Igf1 (insulin-like growth factor 1) - Rat Genome Database

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Gene: Igf1 (insulin-like growth factor 1) Rattus norvegicus
Symbol: Igf1
Name: insulin-like growth factor 1
RGD ID: 2868
Description: Enables protein serine/threonine kinase activator activity; signaling receptor binding activity; and steroid binding activity. Involved in several processes, including cellular response to hormone stimulus; negative regulation of apoptotic process; and positive regulation of cell differentiation. Located in several cellular components, including interstitial matrix; neuronal cell body; and platelet alpha granule. Used to study brain ischemia; diabetic neuropathy; and hypertension. Biomarker of several diseases, including alcoholic neuropathy; artery disease (multiple); congenital diaphragmatic hernia; folic acid deficiency anemia; and hypothyroidism (multiple). Human ortholog(s) of this gene implicated in several diseases, including acne; brain ischemia; diabetes mellitus (multiple); myopia; and neurodegenerative disease (multiple). Orthologous to human IGF1 (insulin like growth factor 1); PARTICIPATES IN altered insulin-like growth factor signaling pathway; cardiovascular system disease pathway; insulin-like growth factor signaling pathway; INTERACTS WITH (+)-schisandrin B; (R)-noradrenaline; (S)-nicotine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: IGF; IGF-I; insulin-like growth factor I; somatomedin
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: QTLs:   Bp102  
Candidate Gene For: Bw19 Lnnr1
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8724,169,608 - 24,249,446 (+)NCBIGRCr8
mRatBN7.2722,282,895 - 22,361,972 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl722,282,930 - 22,359,296 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx724,277,579 - 24,351,455 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0726,440,272 - 26,514,144 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0726,217,310 - 26,291,178 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0728,412,123 - 28,491,815 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl728,412,198 - 28,486,609 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0728,528,165 - 28,607,747 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4724,531,669 - 24,605,742 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1724,553,367 - 24,625,089 (+)NCBI
Celera719,453,213 - 19,527,075 (+)NCBICelera
RH 3.4 Map7116.9RGD
RH 3.4 Map7118.8RGD
Cytogenetic Map7q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acne  (ISO)
acoustic neuroma  (ISO)
acromegaly  (ISO)
acute kidney failure  (ISO)
adenoma  (ISO)
Albuminuria  (ISO)
alcoholic neuropathy  (IEP)
alopecia  (ISO)
Alzheimer's disease  (ISO)
arteriosclerosis  (ISO)
autistic disorder  (ISO)
borna disease  (IEP)
Brain Hypoxia-Ischemia  (IDA,IEP,ISO)
Brain Injuries  (ISO)
brain ischemia  (IDA,ISO)
breast cancer  (IEP)
Breast Neoplasms  (ISO)
Burns  (IEP)
Cachexia  (ISO)
Cardiomegaly  (ISO)
carotid artery disease  (ISO)
Carotid Artery Injuries  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (IEP,ISO)
Closed Head Injuries  (ISO)
Cockayne syndrome  (ISO)
colitis  (ISO)
congenital diaphragmatic hernia  (IEP)
congenital disorder of glycosylation Ia  (ISO)
congenital hypothyroidism  (IEP)
congestive heart failure  (IEP)
corneal disease  (ISO)
Coronary Disease  (ISO)
coronary stenosis  (IEP)
Crohn's disease  (ISO)
cystic fibrosis  (ISO)
Deafness  (ISO)
demyelinating disease  (ISO)
depressive disorder  (ISO)
diabetes mellitus  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Foot  (ISO)
Diabetic Nephropathies  (IEP,ISO)
diabetic neuropathy  (IMP,ISO)
diabetic retinopathy  (ISO)
Diaphragmatic Hernia  (ISO)
