beryllium sulfate  (ISO)
beta-cyclodextrin  (ISO)
bexarotene  (EXP)
bezafibrate  (EXP)
bilirubin IXalpha  (ISO)
biliverdin  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
boric acid  (EXP)
boron atom  (EXP)
BQ 123  (EXP)
Brevianamide A  (ISO)
butyric acid  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
cefaloridine  (EXP)
celastrol  (EXP)
cerium trichloride  (ISO)
chloroethene  (ISO)
chloropicrin  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cimetidine  (ISO)
cinnamyl alcohol  (ISO)
cisplatin  (EXP,ISO)
citral  (ISO)
clenbuterol  (ISO)
clofibrate  (ISO)
cobalt atom  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
copper(II) sulfate  (ISO)
corn oil  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
Curcumol  (ISO)
cycloheximide  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
cypermethrin  (EXP)
D-glucose  (EXP,ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dexmedetomidine  (ISO)
dextran sulfate  (EXP,ISO)
Diallyl sulfide  (ISO)
diarsenic trioxide  (ISO)
dibenziodolium  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
dicrotophos  (ISO)
dieckol  (ISO)
dieldrin  (EXP)
diethyl malate  (ISO)
diethyl maleate  (ISO)
diethyl phthalate  (ISO)
diethylamine  (ISO)
diethylstilbestrol  (EXP)
dihydroartemisinin  (ISO)
Dimaprit  (ISO)
diosmetin  (EXP)
dioxygen  (EXP,ISO)
disodium selenite  (EXP)
disulfiram  (ISO)
doxorubicin  (EXP)
elemental boron  (EXP)
emodin  (ISO)
eplerenone  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
eugenol  (ISO)
famotidine  (ISO)
fasudil  (EXP)
felodipine  (EXP)
ferulic acid  (ISO)
fluvastatin  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
Fraxinellone  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
fumonisin B1  (ISO)
furan  (ISO)
genistein  (EXP)
gentamycin  (EXP,ISO)
geranial  (ISO)
geraniol  (EXP,ISO)
glucose  (EXP,ISO)
glyburide  (EXP,ISO)
glyoxal  (ISO)
gossypin  (EXP)
graphene oxide  (ISO)
graphite  (EXP)
hemin  (ISO)
hexachlorobenzene  (EXP)
hexadecanoic acid  (EXP)
histamine  (ISO)
Honokiol  (ISO)
hydrocortisone succinate  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxysafflor yellow A  (ISO)
IC-87114  (ISO)
ICI 118551  (ISO)
imiquimod  (ISO)
immunological adjuvant  (ISO)
indometacin  (EXP)
irinotecan  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoeugenol  (ISO)
isoflurane  (ISO)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
JTE-013  (EXP)
L-methionine  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP)
lipid As  (ISO)
lipopolysaccharide  (EXP,ISO)
loganin  (ISO)
lonafarnib  (ISO)
lonidamine  (ISO)
lovastatin  (ISO)
lucanthone  (ISO)
LY294002  (EXP,ISO)
lycopene  (ISO)
lysophosphatidylcholine  (ISO)
m-xylene  (EXP)
manganese(II) chloride  (ISO)
mangiferin  (EXP)
manumycin A  (ISO)
melatonin  (ISO)
melittin  (ISO)
mesalamine  (ISO)
metam  (ISO)
methamphetamine  (ISO)
methotrexate  (EXP,ISO)
methoxyacetic acid  (ISO)
metronidazole  (ISO)
mevalonic acid  (EXP)
microcystin-LR  (EXP)
mifepristone  (ISO)
mitomycin C  (ISO)
Monobutylphthalate  (ISO)
monocrotaline  (ISO)
muramyl dipeptide  (ISO)
mycophenolic acid  (ISO)
mycotoxin  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodimethylamine  (EXP,ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
neomycin  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (ISO)
nicotinamide  (EXP)
nicotine  (ISO)
nifuroxazide  (EXP)
nilotinib  (ISO)
nitrofen  (EXP)
NMN zwitterion  (EXP,ISO)
Nonylphenol  (EXP,ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
oleic acid  (ISO)
olmesartan  (EXP)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paclitaxel  (ISO)
Palbinone  (EXP)
pamidronate  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
patulin  (ISO)
PD 0325901  (ISO)
pentachlorophenol  (ISO)
pentane-2,3-dione  (EXP)
perfluorodecanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluoroundecanoic acid  (ISO)
permethrin  (ISO)
