Id1 (inhibitor of DNA binding 1) - Rat Genome Database

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Gene: Id1 (inhibitor of DNA binding 1) Rattus norvegicus
Analyze
Symbol: Id1
Name: inhibitor of DNA binding 1
RGD ID: 2858
Description: Enables identical protein binding activity and proteasome binding activity. Involved in several processes, including cell-abiotic substrate adhesion; negative regulation of cell differentiation; and regulation of gene expression. Located in centrosome. Used to study pulmonary hypertension. Biomarker of cholestasis. Orthologous to human ID1 (inhibitor of DNA binding 1); PARTICIPATES IN interleukin-3 signaling pathway; transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DNA-binding protein inhibitor ID-1; ID125A; Idb1; inhibitor of differentiation 1; Inhibitor of DNA binding 1 helix-loop-helix protein (splice varaiation); inhibitor of DNA binding 1, dominant negative helix-loop-helix protein; Inhibitor of DNA binding 1, helix-loop-helix protein (splice variation); inhibitor of DNA binding 1, HLH protein; MGC156482
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83161,671,525 - 161,672,691 (+)NCBIGRCr8
mRatBN7.23141,210,666 - 141,212,420 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3141,211,267 - 141,212,419 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3145,116,210 - 145,117,337 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03153,700,048 - 153,701,175 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03151,439,728 - 151,440,855 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03148,214,623 - 148,216,715 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3148,215,540 - 148,216,718 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03154,619,728 - 154,621,190 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43143,086,162 - 143,087,289 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13142,991,791 - 142,992,906 (+)NCBI
Celera3139,960,608 - 139,961,735 (+)NCBICelera
Cytogenetic Map3q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(R)-pantothenic acid  (ISO)
(S)-nicotine  (ISO)
1,4-dioxane  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
Actein  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
angiotensin II  (ISO)
antimonite  (ISO)
Archazolid B  (ISO)
aristolochic acid A  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
avobenzone  (ISO)
azoxystrobin  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP,ISO)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bucladesine  (ISO)
butan-1-ol  (ISO)
Butylbenzyl phthalate  (EXP)
butyric acid  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
candesartan  (EXP)
cannabidiol  (ISO)
cannabidiolic acid  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
DDE  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diallyl disulfide  (EXP)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (EXP,ISO)
dibenzo[a,l]pyrene  (EXP)
dibutyl phthalate  (EXP)
dichromium trioxide  (ISO)
dioxygen  (EXP,ISO)
dipentyl phthalate  (EXP)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethane  (ISO)
ethanol  (ISO)
fenpyroximate  (ISO)
ferric oxide  (ISO)
flavonoids  (EXP)
fluoranthene  (EXP,ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (ISO)
furosemide  (EXP)
gamma-hexachlorocyclohexane  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
geraniol  (ISO)
glucose  (ISO)
gossypol  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
icariin  (ISO)
iloprost  (ISO)
indometacin  (ISO)
inulin  (ISO)
iron dichloride  (ISO)
isoprenaline  (EXP,ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
leflunomide  (EXP,ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
methamphetamine  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (EXP)
Muraglitazar  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
N-nitrosomorpholine  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
ochratoxin A  (EXP)
octreotide  (ISO)
orphenadrine  (EXP)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
panaxydol  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
pasireotide  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phlorizin  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
pomalidomide  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
propiconazole  (ISO)
prostaglandin F2alpha  (EXP)
quercetin  (EXP)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resorcinol  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