dilated cardiomyopathy  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Dwarfism  (IEP,ISO)
end stage renal disease  (ISO)
endometriosis  (ISO)
Endotoxemia  (IEP)
Experimental Arthritis  (IEP)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Cirrhosis  (IEP,IMP,ISO)
Experimental Mammary Neoplasms  (ISO)
familial mediterranean fever  (ISO)
Female Urogenital Diseases  (ISO)
fetal alcohol spectrum disorder  (IEP)
Fetal Growth Retardation  (IEP,ISO)
Fetal Macrosomia  (ISO)
folic acid deficiency anemia  (IEP)
genetic disease  (ISO)
granulomatosis with polyangiitis  (ISO)
Graves ophthalmopathy  (ISO)
Graves' disease  (ISO)
Growth Disorders  (ISO)
head and neck squamous cell carcinoma  (ISO)
Hearing Loss, Noise-Induced  (ISO)
Henoch-Schoenlein purpura  (ISO)
hepatocellular carcinoma  (ISO)
high grade glioma  (ISO)
Huntington's disease  (ISO)
Hyperalgesia  (ISO)
Hyperoxia  (ISO)
Hyperphagia  (IDA)
hypertension  (IAGP,IEP,ISO)
hypertrophic cardiomyopathy  (ISO)
hypothyroidism  (IEP)
Insulin-Like Growth Factor I Deficiency  (ISO)
intellectual disability  (ISO)
Intervertebral Disc Displacement  (IMP)
kidney disease  (ISO)
Knee Osteoarthritis  (IEP,ISO)
Kuhnt-Junius degeneration  (ISO)
Laron syndrome  (ISO)
lung disease  (ISO)
Malocclusion  (IEP)
Metabolic Bone Diseases  (IEP,ISO)
metabolic dysfunction-associated steatotic liver disease  (IEP)
microcephaly  (ISO)
middle cerebral artery infarction  (ISO)
muscular atrophy  (ISO)
myocardial infarction  (IEP,ISO)
Myocardial Ischemia  (IDA,ISO)
myopia  (ISO)
Nasal Polyps  (ISO)
Neointima  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Nerve Degeneration  (ISO)
Noonan syndrome  (ISO)
osteoarthritis  (ISO)
Osteophytes  (IEP)
osteoporosis  (IEP,ISO)
Osteoporotic Fractures  (IDA,ISO)
Oxygen-Induced Retinopathy  (IEP)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
PEHO syndrome  (ISO)
peripheral nervous system disease  (ISO)
Pituitary Neoplasms  (ISO)
Plaque, Atherosclerotic  (ISO)
polycystic ovary syndrome  (ISO)
Postmenopausal Osteoporosis  (ISO)
Precocious Puberty  (ISO)
progeria  (ISO)
prostate carcinoma in situ  (IEP)
Prostatic Neoplasms  (IEP,ISO)
psoriasis  (ISO)
pulmonary fibrosis  (ISO)
pycnodysostosis  (ISO)
Reperfusion Injury  (ISO)
retinopathy of prematurity  (IEP,ISO)
rheumatic heart disease  (ISO)
Rhinosinusitis  (ISO)
Right Ventricular Hypertrophy  (IEP)
Sarcopenia  (ISO)
severe acute respiratory syndrome  (ISO)
Skin Neoplasms  (ISO)
Skull Fractures  (ISO)
Spontaneous Abortions  (ISO)
Stroke  (IEP,ISO)
Sudden Hearing Loss  (ISO)
Thinness  (ISO)
Tongue Neoplasms  (ISO)
transient cerebral ischemia  (IEP)
Turner syndrome  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (IEP,ISO)
urinary bladder cancer  (ISO)
uveal melanoma  (ISO)
vascular dementia  (IEP,ISO)
Wounds and Injuries  (IEP,ISO)
Zinc Deficiency  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-anisomycin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(R)-noradrenaline  (EXP)
(S)-nicotine  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,1-dichloroethene  (ISO)
1,2,3,4,7,8-Hexachlorodibenzodioxin  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-methylphenanthrene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-nitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
4-tert-Octylphenol  (EXP)
5-fluorouracil  (EXP,ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
actinomycin D  (ISO)
adenosine  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (EXP)
albuterol  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-(methylamino)isobutyric acid  (EXP)
aluminium atom  (ISO)
aluminium oxide  (ISO)
aluminium sulfate (anhydrous)  (ISO)
aluminium(0)  (ISO)
amino acid  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
anandamide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
astemizole  (ISO)
