Il10 (interleukin 10) - Rat Genome Database

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Gene: Il10 (interleukin 10) Rattus norvegicus
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Symbol: Il10
Name: interleukin 10
RGD ID: 2886
Description: Exhibits interleukin-10 receptor binding activity. Involved in several processes, including cellular response to estradiol stimulus; liver regeneration; and negative regulation of nitric oxide biosynthetic process. Localizes to extracellular space. Used to study several diseases, including lung disease (multiple); perinatal necrotizing enterocolitis; sciatic neuropathy; toxic encephalopathy; and transient cerebral ischemia. Biomarker of several diseases, including artery disease (multiple); decubitus ulcer; lung disease (multiple); obstructive sleep apnea; and postpartum depression. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Orthologous to human IL10 (interleukin 10); PARTICIPATES IN Interleukin-10 signaling pathway; interleukin-4 signaling pathway; allograft rejection pathway; INTERACTS WITH (+)-alpha-tocopherol; (+)-pilocarpine; (-)-epigallocatechin 3-gallate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: CSIF; cytokine synthesis inhibitory factor; If2a; IL-10; IL10X; interferon 2a; interleukin-10
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21342,472,625 - 42,477,308 (+)NCBI
Rnor_6.0 Ensembl1347,739,526 - 47,743,392 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01347,738,933 - 47,743,392 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01352,824,594 - 52,828,560 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41343,953,900 - 43,957,766 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11343,967,906 - 43,972,374 (+)NCBI
Celera1342,821,569 - 42,825,416 (+)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (IEP)
Actinic Cheilitis  (ISO)
acute kidney failure  (ISO)
Acute Liver Failure  (ISO)
Acute Lung Injury  (IDA,IEP,ISO)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
acute pancreatitis  (ISO)
adult respiratory distress syndrome  (IEP)
adult T-cell leukemia  (ISO)
aggressive periodontitis  (ISO)
Airway Obstruction  (ISO)
allergic conjunctivitis  (ISO)
allergic contact dermatitis  (ISO)
allergic rhinitis  (ISO)
Alveolar Bone Loss  (IEP)
Alzheimer's disease  (ISO)
anemia  (ISO)
Animal Disease Models  (ISO)
anogenital venereal wart  (ISO)
anti-basement membrane glomerulonephritis  (IDA)
aphthous stomatitis  (ISO)
appendicitis  (ISO)
arteriosclerosis  (ISO)
Asthenopia  (ISO)
asthma  (IEP,IGI,ISO)
atopic dermatitis  (ISO)
autistic disorder  (ISO)
autoimmune hemolytic anemia  (ISO)
autoimmune hepatitis  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
bacterial infectious disease  (ISO)
bacterial pneumonia  (ISO)
Behcet's disease  (ISO)
Brain Injuries  (IDA,ISO)
Breast Neoplasms  (ISO)
Bronchial Hyperreactivity  (ISO)
bronchus carcinoma  (ISO)
Burns  (IEP,ISO)
carotid artery disease  (ISO)
carotid stenosis  (ISO)
celiac disease  (ISO)
central nervous system lymphoma  (ISO)
cervical cancer  (ISO)
Chagas Cardiomyopathy  (IDA)
choroid disease  (ISO)
Choroidal Neovascularization  (ISO)
Chronic Bronchitis  (IEP)
Chronic Hepatitis C  (ISO)
chronic myeloid leukemia  (ISO)
Chronic Periodontitis  (ISO)
colitis  (IEP,ISO)
colon cancer  (ISO)