phenethyl caffeate  (ISO)
phenytoin  (ISO)
phosgene  (EXP)
phthalic anhydride  (ISO)
Phytolaccoside E  (ISO)
pioglitazone  (EXP)
pirinixic acid  (ISO)
prednisolone  (ISO)
procyanidin B2  (EXP)
progesterone  (ISO)
propofol  (ISO)
protein kinase inhibitor  (ISO)
pterostilbene  (ISO)
puerarin  (ISO)
Pyridostigmine bromide  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quartz  (EXP)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
ranitidine  (ISO)
reactive oxygen species  (ISO)
Rebamipide  (EXP)
reserpine  (EXP)
resorcinol  (ISO)
resveratrol  (EXP,ISO)
Rhein  (ISO)
rifampicin  (ISO)
rimonabant  (ISO)
rolipram  (ISO)
rotenone  (EXP,ISO)
rutin  (EXP)
Salidroside  (ISO)
sarpogrelate  (ISO)
SB 203580  (ISO)
scutellarin  (EXP)
serpentine asbestos  (ISO)
sevoflurane  (EXP,ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
Soman  (EXP)
sphingosine 1-phosphate  (EXP)
spironolactone  (EXP)
sterigmatocystin  (ISO)
streptozocin  (EXP,ISO)
sulfamic acid  (ISO)
sulfasalazine  (EXP)
sulfur dioxide  (EXP)
tetrachloromethane  (ISO)
thalidomide  (ISO)
thapsigargin  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
tipifarnib  (ISO)
titanium dioxide  (ISO)
TMC-120A  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
trans-isoeugenol  (ISO)
trichostatin A  (ISO)
Triptolide  (ISO)
trovafloxacin  (ISO)
tungsten  (EXP)
ubiquinone-0  (ISO)
undecan-2-one  (ISO)
uranium atom  (ISO)
usnic acid  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vanillin  (EXP)
vinclozolin  (EXP)
vorinostat  (ISO)
wortmannin  (ISO)
zearalenone  (ISO)
zinc protoporphyrin  (ISO)
zirconium atom  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA,ISO,ISS)
cell population proliferation  (IEA,ISO)
cellular response to cAMP  (IEP)
cellular response to hydrogen peroxide  (IEP)
cellular response to lipopolysaccharide  (IEA,IEP)
cellular response to mechanical stimulus  (IEP)
cellular response to parathyroid hormone stimulus  (IEP)
cellular response to peptide hormone stimulus  (IMP)
cellular response to tumor necrosis factor  (IEP)
cellular response to type II interferon  (IEP)
cholesterol homeostasis  (IEA,ISO)
cytokine-mediated signaling pathway  (IEA)
defense response to Gram-positive bacterium  (IEA,ISO,ISS)
detection of mechanical stimulus involved in sensory perception of pain  (IDA)
digestive tract morphogenesis  (IEP)
establishment of skin barrier  (IEA,ISO,ISS)
extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
immune response  (IEA)
inflammatory response  (IEA,ISO)
interleukin-18-mediated signaling pathway  (IEA,ISO,ISS)
learning or memory  (TAS)
liver regeneration  (IEP)
lung development  (IEP)
natural killer cell activation  (IEA,ISO)
natural killer cell mediated cytotoxicity  (IEA,ISO)
negative regulation of myoblast differentiation  (IEA,ISO)
negative regulation of neutrophil apoptotic process  (IMP)
negative regulation of peptidyl-tyrosine phosphorylation  (IMP)
neutrophil activation  (IEA,ISO)
osteoblast differentiation  (IEP)
positive regulation of activated T cell proliferation  (IEA,ISO,ISS)
positive regulation of apoptotic process  (IMP)
positive regulation of blood vessel remodeling  (IDA)
positive regulation of cell population proliferation  (ISO)
positive regulation of chemokine production  (IMP)
positive regulation of cold-induced thermogenesis  (IEA,ISO,ISS)
positive regulation of collagen biosynthetic process  (IDA)
positive regulation of cytokine production  (IEA)
positive regulation of gene expression  (ISO)
positive regulation of granulocyte macrophage colony-stimulating factor production  (IEA,ISO)
positive regulation of hepatocyte proliferation  (IDA)
positive regulation of inflammatory response  (IEA,ISO,ISS)
positive regulation of interleukin-1 beta production  (IEP)
positive regulation of interleukin-17 production  (IEA,ISO)
positive regulation of interleukin-8 production  (IDA)
