Id2 (inhibitor of DNA binding 2) - Rat Genome Database

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Gene: Id2 (inhibitor of DNA binding 2) Rattus norvegicus
Analyze
Symbol: Id2
Name: inhibitor of DNA binding 2
RGD ID: 2859
Description: Predicted to enable several functions, including transcription corepressor activity; transcription regulator inhibitor activity; and transmembrane transporter binding activity. Involved in several processes, including cellular response to follicle-stimulating hormone stimulus; negative regulation of macromolecule biosynthetic process; and positive regulation of cell population proliferation. Located in chromatin; cytoplasm; and nucleus. Orthologous to human ID2 (inhibitor of DNA binding 2); PARTICIPATES IN hypoxia inducible factor pathway; transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Ac2-300; DNA-binding protein inhibitor ID-2; inhibitor of differentiation 2; inhibitor of DNA binding 2, dominant negative helix-loop-helix protein; inhibitor of DNA binding 2, HLH protein; MGC105494
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Kiddil2 Kiddil4
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8647,469,162 - 47,470,995 (-)NCBIGRCr8
mRatBN7.2641,740,556 - 41,742,393 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl641,728,946 - 41,744,400 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx642,055,220 - 42,057,023 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0642,370,032 - 42,371,841 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0641,803,153 - 41,804,964 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0644,360,077 - 44,361,908 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl644,348,501 - 44,363,915 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0653,084,391 - 53,086,222 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4642,781,476 - 42,783,307 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1642,784,059 - 42,786,427 (-)NCBI
Celera641,019,266 - 41,021,097 (-)NCBICelera
RH 3.4 Map6240.21RGD
Cytogenetic Map6q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,3,5-trinitro-1,3,5-triazinane  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butoxyethanol  (ISO)
2-methoxyethanol  (EXP)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-aminobenzamide  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3-Nitrobenzanthrone  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
acetamide  (EXP)
acetylsalicylic acid  (EXP)
aflatoxin B1  (EXP)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
amiodarone  (ISO)
amitrole  (EXP,ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
amphotericin B  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
baricitinib  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-D-glucosamine  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
butanal  (ISO)
butyric acid  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
ceric oxide  (ISO)
chloroprene  (EXP,ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
Clofop  (ISO)
clozapine  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diallyl disulfide  (EXP)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (EXP)
dichromium trioxide  (ISO)
diclofenac  (ISO)
dieldrin  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (EXP,ISO)
disulfiram  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
enzacamene  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenofibrate  (ISO)
fenpyroximate  (ISO)
fenvalerate  (ISO)
flusilazole  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gentamycin  (EXP)
glafenine  (EXP)
glycine betaine  (EXP)
glyphosate  (ISO)
haloperidol  (EXP)
harmine  (ISO)
hexaconazole  (ISO)
hydrogen chloride  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
inulin  (ISO)
iodoacetic acid  (ISO)
irinotecan  (ISO)
iron dichloride  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
Licochalcone B  (ISO)
linalool  (ISO)
lipopolysaccharide  (EXP,ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
methimazole  (EXP,ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (EXP)
methylseleninic acid  (ISO)
mianserin  (ISO)
motexafin gadolinium  (ISO)
N(4)-hydroxycytidine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-acetylsphingosine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
n-propyl gallate  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nickel sulfate  (ISO)
nicotine  (ISO)
nitrofen  (ISO)
nitroglycerin  (EXP)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
