Igf2 (insulin-like growth factor 2) - Rat Genome Database

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Gene: Igf2 (insulin-like growth factor 2) Rattus norvegicus
Analyze
Symbol: Igf2
Name: insulin-like growth factor 2
RGD ID: 2870
Description: Predicted to enable protein kinase activator activity and signaling receptor binding activity. Involved in several processes, including cellular response to mechanical stimulus; positive regulation of blood vessel endothelial cell migration; and positive regulation of vascular endothelial cell proliferation. Located in extracellular space. Used to study osteoporosis. Biomarker of several diseases, including alcoholic neuropathy; brain infarction; congenital diaphragmatic hernia; diabetes mellitus (multiple); and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in Silver-Russell syndrome; choriocarcinoma; hepatocellular carcinoma; and rheumatoid arthritis. Orthologous to human IGF2 (insulin like growth factor 2); PARTICIPATES IN insulin-like growth factor signaling pathway; INTERACTS WITH (S)-nicotine; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: IGF-II; IGFII; insulin-like growth factor II; insulin-like growth factor II (IGF-II); Insulin-like growth factor II (somatomedin A); insulin-like growth factor II isoform 2 variant 4 preprotein; MSA; multiplication-stimulating activity; multiplication-stimulating polypeptide; RNIGF2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   SHR.BN-(D1Mit3-Igf2)/Ipcv   BB.SHR-(Acsm3-Igf2)/K  
QTLs:   Bp30   Bp42   Thym4   Bw39  
Candidate Gene For: Niddm7 Hcar4 Iddm25
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21197,814,409 - 197,831,802 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1197,814,410 - 197,823,018 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1206,187,237 - 206,197,377 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01213,273,145 - 213,283,290 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01205,947,308 - 205,957,453 (-)NCBIRnor_WKY
Rnor_6.01215,828,102 - 215,839,081 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1215,828,102 - 215,846,911 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01222,722,921 - 222,733,868 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41202,906,624 - 202,915,231 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11203,094,689 - 203,103,297 (-)NCBI
Celera1195,432,460 - 195,442,561 (-)NCBICelera
Cytogenetic Map1q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acquired immunodeficiency syndrome  (ISO)
adrenocortical carcinoma  (ISO)
Alcoholic Liver Diseases  (IEP)
alcoholic neuropathy  (IEP)
Alzheimer's disease  (IEP,ISO)
anemia  (ISO)
Animal Mammary Neoplasms  (IEP)
atherosclerosis  (ISO)
autistic disorder  (ISO)
Beckwith-Wiedemann syndrome  (ISO)
bone development disease  (ISO)
Brain Hypoxia-Ischemia  (ISO)
brain infarction  (IEP)
Brain Injuries  (IEP)
breast cancer  (ISO)
choriocarcinoma  (ISO)
Chronic Hepatitis C  (ISO)
cognitive disorder  (ISO)
Colonic Neoplasms  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
congenital diaphragmatic hernia  (IEP)
congenital disorder of glycosylation Ia  (ISO)
delta beta-thalassemia  (ISO)
developmental and epileptic encephalopathy  (ISO)
Diabetic Nephropathies  (IEP,ISO)
Diaphragmatic Hernia  (ISO)
early infantile epileptic encephalopathy  (ISO)
Embryo Loss  (IDA)
Ependymomas  (ISO)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Neoplasms  (IEP)
Experimental Radiation Injuries  (IEP)
Fetal Growth Retardation  (IEP,ISO)
gastrointestinal system disease  (ISO)
genetic disease  (ISO)
Growth Disorders  (ISO)
Hepatic Echinococcosis  (ISO)
hepatoblastoma  (ISO)
hepatocellular carcinoma  (IEP,ISO)
hypoglycemia  (ISO)
immunodeficiency 39  (ISO)
inflammatory bowel disease  (IEP,ISO)
Lewy body dementia  (ISO)
liver cirrhosis  (ISO)
Liver Neoplasms  (ISO)
Lung Injury  (IEP)
maturity-onset diabetes of the young  (ISO)
maturity-onset diabetes of the young type 10  (ISO)
Memory Disorders  (IEP,ISO)
meningitis  (ISO)
Metabolic Syndrome  (IAGP)
multiple sclerosis  (ISO)
multiple system atrophy  (ISO)
Neoplasm Metastasis  (ISO)
nephroblastoma  (ISO)
Nerve Degeneration  (ISO)
neuronal ceroid lipofuscinosis  (ISO)
obesity  (ISO)
osteoarthritis  (ISO)
osteoporosis  (IDA)
Parkinson's disease  (ISO)
placenta disease  (ISO)
polyhydramnios  (ISO)
Postmenopausal Osteoporosis  (ISO)
pre-malignant neoplasm  (ISO)
rhabdomyosarcoma  (ISO)
rheumatoid arthritis  (ISO)
Segawa Syndrome, Autosomal Recessive  (ISO)
Silver-Russell syndrome  (ISO)
Silver-Russell Syndrome 1  (ISO)
Silver-Russell Syndrome 3  (ISO)
Spontaneous Abortions  (ISO)
type 1 diabetes mellitus  (IEP)
type 1 diabetes mellitus 2  (ISS)
type 2 diabetes mellitus  (IEP,ISO)
ulcerative colitis  (ISO)
ventricular septal defect  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-acetamidofluorene  (EXP)
2-ethoxyethanol  (EXP)
2-methoxyethanol  (EXP)
28-Homobrassinolide  (EXP)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
7,12-dimethyltetraphene  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-naphthoflavone  (EXP)
aluminium sulfate (anhydrous)  (ISO)
aluminium trifluoride  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
benzimidazoles  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzylpenicillin  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
budesonide  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calciol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
capsaicin  (EXP)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
carmustine  (ISO)
choline  (EXP,ISO)
chromium atom  (EXP)
cisplatin  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
corticosterone  (EXP)
cortisol  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
dantrolene  (ISO)
DDE  (EXP)
DDT  (EXP)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (EXP,ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
estrone  (ISO)
ethanol  (EXP)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
fenvalerate  (EXP,ISO)
fluoxetine  (EXP)
folic acid  (ISO)
fonofos  (ISO)
fulvestrant  (EXP,ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glycidol  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
L-methionine  (ISO)