positive regulation of macrophage derived foam cell differentiation  (IEA,ISO)
positive regulation of male germ cell proliferation  (IDA)
positive regulation of natural killer cell proliferation  (IEA,ISO)
positive regulation of neuron apoptotic process  (IMP)
positive regulation of NK T cell proliferation  (IEA,ISO)
positive regulation of non-canonical NF-kappaB signal transduction  (IEA,ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
positive regulation of smooth muscle cell migration  (IMP)
positive regulation of smooth muscle cell proliferation  (IEA,IMP,ISO)
positive regulation of superoxide anion generation  (IMP)
positive regulation of T-helper 1 cell cytokine production  (IEA,ISO,ISS)
positive regulation of T-helper 2 cell differentiation  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of tumor necrosis factor production  (IMP)
positive regulation of type II interferon production  (IEA,ISO,ISS)
positive regulation of tyrosine phosphorylation of STAT protein  (IEA,ISO)
positive regulation of vascular permeability  (IMP)
regulation of cell adhesion  (ISO,ISS)
regulation of circadian sleep/wake cycle, non-REM sleep  (TAS)
response to hyperoxia  (IEP)
response to hypoxia  (IMP)
response to peptide hormone  (IEP)
signal transduction  (ISO)
sleep  (IDA)
T-helper 1 type immune response  (IEA,ISO,ISS)
triglyceride homeostasis  (IEA,ISO)

Cellular Component

Molecular Function


References - curated
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111. Endogenous interleukin-18 is involved in immunity to Leishmania donovani but its absence does not adversely influence the therapeutic activity of sodium stibogluconate. Mullen AB, etal., Immunology. 2006 Nov;119(3):348-54. Epub 2006 Jul 26.
112. Interleukin 18 and transforming growth factor beta1 in the serum of patients with Graves' ophthalmopathy treated with corticosteroids. Mysliwiec J, etal., Int Immunopharmacol. 2003 Apr;3(4):549-52.
113. Gene transfer of secreted-type modified interleukin-18 gene to B16F10 melanoma cells suppresses in vivo tumor growth through inhibition of tumor vessel formation. Nagai H, etal., J Invest Dermatol. 2002 Sep;119(3):541-8.
114. Involvement of interleukin 18 in lens opacification of Otsuka Long-Evans Tokushima Fatty rats, a model of human type 2 diabetes. Nagai N, etal., Curr Eye Res. 2011 Jun;36(6):497-506. doi: 10.3109/02713683.2010.549602.
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142. Interleukin-18 in induced sputum: association with lung function in chronic obstructive pulmonary disease. Rovina N, etal., Respir Med. 2009 Jul;103(7):1056-62. Epub 2009 Feb 8.
143. The protective effects of interleukin-18 and interferon-gamma on neuronal damages in the rat hippocampus following status epilepticus. Ryu HJ, etal., Neuroscience. 2010 Oct 27;170(3):711-21. Epub 2010 Jul 29.
144. ANALYSIS OF POLYMORPHISMS IN THE INTERLEUKIN 18 GENE PROMOTOR (-137 G/C AND -607 C/A) IN PATIENTS INFECTED WITH HEPATITIS C VIRUS FROM THE BRAZILIAN AMAZON. Santos KN, etal., Arq Gastroenterol. 2015 Jul-Sep;52(3):222-7. doi: 10.1590/S0004-28032015000300013.
145. IL-18 with IL-2 protects against Strongyloides venezuelensis infection by activating mucosal mast cell-dependent type 2 innate immunity. Sasaki Y, etal., J Exp Med. 2005 Sep 5;202(5):607-16. Epub 2005 Aug 29.
146. Involvement of NK1.1+ {gamma}{delta}T Cells in the IL-18 Plus IL-2-Induced Interstitial Lung Disease. Segawa S, etal., Am J Respir Cell Mol Biol. 2011 Jan 21.
147. In vivo IL-18 supplementation ameliorates lethal acute lung injury in burn-primed endotoxemic mice: a novel anti-inflammatory role of IL-18. Sekine K, etal., Shock. 2009 Nov;32(5):554-62.
148. Shock wave therapy effectively attenuates inflammation in rat carotid artery following endothelial denudation by balloon catheter. Shao PL, etal., Cardiology. 2010;115(2):130-44. Epub 2009 Dec 2.
