Igfbp4 (insulin-like growth factor binding protein 4)

	Submit Data \| Help \| Video Tutorials \| News \| Publications \| Download \| REST API \| Citing RGD \| Contact
	Search RGD Grant Resources Citing RGD About Us Contact Us Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease Find Models new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive Pathways Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
	Advanced Search (OLGA)

Gene: Igfbp4 (insulin-like growth factor binding protein 4) Rattus norvegicus

Analyze

Symbol:

Igfbp4

Name:

insulin-like growth factor binding protein 4

RGD ID:

2875

Description:

Predicted to enable insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Involved in response to organic cyclic compound. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human IGFBP4 (insulin like growth factor binding protein 4); PARTICIPATES IN insulin-like growth factor signaling pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

IBP-4; IBP4; IGF-binding protein 4; IGF-BP4; IGFBP-4; insulin-like growth factor-binding protein 4

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Is Marker For:

Strains: SS.LEW-(D10Rat24-Igfbp4)/Ayd SS.LEW-(D10Rat27-Igfbp4)/Ayd SS.LEW-(D10Got112-Igfbp4)/Ayd
QTLs: Rends3 Kidm38 Bp346 Am11 Am10

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	83,995,253 - 84,007,272 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	83,989,591 - 84,007,225 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	88,939,170 - 88,951,179 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	10	88,437,283 - 88,449,292 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	10	83,829,446 - 83,841,461 (+)	NCBI	Rnor_WKY
Rnor_6.0	10	86,950,555 - 86,962,563 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	86,950,557 - 86,962,578 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	86,747,476 - 86,759,484 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	87,822,429 - 87,834,315 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	87,836,798 - 87,848,684 (+)	NCBI
Celera	10	82,736,335 - 82,748,330 (+)	NCBI		Celera
RH 3.4 Map	10	860.1	RGD
Cytogenetic Map	10	q31	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-trinitrobenzenesulfonic acid (ISO)

2-amino-2-deoxy-D-glucopyranose (ISO)

2-butoxyethanol (ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3,3',4,4'-tetrachlorobiphenyl (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-chloropropane-1,2-diol (EXP)

3-Nitrobenzanthrone (ISO)

4,4'-sulfonyldiphenol (ISO)

5-azacytidine (ISO)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrylamide (ISO)

afimoxifene (ISO)

aflatoxin B1 (ISO)

aldehydo-D-glucosamine (ISO)

aldehydo-D-glucose (ISO)

all-trans-retinoic acid (ISO)

alpha-naphthoflavone (EXP)

aluminium sulfate (anhydrous) (ISO)

aluminium trifluoride (ISO)

ammonium chloride (EXP)

arsenite(3-) (ISO)

arsenous acid (ISO)

atrazine (ISO)

azoxystrobin (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

beta-D-glucosamine (ISO)

bicalutamide (EXP)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

bucladesine (ISO)

butyric acid (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

calciol (ISO)

cannabidiol (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

ciguatoxin CTX1B (ISO)

cisplatin (ISO)

clofibrate (ISO)

cobalt dichloride (EXP,ISO)

copper(II) sulfate (ISO)

coumestrol (ISO)

cumene (ISO)

curcumin (ISO)

cycloheximide (ISO)

cyclophosphamide (ISO)

cyclosporin A (ISO)

D-glucose (ISO)

daidzein (ISO)

decabromodiphenyl ether (ISO)

dexamethasone (ISO)

dextran sulfate (ISO)

diarsenic trioxide (ISO)

dibenzo[a,l]pyrene (ISO)

diethylstilbestrol (EXP)

dioxygen (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

ellagic acid (ISO)

endosulfan (EXP)

Enterolactone (ISO)

ethanol (ISO)

flutamide (EXP)

formaldehyde (ISO)

fulvestrant (ISO)

genistein (ISO)

glucose (ISO)

hydrogen peroxide (ISO)

inulin (ISO)

isotretinoin (ISO)

leflunomide (ISO)

lipopolysaccharide (ISO)

medroxyprogesterone acetate (ISO)

methidathion (ISO)

methotrexate (ISO)