lanthanum atom  (ISO)
lead diacetate  (EXP,ISO)
lead nitrate  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lipopolysaccharide  (EXP,ISO)
LY294002  (EXP,ISO)
manganese(II) chloride  (ISO)
metformin  (ISO)
monosodium L-glutamate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
nickel subsulfide  (EXP)
nicotine  (EXP)
nifedipine  (ISO)
nitrofen  (EXP)
ochratoxin A  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenylarsine oxide  (EXP)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
phthalic acid  (ISO)
progesterone  (ISO)
propanal  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
raloxifene  (EXP)
resveratrol  (ISO)
rotenone  (EXP)
SB 203580  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
Tanshinone I  (EXP)
temozolomide  (ISO)
terbufos  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetramethrin  (ISO)
thioacetamide  (EXP)
tipifarnib  (EXP)
topotecan  (EXP)
trichloroacetic acid  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vinyl carbamate  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (ISO)
cellular response to mechanical stimulus  (IEP)
embryonic placenta development  (ISO,ISS)
embryonic placenta morphogenesis  (ISO)
exocrine pancreas development  (ISO)
female pregnancy  (IEP)
glucose metabolic process  (IEA)
in utero embryonic development  (ISO)
insulin receptor signaling pathway via phosphatidylinositol 3-kinase  (ISO)
insulin-like growth factor receptor signaling pathway  (ISO)
memory  (IMP)
negative regulation of muscle cell differentiation  (ISO,ISS)
negative regulation of natural killer cell mediated cytotoxicity  (IDA)
negative regulation of transcription by RNA polymerase II  (ISO,ISS)
ossification  (IEA)
osteoblast differentiation  (ISO)
positive regulation of activated T cell proliferation  (IBA,ISO)
positive regulation of angiogenesis  (IGI)
positive regulation of blood vessel endothelial cell migration  (IGI)
positive regulation of catalytic activity  (ISO)
positive regulation of cell division  (IEA)
positive regulation of cell population proliferation  (ISO,ISS)
positive regulation of glycogen (starch) synthase activity  (IBA,ISO)
positive regulation of glycogen biosynthetic process  (ISO)
positive regulation of insulin receptor signaling pathway  (IBA,ISO)
positive regulation of MAPK cascade  (IBA,ISO)
positive regulation of mitotic nuclear division  (ISO)
positive regulation of multicellular organism growth  (ISO)
positive regulation of organ growth  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (IBA,ISO)
positive regulation of protein kinase B signaling  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of skeletal muscle tissue growth  (ISO)
positive regulation of steroid hormone biosynthetic process  (IDA)
positive regulation of transcription by RNA polymerase II  (IBA,ISO)
positive regulation of vascular endothelial cell proliferation  (IBA,IGI)
regulation of muscle cell differentiation  (IBA,ISO,ISS)
response to estradiol  (IEP)
response to ethanol  (IEP)
response to nicotine  (IDA,IEP)
response to nutrient levels  (IEP)
response to organic cyclic compound  (IDA)
response to xenobiotic stimulus  (IDA)
signal transduction  (IEA)
spongiotrophoblast cell proliferation  (ISO)
striated muscle cell differentiation  (ISO)

Cellular Component
extracellular space  (IBA,IDA,IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Oleic acid ameliorates amyloidosis in cellular and mouse models of Alzheimer's disease. Amtul Z, etal., Brain Pathol. 2011 May;21(3):321-9. doi: 10.1111/j.1750-3639.2010.00449.x. Epub 2010 Nov 11.
2. Uptake of circulating insulin-like growth factor-I into the cerebrospinal fluid of normal and diabetic rats and normalization of IGF-II mRNA content in diabetic rat brain. Armstrong CS, etal., J Neurosci Res. 2000 Mar 1;59(5):649-60.
3. [Changes of serum and cerebrospinal fluid insulin-like growth factor-II levels in neonates with hypoxic-ischemic encephalopathy]. Bai B, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2006 Jun;8(3):187-90.
4. Gastrointestinal inflammation and the circulating IGF system in humans. Baricevic I, etal., Horm Metab Res. 2006 Jan;38(1):22-7.
5. Insulin-like growth factor II is induced during wound repair following hypoxic-ischemic injury in the developing rat brain. Beilharz EJ, etal., Brain Res Mol Brain Res. 1995 Mar;29(1):81-91.
6. In utero radiation-induced changes in growth factor levels in the developing rat brain. Benekou A, etal., Int J Radiat Biol. 2001 Jan;77(1):83-93.
7. Nucleotide sequence and expression of a cDNA clone encoding a fetal rat binding protein for insulin-like growth factors. Brown AL, etal., J Biol Chem 1989 Mar 25;264(9):5148-54.
8. Defective IGF2 and IGF1R protein production in embryonic pancreas precedes beta cell mass anomaly in the Goto-Kakizaki rat model of type 2 diabetes. Calderari S, etal., Diabetologia. 2007 Jul;50(7):1463-71. Epub 2007 May 3.
9. Effects of maternal undernutrition on lung growth and insulin-like growth factor system expression in rat offspring. Chen CM, etal., Acta Paediatr Taiwan. 2007 Mar-Apr;48(2):62-7.
10. A critical role for IGF-II in memory consolidation and enhancement. Chen DY, etal., Nature. 2011 Jan 27;469(7331):491-7.
11. Insulin-like growth factor-I is an important antiapoptotic factor for rat leydig cells during postnatal development. Colon E, etal., Endocrinology. 2007 Jan;148(1):128-39. Epub 2006 Oct 5.
12. Subcutaneous administration of insulin-like growth factor (IGF)-II/IGF binding protein-2 complex stimulates bone formation and prevents loss of bone mineral density in a rat model of disuse osteoporosis. Conover CA, etal., Growth Horm IGF Res. 2002 Jun;12(3):178-83.
13. The insulin-like growth factor axis in children with inflammatory bowel disease. Corkins MR, etal., J Pediatr Gastroenterol Nutr. 2003 Feb;36(2):228-34.
14. Various components of the insulin-like growth factor system in tumor tissue, cerebrospinal fluid and peripheral blood of pediatric medulloblastoma and ependymoma patients. de Bont JM, etal., Int J Cancer. 2008 Aug 1;123(3):594-600.
15. Insulin resistance in experimental alcohol-induced liver disease. de la Monte SM, etal., J Gastroenterol Hepatol. 2008 Aug;23(8 Pt 2):e477-86. Epub 2008 May 26.
