Hsd17b1 (hydroxysteroid (17-beta) dehydrogenase 1) - Rat Genome Database

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Gene: Hsd17b1 (hydroxysteroid (17-beta) dehydrogenase 1) Rattus norvegicus
Analyze
Symbol: Hsd17b1
Name: hydroxysteroid (17-beta) dehydrogenase 1
RGD ID: 2836
Description: Enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity and testosterone dehydrogenase (NAD+) activity. Involved in bone development; cellular response to metal ion; and steroid biosynthetic process. Predicted to be active in cytosol. Orthologous to human HSD17B1 (hydroxysteroid 17-beta dehydrogenase 1); PARTICIPATES IN estradiol biosynthetic pathway; steroid hormone biosynthetic pathway; INTERACTS WITH (+)-taxifolin; (S)-nicotine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 17-beta-HSD 1; 17-beta-hydroxysteroid dehydrogenase type 1; 17BHD1; estradiol 17-beta-dehydrogenase 1; hydroxysteroid 17-beta dehydrogenase 1; Hydroxysteroid dehydrogenase 17 beta type 1; Hydroxysteroid dehydrogenase 17 beta, type 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Eau3 Pia10 Ciaa2
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,510,011 - 86,512,211 (+)NCBIGRCr8
mRatBN7.21086,009,728 - 86,011,928 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1086,009,728 - 86,011,927 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1091,046,170 - 91,048,370 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,524,986 - 90,527,186 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01085,918,153 - 85,920,353 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01088,987,558 - 88,989,758 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,987,558 - 88,989,757 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,786,054 - 88,788,254 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41090,094,249 - 90,096,451 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11090,108,618 - 90,110,820 (+)NCBI
Celera1084,727,443 - 84,729,643 (+)NCBICelera
Cytogenetic Map10q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-taxifolin  (EXP)
(S)-nicotine  (EXP,ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenol  (ISO)
2,6-dibromophenol  (ISO)
2-bromophenol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (ISO)
acetaldehyde  (ISO)
acetamiprid  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
aminoglutethimide  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
androst-5-ene-3beta,17beta-diol  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
atrazine  (EXP)
benzo[a]pyrene diol epoxide I  (ISO)
benzofurans  (ISO)
beta-naphthoflavone  (ISO)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bucladesine  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (EXP)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
coumarin  (ISO)
Cuprizon  (EXP)
cyhexatin  (ISO)
cypermethrin  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (EXP,ISO)
dehydroepiandrosterone  (ISO)
dexamethasone  (EXP)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP,ISO)
diethylstilbestrol  (EXP,ISO)
dutasteride  (ISO)
endosulfan  (EXP,ISO)
Enterolactone  (ISO)
epoxiconazole  (ISO)
estrone  (ISO)
ethylparaben  (ISO)
fentin chloride  (ISO)
fentin hydroxide  (ISO)
fenvalerate  (EXP,ISO)
Finrozole  (ISO)
flufenoxuron  (ISO)
flutamide  (EXP)
fluvastatin  (EXP)
formaldehyde  (ISO)
formestane  (ISO)
fulvestrant  (ISO)
gamma-hexachlorocyclohexane  (EXP)
genistein  (EXP,ISO)
glutathione  (EXP)
HT-2 toxin  (ISO)
iodoacetic acid  (ISO)
iron dichloride  (ISO)
isoliquiritigenin  (ISO)
L-ascorbic acid  (EXP)
lead diacetate  (ISO)
methimazole  (EXP)
methoxychlor  (EXP,ISO)
methylmercury chloride  (ISO)
metyrapone  (ISO)
microcystin-LR  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
naphthalenes  (ISO)
nicotine  (EXP,ISO)
ochratoxin A  (EXP)
paracetamol  (EXP,ISO)
perflubron  (ISO)
perfluorododecanoic acid  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
pregnenolone  (ISO)
procymidone  (ISO)
resveratrol  (ISO)
sarin  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
taurine  (EXP)
testosterone  (ISO)
tetracycline  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zearalenone  (ISO)
zinc oxide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IBA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cloning of rat 17 beta-hydroxysteroid dehydrogenase type 2 and characterization of tissue distribution and catalytic activity of rat type 1 and type 2 enzymes. Akinola LA, etal., Endocrinology 1996 May;137(5):1572-9.
2. Characterization of rat 17 beta-hydroxysteroid dehydrogenase type 1 gene and mRNA transcripts. Akinola LA, etal., Gene 1998 Feb 27;208(2):229-38.
3. Lactational exposure to hexavalent chromium delays puberty by impairing ovarian development, steroidogenesis and pituitary hormone synthesis in developing Wistar rats. Banu SK, etal., Toxicol Appl Pharmacol. 2008 Oct 15;232(2):180-9. Epub 2008 Jun 17.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat 17 beta-hydroxysteroid dehydrogenase type 1: primary structure and regulation of enzyme expression in rat ovary by diethylstilbestrol and gonadotropins in vivo. Ghersevich S, etal., Endocrinology 1994 Oct;135(4):1477-87.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Aging reduces the efficacy of estrogen substitution to attenuate cardiac hypertrophy in female spontaneously hypertensive rats. Jazbutyte V, etal., Hypertension. 2006 Oct;48(4):579-86. Epub 2006 Aug 28.
8. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
9. FSH and FOXO1 regulate genes in the sterol/steroid and lipid biosynthetic pathways in granulosa cells. Liu Z, etal., Mol Endocrinol. 2009 May;23(5):649-61. Epub 2009 Feb 5.
10. Androgen synthesis in adrenarche. Miller WL Rev Endocr Metab Disord. 2009 Mar;10(1):3-17.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. Payne AH and Hales DB, Endocr Rev. 2004 Dec;25(6):947-70.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. GOA pipeline RGD automated data pipeline
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Identification of genomic regions controlling experimental autoimmune uveoretinitis in rats. Sun SH, etal., Int Immunol 1999 Apr;11(4):529-34
17. 17Beta-hydroxysteroid dehydrogenase type 1 and type 2 in human breast carcinoma: a correlation to clinicopathological parameters. Suzuki T, etal., Br J Cancer. 2000 Feb;82(3):518-23.
18. Expression of estrogen receptors and enzymes involved in sex steroid metabolism in the rat tibia during sexual maturation. van der Eerden BC, etal., J Endocrinol. 2004 Mar;180(3):457-67.
19. Disruption in the expression and immunolocalisation of steroid receptors and steroidogenic enzymes in letrozole-induced polycystic ovaries in rat. Zurvarra FM, etal., Reprod Fertil Dev. 2009;21(7):827-39.
Additional References at PubMed
PMID:4396689   PMID:8805577   PMID:9525918   PMID:10625652   PMID:12477932   PMID:15489334   PMID:34038751  