Securinine  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP,ISO)
Soman  (EXP)
succimer  (ISO)
sulfadimethoxine  (EXP)
sulindac sulfide  (ISO)
sunitinib  (ISO)
tacrolimus (anhydrous)  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
treprostinil  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
troglitazone  (EXP)
trovafloxacin  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zearalenone  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (ISO)
BMP signaling pathway  (ISO)
cell differentiation  (IEA)
cell-abiotic substrate adhesion  (IEP)
cellular response to dopamine  (IEP)
cellular response to epidermal growth factor stimulus  (IEP)
cellular response to nerve growth factor stimulus  (IEP)
cellular response to peptide  (IEP)
cellular response to transforming growth factor beta stimulus  (IEP)
circadian rhythm  (ISO)
collagen metabolic process  (ISO)
endothelial cell apoptotic process  (ISO)
endothelial cell morphogenesis  (ISO)
heart development  (ISO)
lung morphogenesis  (ISO)
lung vasculature development  (ISO)
negative regulation of apoptotic process  (IMP)
negative regulation of cold-induced thermogenesis  (ISO,ISS)
negative regulation of dendrite morphogenesis  (IMP)
negative regulation of DNA binding  (IMP)
negative regulation of DNA-binding transcription factor activity  (ISO)
negative regulation of DNA-templated transcription  (ISO,ISS)
negative regulation of endothelial cell apoptotic process  (ISO)
negative regulation of endothelial cell differentiation  (IMP)
negative regulation of gene expression  (ISO)
negative regulation of osteoblast differentiation  (ISO)
negative regulation of protein binding  (IMP)
negative regulation of transcription by RNA polymerase II  (IBA,IEA,IMP,ISO)
neuron differentiation  (IBA,IEP)
positive regulation of actin filament bundle assembly  (IMP)
positive regulation of epithelial cell proliferation  (IMP)
positive regulation of gene expression  (IMP,ISO)
protein destabilization  (ISO)
regulation of angiogenesis  (ISO)
regulation of MAPK cascade  (ISO)
regulation of vasculature development  (IMP)
response to antibiotic  (ISO)

Cellular Component
centrosome  (IDA)
cytoplasm  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Regeneration of three layers vascular wall by using BMP2-treated MSC involving HIF-1alpha and Id1 expressions through JAK/STAT pathways. Belmokhtar K, etal., Stem Cell Rev. 2011 Nov;7(4):847-59. doi: 10.1007/s12015-011-9254-6.
2. TGF-beta repression of Id2 induces apoptosis in gut epithelial cells. Cao Y, etal., Oncogene. 2009 Feb 26;28(8):1089-98. doi: 10.1038/onc.2008.456. Epub 2009 Jan 12.
3. Bone morphogenetic protein 4, inhibitor of differentiation 1, and epidermal growth factor receptor regulate the survival of cochlear sensory epithelial cells. Chen J, etal., J Neurosci Res. 2013 Apr;91(4):515-26. doi: 10.1002/jnr.23175. Epub 2013 Jan 18.
4. Regulation of Id1 and its association with basic helix-loop-helix proteins during nerve growth factor-induced differentiation of PC12 cells. Einarson MB and Chao MV, Mol Cell Biol. 1995 Aug;15(8):4175-83.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. A centrosomal Cdc20-APC pathway controls dendrite morphogenesis in postmitotic neurons. Kim AH, etal., Cell. 2009 Jan 23;136(2):322-36.
8. Id1, Id2 and Id3 are induced in rat melanotrophs of the pituitary gland by dopamine suppression under continuous stress. Konishi H, etal., Neuroscience. 2010 Sep 15;169(4):1527-34. doi: 10.1016/j.neuroscience.2010.06.030. Epub 2010 Jun 20.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Activation of helix-loop-helix proteins Id1, Id2 and Id3 during neural differentiation. Nagata Y and Todokoro K, Biochem Biophys Res Commun 1994 Mar 30;199(3):1355-62.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Id1 Promotes Obesity by Suppressing Brown Adipose Thermogenesis and White Adipose Browning. Patil M, etal., Diabetes. 2017 Jun;66(6):1611-1625. doi: 10.2337/db16-1079. Epub 2017 Mar 7.
13. Requirement for Id1 in opioid-induced oligodendrogenesis in cultured adult rat hippocampal progenitors. Persson AI, etal., Eur J Neurosci. 2006 May;23(9):2277-88.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
16. The ubiquitin receptor S5a/Rpn10 links centrosomal proteasomes with dendrite development in the mammalian brain. Puram SV, etal., Cell Rep. 2013 Jul 11;4(1):19-30. doi: 10.1016/j.celrep.2013.06.006. Epub 2013 Jul 3.