149. Effect of Histone Deacetylase HDAC3 on Cytokines IL-18, IL-12 and TNF-α in Patients with Intrahepatic Cholestasis of Pregnancy. Shao Y, etal., Cell Physiol Biochem. 2017;42(4):1294-1302. doi: 10.1159/000478958. Epub 2017 Jul 11.
150. Elevation of interleukin-18 in chronic hepatitis C: implications for hepatitis C virus pathogenesis. Sharma A, etal., Immunology. 2009 Sep;128(1 Suppl):e514-22. doi: 10.1111/j.1365-2567.2008.03021.x. Epub 2008 Nov 24.
151. Serum IL-18 is closely associated with renal tubulointerstitial injury and predicts renal prognosis in IgA nephropathy. Shi B, etal., Mediators Inflamm. 2012;2012:728417. Epub 2012 Feb 6.
152. Distinct cytokine profiles of systemic-onset juvenile idiopathic arthritis-associated macrophage activation syndrome with particular emphasis on the role of interleukin-18 in its pathogenesis. Shimizu M, etal., Rheumatology (Oxford). 2010 Sep;49(9):1645-53. doi: 10.1093/rheumatology/keq133. Epub 2010 May 14.
153. Erythropoietin attenuates hyperoxia-induced cell death by modulation of inflammatory mediators and matrix metalloproteinases. Sifringer M, etal., Dev Neurosci. 2009;31(5):394-402. Epub 2009 Aug 11.
154. Activation of caspase-1 dependent interleukins in developmental brain trauma. Sifringer M, etal., Neurobiol Dis. 2007 Mar;25(3):614-22. Epub 2006 Dec 22.
155. Increased interleukin-18 content and angiogenic activity of sera from diabetic (Type 2) patients with background retinopathy. Skopinski P, etal., J Diabetes Complications. 2005 Nov-Dec;19(6):335-8.
156. Multiplex analysis of urinary cytokine levels in rat model of cyclophosphamide-induced cystitis. Smaldone MC, etal., Urology. 2009 Feb;73(2):421-6. Epub 2008 Oct 9.
157. Interleukin-18 is associated with increased severity of atopic dermatitis in children. Sohn MH, etal., Allergy Asthma Proc. 2004 May-Jun;25(3):181-4.
158. Circulating concentrations of interleukin-18, interleukin-18 binding protein, and gamma interferon in patients with alcoholic hepatitis. Spahr L, etal., Liver Int. 2004 Dec;24(6):582-7. doi: 10.1111/j.1478-3231.2004.0967.x.
159. Interleukin 18 expression in the primary breast cancer tumour tissue. Srabovic N, etal., Med Glas (Zenica). 2011 Feb;8(1):109-15.
160. The evolving systemic and local biomarker milieu at different stages of disease progression in rat collagen-induced arthritis. Stolina M, etal., Biomarkers. 2008 Nov;13(7):692-712.
161. Interleukin-18 is expressed in rat testis and may promote germ cell growth. Strand ML, etal., Mol Cell Endocrinol. 2005 Aug 30;240(1-2):64-73.
162. Neurons of the superior nucleus of the medial habenula and ependymal cells express IL-18 in rat CNS. Sugama S, etal., Brain Res 2002 Dec 20;958(1):1-9.
163. Tissue-specific expression of rat IL-18 gene and response to adrenocorticotropic hormone treatment. Sugama S, etal., J Immunol. 2000 Dec 1;165(11):6287-92.
164. Caspase 1 activation is protective against hepatocyte cell death by up-regulating beclin 1 protein and mitochondrial autophagy in the setting of redox stress. Sun Q, etal., J Biol Chem. 2013 May 31;288(22):15947-58. doi: 10.1074/jbc.M112.426791. Epub 2013 Apr 15.
165. Interleukin 18 causes hepatic ischemia/reperfusion injury by suppressing anti-inflammatory cytokine expression in mice. Takeuchi D, etal., Hepatology. 2004 Mar;39(3):699-710. doi: 10.1002/hep.20117.
166. Interleukin-18 exacerbates pulmonary injury after hepatic ischemia/reperfusion in mice. Takeuchi D, etal., J Surg Res. 2010 Jan;158(1):87-93. Epub .
167. Thyroid-stimulating hormone induces interleukin-18 gene expression in FRTL-5 cells: immunohistochemical detection of interleukin-18 in autoimmune thyroid disease. Takiyama Y, etal., Thyroid. 2002 Nov;12(11):935-43.
