Hrh2 (histamine receptor H 2) - Rat Genome Database

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Gene: Hrh2 (histamine receptor H 2) Rattus norvegicus
Analyze
Symbol: Hrh2
Name: histamine receptor H 2
RGD ID: 2831
Description: Enables heterocyclic compound binding activity and histamine receptor activity. Involved in cellular response to histamine and negative regulation of arachidonate secretion. Predicted to be located in synapse. Predicted to be active in dendrite and plasma membrane. Biomarker of transient cerebral ischemia. Orthologous to human HRH2 (histamine receptor H2); PARTICIPATES IN cimetidine pharmacodynamics pathway; cimetidine pharmacokinetics pathway; esomeprazole pharmacodynamics pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: gastric receptor I; H2R; HH2R; histamine H2 receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81710,371,083 - 10,412,979 (-)NCBIGRCr8
mRatBN7.21710,366,004 - 10,407,791 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1710,368,298 - 10,407,631 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1710,398,835 - 10,399,911 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01711,932,184 - 11,933,260 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01710,395,275 - 10,396,351 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01710,912,959 - 10,931,389 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1710,921,507 - 10,952,441 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01713,025,894 - 13,065,409 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41716,497,967 - 16,499,043 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11716,497,966 - 16,499,043 (-)NCBI
Celera1710,455,208 - 10,456,284 (-)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
dendrite  (IBA)
membrane  (IEA)
plasma membrane  (IBA,IEA)
synapse  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Expression of mRNA encoding the H1, H2, and H3 histamine receptors in the rat cochlea. Azuma H, etal., Neuroreport 2003 Mar 3;14(3):423-5.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Postischemic regulation of central histamine receptors. Lozada A, etal., Neuroscience. 2005;136(1):371-9. Epub 2005 Sep 21.
5. Histamine H2 receptor activation exacerbates myocardial ischemia/reperfusion injury by disturbing mitochondrial and endothelial function. Luo T, etal., Basic Res Cardiol. 2013 May;108(3):342. doi: 10.1007/s00395-013-0342-4. Epub 2013 Mar 7.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Cloning and tissue expression of a rat histamine H2-receptor gene. Ruat M, etal., Biochem Biophys Res Commun 1991 Sep 30;179(3):1470-8.
13. Expression of a cloned rat histamine H2 receptor mediating inhibition of arachidonate release and activation of cAMP accumulation. Traiffort E, etal., Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):2649-53.
14. Disruption of histamine H2 receptor slows heart failure progression through reducing myocardial apoptosis and fibrosis. Zeng Z, etal., Clin Sci (Lond). 2014 Oct;127(7):435-48. doi: 10.1042/CS20130716.
Additional References at PubMed
PMID:10862789   PMID:15086532   PMID:15476751   PMID:16858644   PMID:17145090   PMID:18345502   PMID:21211106   PMID:21602597   PMID:22986235   PMID:23077168   PMID:23713466   PMID:23716698  
PMID:24702851   PMID:28964277   PMID:29498008  