ouabain  (ISO)
oxaliplatin  (EXP)
ozone  (EXP)
panaxydol  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
PhIP  (EXP)
pinosylvin  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
pomalidomide  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
propiconazole  (ISO)
prostaglandin F2alpha  (EXP)
quercetin  (EXP,ISO)
ranitidine  (EXP)
resorcinol  (ISO)
rotenone  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (EXP)
streptozocin  (EXP)
succimer  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
Tanshinone I  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trans-pinosylvin  (ISO)
triadimefon  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
uranium atom  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
vincaleukoblastine  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
WIN 18446  (ISO)
zearalenone  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adipose tissue development  (ISO)
adult locomotory behavior  (ISO)
astrocyte differentiation  (ISO)
B cell differentiation  (ISO)
bundle of His development  (ISO)
cell development  (ISO)
cell differentiation  (IEA)
cell maturation  (ISO)
cell morphogenesis involved in neuron differentiation  (ISO)
cellular response to follicle-stimulating hormone stimulus  (IEP)
cellular response to lithium ion  (ISO)
cellular senescence  (ISO,ISS)
circadian regulation of gene expression  (ISO,ISS)
circadian rhythm  (ISO)
dopaminergic neuron differentiation  (ISO)
embryonic digestive tract morphogenesis  (ISO,ISS)
endodermal digestive tract morphogenesis  (ISO,ISS)
entrainment of circadian clock  (ISO)
entrainment of circadian clock by photoperiod  (ISO,ISS)
enucleate erythrocyte differentiation  (ISO)
epithelial cell differentiation involved in mammary gland alveolus development  (ISO,ISS)
erythrocyte differentiation  (ISO)
heart development  (ISO)
leukocyte differentiation  (ISO)
locomotor rhythm  (ISO,ISS)
mammary gland alveolus development  (ISO,ISS)
mammary gland epithelial cell proliferation  (ISO,ISS)
membranous septum morphogenesis  (ISO)
metanephros development  (ISO)
natural killer cell differentiation  (ISO)
negative regulation of B cell differentiation  (ISO)
negative regulation of DNA-binding transcription factor activity  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of dopaminergic neuron differentiation  (ISO)
negative regulation of gene expression  (IMP,ISO,ISS)
negative regulation of muscle cell differentiation  (ISO)
negative regulation of oligodendrocyte differentiation  (ISO)
negative regulation of osteoblast differentiation  (ISO)
negative regulation of transcription by RNA polymerase II  (IBA,IDA,IEA,ISO)
neuron differentiation  (IBA,IEP)
neuron fate commitment  (ISO,ISS)
olfactory bulb development  (ISO)
oligodendrocyte development  (ISO)
oligodendrocyte differentiation  (ISO)
Peyer's patch development  (ISO)
positive regulation of astrocyte differentiation  (ISO)
positive regulation of blood pressure  (ISO,ISS)
positive regulation of cell cycle  (IDA)
positive regulation of cell population proliferation  (IDA)
positive regulation of DNA-templated transcription  (ISO,ISS)
positive regulation of erythrocyte differentiation  (ISO)
positive regulation of fat cell differentiation  (ISO)
positive regulation of gene expression  (ISO,ISS)
positive regulation of macrophage differentiation  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO,ISS)
regulation of circadian rhythm  (ISO,ISS)
regulation of G1/S transition of mitotic cell cycle  (ISO)
regulation of gene expression  (ISO,ISS)
regulation of lipid metabolic process  (ISO,ISS)
regulation of neural precursor cell proliferation  (ISO,ISS)
regulation of neuron differentiation  (ISO,ISS)
regulation of transcription by RNA polymerase II  (ISO)
rhythmic process  (IEA)
thigmotaxis  (ISO)
white fat cell differentiation  (ISO)

Cellular Component
chromatin  (IDA)
cytoplasm  (IDA,IEA,ISO)
cytosol  (ISO)
euchromatin  (ISO)
nucleus  (IBA,IDA,IEA,ISO)
protein-containing complex  (ISO,ISS)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
4. Contribution of the helix-loop-helix factor Id2 to regulation of vascular smooth muscle cell proliferation. Matsumura ME, etal., J Biol Chem 2002 Mar 1;277(9):7293-7.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Role of the basic helix-loop-helix transcription factor, scleraxis, in the regulation of Sertoli cell function and differentiation. Muir T, etal., Mol Endocrinol. 2005 Aug;19(8):2164-74. Epub 2005 Apr 14.