168. IL-18 overexpression promotes vascular inflammation and remodeling in a rat model of metabolic syndrome. Tan HW, etal., Atherosclerosis. 2010 Feb;208(2):350-7. Epub 2009 Aug 7.
169. IL-18 might reflect disease activity in mild and moderate asthma exacerbation. Tanaka H, etal., J Allergy Clin Immunol. 2001 Feb;107(2):331-6.
170. Interleukin-18 is elevated in the sera from patients with atopic dermatitis and from atopic dermatitis model mice, NC/Nga. Tanaka T, etal., Int Arch Allergy Immunol. 2001 Jul;125(3):236-40.
171. Interleukin-18 overexpression as a hallmark of the activity of autoimmune inflammatory myopathies. Tucci M, etal., Clin Exp Immunol. 2006 Oct;146(1):21-31.
172. Elevation of serum interleukin-18 levels and activation of Kupffer cells in biliary atresia. Urushihara N, etal., J Pediatr Surg. 2000 Mar;35(3):446-9.
173. Angiotensin II enhances AT1-Nox1 binding and stimulates arterial smooth muscle cell migration and proliferation through AT1, Nox1, and interleukin-18. Valente AJ, etal., Am J Physiol Heart Circ Physiol. 2012 Aug 1;303(3):H282-96. doi: 10.1152/ajpheart.00231.2012. Epub 2012 May 25.
174. Enhanced viral clearance in interleukin-18 gene-deficient mice after pulmonary infection with influenza A virus. Van Der Sluijs KF, etal., Immunology. 2005 Jan;114(1):112-20.
175. Systemic Elevation of Proinflammatory Interleukin 18 in HIV/HCV Coinfection versus HIV or HCV Monoinfection. Veenhuis RT, etal., Clin Infect Dis. 2017 Mar 1;64(5):589-596. doi: 10.1093/cid/ciw771. Epub 2016 Dec 7.
176. Neutralization of interleukin-18 ameliorates ischemia/reperfusion-induced myocardial injury. Venkatachalam K, etal., J Biol Chem. 2009 Mar 20;284(12):7853-65. Epub 2009 Jan 21.
177. Dynamics of neuroinflammation in the macrosphere model of arterio-arterial embolic focal ischemia: an approximation to human stroke patterns. Walberer M, etal., Exp Transl Stroke Med. 2010 Dec 20;2(1):22.
178. Small interfering RNA targeting IKKbeta prevents renal ischemia-reperfusion injury in rats. Wan X, etal., Am J Physiol Renal Physiol. 2011 Apr;300(4):F857-63. Epub 2011 Feb 2.
179. Inhibition of hepatic interleukin-18 production by rosiglitazone in a rat model of nonalcoholic fatty liver disease. Wang HN, etal., World J Gastroenterol. 2008 Dec 21;14(47):7240-6.
180. Protective effects of exogenous interleukin 18-binding protein in a rat model of acute renal ischemia-reperfusion injury. Wang J, etal., Shock. 2012 Mar;37(3):333-40. doi: 10.1097/SHK.0b013e318240bdc8.
181. [Influence of electroacupuncture stimulation on serum and hepatic interleukin-18 expression in nonalcoholic fatty liver rats]. Wang L, etal., Zhen Ci Yan Jiu. 2013 Jun;38(3):208-13.
182. Ethyl pyruvate protects against experimental acute-on-chronic liver failure in rats. Wang LW, etal., World J Gastroenterol. 2012 Oct 28;18(40):5709-18. doi: 10.3748/wjg.v18.i40.5709.
183. IL-18 binding protein-expressing mesenchymal stem cells improve myocardial protection after ischemia or infarction. Wang M, etal., Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17499-504. Epub 2009 Sep 25.
184. Breviscapine reduces acute lung injury induced by left heart ischemic reperfusion in rats by inhibiting the expression of ICAM-1 and IL-18. Wang Y, etal., Exp Ther Med. 2013 Nov;6(5):1322-1326. Epub 2013 Sep 4.
185. Expression and localization of IL-18 in the hypothalamic-pituitary-ovarian axis of non-pregnant, pregnant, and abortive rats. Wang Y, etal., J Reprod Immunol. 2011 Dec;92(1-2):45-53. doi: 10.1016/j.jri.2011.07.002. Epub 2011 Sep 13.