16. Transgenic mice overexpressing insulin-like growth factor-II in beta cells develop type 2 diabetes. Devedjian JC, etal., J Clin Invest. 2000 Mar;105(6):731-40.
17. IGF-II regulates metastatic properties of choriocarcinoma cells through the activation of the insulin receptor. Diaz LE, etal., Mol Hum Reprod. 2007 Aug;13(8):567-76. Epub 2007 Jun 6.
18. Roles of insulin-like growth factor (IGF) binding proteins in regulating IGF actions. Duan C and Xu Q, Gen Comp Endocrinol. 2005 May 15;142(1-2):44-52. Epub 2005 Feb 5.
19. Insulin-like growth factor II precursor gene organization in relation to insulin gene family. Dull TJ, etal., Nature 1984 Aug 30-Sep 5;310(5980):777-81.
20. The insulin-like growth factor system and markers of inflammation in adult patients with inflammatory bowel disease. Eivindson M, etal., Horm Res. 2005;64(1):9-15. Epub 2005 Jul 25.
21. Elevated free IGF2 levels in localized, early-stage breast cancer in women. Espelund U, etal., Eur J Endocrinol. 2008 Nov;159(5):595-601. Epub 2008 Aug 21.
22. Comparative effects of probiotics, prebiotics, and synbiotics on growth factors in the large bowel in a rat model of formula-induced bowel inflammation. Fordjour L, etal., J Pediatr Gastroenterol Nutr. 2010 Oct;51(4):507-13.
23. The in vivo effect of hepatotrophic factors augmenter of liver regeneration, hepatocyte growth factor, and insulin-like growth factor-II on liver natural killer cell functions. Francavilla A, etal., Hepatology. 1997 Feb;25(2):411-5.
24. Structure and expression of the rat insulin-like growth factor II (rIGF-II) gene. rIGF-II RNAs are transcribed from two promoters. Frunzio R, etal., J Biol Chem 1986 Dec 25;261(36):17138-49.
25. Genome scan and congenic strains for blood pressure QTL using Dahl salt-sensitive rats. Garrett MR, etal., Genome Res 1998 Jul;8(7):711-23
26. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
27. Positive associations between single nucleotide polymorphisms in the IGF2 gene region and body mass index in adult males. Gaunt TR, etal., Hum Mol Genet. 2001 Jul 1;10(14):1491-501.
28. NMDA receptor mediated changes in IGF-II gene expression in the rat brain after injury and the possible role of nitric oxide. Giannakopoulou M, etal., Neuropathol Appl Neurobiol. 2000 Dec;26(6):513-21.
29. A simple in silico strategy identifies candidate biomarkers for the diagnosis of liver fibrosis in morbidly obese subjects. Giraudi PJ, etal., Liver Int. 2018 Jan;38(1):155-163. doi: 10.1111/liv.13505. Epub 2017 Jul 21.
30. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
31. Inverse correlation between insulin-like growth factor (IGF)-binding protein-5 and IGF-I and II during postnatal development of the anterior pituitary gland. Gonzalez-Parra S, etal., Horm Res 2002;57(1-2):10-4.
32. Effect of nicotine exposure during pregnancy and lactation on maternal, fetal, and postnatal rat IGF-II profile. Gruslin A, etal., Reprod Sci. 2009 Sep;16(9):875-82. Epub 2009 Jun 3.
33. Genetic mapping of two blood pressure quantitative trait loci on rat chromosome 1. Gu L, etal., J Clin Invest 1996 Feb 1;97(3):777-88
34. Insulin-like growth factors and binding proteins in multiple sclerosis plaques. Gveric D, etal., Neuropathol Appl Neurobiol. 1999 Jun;25(3):215-25.
35. Tissue-specific regulation of insulin-like growth factors and insulin-like growth factor binding proteins in male diabetic rats in vivo and in vitro. Han HJ, etal., Clin Exp Pharmacol Physiol. 2006 Dec;33(12):1172-9.
36. The insulin-like growth factor system in human immunodeficiency virus infection: relations to immunological parameters, disease progression, and antiretroviral therapy. Helle SI, etal., J Clin Endocrinol Metab. 2001 Jan;86(1):227-33.
37. Changes in cerebrospinal fluid and blood plasma levels of IGF-II and its binding proteins in Alzheimer's disease: an observational study. Hertze J, etal., BMC Neurol. 2014 Apr 1;14:64. doi: 10.1186/1471-2377-14-64.
38. Insulin-Like growth factor-II (IGF-II) prevents proinflammatory cytokine-induced apoptosis and significantly improves islet survival after transplantation. Hughes A, etal., Transplantation. 2013 Mar 15;95(5):671-8. doi: 10.1097/TP.0b013e31827fa453.
39. The primary structure of the rat insulin-like growth factor II gene region. Ikejiri K, etal., Biochim Biophys Acta 1990 Jul 30;1049(3):350-3.
40. Gene Expression Profiling Distinguishes Between Spontaneous and Radiation-induced Rat Mammary Carcinomas. Imaoka T, etal., J Radiat Res (Tokyo). 2008 Apr 16;.
41. Abnormal Igf2 gene in Prague hereditary hypertriglyceridemic rats: its relation to blood pressure and plasma lipids. Kadlecova M, etal., Mol Cell Biochem. 2008 Jul;314(1-2):37-43. Epub 2008 Apr 17.
42. Thymic expression of insulin-related genes in an animal model of autoimmune type 1 diabetes. Kecha-Kamoun O, etal., Diabetes Metab Res Rev. 2001 Mar-Apr;17(2):146-52.
43. IGF2 polymorphisms are associated with hepatitis B virus clearance and hepatocellular carcinoma. Kim YJ, etal., Biochem Biophys Res Commun. 2006 Jul 21;346(1):38-44. doi: 10.1016/j.bbrc.2006.05.080. Epub 2006 May 24.
44. Novel quantitative trait loci for blood pressure and related traits on rat chromosomes 1, 10, and 18. Kovacs P, etal., Biochem Biophys Res Commun 1997 Jun 18;235(2):343-8
45. Prenatal administration of retinoic acid increases the trophoblastic insulin-like growth factor 2 protein expression in the nitrofen model of congenital diaphragmatic hernia. Kutasy B, etal., Pediatr Surg Int. 2014 Feb;30(2):137-42. doi: 10.1007/s00383-013-3449-7.