common cold  (ISO)
congestive heart failure  (IEP)
coronary artery disease  (ISO)
Coronavirus infectious disease  (ISO)
COVID-19  (ISO)
Crohn's disease  (ISO)
cutaneous leishmaniasis  (ISO)
cytomegalovirus retinitis  (ISO)
decubitus ulcer  (IEP)
diabetes mellitus  (ISO)
Diabetic Cardiomyopathies  (IDA)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
diffuse scleroderma  (ISO)
dilated cardiomyopathy  (IEP)
disseminated intravascular coagulation  (ISO)
drug allergy  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
dry eye syndrome  (ISO)
Dysbiosis  (IEP)
Dyspepsia  (ISO)
Eales Disease  (ISO)
endometrial cancer  (ISO)
endometriosis  (IDA,ISO)
Endotoxemia  (IEP,ISO)
Entamoebiasis  (ISO)
Enterocolitis  (ISO)
Enterovirus Infections  (ISO)
Experimental Arthritis  (IDA,IEP,ISO)
Experimental Autoimmune Encephalomyelitis  (IDA)
Experimental Autoimmune Myocarditis  (IEP)
Experimental Autoimmune Uveitis  (ISO)
Experimental Autoimmune Uveoretinitis  (IDA,ISO)
Experimental Colitis  (IEP,ISO)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Cirrhosis  (IDA,IMP,ISO)
Experimental Pancreatitis, Acute  (IEP)
Eye Burns  (IDA)
factor VIII deficiency  (ISO)
Fanconi anemia  (ISO)
fatty liver disease  (IEP)
Femoral Fractures  (IEP)
gallbladder carcinoma  (ISO)
gastric dilatation  (ISO)
Gastro-Enteropancreatic Neuroendocrine Tumor  (ISO)
gastrointestinal stromal tumor  (ISO)
Genetic Predisposition to Disease  (ISO)
gestational diabetes  (ISO)
glomerulonephritis  (ISO)
glucosephosphate dehydrogenase deficiency  (ISO)
Graft vs Host Disease  (ISO)
granulomatosis with polyangiitis  (ISO)
Graves Ophthalmopathy  (ISO)
Graves' disease  (ISO)
Hearing Loss  (IDA,ISO)
Heat Stroke  (ISO)
Hemorrhagic Shock  (IEP)
Heparin-induced Thrombocytopenia  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (IDA,ISO)
herpes simplex virus keratitis  (ISO)
herpes zoster  (ISO)
high grade glioma  (ISO)
Hodgkin's lymphoma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (ISO)
Human Viral Hepatitis  (ISO)
Hyperalgesia  (IDA,IEP,ISO)
hypertension  (IEP)
hyperthyroidism  (IEP,ISO)
hypothyroidism  (IEP)
ileitis  (ISO)
Immediate Hypersensitivity  (ISO)
Inflammation  (IEP,ISO)
inflammatory bowel disease  (ISO)
intermediate uveitis  (ISO)
intestinal obstruction  (IEP)
irritable bowel syndrome  (ISO)
Kidney Reperfusion Injury  (IDA,ISO)
leishmaniasis  (ISO)
lip cancer  (ISO)
liver benign neoplasm  (IEP)
liver cancer  (ISO)
liver carcinoma  (ISO)
liver cirrhosis  (ISO)
Liver Reperfusion Injury  (IDA)
lung disease  (IDA,IEP,ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
major depressive disorder  (ISO)
Malignant Pleural Effusions  (ISO)
Mammary Neoplasms, Experimental  (ISO)
Middle East respiratory syndrome  (ISO)
mitral valve stenosis  (ISO)
mucositis  (ISO)
multiple myeloma  (ISO)
Multiple Organ Failure  (ISO)
multiple sclerosis  (ISO)
Murine Acquired Immunodeficiency Syndrome  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (IDA,IEP)
myocarditis  (IDA,ISO)
Nasal Polyps  (ISO)
Neoplasm Metastasis  (ISO)
Neuralgia  (IDA,IMP,ISO)
non-alcoholic fatty liver disease  (ISO)
non-alcoholic steatohepatitis  (ISO)
obesity  (IEP,ISO)
obstructive sleep apnea  (IEP)
occupational dermatitis  (ISO)
Ocular Toxoplasmosis  (ISO)
ocular tuberculosis  (ISO)