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. BMP type I receptor ALK2 is required for angiotensin II-induced cardiac hypertrophy. Shahid M, etal., Am J Physiol Heart Circ Physiol. 2016 Apr 15;310(8):H984-94. doi: 10.1152/ajpheart.00879.2015. Epub 2016 Feb 12.
19. FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension. Spiekerkoetter E, etal., J Clin Invest. 2013 Aug;123(8):3600-13. doi: 10.1172/JCI65592. Epub 2013 Jul 15.
20. Transcriptional regulation in cardiac muscle. Coordinate expression of Id with a neonatal phenotype during development and following a hypertrophic stimulus in adult rat ventricular myocytes in vitro. Springhorn JP, etal., J Biol Chem 1992 Jul 15;267(20):14360-5.
21. Posttranscriptional regulation of Id1 activity in cardiac muscle. Alternative splicing of novel Id1 transcript permits homodimerization. Springhorn JP, etal., J Biol Chem 1994 Feb 18;269(7):5132-6.
22. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
23. Id1, Id2, and Id3 gene expression in neural cells during development. Tzeng SF and de Vellis J, Glia. 1998 Dec;24(4):372-81.
24. Upregulation of the HLH Id gene family in neural progenitors and glial cells of the rat spinal cord following contusion injury. Tzeng SF, etal., J Neurosci Res. 2001 Dec 15;66(6):1161-72.
25. Regulation of E-box DNA binding during in vivo and in vitro activation of rat and human hepatic stellate cells. Vincent KJ, etal., Gut. 2001 Nov;49(5):713-9.
26. Integrated microarray analysis provided novel insights to the pathogenesis of glaucoma. Wang J, etal., Mol Med Rep. 2017 Dec;16(6):8735-8746. doi: 10.3892/mmr.2017.7711. Epub 2017 Oct 4.
27. Id1 is a critical mediator in TGF-beta-induced transdifferentiation of rat hepatic stellate cells. Wiercinska E, etal., Hepatology. 2006 May;43(5):1032-41.
28. Smad-dependent and smad-independent induction of id1 by prostacyclin analogues inhibits proliferation of pulmonary artery smooth muscle cells in vitro and in vivo. Yang J, etal., Circ Res. 2010 Jul 23;107(2):252-62. doi: 10.1161/CIRCRESAHA.109.209940. Epub 2010 Jun 3.
29. CCN1 promotes the differentiation of endothelial progenitor cells and reendothelialization in the early phase after vascular injury. Yu Y, etal., Basic Res Cardiol. 2010 Nov;105(6):713-24. doi: 10.1007/s00395-010-0117-0. Epub 2010 Sep 10.
Additional References at PubMed
PMID:1922066   PMID:7864897   PMID:8889548   PMID:9013644   PMID:9418957   PMID:12477932   PMID:12495223   PMID:12498716   PMID:15138269   PMID:15161906   PMID:15322112   PMID:15361847  
PMID:15472070   PMID:15564458   PMID:15647457   PMID:15809768   PMID:15820682   PMID:16304207   PMID:16638616   PMID:16728343   PMID:17149750   PMID:17681138   PMID:17717145   PMID:19217292  
PMID:19796622   PMID:20231428   PMID:22139302   PMID:25010525   PMID:25502463   PMID:27127787   PMID:29721855  


Genomics

Comparative Map Data
Id1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83161,671,525 - 161,672,691 (+)NCBIGRCr8
mRatBN7.23141,210,666 - 141,212,420 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3141,211,267 - 141,212,419 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3145,116,210 - 145,117,337 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03153,700,048 - 153,701,175 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03151,439,728 - 151,440,855 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03148,214,623 - 148,216,715 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3148,215,540 - 148,216,718 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03154,619,728 - 154,621,190 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43143,086,162 - 143,087,289 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13142,991,791 - 142,992,906 (+)NCBI
Celera3139,960,608 - 139,961,735 (+)NCBICelera
Cytogenetic Map3q41NCBI
ID1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382031,605,289 - 31,606,510 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2031,573,014 - 31,606,515 (+)EnsemblGRCh38hg38GRCh38
GRCh372030,193,092 - 30,194,313 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362029,656,753 - 29,657,974 (+)NCBINCBI36Build 36hg18NCBI36
Build 342029,656,752 - 29,657,974NCBI
Celera2026,949,273 - 26,950,494 (+)NCBICelera
Cytogenetic Map20q11.21NCBI
HuRef2026,981,781 - 26,983,013 (+)NCBIHuRef