N(6)-methyladenosine (ISO)

N-acetyl-L-cysteine (ISO)

N-nitrosodiethylamine (ISO)

nefazodone (EXP)

nickel dichloride (ISO)

nickel sulfate (ISO)

nitrofen (EXP)

ochratoxin A (EXP)

oxaliplatin (EXP)

p-menthan-3-ol (ISO)

paclitaxel (ISO)

paracetamol (EXP)

parathion (ISO)

pentane-2,3-dione (EXP)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

phenylephrine (EXP)

phytoestrogen (ISO)

picoxystrobin (ISO)

pirinixic acid (ISO)

potassium chloride (EXP)

potassium chromate (ISO)

progesterone (ISO)

pyrimidifen (ISO)

quercetin (ISO)

raloxifene (ISO)

resveratrol (ISO)

rifampicin (ISO)

rotenone (EXP)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

Salinomycin (ISO)

selenium atom (ISO)

senecionine (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP,ISO)

succimer (ISO)

sulforaphane (ISO)

T-2 toxin (EXP)

tamoxifen (ISO)

tert-butyl hydroperoxide (ISO)

tetrachloromethane (EXP,ISO)

thapsigargin (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

topotecan (EXP)

Triptolide (ISO)

triptonide (ISO)

tris(2-butoxyethyl) phosphate (ISO)

troglitazone (ISO)

tungsten (ISO)

valproic acid (ISO)

vanadium atom (ISO)

vanadium(0) (ISO)

vitamin E (ISO)

zinc atom (EXP)

zinc(0) (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

intracellular signal transduction (TAS)

MAPK cascade (ISO)

positive regulation of insulin-like growth factor receptor signaling pathway (ISO)

positive regulation of MAPK cascade (ISO)

regulation of cell growth (ISO)

regulation of glucose metabolic process (ISO)

regulation of growth (ISO)

regulation of insulin-like growth factor receptor signaling pathway (IBA)

response to organic cyclic compound (IEP)

type B pancreatic cell proliferation (ISO)

Cellular Component

extracellular region (IEA)

extracellular space (IBA,ISO)

Molecular Function

insulin-like growth factor binding (IEA,ISO,TAS)

insulin-like growth factor I binding (IBA)

insulin-like growth factor II binding (IBA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

insulin-like growth factor signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Regulation of granulosa cell-derived insulin-like growth factor binding proteins (IGFBPs): role for protein kinase-C in the pre- and posttranslational modulation of IGFBP-4 and IGFBP-5.	Chamoun D, etal., Biol Reprod 2002 Sep;67(3):1003-12.
2.	Roles of insulin-like growth factor (IGF) binding proteins in regulating IGF actions.	Duan C and Xu Q, Gen Comp Endocrinol. 2005 May 15;142(1-2):44-52. Epub 2005 Feb 5.
3.	Interleukin-6 stimulates hepatic insulin-like growth factor binding protein-4 messenger ribonucleic acid and protein.	Fernandez-Celemin L and Thissen JP, Endocrinology 2001 Jan;142(1):241-8.
4.	Structure of the rat insulin-like growth factor binding protein-4 gene.	Gao L, etal., Biochem Biophys Res Commun 1993 Feb 15;190(3):1053-9.
5.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
7.	High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence.	Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
8.	Expression of insulin-like growth factor binding proteins in the rat kidney: effects of long-term diabetes.	Landau D, etal., Endocrinology. 1995 May;136(5):1835-42. doi: 10.1210/endo.136.5.7536658.
9.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
10.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
11.	GOA pipeline	RGD automated data pipeline
12.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:7510770	PMID:7679139	PMID:11068878	PMID:12162998	PMID:12477932	PMID:14983400	PMID:15204833	PMID:16339387	PMID:16675541	PMID:20938897	PMID:21846294	PMID:23639626
PMID:24006456	PMID:24175938	PMID:28595186	PMID:34906040	PMID:36868516