46. Intracerebral streptozotocin model of type 3 diabetes: relevance to sporadic Alzheimer's disease. Lester-Coll N, etal., J Alzheimers Dis. 2006 Mar;9(1):13-33.
47. Effect of two selenium sources on hepatocarcinogenesis and several angiogenic cytokines in diethylnitrosamine-induced hepatocarcinoma rats. Liu JG, etal., J Trace Elem Med Biol. 2012 Oct;26(4):255-61. doi: 10.1016/j.jtemb.2012.02.001. Epub 2012 Mar 16.
48. Teriparatide increases bone formation in modeling and remodeling osteons and enhances IGF-II immunoreactivity in postmenopausal women with osteoporosis. Ma YL, etal., J Bone Miner Res. 2006 Jun;21(6):855-64.
49. Loss of imprinting of IGF2 characterises high IGF2 mRNA-expressing type of fibroblast-like synoviocytes in rheumatoid arthritis. Martin-Trujillo A, etal., Ann Rheum Dis. 2010 Jun;69(6):1239-42. Epub 2009 Jun 24.
50. Functional analysis of multiple promoters of the rat insulin-like factor II gene. Matsuguchi T, etal., Biochim Biophys Acta 1990 Apr 6;1048(2-3):165-70.
51. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
52. IGF system in children with congenital disorders of glycosylation. Miller BS, etal., Clin Endocrinol (Oxf). 2009 Jun;70(6):892-7. doi: 10.1111/j.1365-2265.2009.03531.x. Epub 2009 Jan 22.
53. Changes in the antioxidant defense and hepatic drug metabolizing enzyme and isoenzyme levels, 8-hydroxydeoxyguanosine formation and expressions of c-raf.1 and insulin-like growth factor II genes during the stages of development of hepatocellular carcinoma in rats. Mukherjee B, etal., Eur J Cancer Prev. 2007 Aug;16(4):363-71.
54. Concentrations of insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3), IGF, and IGFBP-3 protease activity in cerebrospinal fluid of children with leukemia, central nervous system tumor, or meningitis. Muller HL, etal., J Clin Endocrinol Metab. 1993 Nov;77(5):1113-9.
55. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
56. Insulin-like growth factors and their binding proteins in the circulation of patients with echinococcosis, trichinellosis and toxoplasmosis. Nedic O, etal., Clin Chim Acta. 2003 Sep;335(1-2):83-8.
57. Changes in systemic levels of insulin-like growth factors and their binding proteins in patients with rheumatoid arthritis. Neidel J Clin Exp Rheumatol. 2001 Jan-Feb;19(1):81-4.
58. Experimental alcohol-related peripheral neuropathy: role of insulin/IGF resistance. Nguyen VA, etal., Nutrients. 2012 Aug;4(8):1042-57. Epub 2012 Aug 17.
59. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
60. Effect of tamoxifen treatment on global and insulin-like growth factor 2-H19 locus-specific DNA methylation in rat spermatozoa and its association with embryo loss. Pathak S, etal., Fertil Steril. 2009 May;91(5 Suppl):2253-63. Epub 2008 Sep 7.
61. Early alterations in energy metabolism in the hippocampus of APPswe/PS1dE9 mouse model of Alzheimer's disease. Pedros I, etal., Biochim Biophys Acta. 2014 Sep;1842(9):1556-66. doi: 10.1016/j.bbadis.2014.05.025. Epub 2014 Jun 2.
62. Multiple system atrophy is associated with changes in peripheral insulin-like growth factor system. Pellecchia MT, etal., Mov Disord. 2010 Nov 15;25(15):2621-6.
63. Changes in IGF-I and -II, IGF binding protein, and IGF receptor transcript abundance after uterine artery ligation. Price WA, etal., Pediatr Res. 1992 Sep;32(3):291-5. doi: 10.1203/00006450-199209000-00009.
64. Expression of bone-related genes in bone marrow MSCs after cyclic mechanical strain: implications for distraction osteogenesis. Qi MC, etal., Int J Oral Sci. 2009 Sep;1(3):143-50.
65. GOA pipeline RGD automated data pipeline
66. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
67. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
68. Collagen induced arthritis increases secondary metastasis in MMTV-PyV MT mouse model of mammary cancer. Roy LD, etal., BMC Cancer. 2011 Aug 22;11:365.
69. Changes in the mRNA expressions of insulin-like growth factors, their receptors, and binding proteins during the postnatal development of rat masseter muscle. Saito T, etal., Zoolog Sci 2003 Apr;20(4):441-7.
70. Alterations in methylation and expression levels of imprinted genes H19 and Igf2 in the fetuses of diabetic mice. Shao WJ, etal., Comp Med. 2008 Aug;58(4):341-6.
71. Developmental and tissue-specific expression of a family of transcripts related to rat insulin-like growth factor II mRNA. Soares MB, etal., Nucleic Acids Res 1985 Feb 25;13(4):1119-34.
72. Genetic isolation of a chromosome 1 region affecting blood pressure in the spontaneously hypertensive rat. St. Lezin E, etal., Hypertension 1997 Oct;30(4):854-9
73. Regulation of H19 and its encoded microRNA-675 in osteoarthritis and under anabolic and catabolic in vitro conditions. Steck E, etal., J Mol Med (Berl). 2012 Oct;90(10):1185-95. doi: 10.1007/s00109-012-0895-y. Epub 2012 Apr 21.
74. Identification of Igf2, Igfbp2 and Enpp2 as estrogen-responsive genes in rat hippocampus. Takeo C, etal., Endocr J. 2009 Mar;56(1):113-20. Epub 2008 Oct 22.
75. Brain insulin-like growth factor and neurotrophin resistance in Parkinson's disease and dementia with Lewy bodies: potential role of manganese neurotoxicity. Tong M, etal., J Alzheimers Dis. 2009;16(3):585-99.
76. IGF-II and MMP9 as surgical repair indicators of ventricular septal defects. Tsai CY, etal., Clin Chim Acta. 2011 Apr 11;412(9-10):761-5. doi: 10.1016/j.cca.2011.01.005. Epub 2011 Jan 14.
77. A new leader exon identified in the rat insulin-like growth factor II gene. Ueno T, etal., Biochem Biophys Res Commun 1987 Oct 14;148(1):344-9.