open-angle glaucoma  (ISO)
oral squamous cell carcinoma  (ISO)
otitis media  (IEP,ISO)
ovarian cancer  (ISO)
pancreatic cancer  (ISO)
pancreatitis  (IEP)
panuveitis  (ISO)
parathyroid carcinoma  (ISO)
pericardial effusion  (ISO)
perinatal necrotizing enterocolitis  (IDA,ISO)
periodontitis  (IEP,ISO)
plasmacytoma  (ISO)
pleurisy  (ISO)
pneumonia  (ISO)
postpartum depression  (IEP)
Pregnancy-associated Malaria  (ISO)
primary biliary cholangitis  (ISO)
Primary Graft Dysfunction  (IDA)
Prostatic Neoplasms  (ISO)
prostatitis  (IEP,ISO)
Pseudomonas Aeruginosa Keratitis  (ISO)
psoriasis  (ISO)
pulmonary eosinophilia  (ISO)
pulmonary hypertension  (ISO)
Radiation Injuries, Experimental  (IDA,IEP)
Reperfusion Injury  (IDA,IEP,ISO)
respiratory allergy  (ISO)
respiratory syncytial virus infectious disease  (ISO)
retinal artery occlusion  (ISO)
retinal disease  (ISO)
retinopathy of prematurity  (ISO)
Retroviridae Infections  (ISO)
rheumatic heart disease  (ISO)
rheumatoid arthritis  (ISO)
Rhinosinusitis  (ISO)
schizophrenia  (ISO)
sciatic neuropathy  (IDA,IEP)
Seasonal Allergic Rhinitis  (ISO)
Sepsis  (IDA,IEP,ISO)
severe acute respiratory syndrome  (IEP,ISO)
shigellosis  (ISO)
Shwartzman phenomenon  (ISO)
sickle cell anemia  (ISO)
Sjogren's syndrome  (ISO)
skin disease  (ISO)
Spinal Cord Injuries  (IEP)
Splenomegaly  (ISO)
Staphylococcal Infections  (IDA)
Staphylococcal Pneumonia  (ISO)
stomach cancer  (ISO)
Stroke  (IDA,IEP,ISO)
systemic lupus erythematosus  (ISO)
thrombocytopenia  (ISO)
thrombosis  (ISO)
thyrotoxicosis  (IEP)
tongue squamous cell carcinoma  (IEP)
toxic encephalopathy  (IDA)
toxic shock syndrome  (ISO)
Toxoplasma Chorioretinitis  (ISO)
trachoma  (ISO)
transient cerebral ischemia  (IDA)
Transplant Rejection  (IDA,ISO)
trichinosis  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
uveitis  (ISO)
vasculitis  (ISO)
Venous Thrombosis  (ISO)
Ventilator-Induced Lung Injury  (IDA)
viral pneumonia  (ISO)
visceral leishmaniasis  (ISO)
Waldenstroem's macroglobulinemia  (ISO)
Weight Loss  (ISO)
Wilson disease  (ISO)
Wounds and Injuries  (IEP)
Wounds, Penetrating  (IDA)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-tocopherol  (EXP,ISO)
(+)-catechin  (ISO)
(+)-pilocarpine  (EXP)
(+)-syringaresinol beta-D-glucoside  (ISO)
(+)-Tetrandrine  (ISO)
(-)-citrinin  (ISO)
(-)-epigallocatechin 3-gallate  (EXP)
(4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid  (ISO)
(R)-adrenaline  (ISO)
(R)-carnitine  (EXP)
(R)-lipoic acid  (EXP)
(S)-amphetamine  (ISO)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1,3,5-trinitrobenzene  (ISO)
1,4-benzoquinone  (ISO)
1,4-phenylenediamine  (ISO)
1-chloro-2,4,6-trinitrobenzene  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-galactopyranose  (EXP,ISO)
2-chloroethanol  (ISO)
2-naphthylamine  (ISO)
2-tert-butylhydroquinone  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-dihydroxybenzoic acid  (EXP)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-phenylprop-2-enal  (ISO)
4'-hydroxydiclofenac  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-chloro-m-cresol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-methylhistamine  (ISO)
4-nitroquinoline N-oxide  (ISO)
4-nonylphenol  (ISO)
4-octylphenol  (ISO)
4-tolyl isocyanate  (ISO)
5-(1,4-diazepane-1-sulfonyl)isoquinoline  (EXP)