Genomics

Comparative Map Data

Igfbp4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	83,995,253 - 84,007,272 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	83,989,591 - 84,007,225 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	88,939,170 - 88,951,179 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	10	88,437,283 - 88,449,292 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	10	83,829,446 - 83,841,461 (+)	NCBI	Rnor_WKY
Rnor_6.0	10	86,950,555 - 86,962,563 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	86,950,557 - 86,962,578 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	86,747,476 - 86,759,484 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	87,822,429 - 87,834,315 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	87,836,798 - 87,848,684 (+)	NCBI
Celera	10	82,736,335 - 82,748,330 (+)	NCBI		Celera
RH 3.4 Map	10	860.1	RGD
Cytogenetic Map	10	q31	NCBI

IGFBP4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	40,443,450 - 40,457,725 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	17	40,443,450 - 40,457,725 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	38,599,702 - 38,613,977 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	35,853,202 - 35,867,508 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	35,853,248 - 35,867,457	NCBI
Celera	17	35,259,825 - 35,274,137 (+)	NCBI		Celera
Cytogenetic Map	17	q21.2	NCBI
HuRef	17	34,392,540 - 34,406,855 (+)	NCBI		HuRef
CHM1_1	17	38,834,974 - 38,849,254 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	17	41,306,951 - 41,321,232 (+)	NCBI		T2T-CHM13v2.0

Igfbp4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	98,930,820 - 98,943,481 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	98,932,070 - 98,945,218 (+)	Ensembl		GRCm39 Ensembl
GRCm38	11	99,040,005 - 99,052,655 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	99,041,244 - 99,054,392 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	98,902,574 - 98,913,960 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	98,857,350 - 98,868,736 (+)	NCBI		MGSCv36	mm8
Celera	11	108,707,143 - 108,718,579 (+)	NCBI		Celera
Cytogenetic Map	11	D	NCBI

Igfbp4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955451	15,027,184 - 15,029,830 (+)	NCBI	ChiLan1.0	ChiLan1.0

IGFBP4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	17	26,391,701 - 26,405,947 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	16,830,994 - 16,845,339 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	17,055,544 - 17,060,712 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

IGFBP4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	22,168,241 - 22,182,272 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	22,126,470 - 22,182,518 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	21,642,296 - 21,654,538 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	22,962,295 - 22,974,991 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	22,962,298 - 22,975,086 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	21,736,648 - 21,748,885 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	21,995,532 - 22,007,775 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	22,120,045 - 22,132,291 (-)	NCBI		UU_Cfam_GSD_1.0

Igfbp4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	21,580,785 - 21,592,658 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936490	15,482,431 - 15,494,436 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936490	15,482,483 - 15,494,402 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

IGFBP4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	21,965,502 - 21,980,945 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	21,966,524 - 21,980,043 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	22,276,126 - 22,289,602 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