78. Insulin-like growth factor-II regulates maternal hemodynamic adaptation to pregnancy in rats. Van Mieghem T, etal., Am J Physiol Regul Integr Comp Physiol. 2009 Nov;297(5):R1615-21. Epub 2009 Sep 23.
79. Re-emergence of a fetal pattern of insulin-like growth factor expression during hyperoxic rat lung injury. Veness-Meehan KA, etal., Am J Respir Cell Mol Biol. 1997 May;16(5):538-48.
80. [The role of insulin-like growth factor-2 gene differentially methylated regions in TCDD-induced malformation] Wang J, etal., Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2007 Apr;24(2):162-6.
81. Isolation of a biologically active fragment from the carboxy terminus of the fetal rat binding protein for insulin-like growth factors. Wang JF, etal., Biochem Biophys Res Commun. 1988 Dec 15;157(2):718-26.
82. Acetyl-L-carnitine rescues scopolamine-induced memory deficits by restoring insulin-like growth factor II via decreasing p53 oxidation. Wang X, etal., Neuropharmacology. 2014 Jan;76 Pt A:80-7. doi: 10.1016/j.neuropharm.2013.08.022. Epub 2013 Sep 4.
83. Connective tissue growth factor and insulin-like growth factor 2 show upregulation in early growth plate radiorecovery response following irradiation. Wang Y, etal., Cells Tissues Organs. 2007;186(3):192-203. Epub 2007 Jul 12.
84. Isolation of a cDNA clone encoding rat insulin-like growth factor-II precursor. Whitfield HJ, etal., Nature. 1984 Nov 15-21;312(5991):277-80.
85. Brain insulin-like growth factor-II mRNA content is reduced in insulin-dependent and non-insulin-dependent diabetes mellitus. Wuarin L, etal., J Neurochem. 1996 Aug;67(2):742-51.
86. MicroRNA-193-5p modulates angiogenesis through IGF2 in type 2 diabetic cardiomyopathy. Yi F, etal., Biochem Biophys Res Commun. 2017 Sep 30;491(4):876-882. doi: 10.1016/j.bbrc.2017.07.108. Epub 2017 Jul 20.
87. Immunolocalization of insulin-like growth factors and their receptors in the diabetic mouse oviduct and uterine tissues during the preimplantation period. Zakaria R, etal., Acta Histochem. 2009;111(1):52-60. Epub 2008 Aug 3.
88. Insulin-like growth factor (IGF) gene expression is reduced in neural tissues and liver from rats with non-insulin-dependent diabetes mellitus, and IGF treatment ameliorates diabetic neuropathy. Zhuang HX, etal., J Pharmacol Exp Ther. 1997 Oct;283(1):366-74.
Additional References at PubMed
PMID:2438416   PMID:2477062   PMID:2967174   PMID:3167060   PMID:3221878   PMID:7016879   PMID:9203585   PMID:11500939   PMID:12087403   PMID:12101187   PMID:12138094   PMID:12532445  
PMID:14566968   PMID:15694994   PMID:15833775   PMID:16311053   PMID:16448778   PMID:16825605   PMID:16901893   PMID:17393425   PMID:17628003   PMID:17724018   PMID:18693177   PMID:18762576  
PMID:19592596   PMID:19648158   PMID:19683557   PMID:19764351   PMID:19919529   PMID:20032056   PMID:20671425   PMID:21598309   PMID:21613208   PMID:21959847   PMID:22434232   PMID:22562201  
PMID:23016132   PMID:23229416   PMID:23376485   PMID:24667322   PMID:24845189   PMID:25268143   PMID:26276081   PMID:26455773   PMID:26495851   PMID:28362134   PMID:28417351   PMID:28522536  
PMID:28812967   PMID:28867213   PMID:28873464   PMID:28910276   PMID:28916632   PMID:30956007   PMID:32934005   PMID:33781005   PMID:33915127  


Genomics

Comparative Map Data
Igf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21197,814,409 - 197,831,802 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1197,814,410 - 197,823,018 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1206,187,237 - 206,197,377 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01213,273,145 - 213,283,290 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01205,947,308 - 205,957,453 (-)NCBIRnor_WKY
Rnor_6.01215,828,102 - 215,839,081 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1215,828,102 - 215,846,911 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01222,722,921 - 222,733,868 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41202,906,624 - 202,915,231 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11203,094,689 - 203,103,297 (-)NCBI
Celera1195,432,460 - 195,442,561 (-)NCBICelera
Cytogenetic Map1q41NCBI
IGF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38112,129,117 - 2,149,566 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl112,129,112 - 2,158,391 (-)EnsemblGRCh38hg38GRCh38
GRCh37112,150,347 - 2,170,796 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36112,106,923 - 2,127,409 (-)NCBINCBI36Build 36hg18NCBI36
Build 34112,110,531 - 2,116,578NCBI
Celera112,186,838 - 2,207,338 (-)NCBICelera
Cytogenetic Map11p15.5NCBI
HuRef111,940,869 - 1,961,095 (-)NCBIHuRef
CHM1_1112,148,973 - 2,169,786 (-)NCBICHM1_1
T2T-CHM13v2.0112,216,758 - 2,237,216 (-)NCBIT2T-CHM13v2.0
Igf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397142,204,505 - 142,220,566 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7142,204,503 - 142,220,553 (-)EnsemblGRCm39 Ensembl
GRCm387142,650,768 - 142,666,816 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7142,650,766 - 142,666,816 (-)EnsemblGRCm38mm10GRCm38
MGSCv377149,836,673 - 149,846,940 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367142,460,158 - 142,468,879 (-)NCBIMGSCv36mm8
Celera7142,407,105 - 142,417,364 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map787.99NCBI
Igf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542213,880,471 - 13,888,566 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542213,880,525 - 13,907,963 (-)NCBIChiLan1.0ChiLan1.0
IGF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1113,767,218 - 3,777,154 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0112,170,190 - 2,199,442 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1112,202,764 - 2,228,890 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl112,202,743 - 2,228,890 (-)Ensemblpanpan1.1panPan2
IGF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11846,294,036 - 46,311,982 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1846,294,019 - 46,311,982 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1844,906,773 - 44,921,790 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01846,973,499 - 46,991,455 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1846,973,482 - 47,002,253 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11846,425,198 - 46,440,216 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01846,005,530 - 46,020,544 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01846,751,952 - 46,766,988 (-)NCBIUU_Cfam_GSD_1.0