5-[3-(tert-butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydronaphthalene-2,3-diol  (ISO)
5-aminoimidazole-4-carboxamide  (EXP)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP)
6alpha-methylprednisolone  (ISO)
7,12-dimethyltetraphene  (EXP)
7-ketocholesterol  (ISO)
acetaldehyde  (ISO)
acetic acid  (EXP)
acetylsalicylic acid  (EXP,ISO)
acrolein  (ISO)
actinomycin D  (ISO)
adapalene  (ISO)
adenosine  (ISO)
adenosine 5'-[gamma-thio]triphosphate  (ISO)
aflatoxin B1  (ISO)
aflatoxin B2  (ISO)
Aflatoxin G1  (ISO)
agathisflavone  (EXP)
albendazole  (ISO)
albuterol  (EXP)
all-trans-retinoic acid  (ISO)
all-trans-retinyl palmitate  (ISO)
alloxan  (ISO)
alpha-galactosylceramide  (ISO)
alpha-naphthoflavone  (ISO)
aluminium oxide  (ISO)
amitrole  (EXP)
amlexanox  (ISO)
ammonium chloride  (EXP)
Ammothamnine  (EXP)
amphibole asbestos  (ISO)
amphotericin B  (ISO)
anthocyanin  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apigenin  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
asperentin  (ISO)
atrazine  (ISO)
beclomethasone  (ISO)
benzalkonium chloride  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzocaine  (ISO)
berberine  (EXP,ISO)
Bergenin  (EXP)
beta-D-glucan  (ISO)
biliverdin  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisoprolol  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
bisphenol F  (ISO)
bleomycin A2  (ISO)
boric acid  (EXP)
boron atom  (EXP)
bortezomib  (ISO)
BQ 123  (ISO)
bryostatin 1  (ISO)
bucladesine  (ISO)
butan-1-ol  (ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium selenide  (ISO)
caffeine  (ISO)
calciol  (EXP,ISO)
calcitriol  (EXP,ISO)
capsaicin  (EXP,ISO)
carbachol  (ISO)
carbamate ester  (ISO)
carbon monoxide  (EXP,ISO)
carbon nanotube  (ISO)
carnosine  (ISO)
carrageenan  (EXP,ISO)
carvedilol  (EXP,ISO)
catechol  (ISO)
cefotaxime  (ISO)
ceftazidime pentahydrate  (ISO)
cefuroxime  (ISO)
celastrol  (ISO)
celecoxib  (EXP,ISO)
cerium trichloride  (ISO)
ceruletide  (EXP)
CGS-21680  (ISO)
chenodeoxycholic acid  (ISO)
chitosan  (ISO)
chloroethene  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium atom  (EXP)
chrysin  (EXP,ISO)
ciprofloxacin  (EXP,ISO)
cis-caffeic acid  (ISO)
cisplatin  (EXP,ISO)
citronellol  (EXP)
clenbuterol  (EXP,ISO)
clodronic acid  (ISO)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
clozapine  (EXP)
cobalt dichloride  (ISO)
cocaine  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (EXP)
cortisol  (ISO)
costunolide  (ISO)
coumarins  (ISO)
crocidolite asbestos  (ISO)
crocin-1  (EXP)
crotonaldehyde  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (EXP,ISO)
Cyclopamine  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
D-penicillamine  (EXP)
danazol  (EXP)
dantrolene  (EXP,ISO)
DAPT  (EXP)
decabromodiphenyl ether  (ISO)
Deguelin  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (EXP)
dexamethasone  (ISO)
dextran  (ISO)
dextran sulfate  (EXP,ISO)
dextromethorphan  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
diazoxide  (ISO)
dichloroacetic acid  (ISO)
dichloromethane  (ISO)
diclofenac  (EXP,ISO)
dicyclohexylmethane-4,4'-diisocyanate  (ISO)
dieldrin  (EXP)
diethyl maleate  (ISO)
diisopropyl fluorophosphate  (ISO)
Dimaprit  (ISO)
dimethoate  (ISO)
dioxygen  (EXP,ISO)
diphenylmethane-4,4'-diisocyanate  (ISO)