IGFBP4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	65,722,216 - 65,737,380 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	65,723,361 - 65,737,072 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666077	36,607,867 - 36,623,001 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Igfbp4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624795	2,844,526 - 2,851,942 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624795	2,843,759 - 2,851,796 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Igfbp4
56 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	155
Count of miRNA genes:	98
Interacting mature miRNAs:	125
Transcripts:	ENSRNOT00000014153
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61427	Cia16	Collagen induced arthritis QTL 16	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	6357896	96121100	Rat
2303118	Mamtr7	Mammary tumor resistance QTL 7		0.003	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	9658275	104670812	Rat
2301967	Cm73	Cardiac mass QTL 73	4.55		heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	14487011	89062041	Rat
631268	Cia21	Collagen induced arthritis QTL 21	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	14487011	104060283	Rat
2316949	Gluco60	Glucose level QTL 60	3.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	14487011	107057807	Rat
1554317	Bmd4	Bone mineral density QTL 4	9.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	19816042	99406971	Rat
724556	Pur2	Proteinuria QTL 2	5.5		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	10	22427500	90627625	Rat
61354	Pia10	Pristane induced arthritis QTL 10		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
631267	Cia20	Collagen induced arthritis QTL 20	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
61325	Aia5	Adjuvant induced arthritis QTL 5		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
1298069	Bp168	Blood pressure QTL 168	5.5		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	10	26521957	98003205	Rat
631542	Bp82	Blood pressure QTL 82	6.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	26521957	98952741	Rat
1331791	Cm31	Cardiac mass QTL 31	3.84606		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	10	29299504	107211142	Rat
1576308	Schws1	Schwannoma susceptibility QTL 1		0.0041	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	10	40035094	102359817	Rat
631269	Cia22	Collagen induced arthritis QTL 22	8.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40035094	104060283	Rat
631270	Cia23	Collagen induced arthritis QTL 23	3.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40035094	104060283	Rat
631552	Vetf2	Vascular elastic tissue fragility QTL 2	4.5	0.0002	aorta elastic tissue integrity trait (VT:0010556)	artery internal elastic lamina non-tumorous lesion count (CMO:0001913)	10	41142633	86142633	Rat
61463	Bp12	Blood pressure QTL 12	6.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	41333258	86333258	Rat
1298078	Stresp5	Stress response QTL 5	2.99	0.00025	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	42045676	104670812	Rat
70188	BpQTLcluster1	Blood pressure QTL cluster 1	4.864		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	42323132	87323132	Rat
70188	BpQTLcluster1	Blood pressure QTL cluster 1	4.864		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	42323132	87323132	Rat
70188	BpQTLcluster1	Blood pressure QTL cluster 1	4.864		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	42323132	87323132	Rat
70188	BpQTLcluster1	Blood pressure QTL cluster 1	4.864		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	42323132	87323132	Rat
70198	BpQTLcluster9	Blood pressure QTL cluster 9	2.94		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	42323132	87323132	Rat
9589030	Epfw9	Epididymal fat weight QTL 9	19.24	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	10	44441699	89441699	Rat
7411614	Foco18	Food consumption QTL 18		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	10	44441699	89441699	Rat
8694173	Bw149	Body weight QTL 149	4.38	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	10	44441699	89441699	Rat
2300218	Hpcl2	Hepatic cholesterol level QTL 2			liver cholesterol amount (VT:0010498)	liver cholesterol level (CMO:0001597)	10	45029650	95600334	Rat
631547	Bp87	Blood pressure QTL 87	4.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	47369470	92369470	Rat
1549846	Scl47	Serum cholesterol level QTL 47	3.6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	10	50574707	95574707	Rat
70364	Bp72	Blood pressure QTL 72			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	51121100	96121100	Rat
61387	Bp1	Blood pressure QTL 1	5.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	51770177	107211142	Rat
61387	Bp1	Blood pressure QTL 1	5.1		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	10	51770177	107211142	Rat
1359017	Hrtrt21	Heart rate QTL 21	2.4		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	10	51772940	96772940	Rat
631530	Tls3	T-lymphoma susceptibility QTL 3	0	0.0001	thymus integrity trait (VT:0010555)	percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)	10	51774612	95600334	Rat
631535	Cm51	Cardiac mass QTL 51	3		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	10	51786282	91669536	Rat
70171	Cari1	Carrageenan-induced inflammation QTL 1	4.9	0.0005	hypodermis integrity trait (VT:0010550)	inflammatory exudate volume (CMO:0001429)	10	53797385	107211142	Rat
70164	Bw21	Body weight QTL 21	4.36	0.00005	body mass (VT:0001259)	body weight (CMO:0000012)	10	53797494	98952626	Rat
1354608	Cm33	Cardiac mass QTL 33	2.8		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	10	54809292	99809292	Rat
2312662	Slep8	Serum leptin concentration QTL 8		0.05	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	10	57134272	102134272	Rat
2312668	Scl65	Serum cholesterol level QTL 65		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	10	57134272	102134272	Rat