CHM1_12030,096,962 - 30,098,194 (+)NCBICHM1_1
T2T-CHM13v2.02033,329,528 - 33,330,749 (+)NCBIT2T-CHM13v2.0
Id1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392152,578,171 - 152,579,330 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2152,578,171 - 152,579,330 (+)EnsemblGRCm39 Ensembl
GRCm382152,736,251 - 152,737,410 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2152,736,251 - 152,737,410 (+)EnsemblGRCm38mm10GRCm38
MGSCv372152,562,010 - 152,563,146 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362152,427,715 - 152,428,851 (+)NCBIMGSCv36mm8
Celera2158,552,315 - 158,553,451 (+)NCBICelera
Cytogenetic Map2H1NCBI
cM Map275.41NCBI
Id1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542229,337,757 - 29,339,178 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542229,337,969 - 29,339,178 (-)NCBIChiLan1.0ChiLan1.0
ID1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22137,296,445 - 37,299,392 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12037,290,399 - 37,292,483 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02027,895,177 - 27,896,414 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12028,535,470 - 28,536,726 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2028,535,582 - 28,536,311 (+)Ensemblpanpan1.1panPan2
ID1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12421,094,339 - 21,096,276 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2421,094,755 - 21,096,276 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2420,741,568 - 20,743,501 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02421,780,949 - 21,782,885 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2421,781,704 - 21,782,885 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12421,059,018 - 21,060,951 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02421,163,982 - 21,165,918 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02421,594,218 - 21,596,151 (+)NCBIUU_Cfam_GSD_1.0
Id1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640170,179,346 - 170,180,525 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648518,610,665 - 18,612,059 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648518,610,721 - 18,611,889 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ID1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1735,316,514 - 35,317,736 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11735,316,518 - 35,317,742 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21740,187,160 - 40,188,384 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103247994
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1236,008,660 - 36,009,880 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl236,008,636 - 36,010,017 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605090,944,637 - 90,945,863 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Id1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624741896,932 - 898,343 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624741897,038 - 898,249 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Id1
8 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:391
Count of miRNA genes:230
Interacting mature miRNAs:270
Transcripts:ENSRNOT00000029660
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3121056165145956249Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3140069424146976080Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat

Markers in Region
PMC156147P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23141,211,531 - 141,211,611 (+)MAPPERmRatBN7.2
Rnor_6.03148,215,827 - 148,215,906NCBIRnor6.0
Rnor_5.03154,620,302 - 154,620,381UniSTSRnor5.0
RGSC_v3.43143,086,401 - 143,086,480UniSTSRGSC3.4
Celera3139,960,847 - 139,960,926UniSTS
Cytogenetic Map3q41UniSTS
PMC305683P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23141,211,352 - 141,212,020 (+)MAPPERmRatBN7.2
Rnor_6.03148,215,648 - 148,216,315NCBIRnor6.0
Rnor_5.03154,620,123 - 154,620,790UniSTSRnor5.0
RGSC_v3.43143,086,222 - 143,086,889UniSTSRGSC3.4
Celera3139,960,668 - 139,961,335UniSTS
Cytogenetic Map3q41UniSTS
PMC133998P5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23141,211,352 - 141,212,020 (+)MAPPERmRatBN7.2
Rnor_6.03148,215,648 - 148,216,315NCBIRnor6.0
Rnor_5.03154,620,123 - 154,620,790UniSTSRnor5.0