Genomics

Comparative Map Data
Hrh2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81710,371,083 - 10,412,979 (-)NCBIGRCr8
mRatBN7.21710,366,004 - 10,407,791 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1710,368,298 - 10,407,631 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1710,398,835 - 10,399,911 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01711,932,184 - 11,933,260 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01710,395,275 - 10,396,351 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01710,912,959 - 10,931,389 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1710,921,507 - 10,952,441 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01713,025,894 - 13,065,409 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41716,497,967 - 16,499,043 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11716,497,966 - 16,499,043 (-)NCBI
Celera1710,455,208 - 10,456,284 (-)NCBICelera
Cytogenetic Map17p14NCBI
HRH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385175,658,071 - 175,710,756 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5175,658,030 - 175,710,756 (+)EnsemblGRCh38hg38GRCh38
GRCh375175,085,074 - 175,137,759 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365175,042,318 - 175,044,164 (+)NCBINCBI36Build 36hg18NCBI36
Build 345175,042,317 - 175,044,162NCBI
Celera5171,124,127 - 171,152,332 (+)NCBICelera
Cytogenetic Map5q35.2NCBI
HuRef5170,183,933 - 170,212,137 (+)NCBIHuRef
CHM1_15174,517,757 - 174,545,962 (+)NCBICHM1_1
T2T-CHM13v2.05176,201,850 - 176,254,534 (+)NCBIT2T-CHM13v2.0
Hrh2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391354,345,990 - 54,390,201 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1354,346,148 - 54,390,199 (+)EnsemblGRCm39 Ensembl
GRCm381354,191,970 - 54,236,182 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1354,192,129 - 54,236,180 (+)EnsemblGRCm38mm10GRCm38
MGSCv371354,287,498 - 54,317,801 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361354,201,750 - 54,232,053 (+)NCBIMGSCv36mm8
Celera1355,266,772 - 55,297,106 (+)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1328.4NCBI
Hrh2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540828,186,249 - 28,229,411 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540828,186,316 - 28,225,146 (+)NCBIChiLan1.0ChiLan1.0
HRH2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24170,788,692 - 170,841,335 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15168,928,231 - 168,980,873 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05171,004,893 - 171,057,539 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15177,928,039 - 177,955,714 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5177,928,039 - 177,931,566 (+)Ensemblpanpan1.1panPan2
HRH2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1437,333,843 - 37,407,146 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl437,275,852 - 37,386,072 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha437,330,979 - 37,332,058 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0437,699,668 - 37,772,370 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl437,641,724 - 37,772,357 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1437,574,680 - 37,575,759 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0437,762,745 - 37,763,824 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0438,272,467 - 38,273,546 (-)NCBIUU_Cfam_GSD_1.0
Hrh2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721391,901,767 - 91,941,401 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936609622,311 - 664,084 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936609624,446 - 664,049 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HRH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl281,883,673 - 81,932,275 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1281,883,670 - 81,932,464 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2283,505,532 - 83,554,274 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HRH2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12377,808,108 - 77,858,936 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2377,807,998 - 77,841,467 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666034729,121 - 782,228 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hrh2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473314,260,720 - 14,308,217 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473314,261,799 - 14,308,320 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hrh2
187 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:26
Count of miRNA genes:24
Interacting mature miRNAs:26
Transcripts:ENSRNOT00000024580
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17999128640540197Rat
631499Stl1Serum triglyceride level QTL 13.6blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)17327139827389946Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17435448727028127Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
1582224Epfw4Epididymal fat weight QTL 43.50.0058epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)17920136523653323Rat
1582225Bw67Body weight QTL 676.20.0001body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1582226Bw64Body weight QTL 644.20.0017body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1582208Kidm32Kidney mass QTL 323.90.0018kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17920136523653323Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17429913035837242Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17429913021293263Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
1581553Pur14Proteinuria QTL 145.30.0001urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)17797996816317111Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
1582258Bw76Body weight QTL 764.60.0005body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
1582199Insul5Insulin level QTL 53.40.0119blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)17920136523653323Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17435448727028127Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17211514921881669Rat
1582241Bw70Body weight QTL 704.60.0003body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1582245Bw73Body weight QTL 734.60.0004body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122871563Rat

Markers in Region
Hrh2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21710,385,019 - 10,385,515 (+)MAPPERmRatBN7.2
Rnor_6.01710,929,564 - 10,930,059NCBIRnor6.0
Rnor_5.01713,042,372 - 13,042,867UniSTSRnor5.0
RGSC_v3.41716,498,546 - 16,499,041UniSTSRGSC3.4
Celera1710,455,787 - 10,456,282UniSTS
Cytogenetic Map17p14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 9 26 105 62 61 30 25 30 6 162 72 85 43 44 31

Sequence


Ensembl Acc Id: ENSRNOT00000024580   ⟹   ENSRNOP00000024580
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1710,368,298 - 10,407,631 (-)Ensembl
Rnor_6.0 Ensembl1710,921,507 - 10,952,441 (-)Ensembl
RefSeq Acc Id: NM_001413011   ⟹   NP_001399940
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81710,371,083 - 10,412,724 (-)NCBI
mRatBN7.21710,366,004 - 10,407,643 (-)NCBI
RefSeq Acc Id: XM_063276079   ⟹   XP_063132149
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81710,371,083 - 10,391,904 (-)NCBI
RefSeq Acc Id: XR_005495238
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81710,371,083 - 10,412,979 (-)NCBI
mRatBN7.21710,368,355 - 10,407,791 (-)NCBI
RefSeq Acc Id: XR_596619
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81710,371,083 - 10,412,979 (-)NCBI
mRatBN7.21710,368,355 - 10,407,788 (-)NCBI
Rnor_6.01710,912,959 - 10,931,389 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001399940 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132149 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB19935 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000024580.2
  ENSRNOP00000111031
GenBank Protein P25102 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Acc Id: ENSRNOP00000024580   ⟸   ENSRNOT00000024580
RefSeq Acc Id: NP_001399940   ⟸   NM_001413011
- UniProtKB: P25102 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063132149   ⟸   XM_063276079
- Peptide Label: isoform X1
- UniProtKB: P25102 (UniProtKB/Swiss-Prot)
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P25102-F1-model_v2 AlphaFold P25102 1-358 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2831 AgrOrtholog
BioCyc Gene G2FUF-10162 BioCyc
Ensembl Genes ENSRNOG00000018260 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024580.4 UniProtKB/TrEMBL
  ENSRNOT00000141382 ENTREZGENE
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Histamine_H2_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25461 ENTREZGENE
PANTHER 5-HYDROXYTRYPTAMINE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HISTAMINE H2 RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hrh2 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HISTAMINEH2R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018260 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F1LNK8_RAT UniProtKB/TrEMBL
  HRH2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Hrh2  Histamine H2 receptor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression highly expressed in brain and stomach 728427
gene_protein 358 amino acid protein 728427
gene_transcript intronless gene 728427