azathioprine  (ISO)
baicalein  (ISO)
belinostat  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzoyl peroxide  (ISO)
beta-naphthoflavone  (EXP)
bexarotene  (EXP)
bezafibrate  (ISO)
bicalutamide  (ISO)
biochanin A  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bosentan  (ISO)
bromobenzene  (EXP)
bromochloroacetic acid  (EXP)
bucladesine  (ISO)
buspirone  (EXP)
Butylbenzyl phthalate  (EXP)
butyric acid  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP,ISO)
calcidiol  (EXP)
calcitriol  (ISO)
calcium atom  (EXP,ISO)
calcium silicate  (ISO)
calcium(0)  (EXP,ISO)
Candesartan cilexetil  (EXP)
cannabidiolic acid  (ISO)
capsaicin  (EXP,ISO)
capsazepine  (EXP)
capsiate  (ISO)
captan  (ISO)
carbamazepine  (EXP)
carbon nanotube  (ISO)
carmustine  (ISO)
cetrorelix  (ISO)
CGP 52608  (ISO)
chelerythrine  (EXP)
chlormequat chloride  (EXP)
chloroacetic acid  (ISO)
chloroethene  (ISO)
chlorohydrocarbon  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP)
chromium atom  (EXP)
chromium(3+) trichloride  (EXP,ISO)
chrysin  (EXP)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
clozapine  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
cobalt(2+) sulfate  (EXP)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
cordycepin  (ISO)
corticosterone  (EXP)
cortisol  (ISO)
coumestrol  (EXP)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP,ISO)
cypermethrin  (EXP)
cyproconazole  (ISO)
cyproterone acetate  (ISO)
D-glucose  (ISO)
D-mannitol  (ISO)
D-penicillamine  (ISO)
dantrolene  (ISO)
deguelin  (ISO)
Deoxycorticosterone acetate  (EXP)
deoxynivalenol  (EXP,ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
dibenziodolium  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
dicoumarol  (ISO)
dieldrin  (EXP)
dienogest  (ISO)
diethyl malate  (ISO)
diethyl phthalate  (EXP)
diethylstilbestrol  (EXP,ISO)
dihydrocapsaicin  (ISO)
dimethyl fumarate  (EXP)
Dimethyl phthalate  (EXP)
dimethylarsinic acid  (EXP)
dioxygen  (EXP,ISO)
dipentyl phthalate  (EXP)
diquat  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
dobutamine  (EXP)
doxorubicin  (EXP,ISO)
enalapril  (EXP)
endosulfan  (EXP)
enzalutamide  (ISO)
epoxiconazole  (ISO)
estriol  (ISO)
ethanol  (EXP,ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
felbamate  (EXP)
fenarimol  (EXP)
fenvalerate  (ISO)
fipronil  (ISO)
flavonoids  (ISO)
flavonol  (ISO)
fluoranthene  (ISO)
flutamide  (EXP,ISO)
fluvastatin  (ISO)
folpet  (ISO)
formoterol fumarate  (ISO)
fulvestrant  (EXP,ISO)
fumonisin B1  (ISO)
furan  (EXP)
furazolidone  (ISO)
furosemide  (EXP)
gabapentin  (EXP)
gadolinium trichloride  (EXP)
gamma-hexachlorocyclohexane  (EXP)
genistein  (EXP,ISO)
ginsenoside Rb1  (EXP)
Ginsenoside Rh4  (ISO)
glucose  (ISO)
glutathione  (ISO)
glyburide  (EXP)
glycidol  (EXP)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
griseofulvin  (ISO)
heptachlor  (EXP)
herbicide  (EXP)
hexachlorobenzene  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
ibuprofen  (EXP)
icariin  (EXP)
indometacin  (EXP,ISO)
inulin  (ISO)
irinotecan  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
isoflavones  (EXP,ISO)
isoflurane  (EXP)
isoprenaline  (EXP,ISO)
isotretinoin  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-ethionine  (EXP)
L-methionine  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP,ISO)
leflunomide  (ISO)
leuprolide  (ISO)
levonorgestrel  (ISO)
lidocaine  (EXP)
linuron  (EXP)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (ISO)
loliolide  (ISO)
lornoxicam  (EXP)
lovastatin  (ISO)
LY294002  (EXP,ISO)
lycopene  (EXP,ISO)
maleic acid  (ISO)
maneb  (ISO)
manganese(II) chloride  (EXP)
masoprocol  (ISO)
melatonin  (ISO)
mercury atom  (ISO)
mercury dichloride  (EXP)
mercury(0)  (ISO)
metformin  (EXP,ISO)
methimazole  (ISO)