RGSC_v3.43143,086,222 - 143,086,889UniSTSRGSC3.4
Celera3139,960,668 - 139,961,335UniSTS
Cytogenetic Map3q41UniSTS
PMC145454P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23141,211,592 - 141,211,668 (+)MAPPERmRatBN7.2
Rnor_6.03148,215,888 - 148,215,963NCBIRnor6.0
Rnor_5.03154,620,363 - 154,620,438UniSTSRnor5.0
RGSC_v3.43143,086,462 - 143,086,537UniSTSRGSC3.4
Celera3139,960,908 - 139,960,983UniSTS
Cytogenetic Map3q41UniSTS
PMC33181P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23141,211,344 - 141,212,059 (+)MAPPERmRatBN7.2
Rnor_6.03148,215,640 - 148,216,354NCBIRnor6.0
Rnor_5.03154,620,115 - 154,620,829UniSTSRnor5.0
RGSC_v3.43143,086,214 - 143,086,928UniSTSRGSC3.4
Celera3139,960,660 - 139,961,374UniSTS
Cytogenetic Map3q41UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000029660   ⟹   ENSRNOP00000052261
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3141,211,267 - 141,212,419 (+)Ensembl
Rnor_6.0 Ensembl3148,215,540 - 148,216,718 (+)Ensembl
RefSeq Acc Id: NM_012797   ⟹   NP_036929
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,671,564 - 161,672,691 (+)NCBI
mRatBN7.23141,211,293 - 141,212,420 (+)NCBI
Rnor_6.03148,215,588 - 148,216,715 (+)NCBI
Rnor_5.03154,619,728 - 154,621,190 (+)NCBI
RGSC_v3.43143,086,162 - 143,087,289 (+)RGD
Celera3139,960,608 - 139,961,735 (+)RGD
Sequence:
RefSeq Acc Id: XM_006235267   ⟹   XP_006235329
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,671,525 - 161,672,688 (+)NCBI
mRatBN7.23141,210,666 - 141,212,417 (+)NCBI
Rnor_6.03148,214,623 - 148,216,712 (+)NCBI
Rnor_5.03154,619,728 - 154,621,190 (+)NCBI
Sequence:
RefSeq Acc Id: NP_036929   ⟸   NM_012797
- UniProtKB: P41135 (UniProtKB/Swiss-Prot),   A0JPJ2 (UniProtKB/TrEMBL),   A6KHQ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235329   ⟸   XM_006235267
- Peptide Label: isoform X1
- UniProtKB: P41135 (UniProtKB/Swiss-Prot),   A0A8L2QPI3 (UniProtKB/TrEMBL),   A6KHQ6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000052261   ⟸   ENSRNOT00000029660
Protein Domains
bHLH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P41135-F1-model_v2 AlphaFold P41135 1-164 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692549
Promoter ID:EPDNEW_R3073
Type:single initiation site
Name:Id1_1
Description:inhibitor of DNA binding 1, HLH protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03148,215,562 - 148,215,622EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2858 AgrOrtholog
BioCyc Gene G2FUF-47250 BioCyc
Ensembl Genes ENSRNOG00000021750 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000029660.6 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:8372348 IMAGE-MGC_LOAD
InterPro bHLH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA-bd_prot-inh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25261 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:156482 IMAGE-MGC_LOAD
NCBI Gene 25261 ENTREZGENE
PANTHER DNA-BINDING PROTEIN INHIBITOR ID-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11723 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Id1 PhenoGen
PROSITE BHLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000021750 RatGTEx
SMART HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC204468
UniProt A0A8L2QPI3 ENTREZGENE, UniProtKB/TrEMBL
  A0JPJ2 ENTREZGENE, UniProtKB/TrEMBL
  A6KHQ6 ENTREZGENE, UniProtKB/TrEMBL
  ID1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-10-13 Id1  inhibitor of DNA binding 1  Id1  inhibitor of DNA binding 1, HLH protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-03-15 Id1  inhibitor of DNA binding 1, HLH protein  Id1  inhibitor of DNA binding 1, dominant negative helix-loop-helix protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-25 Id1  inhibitor of DNA binding 1, dominant negative helix-loop-helix protein  Id1  inhibitor of DNA binding 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Id1  inhibitor of DNA binding 1    Inhibitor of DNA binding 1, helix-loop-helix protein (splice variation)  Name updated 1299863 APPROVED
2002-06-10 Id1  Inhibitor of DNA binding 1, helix-loop-helix protein (splice variation)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process may be involved in control of cardiac muscle cell phenotype 727553
gene_process may be involved in the early stage of neural differentiation 729182