186. IL-18 enhances protective effect in mice immunized with a Schistosoma japonicum FABP DNA vaccine. Wei F, etal., Acta Trop. 2009 Sep;111(3):284-8. doi: 10.1016/j.actatropica.2009.03.010. Epub 2009 May 23.
187. Host genetic background determines whether IL-18 deficiency results in increased susceptibility or resistance to murine Leishmania major infection. Wei XQ, etal., Immunol Lett. 2004 Jun 15;94(1-2):35-7.
188. Up-regulation of IL-18BP, but not IL-18 mRNA in rat liver by LPS. Wheeler RD, etal., Cytokine. 2003 Feb 21;21(4):161-6.
189. Interleukin 18 participates in the early inflammatory response and bacterial clearance during pneumonia caused by nontypeable Haemophilus influenzae. Wieland CW, etal., Infect Immun. 2007 Oct;75(10):5068-72. Epub 2007 Jul 30.
190. Neutralizing antibodies to IFN-gamma-inducing factor prevent experimental autoimmune encephalomyelitis. Wildbaum G, etal., J Immunol. 1998 Dec 1;161(11):6368-74.
191. Overexpression of interleukin-18 aggravates cardiac fibrosis and diastolic dysfunction in fructose-fed rats. Xing SS, etal., Mol Med. 2010 Nov-Dec;16(11-12):465-70. Epub 2010 Jul 12.
192. Expression of interleukin-18 in murine contact hypersensitivity. Xu B, etal., J Interferon Cytokine Res. 1998 Sep;18(9):653-9.
193. Adenoviral-mediated interleukin-18 expression in mesenchymal stem cells effectively suppresses the growth of glioma in rats. Xu G, etal., Cell Biol Int. 2009 Apr;33(4):466-74. doi: 10.1016/j.cellbi.2008.07.023. Epub 2008 Aug 6.
194. Ileal immune dysregulation in necrotizing enterocolitis: role of CD40/CD40L in the pathogenesis of disease. Xu J, etal., J Pediatr Gastroenterol Nutr. 2011 Feb;52(2):140-6.
195. Interleukin-18-deficient mice exhibit diminished chronic inflammation and airway remodelling in ovalbumin-induced asthma model. Yamagata S, etal., Clin Exp Immunol. 2008 Dec;154(3):295-304. Epub 2008 Sep 23.
196. Expression of interleukin-18 and caspase-1 in cutaneous T-cell lymphoma. Yamanaka K, etal., Clin Cancer Res. 2006 Jan 15;12(2):376-82.
197. Therapeutic effect of pEgr-IL18-B7.2 gene radiotherapy in B16 melanoma-bearing mice. Yang J, etal., Hum Gene Ther. 2007 Apr;18(4):323-32.
198. Baicalein reduces inflammatory process in a rodent model of diabetic retinopathy. Yang LP, etal., Invest Ophthalmol Vis Sci. 2009 May;50(5):2319-27. Epub 2008 Nov 14.
199. Plasma IP-10 and MCP-3 levels are highly associated with disease severity and predict the progression of COVID-19. Yang Y, etal., J Allergy Clin Immunol. 2020 Apr 29. pii: S0091-6749(20)30576-5. doi: 10.1016/j.jaci.2020.04.027.
200. Role of interleukin 18 in acute lung inflammation induced by gut ischemia reperfusion. Yang YJ, etal., World J Gastroenterol. 2005 Aug 7;11(29):4524-9.
201. The roles of interleukin-18 in collagen-induced arthritis in the BB rat. Ye XJ, etal., Clin Exp Immunol. 2004 Jun;136(3):440-7.
202. The effects of interleukin-18 on rat articular chondrocytes: a study of mRNA expression and protein synthesis of proinflammatory substances. Ye XJ, etal., Clin Exp Immunol. 2007 Sep;149(3):553-60. Epub 2007 Jul 10.
203. Effects of hydrogen-rich saline on taurocholate-induced acute pancreatitis in rat. Zhang DQ, etal., Evid Based Complement Alternat Med. 2013;2013:731932. doi: 10.1155/2013/731932. Epub 2013 Jul 28.
204. Interleukin 18 accelerates the hepatic cell proliferation in rat liver regeneration after partial hepatectomy. Zhang J, etal., Gene. 2014 Mar 10;537(2):230-7. doi: 10.1016/j.gene.2013.12.062. Epub 2014 Jan 9.