Genomics

Comparative Map Data
Hsd17b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,510,011 - 86,512,211 (+)NCBIGRCr8
mRatBN7.21086,009,728 - 86,011,928 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1086,009,728 - 86,011,927 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1091,046,170 - 91,048,370 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,524,986 - 90,527,186 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01085,918,153 - 85,920,353 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01088,987,558 - 88,989,758 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,987,558 - 88,989,757 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,786,054 - 88,788,254 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41090,094,249 - 90,096,451 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11090,108,618 - 90,110,820 (+)NCBI
Celera1084,727,443 - 84,729,643 (+)NCBICelera
Cytogenetic Map10q31NCBI
HSD17B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381742,552,923 - 42,555,214 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1742,552,922 - 42,555,214 (+)EnsemblGRCh38hg38GRCh38
GRCh371740,704,941 - 40,707,232 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361737,957,510 - 37,960,757 (+)NCBINCBI36Build 36hg18NCBI36
Build 341737,957,509 - 37,960,757NCBI
Celera1737,359,920 - 37,363,168 (+)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1736,468,996 - 36,472,244 (+)NCBIHuRef
CHM1_11740,939,828 - 40,943,076 (+)NCBICHM1_1
T2T-CHM13v2.01743,410,112 - 43,412,403 (+)NCBIT2T-CHM13v2.0
Hsd17b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911100,968,792 - 100,972,014 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11100,969,237 - 100,971,353 (+)EnsemblGRCm39 Ensembl
GRCm3811101,077,968 - 101,081,188 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11101,078,411 - 101,080,527 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711100,939,725 - 100,941,819 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611100,894,501 - 100,896,595 (+)NCBIMGSCv36mm8
Celera11112,374,513 - 112,376,607 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1164.17NCBI
Hsd17b1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545116,449,683 - 16,451,945 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545116,449,333 - 16,452,036 (+)NCBIChiLan1.0ChiLan1.0
HSD17B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21922,429,368 - 22,431,647 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11724,319,367 - 24,325,778 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01714,760,856 - 14,763,584 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11714,986,538 - 14,989,741 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1714,986,814 - 14,988,820 (-)Ensemblpanpan1.1panPan2
HSD17B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1920,402,124 - 20,407,143 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl920,405,019 - 20,406,792 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha919,866,871 - 19,868,985 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0921,123,971 - 21,126,087 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl921,123,971 - 21,125,745 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1919,909,803 - 19,911,916 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0920,175,037 - 20,177,147 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0920,279,091 - 20,281,208 (-)NCBIUU_Cfam_GSD_1.0
Hsd17b1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560219,760,718 - 19,762,826 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649017,312,390 - 17,314,409 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649017,312,390 - 17,314,423 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSD17B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,269,056 - 20,271,548 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11220,269,468 - 20,271,349 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21220,482,373 - 20,484,253 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HSD17B1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11663,730,303 - 63,733,974 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1663,728,777 - 63,732,411 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607734,525,962 - 34,529,030 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hsd17b1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247951,551,311 - 1,553,493 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247951,551,311 - 1,553,432 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hsd17b1
5 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:182
Count of miRNA genes:132
Interacting mature miRNAs:147
Transcripts:ENSRNOT00000026878
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108051528791230079Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108256485692369470Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)108402232193995963Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)107889965587307728Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108400727295933025Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108400727295933025Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)107563188787055282Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat

Markers in Region
D10Wox46  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21086,012,200 - 86,012,394 (+)MAPPERmRatBN7.2
Rnor_6.01088,990,031 - 88,990,224NCBIRnor6.0
Rnor_5.01088,788,527 - 88,788,720UniSTSRnor5.0
RGSC_v3.41090,096,724 - 90,096,917UniSTSRGSC3.4
Celera1084,729,916 - 84,730,103UniSTS
Cytogenetic Map10q32.1UniSTS
RH134495  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21086,008,718 - 86,008,899 (+)MAPPERmRatBN7.2
Rnor_6.01088,986,549 - 88,986,729NCBIRnor6.0
Rnor_5.01088,785,045 - 88,785,225UniSTSRnor5.0
RGSC_v3.41090,093,240 - 90,093,420UniSTSRGSC3.4
Celera1084,726,434 - 84,726,614UniSTS
RH 3.4 Map10877.1UniSTS
Cytogenetic Map10q32.1UniSTS
RH142272  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21086,008,746 - 86,008,938 (+)MAPPERmRatBN7.2
Rnor_6.01088,986,577 - 88,986,768NCBIRnor6.0
Rnor_5.01088,785,073 - 88,785,264UniSTSRnor5.0
RGSC_v3.41090,093,268 - 90,093,459UniSTSRGSC3.4
Celera1084,726,462 - 84,726,653UniSTS
RH 3.4 Map10875.29UniSTS
Cytogenetic Map10q32.1UniSTS
Hsd17b1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21086,010,526 - 86,011,321 (+)MAPPERmRatBN7.2
Rnor_6.01088,988,357 - 88,989,151NCBIRnor6.0
Rnor_5.01088,786,853 - 88,787,647UniSTSRnor5.0
RGSC_v3.41090,095,050 - 90,095,844UniSTSRGSC3.4
Celera1084,728,242 - 84,729,036UniSTS
Cytogenetic Map10q32.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000026878   ⟹   ENSRNOP00000026878
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1086,009,728 - 86,011,927 (+)Ensembl
Rnor_6.0 Ensembl1088,987,558 - 88,989,757 (+)Ensembl
RefSeq Acc Id: NM_012851   ⟹   NP_036983
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,510,011 - 86,512,211 (+)NCBI
mRatBN7.21086,009,728 - 86,011,928 (+)NCBI
Rnor_6.01088,987,558 - 88,989,758 (+)NCBI
Rnor_5.01088,786,054 - 88,788,254 (+)NCBI
RGSC_v3.41090,094,249 - 90,096,451 (+)RGD
Celera1084,727,443 - 84,729,643 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036983 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH86365 (Get FASTA)   NCBI Sequence Viewer  
  CAA55389 (Get FASTA)   NCBI Sequence Viewer  
  CAA66349 (Get FASTA)   NCBI Sequence Viewer  
  CAA66657 (Get FASTA)   NCBI Sequence Viewer  
  EDM06082 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000026878.5
  ENSRNOP00060018063
GenBank Protein P51657 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036983   ⟸   NM_012851
- UniProtKB: P51657 (UniProtKB/Swiss-Prot),   A6HJ77 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026878   ⟸   ENSRNOT00000026878

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51657-F1-model_v2 AlphaFold P51657 1-344 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2836 AgrOrtholog
BioCyc Gene G2FUF-23203 BioCyc
Ensembl Genes ENSRNOG00000019830 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00060013396 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000026878.6 UniProtKB/Swiss-Prot
  ENSRNOT00060022820 UniProtKB/Swiss-Prot
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7305002 IMAGE-MGC_LOAD
InterPro 17beta_DH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sc_DH/Rdtase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SDR_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25322 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:105495 IMAGE-MGC_LOAD
NCBI Gene 25322 ENTREZGENE
PANTHER 17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RETINOL DEHYDROGENASE-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam adh_short UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hsd17b1 PhenoGen
PIRSF 17beta-HSD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS GDHRDH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SDRFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ADH_SHORT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019830 RatGTEx
  ENSRNOG00060013396 RatGTEx
Superfamily-SCOP NAD(P)-binding Rossmann-fold domains UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6HJ77 ENTREZGENE, UniProtKB/TrEMBL
  DHB1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Hsd17b1  hydroxysteroid (17-beta) dehydrogenase 1    hydroxysteroid 17-beta dehydrogenase 1  Name updated 1299863 APPROVED
2003-04-09 Hsd17b1  hydroxysteroid 17-beta dehydrogenase 1    Hydroxysteroid dehydrogenase 17 beta, type 1  Name updated 629478 APPROVED
2002-06-10 Hsd17b1  Hydroxysteroid dehydrogenase 17 beta, type 1      Symbol and Name status set to approved 70586 APPROVED