diprotium oxide  (EXP)
disodium selenite  (EXP)
dobutamine  (ISO)
donepezil hydrochloride  (ISO)
dopamine  (EXP)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
dydrogesterone  (ISO)
edaravone  (EXP)
elemental boron  (EXP)
elemental selenium  (EXP,ISO)
emodin  (ISO)
estriol  (ISO)
ethambutol  (EXP)
ethanol  (EXP,ISO)
ethionamide  (EXP)
eugenol  (ISO)
excitatory amino acid agonist  (EXP)
famotidine  (ISO)
fasudil hydrochloride  (EXP)
flavonoids  (ISO)
flurbiprofen  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fonofos  (ISO)
formaldehyde  (EXP,ISO)
formoterol fumarate  (EXP)
fragrance  (ISO)
fructose  (EXP)
fucoidan  (EXP)
fulvestrant  (ISO)
furan  (EXP)
furosemide  (ISO)
gadolinium trichloride  (EXP)
gemcitabine  (ISO)
gemfibrozil  (EXP)
Geniposide  (ISO)
genistein  (ISO)
gentamycin  (EXP,ISO)
geraniol  (ISO)
gliclazide  (EXP)
glucuronoxylomannan  (ISO)
glutathione  (ISO)
glycocholic acid  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
graphite  (ISO)
helenalin  (ISO)
heroin  (ISO)
hexachlorobenzene  (EXP,ISO)
hexadecanoic acid  (ISO)
hexamethylene diisocyanate  (ISO)
histamine  (ISO)
HU-308  (EXP,ISO)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxychloroquine  (ISO)
hydroxylamine  (EXP)
hypochlorous acid  (ISO)
ibrutinib  (ISO)
ibuprofen  (ISO)
IC-87114  (ISO)
idelalisib  (ISO)
imipramine  (ISO)
imiquimod  (ISO)
indirubin-3'-monoxime  (ISO)
indole-3-methanol  (EXP,ISO)
indometacin  (EXP,ISO)
ionomycin  (EXP,ISO)
irinotecan  (EXP,ISO)
isatin  (EXP)
isoliquiritigenin  (ISO)
isoniazide  (ISO)
isophorone diisocyanate  (ISO)
isoprenaline  (EXP,ISO)
isotretinoin  (EXP)
ivermectin  (ISO)
kainic acid  (EXP)
ketoprofen  (ISO)
L-ascorbic acid  (EXP,ISO)
L-methionine  (ISO)
lansoprazole  (EXP)
lead diacetate  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lead(II) chloride  (ISO)
leflunomide  (ISO)
letrozole  (EXP)
leukotriene B4  (ISO)
linagliptin  (EXP)
linoleic acid  (ISO)
linuron  (ISO)
lipoic acid  (EXP)
lipophosphoglycan  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (EXP,ISO)
lipoxin A4  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
lithocholic acid  (ISO)
losartan  (EXP)
lupeol  (ISO)
luteolin  (ISO)
lycopene  (ISO)
mangiferin  (EXP)
mechlorethamine  (EXP)
melatonin  (ISO)
mercury atom  (ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (ISO)
mesalamine  (EXP)
metam  (ISO)
metformin  (EXP)
methadone  (EXP)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methotrexate  (EXP,ISO)
methyl 3,4,5-trihydroxybenzoate  (ISO)
methyl isocyanate  (ISO)
methyl isothiocyanate  (ISO)
methyl methanesulfonate  (ISO)
Methyl palmitate  (ISO)
methylisothiazolinone  (ISO)
metyrapone  (EXP)
microcystin-LR  (ISO)
mifepristone  (ISO)
minocycline  (EXP,ISO)
misoprostol  (ISO)
mitogen  (EXP,ISO)
mometasone furoate  (ISO)
monocrotaline  (EXP,ISO)
Monocyte locomotion inhibitory factor  (ISO)
monosodium L-glutamate  (ISO)
mycophenolic acid  (EXP)
mycotoxin  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-diethyl-m-toluamide  (EXP,ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP,ISO)
nadolol  (ISO)
naproxen  (EXP)
naringin  (EXP,ISO)
neostigmine  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
nimesulide  (ISO)
nitric oxide  (ISO)
nitrogen dioxide  (ISO)
Nonylphenol  (ISO)
notoginsenoside R1  (ISO)