Igf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049471,719,158 - 1,727,419 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936816972,282 - 979,167 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936816972,902 - 981,232 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IGF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.121,469,183 - 1,496,417 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Pig Cytomap2pNCBI
IGF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111,937,414 - 1,951,238 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11,936,830 - 1,945,388 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603899,135,565 - 99,144,253 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Igf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476714,969,866 - 14,979,026 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476714,969,977 - 14,997,577 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Igf2
54 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1270
Count of miRNA genes:302
Interacting mature miRNAs:417
Transcripts:ENSRNOT00000050760, ENSRNOT00000073850
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642722214537671Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164747424209747424Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1180359209218108781Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1181133855226133855Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1181759564214537555Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1181829673224569684Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1182623426219932796Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1184550676229550676Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1185145134221264292Rat
1359018Hrtrt20Heart rate QTL 203.08heart pumping trait (VT:2000009)heart rate (CMO:0000002)1185356336202902618Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1185356336231689108Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1188377360224054420Rat
6480780Insul18Insulin level QTL 184.11blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1189607473200611765Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
10059590Kidm44Kidney mass QTL 443.420.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1191033875236033875Rat
631260Tcas2Tongue tumor susceptibility QTL 24.93tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1192485903199050587Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1193113876238113876Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1193422268214537671Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1196248093241248093Rat
1358292Cm37Cardiac mass QTL 376.20.00000081heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1196248093241248093Rat
6480777Insul17Insulin level QTL 173.86blood insulin amount (VT:0001560)blood insulin level area under curve (AUC) (CMO:0000351)1197260913198211706Rat
6480783Insul19Insulin level QTL 194.33blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1197489281200611765Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1197670404242670404Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1197697768238755659Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1197814409242814409Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1197814409242814409Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat

Markers in Region
D1Mgh22  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.41202,908,570 - 202,908,720RGDRGSC3.4
RGSC_v3.41202,908,571 - 202,908,720UniSTSRGSC3.4
RGSC_v3.11203,096,636 - 203,096,786RGD
Celera1195,434,394 - 195,434,543UniSTS
Cytogenetic Map1q41UniSTS
D1Wox22  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,816,378 - 197,816,499 (+)MAPPERmRatBN7.2
Rnor_6.01215,830,072 - 215,830,192NCBIRnor6.0
Rnor_5.01222,724,891 - 222,725,011UniSTSRnor5.0
RGSC_v3.41202,908,592 - 202,908,713RGDRGSC3.4
RGSC_v3.41202,908,593 - 202,908,713UniSTSRGSC3.4
RGSC_v3.11203,096,658 - 203,096,779RGD
Celera1195,434,416 - 195,434,536UniSTS
RH 2.0 Map11070.1RGD
Cytogenetic Map1q41UniSTS
D1Arb24  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,816,307 - 197,816,572 (+)MAPPERmRatBN7.2
Rnor_6.01215,830,001 - 215,830,265NCBIRnor6.0
Rnor_5.01222,724,820 - 222,725,084UniSTSRnor5.0
RGSC_v3.41202,908,521 - 202,908,786RGDRGSC3.4
RGSC_v3.41202,908,522 - 202,908,786UniSTSRGSC3.4
RGSC_v3.11203,096,587 - 203,096,852RGD
Celera1195,434,345 - 195,434,609UniSTS
SHRSP x BN Map1104.9599UniSTS
SHRSP x BN Map1104.9599RGD
Cytogenetic Map1q41UniSTS
D1Hmgc8  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,816,348 - 197,816,613 (+)MAPPERmRatBN7.2
Rnor_6.01215,830,042 - 215,830,306NCBIRnor6.0
Rnor_5.01222,724,861 - 222,725,125UniSTSRnor5.0
RGSC_v3.41202,908,562 - 202,908,827RGDRGSC3.4
RGSC_v3.41202,908,563 - 202,908,827UniSTSRGSC3.4
Celera1195,434,386 - 195,434,650UniSTS
RH 3.4 Map11436.7UniSTS
RH 3.4 Map11436.7RGD
Cytogenetic Map1q41UniSTS
D1Mco27  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,816,331 - 197,816,504 (+)MAPPERmRatBN7.2
Rnor_6.01215,830,025 - 215,830,197NCBIRnor6.0
Rnor_5.01222,724,844 - 222,725,016UniSTSRnor5.0
RGSC_v3.41202,908,546 - 202,908,718UniSTSRGSC3.4
Celera1195,434,369 - 195,434,541UniSTS
Cytogenetic Map1q41UniSTS
D1Wox58  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,816,375 - 197,816,551 (+)MAPPERmRatBN7.2
Rnor_6.01215,830,069 - 215,830,244NCBIRnor6.0
Rnor_5.01222,724,888 - 222,725,063UniSTSRnor5.0
RGSC_v3.41202,908,590 - 202,908,765UniSTSRGSC3.4
Celera1195,434,413 - 195,434,588UniSTS
Cytogenetic Map1q41UniSTS
AW742446  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,814,854 - 197,815,103 (+)MAPPERmRatBN7.2
Rnor_6.01215,828,548 - 215,828,796NCBIRnor6.0
Rnor_5.01222,723,367 - 222,723,615UniSTSRnor5.0
RGSC_v3.41202,907,069 - 202,907,317UniSTSRGSC3.4
Celera1195,432,906 - 195,433,154UniSTS
Cytogenetic Map1q41UniSTS
RH94794  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,815,192 - 197,815,553 (+)MAPPERmRatBN7.2
Rnor_6.01215,828,886 - 215,829,246NCBIRnor6.0
Rnor_5.01222,723,705 - 222,724,065UniSTSRnor5.0
RGSC_v3.41202,907,407 - 202,907,767UniSTSRGSC3.4
Celera1195,433,244 - 195,433,604UniSTS
Cytogenetic Map1q41UniSTS
BE098867  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,815,641 - 197,815,797 (+)MAPPERmRatBN7.2
Rnor_6.01215,829,335 - 215,829,490NCBIRnor6.0