2312672	Insul15	Insulin level QTL 15		0.01	blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	10	57134272	102134272	Rat
1549831	Bss6	Bone structure and strength QTL 6	4		lumbar vertebra strength trait (VT:0010574)	vertebra ultimate force (CMO:0001678)	10	57576521	102576521	Rat
2293698	Bss43	Bone structure and strength QTL 43	5.33	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra cross-sectional area (CMO:0001689)	10	59209888	104209888	Rat
2306970	Anxrr22	Anxiety related response QTL 22	5.95		fear/anxiety-related behavior trait (VT:1000241)	number of periods of voluntary immobility (CMO:0001045)	10	61345276	98211570	Rat
6893336	Cm75	Cardiac mass QTL 75	0.1	0.87	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	10	61345276	99703528	Rat
1558643	Cm44	Cardiac mass QTL 44	4.8	0.0000368	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	10	61345276	99703528	Rat
2313103	Bss80	Bone structure and strength QTL 80	2	0.0001	tibia strength trait (VT:1000284)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	10	62057807	107057807	Rat
2313105	Bss79	Bone structure and strength QTL 79	1.8	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	62057807	107057807	Rat
61449	Ciaa2	CIA Autoantibody QTL 2	7.1		blood autoantibody amount (VT:0003725)	calculated serum anti-type 2 collagen antibody titer (CMO:0001279)	10	63221094	107211142	Rat
1357344	Bp249	Blood pressure QTL 249		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	66743655	98003205	Rat
2317029	Aia19	Adjuvant induced arthritis QTL 19	2.98		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	10	66978955	107211142	Rat
2317039	Aia6	Adjuvant induced arthritis QTL 6	4.31		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	10	66978955	107211142	Rat
10450498	Bp384	Blood pressure QTL 384		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	67750049	107211142	Rat
1642980	Bp300	Blood pressure QTL 300			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	68383129	107211142	Rat
61396	Bp9	Blood pressure QTL 9	4.8	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	68420376	107211142	Rat
2300172	Bmd57	Bone mineral density QTL 57	9.8	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	10	69738412	107211142	Rat
2293646	Bss25	Bone structure and strength QTL 25	10.96	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	10	69738412	107211142	Rat
2293663	Bss33	Bone structure and strength QTL 33	9.34	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	10	69738412	107211142	Rat
6893366	Bw106	Body weight QTL 106	0.3	0.47	body mass (VT:0001259)	body weight (CMO:0000012)	10	70199100	107211142	Rat
70193	Mcs7	Mammary carcinoma susceptibility QTL 7	2.38		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	10	72224939	107211142	Rat
2298548	Neuinf7	Neuroinflammation QTL 7	3.4		nervous system integrity trait (VT:0010566)	spinal cord RT1-B protein level (CMO:0002132)	10	72224939	107211142	Rat
2306793	Ean5	Experimental allergic neuritis QTL 5	4.7		nervous system integrity trait (VT:0010566)	IFNG-secreting splenocyte count (CMO:0002122)	10	72552416	93995749	Rat
1358188	Ept9	Estrogen-induced pituitary tumorigenesis QTL 9	3.9		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	10	73453136	96120911	Rat
2292617	Ept18	Estrogen-induced pituitary tumorigenesis QTL 18	3.9		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	10	73453136	96120911	Rat
12880050	Am10	Aortic mass QTL 10		0.016	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	10	74372084	84007272	Rat
1579919	Bp281	Blood pressure QTL 281		0.01	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	74372084	94965338	Rat
631537	Oia4	Oil induced arthritis QTL 4			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	75631887	87055282	Rat
2325836	Bp346	Blood pressure QTL 346		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	76246085	84007272	Rat
10450495	Bp383	Blood pressure QTL 383		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	76246085	94965338	Rat
2292438	Bp311	Blood pressure QTL 311			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	76246085	107211142	Rat
1302404	Cia27	Collagen induced arthritis QTL 27	2.6	0.0045	joint integrity trait (VT:0010548)	experimental arthritis severity measurement (CMO:0001459)	10	76452683	107211142	Rat
4889492	Pancm2	Pancreatic morphology QTL 2	3.2		pancreatic beta cell morphology trait (VT:0005217)	ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)	10	76748906	107211142	Rat
724516	Uae17	Urinary albumin excretion QTL 17	3.6		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	10	78210622	85220348	Rat
1300107	Rf18	Renal function QTL 18	3.41		urine output (VT:0003620)	timed urine volume (CMO:0000260)	10	78775516	98279596	Rat
1358915	Stresp7	Stress response QTL 7	3.52		blood norepinephrine amount (VT:0005663)	plasma norepinephrine level (CMO:0001010)	10	78899655	87307728	Rat
634354	Rends3	Renal damage susceptibility QTL 3		0.05	kidney blood vessel morphology trait (VT:0000530)	organ lesion measurement (CMO:0000677)	10	79813789	85160854	Rat
631555	Bp134	Blood pressure QTL 134		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	80515287	91230079	Rat
6893357	Bw102	Body weight QTL 102	0.5	0.36	body mass (VT:0001259)	body weight (CMO:0000012)	10	80515287	101325465	Rat
2303589	Bw87	Body weight QTL 87	2		body mass (VT:0001259)	body weight (CMO:0000012)	10	81285008	107211142	Rat
4889948	Bss91	Bone structure and strength QTL 91	4		tibia area (VT:1000281)	tibia midshaft total cross-sectional area (CMO:0001715)	10	82564856	92369470	Rat
2317754	Glom25	Glomerulus QTL 25	3.5		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	10	82685200	107211142	Rat
12880055	Am11	Aortic mass QTL 11		0.004	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	10	84007272	95933025	Rat
2301398	Kidm38	Kidney mass QTL 38		0.002	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	10	84007272	95933025	Rat