NS-398  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP)
olanzapine  (ISO)
Olmesartan medoxomil  (EXP)
omeprazole  (ISO)
oridonin  (EXP)
orlistat  (EXP)
oroxylin A  (EXP)
oxidopamine  (ISO)
ozone  (EXP,ISO)
paclitaxel  (EXP,ISO)
paeoniflorin  (EXP,ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
paroxetine  (ISO)
patchouli alcohol  (EXP)
patulin  (ISO)
pentachlorophenol  (ISO)
pentamidine  (ISO)
Pentoxifylline  (ISO)
peptidoglycan  (ISO)
perfluorodecanoic acid  (ISO)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perindopril  (ISO)
permethrin  (EXP)
phenanthrene  (EXP)
phenanthridone  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP)
phloretin  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosgene  (EXP)
phosphatidylcholine  (ISO)
phthalaldehyde  (ISO)
phthalic anhydride  (ISO)
pioglitazone  (EXP,ISO)
pirinixic acid  (EXP,ISO)
platycodin D  (ISO)
poly(I:C)  (EXP,ISO)
polymyxin B2  (ISO)
polyphosphates  (ISO)
pomalidomide  (ISO)
potassium chloride  (EXP)
prednisolone  (ISO)
procyanidin B2  (EXP)
procyanidin B3  (ISO)
progesterone  (ISO)
propionic acid  (EXP,ISO)
propofol  (ISO)
propranolol  (EXP)
prostaglandin E2  (ISO)
prostaglandin F2alpha  (ISO)
prostaglandin I2  (EXP)
protein kinase inhibitor  (ISO)
pyocyanine  (ISO)
Pyridostigmine bromide  (EXP,ISO)
pyrrolidine dithiocarbamate  (EXP)
quercetin  (EXP,ISO)
ranitidine  (EXP,ISO)
reserpine  (ISO)
resiniferatoxin  (EXP)
resiquimod  (ISO)
resveratrol  (EXP,ISO)
Rhein  (ISO)
ribavirin  (EXP,ISO)
rifampicin  (EXP)
rifaximin  (ISO)
rimonabant  (ISO)
Ro 41-5253  (ISO)
rolipram  (ISO)
rotenone  (EXP,ISO)
rutin  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
S-nitrosoglutathione  (ISO)
SB 203580  (ISO)
SCH 23390  (ISO)
scopolamine  (ISO)
scopoletin  (EXP)
selenium atom  (EXP,ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium aurothiomalate  (ISO)
sodium dichromate  (ISO)
Sodium salicylate  (ISO)
sodium stibogluconate  (ISO)
spironolactone  (ISO)
SR 144528  (ISO)
sterigmatocystin  (ISO)
stigmasterol  (ISO)
streptozocin  (EXP,ISO)
sulfasalazine  (EXP,ISO)
sulfur dioxide  (EXP)
sumatriptan  (EXP)
sunitinib  (EXP)
suramin  (ISO)
synephrine  (ISO)
T-2 toxin  (ISO)
tacrine  (ISO)
tamibarotene  (EXP)
tangeretin  (EXP)
taurine  (ISO)
tauro-beta-muricholic acid  (ISO)
taurochenodeoxycholic acid  (ISO)
taurocholic acid  (ISO)
taurodeoxycholic acid  (ISO)
tauroursodeoxycholic acid  (ISO)
telmisartan  (EXP)
terbufos  (ISO)
terbutaline  (ISO)
Terfenadine  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
theophylline  (ISO)
thioacetamide  (EXP,ISO)
thymoquinone  (EXP)
titanium dioxide  (ISO)
tofacitinib  (ISO)
toluene 2,4-diisocyanate  (ISO)
trans-caffeic acid  (ISO)
trans-rhaponticin  (EXP)
tributylstannane  (ISO)
trichloroacetic acid  (ISO)
trichloroethene  (EXP)
triclocarban  (ISO)
trimellitic anhydride  (ISO)
trimethyltin  (ISO)
triptonide  (ISO)
uranium atom  (EXP,ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP,ISO)
valproic acid  (EXP,ISO)
vanadium atom  (EXP)
vanadium(0)  (EXP)
vancomycin  (ISO)
vinclozolin  (EXP)
vinorelbine  (ISO)
vitamin E  (EXP,ISO)
water  (EXP)
WIN 55212-2  (EXP,ISO)
zearalenone  (ISO)
zidovudine  (ISO)
zinc acetate  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc oxide  (ISO)