7. Activation of helix-loop-helix proteins Id1, Id2 and Id3 during neural differentiation. Nagata Y and Todokoro K, Biochem Biophys Res Commun 1994 Mar 30;199(3):1355-62.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Id2 leaves the chromatin of the E2F4-p130-controlled c-myc promoter during hepatocyte priming for liver regeneration. Rodriguez JL, etal., Biochem J. 2006 Sep 15;398(3):431-7.
14. The Id2 transcriptional repressor is induced by follicle-stimulating hormone and cAMP. Scobey MJ, etal., J Biol Chem. 2004 Apr 16;279(16):16064-70. Epub 2004 Feb 4.
15. Hindlimb unloading increases muscle content of cytosolic but not nuclear Id2 and p53 proteins in young adult and aged rats. Siu PM, etal., J Appl Physiol. 2006 Mar;100(3):907-16. Epub 2005 Nov 10.
16. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
17. Upregulation of the HLH Id gene family in neural progenitors and glial cells of the rat spinal cord following contusion injury. Tzeng SF, etal., J Neurosci Res. 2001 Dec 15;66(6):1161-72.
18. A role for the helix-loop-helix protein Id2 in the control of oligodendrocyte development. Wang S, etal., Neuron. 2001 Mar;29(3):603-14.
Additional References at PubMed
PMID:1922066   PMID:7864897   PMID:8233567   PMID:9418957   PMID:9892729   PMID:10835421   PMID:12456807   PMID:12477932   PMID:12532109   PMID:12878164   PMID:14627819   PMID:15246553  
PMID:15472070   PMID:15489334   PMID:15569159   PMID:15616565   PMID:15647457   PMID:16304207   PMID:16311606   PMID:16443197   PMID:16481593   PMID:16888283   PMID:17452521   PMID:17604724  
PMID:17681138   PMID:18029094   PMID:18367557   PMID:18437010   PMID:18474814   PMID:18498089   PMID:18523151   PMID:18562627   PMID:19109490   PMID:19217292   PMID:19362560   PMID:19740747  
PMID:20815767   PMID:20861012   PMID:21330551   PMID:21675116   PMID:22041901   PMID:23264561   PMID:23994058   PMID:26187693   PMID:26768262   PMID:27938661   PMID:30143582   PMID:31539631  
PMID:33808082  


Genomics

Comparative Map Data
Id2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8647,469,162 - 47,470,995 (-)NCBIGRCr8
mRatBN7.2641,740,556 - 41,742,393 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl641,728,946 - 41,744,400 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx642,055,220 - 42,057,023 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0642,370,032 - 42,371,841 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0641,803,153 - 41,804,964 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0644,360,077 - 44,361,908 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl644,348,501 - 44,363,915 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0653,084,391 - 53,086,222 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4642,781,476 - 42,783,307 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1642,784,059 - 42,786,427 (-)NCBI
Celera641,019,266 - 41,021,097 (-)NCBICelera
RH 3.4 Map6240.21RGD
Cytogenetic Map6q16NCBI
ID2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3828,682,056 - 8,684,461 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl28,678,845 - 8,684,461 (+)EnsemblGRCh38hg38GRCh38
GRCh3728,822,186 - 8,824,591 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3628,739,564 - 8,742,034 (+)NCBINCBI36Build 36hg18NCBI36
Build 3428,772,710 - 8,775,179NCBI
Celera28,735,903 - 8,738,373 (+)NCBICelera
Cytogenetic Map2p25.1NCBI
HuRef28,668,297 - 8,670,767 (+)NCBIHuRef
CHM1_128,751,514 - 8,753,984 (+)NCBICHM1_1
T2T-CHM13v2.028,705,779 - 8,708,184 (+)NCBIT2T-CHM13v2.0
Id2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391225,143,798 - 25,146,091 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1225,143,798 - 25,147,139 (-)EnsemblGRCm39 Ensembl
GRCm381225,093,799 - 25,096,092 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1225,093,799 - 25,097,140 (-)EnsemblGRCm38mm10GRCm38
MGSCv371225,778,664 - 25,780,957 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361225,682,879 - 25,685,148 (-)NCBIMGSCv36mm8
Celera1226,550,909 - 26,553,204 (-)NCBICelera
Cytogenetic Map12A1.3NCBI
cM Map128.57NCBI
Id2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955487878,326 - 880,783 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955487878,326 - 880,783 (-)NCBIChiLan1.0ChiLan1.0