methoxychlor  (EXP,ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
mifepristone  (EXP,ISO)
MK-2206  (EXP)
monodansylcadaverine  (ISO)
monosodium L-glutamate  (EXP,ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
naphthalene  (ISO)
naringin  (EXP,ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
nicotine  (EXP)
nifedipine  (ISO)
nimesulide  (EXP)
nitrofen  (EXP)
nitroprusside  (EXP,ISO)
nonivamide  (ISO)
Nordihydrocapsaicin  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
octreotide  (ISO)
okadaic acid  (ISO)
omeprazole  (EXP)
Osajin  (ISO)
oxaliplatin  (EXP)
p-menthan-3-ol  (ISO)
p-tert-Amylphenol  (EXP)
para-Cresidine  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
PCB138  (EXP)
pendimethalin  (EXP)
pentane-2,3-dione  (EXP)
pentetic acid  (EXP)
pentetrazol  (EXP)
perfluorododecanoic acid  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenacetin  (EXP)
phenobarbital  (EXP,ISO)
phenylarsine oxide  (EXP)
phenylephrine  (EXP)
phenytoin  (EXP)
phloretin  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidylcholine  (ISO)
picolinic acid  (EXP)
picropodophyllotoxin  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
polaprezinc  (ISO)
poly(I:C)  (ISO)
Pomiferin  (ISO)
potassium atom  (EXP)
potassium chloride  (EXP)
potassium dichromate  (EXP)
prazosin  (EXP)
prednisolone  (ISO)
pregnenolone  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
prochloraz  (EXP)
progesterone  (EXP,ISO)
propiconazole  (ISO)
propofol  (ISO)
Ptaquiloside  (ISO)
puerarin  (ISO)
quercetin  (EXP,ISO)
quinidine  (ISO)
raloxifene  (EXP,ISO)
reactive oxygen species  (ISO)
Rebamipide  (EXP)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
rivastigmine  (EXP)
Rosavin  (ISO)
rotenone  (EXP,ISO)
ruthenium red  (ISO)
rutin  (EXP)
SB 203580  (ISO)
serpentine asbestos  (ISO)
sevoflurane  (ISO)
shikimic acid  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sirolimus  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium atom  (EXP)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
Sodium salicylate  (ISO)
sophoraflavanone B  (EXP)
sorafenib  (ISO)
sphingosine 1-phosphate  (ISO)
staurosporine  (EXP)
streptozocin  (EXP,ISO)
succimer  (ISO)
superoxide  (ISO)
tacrolimus hydrate  (EXP)
tamoxifen  (EXP,ISO)
tauroursodeoxycholic acid  (EXP)
tert-butyl hydroperoxide  (EXP)
testosterone  (EXP,ISO)
testosterone enanthate  (EXP)
tetrachloromethane  (EXP,ISO)
tetradecane  (EXP)
tetramethrin  (ISO)
tetrathiomolybdate(2-)  (ISO)
thalidomide  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thymidine  (ISO)
thyroxine  (ISO)
Tiron  (ISO)
titanium dioxide  (ISO)
topiramate  (EXP)
topotecan  (EXP)
tremolite asbestos  (ISO)
triadimefon  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (EXP)
trilostane  (ISO)
trimethyltin  (ISO)
triphenyl phosphate  (ISO)
triphenylstannane  (EXP,ISO)
Triptolide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
undecane  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vincristine  (ISO)
wortmannin  (EXP,ISO)
zearalenone  (ISO)
zerumbone  (ISO)
zinc atom  (EXP,ISO)
zinc oxide  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
androgen receptor signaling pathway  (ISO)
blood vessel remodeling  (ISO)
bone development  (IEP)
bone mineralization involved in bone maturation  (IEA,ISO)
branching morphogenesis of an epithelial tube  (ISO)
cardiac atrium development  (IEP)
cell activation  (IEA,ISO)
cell development  (ISO)
cell population proliferation  (IBA,IEA,ISO)
cellular response to amyloid-beta  (IEA,ISO)
cellular response to dexamethasone stimulus  (IEP)
cellular response to electrical stimulus  (IEP)
cellular response to estradiol stimulus  (IEP)
cellular response to glucose stimulus  (ISO)
cellular response to insulin stimulus  (IEP)
cellular response to insulin-like growth factor stimulus  (ISO)