Markers in Region

RH140035

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	83,993,619 - 83,994,075 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	86,948,923 - 86,949,378	NCBI	Rnor6.0
Rnor_5.0	10	86,745,844 - 86,746,299	UniSTS	Rnor5.0
RGSC_v3.4	10	87,820,797 - 87,821,252	UniSTS	RGSC3.4
Celera	10	82,734,703 - 82,735,158	UniSTS
RH 3.4 Map	10	860.1	UniSTS
Cytogenetic Map	10	q31	UniSTS

Related Rat Strains

The following Strains have been annotated to Igfbp4

SS.LEW-(D10Got112-Igfbp4)/Ayd

SS.LEW-(D10Rat24-Igfbp4)/Ayd

SS.LEW-(D10Rat27-Igfbp4)/Ayd

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High			7	7		7
Medium	3	40	47	34	16	34	5	8	65	35	35	11	5
Low		3	3		3		3	3	9		6		3
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001004274	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY686592	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC098750	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000220	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	L08276	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000014153 ⟹ ENSRNOP00000014153

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	83,989,591 - 84,007,225 (+)	Ensembl
Rnor_6.0 Ensembl	10	86,950,557 - 86,962,578 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000106145 ⟹ ENSRNOP00000093833

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	84,001,567 - 84,007,225 (+)	Ensembl

RefSeq Acc Id:

NM_001004274 ⟹ NP_001004274

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	83,995,253 - 84,007,272 (+)	NCBI
Rnor_6.0	10	86,950,555 - 86,962,563 (+)	NCBI
Rnor_5.0	10	86,747,476 - 86,759,484 (+)	NCBI
RGSC_v3.4	10	87,822,429 - 87,834,315 (+)	RGD
Celera	10	82,736,335 - 82,748,330 (+)	RGD

Sequence:

show sequence

CCCTGCCCCCGCCGCCTGCTGGGCCGGCCGAGGATGCAGCGCAGCGCCTCGGTGTCCAGGCTCG
CTCTGCTCCAGCGTGCTTGCTAACTTCCCTTGGCTCCGTCCCAGCCTGCCGGGGCCGCACCGTG
TCCTCTCGCTCTCCGGGTCTGGTTCTCTAAGCTCTCTGGGAGCTGCCTCCGGGTTCCTTGCAGC
CCGCTCGCGAGCCCGCGCTCCCCTTCTGCGCCCCACCCTCGTTCTCACCATGCTGCCCTTCGGC
CTCGTGGCCGCCCTGCTGCTGGCCGCAGGGCCTCGGCCGAGCCTGGGCGACGAAGCCATCCACT
GCCCTCCTTGCTCCGAGGAGAAGCTGGCGCGCTGCCGCCCCCCCGTGGGTTGTGAGGAGCTGGT
GCGGGAGCCTGGCTGCGGTTGTTGTGCCACTTGCGCCCTGGGCTTGGGGATGCCTTGCGGGGTG
TACACCCCACGCTGTGGCTCAGGCATGCGCTGCTACCCGCCCCGGGGGGTGGAGAAGCCCCTGC
GCACATTGATGCACGGGCAAGGTGTATGCACGGAGCTGTCGGAAATCGAAGCCATCCAGGAAAG
CCTGCAGACCTCTGACAAGGATGAGAGTGAGCATCCCAACAACAGCTTCAACCCCTGCAGCGCC
CACGATCACAGGTGCCTGCAGAAGCATATGGCCAAAGTGAGAGATCGGAGCAAGATGAAGGTTG
TGGGGACACCTCGGGAGGAACCCCGTCCTGTGCCCCAGGGTTCTTGCCAGAGCGAGCTGCACCG
GGCCCTGGAACGACTGGCCGCCTCGCAGAGCCGTACCCACGAAGACCTCTTCATCATCCCCATC
CCCAACTGTGACCGCAACGGCAACTTCCACCCCAAACAGTGTCATCCTGCTCTGGATGGACAGC
GTGGCAAATGCTGGTGTGTGGATCGGAAGACAGGGGTGAAGCTTCCAGGGGGCTTGGAACCCAA
GGGGGAGCTGGACTGCCACCAACTGGCTGACAGCCTCCAAGAGTGAGACCTGCCAGCAGGTGGG
GGGACTCAGTGCCCCCTACTAGGTCCCTATGCTCTGGGGACTGTAGAGTTGACCTGGCATGGAG
TCTTGGCCTGAGTCCTGGCTCTCTGCCTCTGGCCCTGCCCAAAGTTTCCCTTGGTGTGTGTGTG
TCTGTCTCTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTTATGGG
ATGTGCCCCACGGGGTAAACCTGAGCCTTGGCGTGCCCACAGTGGGCTTAGATAGCCCAAGAGG
TCTGAGTGTAGCAACAGGAAACCCCGGTGAGTTTTCAAGTCATTCTTGAATTCATTCATTCATT
CATTCATTCAGCCATCTGAAAACATCTATTGACCACATACTACAAGCCAGCTTTAGTTTTCGGC
CCCAGGAAGCCTCATCCTGACTTCCTCTTGATTGTGGGATGCGAGGTGTTCCCAGCTAGAGGCC
TGTGGGAGAAAAGAAACCTCATTCTTGGAGTCGGAGAGAAAGTTGTGAACATTGAACACCCTCC
CTCTCAATGTGGCCAGAGTGTGGGAAGGAGTGGGGTAGAGGCTTGTAGCTCATGAGACCCACCT
CCGCTCTGTGCTCTGTAGGTCATTCCTCAGGTCCTCCAGGGCACAAGCTTGAGGGACAGGGCCC
AGCTTTGGGTCTGGGGATTCAGTCATCTGACATTGCCTGGCAGGTGGATCTCCACTGTGGGAGG
GGAATGGGGTGAGGAAGGCCTGAGGGACAGGGCGCAGAGAGGTGAGCTCATGGATGTGAGCAAA
CAGGAGAGAAGAAAGAATGTGAGATTGGATTGCGTGTGTATGAAGGAGAGGAAGACTCGTGCTG
GGGGATTAGCTGTGGGGGTCCTGTTCCACTCCCTGTTTGTGGTGACTGGTCATGAAGTAAGTCA
CCAGGATGACCCTGTCTTTCCAATTGCCCACCACCTGTGGCTCTTTTTCCCCCCCCTGCCCCCC
CATATTTCCCTTCCCTGACACCTCCTGTCCCAACCTCTCTAACCCCCCTGGGCATTTTCTGGCT
TGCCTGGATAGTTTTAGAGACCTGCTTGTTGGCTATAATGTCTTTTCATTCATTCATTCTTCTT
TTTCTTTTTTTAAAAAAACAAAATGAAACAACAAAACCAAAAAGTATCCAGAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001004274	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH98750	(Get FASTA)	NCBI Sequence Viewer
	AAN87106	(Get FASTA)	NCBI Sequence Viewer
	AAT96376	(Get FASTA)	NCBI Sequence Viewer
	EDM05968	(Get FASTA)	NCBI Sequence Viewer
	P21744	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_001004274 ⟸ NM_001004274
- Peptide Label:	precursor
- UniProtKB:	Q68J74 (UniProtKB/Swiss-Prot), P21744 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MLPFGLVAALLLAAGPRPSLGDEAIHCPPCSEEKLARCRPPVGCEELVREPGCGCCATCALGLG MPCGVYTPRCGSGMRCYPPRGVEKPLRTLMHGQGVCTELSEIEAIQESLQTSDKDESEHPNNSF NPCSAHDHRCLQKHMAKVRDRSKMKVVGTPREEPRPVPQGSCQSELHRALERLAASQSRTHEDL FIIPIPNCDRNGNFHPKQCHPALDGQRGKCWCVDRKTGVKLPGGLEPKGELDCHQLADSLQE hide sequence