Rnor_5.01222,724,154 - 222,724,309UniSTSRnor5.0
RGSC_v3.41202,907,856 - 202,908,011UniSTSRGSC3.4
Celera1195,433,693 - 195,433,848UniSTS
Cytogenetic Map1q41UniSTS
RH128370  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,814,588 - 197,814,805 (+)MAPPERmRatBN7.2
Rnor_6.01215,828,282 - 215,828,498NCBIRnor6.0
Rnor_5.01222,723,101 - 222,723,317UniSTSRnor5.0
RGSC_v3.41202,906,803 - 202,907,019UniSTSRGSC3.4
Celera1195,432,640 - 195,432,856UniSTS
Cytogenetic Map1q41UniSTS
RH94585  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,823,685 - 197,823,868 (+)MAPPERmRatBN7.2
Rnor_6.01215,837,378 - 215,837,560NCBIRnor6.0
Rnor_5.01222,732,197 - 222,732,379UniSTSRnor5.0
RGSC_v3.41202,915,899 - 202,916,081UniSTSRGSC3.4
Celera1195,441,730 - 195,441,912UniSTS
Cytogenetic Map1q41UniSTS
PMC151856P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,817,495 - 197,817,836 (+)MAPPERmRatBN7.2
Rnor_6.01215,831,188 - 215,831,528NCBIRnor6.0
Rnor_5.01222,726,007 - 222,726,347UniSTSRnor5.0
RGSC_v3.41202,909,709 - 202,910,049UniSTSRGSC3.4
Celera1195,435,532 - 195,435,872UniSTS
Cytogenetic Map1q41UniSTS
ECD21742  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,821,931 - 197,822,164 (+)MAPPERmRatBN7.2
Rnor_6.01215,835,624 - 215,835,856NCBIRnor6.0
Rnor_5.01222,730,443 - 222,730,675UniSTSRnor5.0
RGSC_v3.41202,914,145 - 202,914,377UniSTSRGSC3.4
Celera1195,440,092 - 195,440,324UniSTS
Cytogenetic Map1q41UniSTS
Igf2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,817,882 - 197,819,233 (+)MAPPERmRatBN7.2
Rnor_6.01215,831,575 - 215,832,925NCBIRnor6.0
Rnor_5.01222,726,394 - 222,727,744UniSTSRnor5.0
RGSC_v3.41202,910,096 - 202,911,446UniSTSRGSC3.4
Celera1195,435,919 - 195,437,393UniSTS
Cytogenetic Map1q41UniSTS
UniSTS:276141  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,819,139 - 197,819,224 (+)MAPPERmRatBN7.2
Rnor_6.01215,832,832 - 215,832,916NCBIRnor6.0
Rnor_5.01222,727,651 - 222,727,735UniSTSRnor5.0
RGSC_v3.41202,911,353 - 202,911,437UniSTSRGSC3.4
Celera1195,437,300 - 195,437,384UniSTS
Cytogenetic Map1q41UniSTS
D1Mgh22  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,816,356 - 197,816,506 (+)MAPPERmRatBN7.2
Rnor_6.01215,830,050 - 215,830,199NCBIRnor6.0
Rnor_5.01222,724,869 - 222,725,018UniSTSRnor5.0
RGSC_v3.41202,908,571 - 202,908,720UniSTSRGSC3.4
Celera1195,434,394 - 195,434,543UniSTS
Cytogenetic Map1q41UniSTS
Igf2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,817,313 - 197,817,868 (+)MAPPERmRatBN7.2
Rnor_6.01215,831,006 - 215,831,560NCBIRnor6.0
Rnor_5.01222,725,825 - 222,726,379UniSTSRnor5.0
RGSC_v3.41202,909,527 - 202,910,081UniSTSRGSC3.4
Celera1195,435,350 - 195,435,904UniSTS
Cytogenetic Map1q41UniSTS
Igf2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,817,230 - 197,817,837 (+)MAPPERmRatBN7.2
Rnor_6.01215,830,923 - 215,831,529NCBIRnor6.0
Rnor_5.01222,725,742 - 222,726,348UniSTSRnor5.0
RGSC_v3.41202,909,444 - 202,910,050UniSTSRGSC3.4
Celera1195,435,267 - 195,435,873UniSTS
Cytogenetic Map1q41UniSTS
Igf2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,817,507 - 197,819,204 (+)MAPPERmRatBN7.2
Rnor_6.01215,831,200 - 215,832,896NCBIRnor6.0
Rnor_5.01222,726,019 - 222,727,715UniSTSRnor5.0
RGSC_v3.41202,909,721 - 202,911,417UniSTSRGSC3.4
Cytogenetic Map1q41UniSTS
Igf2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,817,046 - 197,817,789 (+)MAPPERmRatBN7.2
Rnor_6.01215,830,739 - 215,831,481NCBIRnor6.0
Rnor_5.01222,725,558 - 222,726,300UniSTSRnor5.0
RGSC_v3.41202,909,260 - 202,910,002UniSTSRGSC3.4
Celera1195,435,083 - 195,435,825UniSTS
Cytogenetic Map1q41UniSTS
UniSTS:532138  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,816,737 - 197,817,322 (+)MAPPERmRatBN7.2
Rnor_6.01215,830,431 - 215,831,014NCBIRnor6.0
Rnor_5.01222,725,250 - 222,725,833UniSTSRnor5.0
Celera1195,434,775 - 195,435,358UniSTS
Cytogenetic Map1q41UniSTS
UniSTS:532139  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,817,514 - 197,819,181 (+)MAPPERmRatBN7.2
Rnor_6.01215,831,207 - 215,832,873NCBIRnor6.0
Rnor_5.01222,726,026 - 222,727,692UniSTSRnor5.0
Cytogenetic Map1q41UniSTS


Related Rat Strains
The following Strains have been annotated to Igf2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 14 18 18 18 5
Medium 19 11 10 10 4 5 72 18 23 2 4
Low 3 10 19 5 13 5 4 6 2 12 13 9 4
Below cutoff 9 8 6 8 5

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001190162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001190163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_031511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008760074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC098563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH005814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ408382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M17960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M30273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M31221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M38688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X00911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X13101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X14833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X14834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X16703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X17012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000050760   ⟹   ENSRNOP00000047037
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1215,828,102 - 215,838,209 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000073850   ⟹   ENSRNOP00000066983
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1215,828,102 - 215,834,704 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000080246   ⟹   ENSRNOP00000068633
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1197,814,410 - 197,823,018 (-)Ensembl
Rnor_6.0 Ensembl1215,828,102 - 215,836,641 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000089171   ⟹   ENSRNOP00000070557
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1215,830,983 - 215,846,911 (-)Ensembl
RefSeq Acc Id: NM_001190162   ⟹   NP_001177091
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21197,814,409 - 197,821,012 (-)NCBI
Rnor_6.01215,828,102 - 215,834,704 (-)NCBI
Rnor_5.01222,722,921 - 222,733,868 (-)NCBI
Celera1195,432,460 - 195,439,172 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001190163   ⟹   NP_001177092