cellular response to nicotine  (IEP)
cellular response to progesterone stimulus  (IEP)
cellular response to Thyroglobulin triiodothyronine  (IEP)
cellular response to zinc ion starvation  (IEP)
cerebellar granule cell precursor proliferation  (ISO)
chondroitin sulfate proteoglycan biosynthetic process  (ISO)
circadian rhythm  (ISO)
cranial suture morphogenesis  (IEP)
detection of mechanical stimulus involved in sensory perception  (IMP)
exocrine pancreas development  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
female pregnancy  (IEP)
glial cell differentiation  (ISO)
inner ear development  (ISO)
insulin-like growth factor receptor signaling pathway  (IBA,IDA,IEA,ISO)
lung alveolus development  (ISO)
lung development  (ISO)
lung lobe morphogenesis  (ISO)
lung vasculature development  (ISO)
mammary gland development  (ISO)
memory  (IMP)
multicellular organism growth  (ISO)
muscle hypertrophy  (IEA,ISO)
myoblast differentiation  (IEA,ISO)
myoblast proliferation  (IEA,ISO)
myotube cell development  (IEA,ISO)
myotube differentiation  (ISO)
negative regulation of amyloid-beta formation  (IEA,ISO)
negative regulation of androgen receptor signaling pathway  (ISO)
negative regulation of apoptotic process  (IBA,IDA,IEA,ISO,ISS)
negative regulation of cell population proliferation  (ISO)
negative regulation of cholangiocyte apoptotic process  (IMP)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of extrinsic apoptotic signaling pathway  (IDA,IEA,ISO)
negative regulation of gene expression  (ISO)
negative regulation of immune system process  (IMP)
negative regulation of interleukin-1 beta production  (IEA,ISO)
negative regulation of muscle cell apoptotic process  (IMP)
negative regulation of neuroinflammatory response  (IEA,ISO)
negative regulation of oligodendrocyte apoptotic process  (IDA)
negative regulation of oocyte development  (IEA,ISO)
negative regulation of peptidyl-tyrosine phosphorylation  (ISO)
negative regulation of release of cytochrome c from mitochondria  (ISO,ISS)
negative regulation of smooth muscle cell apoptotic process  (IMP,ISO)
negative regulation of tumor necrosis factor production  (IEA,ISO)
negative regulation of vascular associated smooth muscle cell apoptotic process  (IEA,ISO)
nervous system development  (ISO)
osteoblast differentiation  (ISO)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of activated T cell proliferation  (IEA,ISO)
positive regulation of blood vessel endothelial cell migration  (IGI)
positive regulation of calcineurin-NFAT signaling cascade  (IEA,ISO)
positive regulation of cardiac muscle hypertrophy  (ISO)
positive regulation of cell growth  (IDA,IMP)
positive regulation of cell growth involved in cardiac muscle cell development  (IEA,ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (IBA,IEA,ISO,ISS)
positive regulation of cerebellar granule cell precursor proliferation  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of epithelial cell proliferation  (IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO)
positive regulation of fat cell differentiation  (IDA)
positive regulation of fibroblast proliferation  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of glial cell proliferation  (IDA)
positive regulation of glucose import  (IEA,ISO,ISS)
positive regulation of glycogen biosynthetic process  (IEA,ISO,ISS)
positive regulation of glycolytic process  (IEA,ISO)
positive regulation of glycoprotein biosynthetic process  (IEA,ISO)
positive regulation of insulin-like growth factor receptor signaling pathway  (IEA,ISO)
positive regulation of MAPK cascade  (IMP,ISO)
positive regulation of mitotic nuclear division  (IEA,ISO)
positive regulation of myelination  (ISO)
positive regulation of myoblast proliferation  (ISO)