205. Effects of an aqueous extract of Crataegus pinnatifida Bge. var. major N.E.Br. fruit on experimental atherosclerosis in rats. Zhang J, etal., J Ethnopharmacol. 2013 Jul 9;148(2):563-9. doi: 10.1016/j.jep.2013.04.053. Epub 2013 May 16.
206. [Association between interleukin-18 gene polymorphisms and hepatocellular carcinoma caused by hepatitis B virus]. Zhang QX, etal., Zhonghua Gan Zang Bing Za Zhi. 2016 May 20;24(5):352-7. doi: 10.3760/cma.j.issn.1007-3418.2016.05.008.
207. Efficacy and mechanism of Salvia miltiorrhizae injection in the treatment of rats with severe acute pancreatitis. Zhang R, etal., Inflammation. 2009 Apr;32(2):109-19.
208. Reduced MIR130A is involved in primary immune thrombocytopenia via targeting TGFB1 and IL18. Zhao H, etal., Br J Haematol. 2014 Sep;166(5):767-73. doi: 10.1111/bjh.12934. Epub 2014 May 7.
Additional References at PubMed
PMID:9702748   PMID:10048765   PMID:10227969   PMID:10227975   PMID:10653850   PMID:10843730   PMID:10903731   PMID:11131641   PMID:11429161   PMID:11714750   PMID:11894097   PMID:11894098  
PMID:11907086   PMID:12787406   PMID:12829194   PMID:14528293   PMID:15220916   PMID:15843532   PMID:15890643   PMID:16460811   PMID:16482511   PMID:16707557   PMID:16949315   PMID:17010950  
PMID:17220368   PMID:17352829   PMID:18504504   PMID:18662782   PMID:19088061   PMID:19666510   PMID:20027291   PMID:21147091   PMID:21273803   PMID:21321938   PMID:21323571   PMID:21442623  
PMID:21882482   PMID:22642744   PMID:23132931   PMID:23376485   PMID:23725508   PMID:23747799   PMID:23823918   PMID:23844157   PMID:24414074   PMID:24615654   PMID:24816434   PMID:25022959  
PMID:25500532   PMID:25752290   PMID:25918710   PMID:26004155   PMID:26252165   PMID:26424019   PMID:26558633   PMID:26725437   PMID:28373090   PMID:29786104   PMID:31923399   PMID:33051554  
PMID:33137409   PMID:33236152   PMID:34369678   PMID:34890588   PMID:36042379   PMID:36591929   PMID:37566022  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8859,802,072 - 59,829,275 (+)NCBIGRCr8
mRatBN7.2850,904,630 - 50,932,887 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl850,906,960 - 50,932,887 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx856,411,470 - 56,438,574 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0854,690,368 - 54,717,472 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0852,554,644 - 52,581,752 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0855,009,666 - 55,016,286 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl854,993,859 - 55,016,299 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0853,606,988 - 53,613,608 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4853,936,584 - 53,943,228 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1853,955,637 - 53,962,282 (+)NCBI
Celera850,474,845 - 50,479,055 (+)NCBICelera
Cytogenetic Map8q23NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh3811112,143,260 - 112,164,094 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11112,143,253 - 112,164,096 (-)EnsemblGRCh38hg38GRCh38
GRCh3711112,013,983 - 112,034,817 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611111,519,186 - 111,540,050 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411111,519,185 - 111,540,050NCBI
Celera11109,167,214 - 109,188,073 (-)NCBICelera
Cytogenetic Map11q23.1NCBI
HuRef11107,938,095 - 107,959,011 (-)NCBIHuRef
CHM1_111111,897,441 - 111,918,303 (-)NCBICHM1_1
T2T-CHM13v2.011112,153,592 - 112,174,423 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39950,466,000 - 50,493,141 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl950,466,127 - 50,493,140 (+)EnsemblGRCm39 Ensembl
GRCm38950,554,700 - 50,581,841 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl950,554,827 - 50,581,840 (+)EnsemblGRCm38mm10GRCm38
MGSCv37950,373,473 - 50,389,942 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36950,317,598 - 50,334,067 (+)NCBIMGSCv36mm8
Celera947,860,314 - 47,877,082 (+)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map927.75NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495541213,806,553 - 13,825,634 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541213,807,361 - 13,826,007 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v29112,888,641 - 112,913,692 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111113,981,627 - 114,007,032 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011107,024,376 - 107,045,194 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111110,867,586 - 110,888,371 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11110,867,586 - 110,888,371 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1520,972,742 - 20,995,327 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl520,972,871 - 20,995,348 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha520,907,590 - 20,917,853 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0520,994,967 - 21,017,974 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl520,995,094 - 21,019,245 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1521,069,981 - 21,080,260 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0520,970,245 - 20,980,530 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0521,018,633 - 21,028,888 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494794,380,523 - 94,398,669 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366122,306,875 - 2,325,189 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366122,306,963 - 2,325,086 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl939,834,973 - 39,861,219 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1939,839,959 - 39,861,258 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2944,692,120 - 44,713,415 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11103,485,868 - 103,511,632 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1103,482,083 - 103,510,150 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604322,475,303 - 22,498,316 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247847,294,183 - 7,304,687 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247847,294,286 - 7,312,959 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Il18
108 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:60
Count of miRNA genes:53
Interacting mature miRNAs:56
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)82720571554998217Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)82824291253961020Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815458482492Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83084815461290444Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84186687675097878Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)84186701070386132Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)84980583194805831Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85009524982460899Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85009524982460899Rat


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 34 18 19 18 1 11 11
Low 43 23 23 23 8 10 74 34 30 8
Below cutoff 1


Nucleotide Sequences
RefSeq Transcripts NM_019165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC141541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF226163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ222813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY077842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY258448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ230327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ230328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ230329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U77776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U77777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y13337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000013093   ⟹   ENSRNOP00000013093
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl850,926,271 - 50,932,887 (+)Ensembl
Rnor_6.0 Ensembl854,993,859 - 55,016,299 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000108779   ⟹   ENSRNOP00000082676
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl850,906,960 - 50,932,887 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119850   ⟹   ENSRNOP00000081241
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl850,906,960 - 50,932,554 (+)Ensembl
RefSeq Acc Id: NM_019165   ⟹   NP_062038
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr8859,802,072 - 59,829,275 (+)NCBI
mRatBN7.2850,905,681 - 50,932,887 (+)NCBI
Rnor_6.0855,009,666 - 55,016,286 (+)NCBI
Rnor_5.0853,606,988 - 53,613,608 (+)NCBI
RGSC_v3.4853,936,584 - 53,943,228 (+)RGD
Celera850,474,845 - 50,479,055 (+)RGD
RefSeq Acc Id: XM_039080940   ⟹   XP_038936868
Rat AssemblyChrPosition (strand)Source
GRCr8859,807,859 - 59,829,275 (+)NCBI
mRatBN7.2850,916,216 - 50,932,887 (+)NCBI
RefSeq Acc Id: XM_039080944   ⟹   XP_038936872
Rat AssemblyChrPosition (strand)Source
GRCr8859,813,443 - 59,829,275 (+)NCBI
mRatBN7.2850,904,794 - 50,932,887 (+)NCBI
RefSeq Acc Id: XM_039080945   ⟹   XP_038936873
Rat AssemblyChrPosition (strand)Source
GRCr8859,822,599 - 59,829,275 (+)NCBI
mRatBN7.2850,904,788 - 50,932,887 (+)NCBI
RefSeq Acc Id: XM_039080947   ⟹   XP_038936875
Rat AssemblyChrPosition (strand)Source
GRCr8859,823,916 - 59,829,275 (+)NCBI
mRatBN7.2850,927,528 - 50,932,887 (+)NCBI
RefSeq Acc Id: XM_063265003   ⟹   XP_063121073
Rat AssemblyChrPosition (strand)Source
GRCr8859,820,965 - 59,829,275 (+)NCBI
RefSeq Acc Id: XM_063265004   ⟹   XP_063121074
Rat AssemblyChrPosition (strand)Source
GRCr8859,818,805 - 59,829,275 (+)NCBI
RefSeq Acc Id: XM_063265005   ⟹   XP_063121075
Rat AssemblyChrPosition (strand)Source
GRCr8859,813,688 - 59,829,275 (+)NCBI
RefSeq Acc Id: XM_063265006   ⟹   XP_063121076
Rat AssemblyChrPosition (strand)Source
GRCr8859,820,965 - 59,829,275 (+)NCBI
RefSeq Acc Id: XM_063265008   ⟹   XP_063121078
Rat AssemblyChrPosition (strand)Source
GRCr8859,813,688 - 59,829,275 (+)NCBI