ID2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212117,832,530 - 117,834,913 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A117,836,503 - 117,838,791 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A8,681,592 - 8,684,014 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A8,847,776 - 8,850,720 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A8,847,776 - 8,850,720 (+)Ensemblpanpan1.1panPan2
LOC102151783
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11054,954,852 - 54,957,116 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1054,908,126 - 54,908,533 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01055,955,571 - 55,955,978 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11055,647,787 - 55,648,194 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01055,934,604 - 55,935,011 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01056,221,310 - 56,221,717 (+)NCBIUU_Cfam_GSD_1.0
Id2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629250,481,184 - 50,483,643 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365325,236,037 - 5,238,881 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365325,236,175 - 5,238,689 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ID2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3127,500,763 - 127,503,257 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13127,500,759 - 127,503,207 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23135,801,813 - 135,804,261 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ID2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11498,962,001 - 98,964,486 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604513,366,676 - 13,369,585 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Id2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248462,277,961 - 2,283,571 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248462,281,292 - 2,283,596 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Id2
11 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:485
Count of miRNA genes:251
Interacting mature miRNAs:301
Transcripts:ENSRNOT00000009491
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)63878398983783989Rat
8693632Alc27Alcohol consumption QTL 272.20.791drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)63432335751121479Rat
634318Bw118Body weight QTL 1183.55abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)63330954957730294Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)63523041780230417Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)61653614061536140Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63207442872227641Rat
1354632Scl29Serum cholesterol level QTL 293.74blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)63509870971636405Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6143394190Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6142487980Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6142487980Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6142838846Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)62033877762613667Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63330954981132889Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)63569161857730540Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6142487980Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)61653614071636405Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)63443413777102317Rat

Markers in Region
AI255428  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2641,740,539 - 41,740,681 (+)MAPPERmRatBN7.2
Rnor_6.0644,360,061 - 44,360,202NCBIRnor6.0
Rnor_5.0653,084,375 - 53,084,516UniSTSRnor5.0
RGSC_v3.4642,781,460 - 42,781,601UniSTSRGSC3.4
Celera641,019,250 - 41,019,391UniSTS
Cytogenetic Map6q16UniSTS
RH94852  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2641,740,578 - 41,740,693 (+)MAPPERmRatBN7.2
Rnor_6.0644,360,100 - 44,360,214NCBIRnor6.0
Rnor_5.0653,084,414 - 53,084,528UniSTSRnor5.0
RGSC_v3.4642,781,499 - 42,781,613UniSTSRGSC3.4
Celera641,019,289 - 41,019,403UniSTS
RH 3.4 Map6240.21UniSTS
Cytogenetic Map6q16UniSTS
PMC133998P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2641,741,634 - 41,742,329 (+)MAPPERmRatBN7.2
Rnor_6.0644,361,150 - 44,361,844NCBIRnor6.0
Rnor_5.0653,085,464 - 53,086,158UniSTSRnor5.0
RGSC_v3.4642,782,549 - 42,783,243UniSTSRGSC3.4