positive regulation of osteoblast differentiation  (IDA,IEA,ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IDA,IEA,ISO)
positive regulation of protein secretion  (IEA,ISO)
positive regulation of Ras protein signal transduction  (IEA,ISO)
positive regulation of smooth muscle cell migration  (IEA,ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of steroid hormone biosynthetic process  (IDA)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of trophectodermal cell proliferation  (IEA,ISO)
positive regulation of type B pancreatic cell proliferation  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (IEA,ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (IEA,ISO)
positive regulation of vascular endothelial cell proliferation  (IGI)
postsynaptic modulation of chemical synaptic transmission  (ISO)
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis  (ISO)
prostate gland epithelium morphogenesis  (ISO)
prostate gland growth  (ISO)
prostate gland stromal morphogenesis  (ISO)
protein stabilization  (IEA,ISO)
proteoglycan biosynthetic process  (IEA,ISO)
regulation of calcium ion transport  (IDA)
regulation of cell population proliferation  (IDA)
regulation of establishment or maintenance of cell polarity  (ISO)
regulation of gene expression  (ISO)
regulation of nitric oxide biosynthetic process  (ISO)
regulation of protein metabolic process  (ISO)
regulation of protein phosphorylation  (IBA,IEA,ISO)
regulation of translation  (IMP)
response to activity  (IEP)
response to caffeine  (IEP)
response to epidermal growth factor  (IEP)
response to estradiol  (IEP)
response to ethanol  (IDA,IEP)
response to glucocorticoid  (IEP)
response to growth hormone  (IEP)
response to heat  (IEA,ISO)
response to hypoxia  (IEP)
response to lipopolysaccharide  (IEP)
response to mechanical stimulus  (IEP)
response to nicotine  (IEP)
response to nutrient  (IEP)
response to nutrient levels  (IEP)
response to organic cyclic compound  (IEP)
response to organic substance  (IEP)
response to starvation  (IEP)
response to steroid hormone  (IEP)
response to thyroid hormone  (IEP)
retinal cell apoptotic process  (IDA)
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration  (IEA,ISO)
type B pancreatic cell proliferation  (ISO)
type I pneumocyte differentiation  (ISO)
type II pneumocyte differentiation  (ISO)
wound healing  (IEA,ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References - curated
# Reference Title Reference Citation
1. Vascular endothelial growth factor and insulin-like growth factor-1 in polycystic ovary syndrome and their relation to ovarian blood flow. Abd El Aal DE, etal., Eur J Obstet Gynecol Reprod Biol. 2005 Feb 1;118(2):219-24.
2. Stability of local brain levels of insulin-like growth factor-I in two well-characterized models of decreased plasma IGF-I. Adams MM, etal., Growth Factors. 2009 Apr 2:1.
3. Elevated serum insulin-like growth factor-1 (IGF-1) levels in women with postadolescent acne. Aizawa H and Niimura M, J Dermatol. 1995 Apr;22(4):249-52.
4. Growth hormone action on proliferation and differentiation of cerebral cortical cells from fetal rat. Ajo R, etal., Endocrinology 2003 Mar;144(3):1086-97.
5. Identification of IGF-I in the calvarial suture of young rats: histochemical analysis of the cranial sagittal sutures in a hyperthyroid rat model. Akita S, etal., Plast Reconstr Surg. 1996 Jan;97(1):1-12.
6. The intrahepatic biliary epithelium is a target of the growth hormone/insulin-like growth factor 1 axis. Alvaro D, etal., J Hepatol. 2005 Nov;43(5):875-83. Epub 2005 May 31.
7. Cognitive and neuroendocrine response to transdermal estrogen in postmenopausal women with Alzheimer's disease: results of a placebo-controlled, double-blind, pilot study. Asthana S, etal., Psychoneuroendocrinology. 1999 Aug;24(6