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21197,814,409 - 197,824,517 (-)NCBI
Rnor_6.01215,828,102 - 215,838,209 (-)NCBI
Rnor_5.01222,722,921 - 222,733,868 (-)NCBI
Celera1195,432,460 - 195,442,561 (-)NCBI
Sequence:
RefSeq Acc Id: NM_031511   ⟹   NP_113699
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21197,814,409 - 197,822,949 (-)NCBI
Rnor_6.01215,828,102 - 215,836,641 (-)NCBI
Rnor_5.01222,722,921 - 222,733,868 (-)NCBI
RGSC_v3.41202,906,624 - 202,915,231 (-)RGD
Celera1195,432,460 - 195,441,052 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008760074   ⟹   XP_008758296
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21197,814,409 - 197,825,357 (-)NCBI
Rnor_6.01215,828,102 - 215,838,991 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039096366   ⟹   XP_038952294
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21197,817,927 - 197,825,357 (-)NCBI
RefSeq Acc Id: XM_039096378   ⟹   XP_038952306
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21197,814,409 - 197,831,802 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_113699   ⟸   NM_031511
- Peptide Label: isoform 1 preproprotein
- UniProtKB: P01346 (UniProtKB/Swiss-Prot),   A0A0G2JTA6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001177092   ⟸   NM_001190163
- Peptide Label: isoform 2 preproprotein
- UniProtKB: P01346 (UniProtKB/Swiss-Prot),   M9NW49 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001177091   ⟸   NM_001190162
- Peptide Label: isoform 2 preproprotein
- UniProtKB: P01346 (UniProtKB/Swiss-Prot),   M9NW49 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008758296   ⟸   XM_008760074
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000068633   ⟸   ENSRNOT00000080246
RefSeq Acc Id: ENSRNOP00000070557   ⟸   ENSRNOT00000089171
RefSeq Acc Id: ENSRNOP00000066983   ⟸   ENSRNOT00000073850
RefSeq Acc Id: ENSRNOP00000047037   ⟸   ENSRNOT00000050760
RefSeq Acc Id: XP_038952306   ⟸   XM_039096378
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038952294   ⟸   XM_039096366
- Peptide Label: isoform X2
Protein Domains
Insulin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P01346-F1-model_v2 AlphaFold P01346 1-180 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:6850064
Promoter ID:EP25033
Type:single initiation site
Name:RN_IGF2_3
Description:Insulin-like growth factor II, IGF2 or IGF-2 gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 155; Mammalian insulin-like growth factor 2 E3/E4.
Alternative Promoters:alternative promoter #3 of 3; 5' exon 3; site 1; major promoter.; see alsoEP28008  EP25032  
Tissues & Cell Lines:fetal and neonatal tissues, adult brain
Experiment Methods:Nuclease protection; Primer extension; Length measurement of an RNA product; RNA Pol II in vitro; system; Nuclease protection; RNA Pol II in vitro system
Position:
Rat AssemblyChrPosition (strand)Source
RGSC_v3.41202,913,234 - 202,913,294EPD
RGD ID:6850058
Promoter ID:EP25032
Type:single initiation site
Name:RN_IGF2_2
Description:Insulin-like growth factor II, IGF2 or IGF-2 gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 137; Mammalian insulin-like growth factor 2 E2/E3.
Alternative Promoters:alternative promoter #2 of 3; 5' exon 2; site 1.; see alsoEP28008  EP25033  
Tissues & Cell Lines:fetal and neonatal tissues, adult brain
Experiment Methods:Nuclease protection; Primer extension
Position:
Rat AssemblyChrPosition (strand)Source
RGSC_v3.41202,915,229 - 202,915,289EPD
RGD ID:6850054
Promoter ID:EP28008
Type:initiation region
Name:RN_IGF2_1
Description:Insulin-like growth factor II, IGF2 or IGF-2 gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:alternative promoter #1 of 3; 5' exon 1; site 1.; see alsoEP25032  EP25033  
Tissues & Cell Lines:fetal and neonatal tissues, adult brain
Experiment Methods:Nuclease protection with homologous sequence ladder; Primer extension
Position:
Rat AssemblyChrPosition (strand)Source
RGSC_v3.41202,916,987 - 202,917,047EPD
RGD ID:13690565
Promoter ID:EPDNEW_R1090
Type:single initiation site
Name:Igf2_2
Description:insulin-like growth factor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R1091  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01215,834,714 - 215,834,774EPDNEW
RGD ID:13690566
Promoter ID:EPDNEW_R1091
Type:single initiation site
Name:Igf2_1
Description:insulin-like growth factor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R1090  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01215,836,710 - 215,836,770EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2870 AgrOrtholog
BioCyc Gene G2FUF-56899 BioCyc
Ensembl Genes ENSRNOG00000020369 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000068633.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000080246.2 UniProtKB/TrEMBL
Gene3D-CATH Insulin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro IGF2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGF2_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Insulin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Insulin-like_growth_factor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Insulin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Insulin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Insulin_family UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24483 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 24483 ENTREZGENE
PANTHER INSULIN-LIKE GROWTH FACTOR II UniProtKB/Swiss-Prot
  INSULIN-LIKE GROWTH FACTOR II UniProtKB/Swiss-Prot
  INSULIN-LIKE GROWTH FACTOR II UniProtKB/TrEMBL
  INSULIN-LIKE GROWTH FACTOR II UniProtKB/TrEMBL
Pfam IGF2_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Insulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Igf2 PhenoGen
PRINTS INSLNLIKEGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INSLNLIKEGF2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INSULINFAMLY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE INSULIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IlGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56994 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JTA6 ENTREZGENE, UniProtKB/TrEMBL
  IGF2_RAT UniProtKB/Swiss-Prot
  M9NW49 ENTREZGENE, UniProtKB/TrEMBL
  P01346 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Igf2  Insulin-like growth factor II (somatomedin A)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_transcript two alternative transcripts are transcribed from two distinct promoters 729153