Celera641,020,339 - 41,021,033UniSTS
Cytogenetic Map6q16UniSTS
PMC305683P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2641,741,634 - 41,742,329 (+)MAPPERmRatBN7.2
Rnor_6.0644,361,150 - 44,361,844NCBIRnor6.0
Rnor_5.0653,085,464 - 53,086,158UniSTSRnor5.0
RGSC_v3.4642,782,549 - 42,783,243UniSTSRGSC3.4
Celera641,020,339 - 41,021,033UniSTS
Cytogenetic Map6q16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000009491   ⟹   ENSRNOP00000009491
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl641,740,012 - 41,742,410 (-)Ensembl
Rnor_6.0 Ensembl644,360,077 - 44,361,908 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000085925   ⟹   ENSRNOP00000070000
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl641,728,946 - 41,744,400 (-)Ensembl
Rnor_6.0 Ensembl644,348,501 - 44,363,915 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116200   ⟹   ENSRNOP00000088071
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl641,728,946 - 41,744,359 (-)Ensembl
RefSeq Acc Id: NM_013060   ⟹   NP_037192
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8647,469,162 - 47,470,995 (-)NCBI
mRatBN7.2641,740,556 - 41,742,393 (-)NCBI
Rnor_6.0644,360,077 - 44,361,908 (-)NCBI
Rnor_5.0653,084,391 - 53,086,222 (-)NCBI
RGSC_v3.4642,781,476 - 42,783,307 (-)RGD
Celera641,019,266 - 41,021,097 (-)RGD
Sequence:
RefSeq Acc Id: NP_037192   ⟸   NM_013060
- UniProtKB: P41137 (UniProtKB/Swiss-Prot),   A6HAZ2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000009491   ⟸   ENSRNOT00000009491
Ensembl Acc Id: ENSRNOP00000070000   ⟸   ENSRNOT00000085925
Ensembl Acc Id: ENSRNOP00000088071   ⟸   ENSRNOT00000116200
Protein Domains
bHLH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P41137-F1-model_v2 AlphaFold P41137 1-134 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694526
Promoter ID:EPDNEW_R5049
Type:single initiation site
Name:Id2_1
Description:inhibitor of DNA binding 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0644,361,925 - 44,361,985EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2859 AgrOrtholog
BioCyc Gene G2FUF-38016 BioCyc
Ensembl Genes ENSRNOG00000007237 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055005697 UniProtKB/Swiss-Prot
  ENSRNOG00060009478 UniProtKB/Swiss-Prot
  ENSRNOG00065010345 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000009491.7 UniProtKB/Swiss-Prot
  ENSRNOT00000085925.2 UniProtKB/TrEMBL
  ENSRNOT00000116200.1 UniProtKB/TrEMBL
  ENSRNOT00055009187 UniProtKB/Swiss-Prot
  ENSRNOT00060016002 UniProtKB/Swiss-Prot
  ENSRNOT00065016714 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7303450 IMAGE-MGC_LOAD
InterPro bHLH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA-bd_prot-inh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25587 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:105494 IMAGE-MGC_LOAD
NCBI Gene 25587 ENTREZGENE
PANTHER DNA-BINDING PROTEIN INHIBITOR ID-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11723 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Id2 PhenoGen
PROSITE BHLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007237 RatGTEx
  ENSRNOG00055005697 RatGTEx
  ENSRNOG00060009478 RatGTEx
  ENSRNOG00065010345 RatGTEx
SMART HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC204649
UniProt A6HAZ2 ENTREZGENE, UniProtKB/TrEMBL
  ID2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q7TPI4_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-10-19 Id2  inhibitor of DNA binding 2  Id2  inhibitor of DNA binding 2, HLH protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-03-15 Id2  inhibitor of DNA binding 2, HLH protein  Id2  inhibitor of DNA binding 2, dominant negative helix-loop-helix protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-25 Id2  inhibitor of DNA binding 2, dominant negative helix-loop-helix protein  Id2  inhibitor of DNA binding 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Id2  inhibitor of DNA binding 2    Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein  Name updated 1299863 APPROVED
2002-06-10 Id2  Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process may be involved in the early stage of neural differentiation 729182
gene_process overexpression promotes smooth muscle cell (SMC) proliferation 619536
gene_process inhibits p21 expression in smooth muscle cells 619536