RefSeq Acc Id:

ENSRNOP00000014153 ⟸ ENSRNOT00000014153

RefSeq Acc Id:

ENSRNOP00000093833 ⟸ ENSRNOT00000106145

Protein Domains

IGFBP N-terminal Thyroglobulin type-1

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P21744-F1-model_v2	AlphaFold	P21744	1-254	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13697675

Promoter ID:

EPDNEW_R8200

Type:

single initiation site

Name:

Igfbp4_1

Description:

insulin-like growth factor binding protein 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	10	86,950,547 - 86,950,607	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2875	AgrOrtholog
BioCyc Gene	G2FUF-23327	BioCyc
Ensembl Genes	ENSRNOG00000010635	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000014153	ENTREZGENE
	ENSRNOP00000014153.5	UniProtKB/Swiss-Prot
	ENSRNOP00000093833.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000014153	ENTREZGENE
	ENSRNOT00000014153.8	UniProtKB/Swiss-Prot
	ENSRNOT00000106145.1	UniProtKB/TrEMBL
Gene3D-CATH	4.10.40.20	UniProtKB/Swiss-Prot
	4.10.800.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7368649	IMAGE-MGC_LOAD
InterPro	Growth_fac_rcpt_cys_sf	UniProtKB/Swiss-Prot
	IGFBP-4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	IGFBP-like	UniProtKB/Swiss-Prot
	IGFBP_1-6_chordata	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Insulin_GF-bd_Cys-rich_CS	UniProtKB/Swiss-Prot
	Thyroglobulin_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Thyroglobulin_1_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:360622	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:112770	IMAGE-MGC_LOAD
NCBI Gene	360622	ENTREZGENE
PANTHER	INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR11551:SF7	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	IGFBP	UniProtKB/Swiss-Prot
	Thyroglobulin_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Igfbp4	PhenoGen
PRINTS	IGFBPFAMILY	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	IGFBPFAMILY4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	IGFBP_N_1	UniProtKB/Swiss-Prot
	IGFBP_N_2	UniProtKB/Swiss-Prot
	THYROGLOBULIN_1_1	UniProtKB/Swiss-Prot
	THYROGLOBULIN_1_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	SM00121	UniProtKB/Swiss-Prot
	SM00211	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF57184	UniProtKB/Swiss-Prot
	SSF57610	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I6GKG6_RAT	UniProtKB/TrEMBL
	IBP4_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q68J74	ENTREZGENE
UniProt Secondary	Q68J74	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-09-10	Igfbp4	insulin-like growth factor binding protein 4		insulin-like growth factor-binding protein 4	Name updated	1299863	APPROVED
2002-06-10	Igfbp4	insulin-like growth factor-binding protein 4			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in all tissues; highest expression in liver	61527
gene_function	binding to IGF alters the interaction of IGFs with their cell surface receptors	61527
gene_other	gene contains a TATA box and a CAAT box, as well as three cAMP responsive elements, three AP-1 binding sites and one progesterone receptor binding site	729004
gene_process	prolongs the half-life of IGFs and either inhibits or stimulates the growth promoting effects of IGFs on cell culture	61527

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Send us a Message

Imported Disease Annotations - ClinVar

RGD Manual Annotations