zinc protoporphyrin  (EXP)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (IEP)
branching involved in labyrinthine layer morphogenesis  (ISO)
cellular response to estradiol stimulus  (IEP)
cellular response to hepatocyte growth factor stimulus  (ISO)
cellular response to lipopolysaccharide  (ISO)
defense response to bacterium  (ISO)
defense response to protozoan  (ISO)
immune response  (IMP)
liver regeneration  (IEP)
negative regulation of apoptotic process  (IMP)
negative regulation of autophagy  (ISO)
negative regulation of B cell proliferation  (ISO,ISS)
negative regulation of cell population proliferation  (ISO)
negative regulation of chronic inflammatory response to antigenic stimulus  (ISO)
negative regulation of cytokine activity  (ISO)
negative regulation of cytokine production  (IMP,ISO)
negative regulation of cytokine production involved in immune response  (ISO,ISS)
negative regulation of endothelial cell apoptotic process  (ISO)
negative regulation of heterotypic cell-cell adhesion  (ISO)
negative regulation of hydrogen peroxide-induced neuron death  (ISO)
negative regulation of inflammatory response  (IDA,ISO,ISS)
negative regulation of interferon-gamma production  (ISO)
negative regulation of interleukin-12 production  (ISO)
negative regulation of interleukin-6 production  (ISO,ISS)
negative regulation of membrane protein ectodomain proteolysis  (ISO,ISS)
negative regulation of MHC class II biosynthetic process  (ISO)
negative regulation of myeloid dendritic cell activation  (ISO)
negative regulation of neuron apoptotic process  (IDA)
negative regulation of nitric oxide biosynthetic process  (IDA)
negative regulation of sensory perception of pain  (IDA)
negative regulation of tumor necrosis factor production  (IDA,ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
positive regulation of B cell apoptotic process  (ISO,ISS)
positive regulation of cell cycle  (ISO)
positive regulation of cytokine production  (ISO,ISS)
positive regulation of DNA-binding transcription factor activity  (ISO,ISS)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of immunoglobulin production  (ISO)
positive regulation of macrophage activation  (IDA)
positive regulation of MHC class II biosynthetic process  (ISO)
positive regulation of plasma cell differentiation  (ISO)
positive regulation of pri-miRNA transcription by RNA polymerase II  (ISO)
positive regulation of receptor signaling pathway via JAK-STAT  (ISO)
positive regulation of signaling receptor activity  (ISO)
positive regulation of sprouting angiogenesis  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO,ISS)
regulation of complement-dependent cytotoxicity  (ISO)
regulation of gene expression  (ISO)
regulation of response to wounding  (ISO)
regulation of sensory perception of pain  (IDA)
regulation of synapse organization  (IDA)
response to activity  (IEP)
response to carbon monoxide  (IEP)
response to drug  (IEP)
response to glucocorticoid  (IEP,ISO,ISS)
response to inactivity  (IEP)
response to insulin  (IEP)
response to lipopolysaccharide  (IEP)
response to molecule of bacterial origin  (ISO,ISS)
response to organic substance  (IEP)
signal transduction  (IEA)

Cellular Component
extracellular space  (IDA,ISO,ISS)

Molecular Function

References

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